Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor
Caravella, Justin A, Lin, Jian, Diebold, R. Bruce, Campbell, Ann-Marie, Ericsson, Anna, Gustafson, Gary, Wang, Zhongguo, Castro, Jennifer, Clarke, Andrea, Gotur, Deepali, Josephine, Helen R, Katz, Marie, Kershaw, Mark, Yao, Lili, Toms, Angela V, Barr, Kenneth J, Dinsmore, Christopher J, Walker, Duncan, Ashwell, Susan, Lu, Wei
Published in Journal of medicinal chemistry (27.02.2020)
Published in Journal of medicinal chemistry (27.02.2020)
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AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia
Balachander, Srividya B., Criscione, Steven W., Byth, Kate F., Cidado, Justin, Adam, Ammar, Lewis, Paula, Macintyre, Terry, Wen, Shenghua, Lawson, Deborah, Burke, Kathleen, Lubinski, Tristan, Tyner, Jeffrey W., Kurtz, Stephen E., McWeeney, Shannon K., Varnes, Jeffrey, Diebold, R. Bruce, Gero, Thomas, Ioannidis, Stephanos, Hennessy, Edward J., McCoull, William, Saeh, Jamal C., Tabatabai, Areya, Tavana, Omid, Su, Nancy, Schuller, Alwin, Garnett, Mathew J., Jaaks, Patricia, Coker, Elizabeth A., Gregory, Gareth P., Newbold, Andrea, Johnstone, Ricky W., Gangl, Eric, Wild, Martin, Zinda, Michael, Secrist, J. Paul, Davies, Barry R., Fawell, Stephen E., Gibbons, Francis D.
Published in Clinical cancer research (15.12.2020)
Published in Clinical cancer research (15.12.2020)
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3-Amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor
Scott, David A., Dakin, Les A., Del Valle, David J., Bruce Diebold, R., Drew, Lisa, Gero, Thomas W., Ogoe, Claude A., Omer, Charles A., Repik, Galina, Thakur, Kumar, Ye, Qing, Zheng, Xiaolan
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
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Towards the next generation of dual Bcl-2/Bcl-xL inhibitors
Varnes, Jeffrey G., Gero, Thomas, Huang, Shan, Diebold, R. Bruce, Ogoe, Claude, Grover, Paul T., Su, Mei, Mukherjee, Prasenjit, Saeh, Jamal Carlos, MacIntyre, Terry, Repik, Galina, Dillman, Keith, Byth, Kate, Russell, Daniel John, Ioannidis, Stephanos
Published in Bioorganic & medicinal chemistry letters (15.07.2014)
Published in Bioorganic & medicinal chemistry letters (15.07.2014)
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Novel Small-Molecule ROCK2 Inhibitor GNS-3595 Attenuates Pulmonary Fibrosis in Preclinical Studies
Hwang, Soyoung, Lee, Wongil, Ravi, Dashnamoorthy, Devine, William, Yong, Miyong, Diebold, R Bruce, Seung, Sang-Ae, Ng, Nicholas W, Lee, Jaekyoo, Gupta, Anu, Koh, Jong Sung
Published in American journal of respiratory cell and molecular biology (01.10.2024)
Published in American journal of respiratory cell and molecular biology (01.10.2024)
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Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors
Lin, Jian, Lu, Wei, Caravella, Justin A, Campbell, Ann Marie, Diebold, R. Bruce, Ericsson, Anna, Fritzen, Edward, Gustafson, Gary R, Lancia, David R, Shelekhin, Tatiana, Wang, Zhongguo, Castro, Jennifer, Clarke, Andrea, Gotur, Deepali, Josephine, Helen R, Katz, Marie, Diep, Hien, Kershaw, Mark, Yao, Lili, Kauffman, Goss, Hubbs, Stephen E, Luke, George P, Toms, Angela V, Wang, Liann, Bair, Kenneth W, Barr, Kenneth J, Dinsmore, Christopher, Walker, Duncan, Ashwell, Susan
Published in Journal of medicinal chemistry (25.07.2019)
Published in Journal of medicinal chemistry (25.07.2019)
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Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507
Scott, David A., Dakin, Les A., Daly, Kevin, Del Valle, David J., Diebold, R. Bruce, Drew, Lisa, Ezhuthachan, Jayachandran, Gero, Thomas W., Ogoe, Claude A., Omer, Charles A., Redmond, Sean P., Repik, Galina, Thakur, Kumar, Ye, Qing, Zheng, Xiaolan
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
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Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension
Zhu, Gui-Dong, Gandhi, Viraj B, Gong, Jianchun, Thomas, Sheela, Woods, Keith W, Song, Xiaohong, Li, Tongmei, Diebold, R. Bruce, Luo, Yan, Liu, Xuesong, Guan, Ran, Klinghofer, Vered, Johnson, Eric F, Bouska, Jennifer, Olson, Amanda, Marsh, Kennan C, Stoll, Vincent S, Mamo, Mulugeta, Polakowski, James, Campbell, Thomas J, Martin, Ruth L, Gintant, Gary A, Penning, Thomas D, Li, Qun, Rosenberg, Saul H, Giranda, Vincent L
Published in Journal of medicinal chemistry (28.06.2007)
Published in Journal of medicinal chemistry (28.06.2007)
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Towards the next generation of dual Bcl-2/Bcl-x(L) inhibitors
Varnes, Jeffrey G., Gero, Thomas, Huang, Shan, Diebold, R. Bruce, Ogoe, Claude, Grover, Paul T., Su, Mei, Mukherjee, Prasenjit, Saeh, Jamal Carlos, MacIntyre, Terry, Repik, Galina, Dillman, Keith, Byth, Kate, Russell, Daniel John, Ioannidis, Stephanos
Published in Bioorganic & medicinal chemistry letters (15.07.2014)
Published in Bioorganic & medicinal chemistry letters (15.07.2014)
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AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-x L , Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia
Balachander, Srividya B, Criscione, Steven W, Byth, Kate F, Cidado, Justin, Adam, Ammar, Lewis, Paula, Macintyre, Terry, Wen, Shenghua, Lawson, Deborah, Burke, Kathleen, Lubinski, Tristan, Tyner, Jeffrey W, Kurtz, Stephen E, McWeeney, Shannon K, Varnes, Jeffrey, Diebold, R Bruce, Gero, Thomas, Ioannidis, Stephanos, Hennessy, Edward J, McCoull, William, Saeh, Jamal C, Tabatabai, Areya, Tavana, Omid, Su, Nancy, Schuller, Alwin, Garnett, Mathew J, Jaaks, Patricia, Coker, Elizabeth A, Gregory, Gareth P, Newbold, Andrea, Johnstone, Ricky W, Gangl, Eric, Wild, Martin, Zinda, Michael, Secrist, J Paul, Davies, Barry R, Fawell, Stephen E, Gibbons, Francis D
Published in Clinical cancer research (15.12.2020)
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Published in Clinical cancer research (15.12.2020)
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BLOOD BRAIN BARRIER PENETRATING SELECTIVE INHIBITORS OF ROCK2 PROTEIN KINASES AND USES THEREOF
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Year of Publication 31.10.2024
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Year of Publication 31.10.2024
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Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof
Lee, Jaekyoo, Koh, Jong Sung, Seung, Sang-Ae, Yong, Miyong, Lee, Wongil, Choi, Yunggeun, Hwang, So Young, Kim, Sewon, Liu, Yan, Devine, William G, Diebold, R. Bruce
Year of Publication 20.08.2024
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Year of Publication 20.08.2024
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PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS
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Year of Publication 09.05.2024
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Year of Publication 09.05.2024
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PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS
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Year of Publication 12.03.2024
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Year of Publication 12.03.2024
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PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS
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Year of Publication 10.01.2024
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Year of Publication 10.01.2024
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Pyridin-2(1h)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors
Caravella, Justin Andrew, Gustafson, Gary, Lu, Wei, Ashwell, Susan, Campbell, Ann-Marie, Lin, Jian, Ericsson, Anna, Lancia, Jr, Wang, Zhongguo, Diebold, R. Bruce
Year of Publication 22.12.2023
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Year of Publication 22.12.2023
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PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS
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Year of Publication 28.11.2023
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Year of Publication 28.11.2023
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SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF
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Year of Publication 15.11.2023
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Year of Publication 15.11.2023
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Pyridin-2(1h)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors
Caravella, Justin Andrew, Gustafson, Gary, Lu, Wei, Ashwell, Susan, Campbell, Ann-Marie, Lin, Jian, Ericsson, Anna, Lancia Jr., David R, Wang, Zhongguo, Diebold, R. Bruce
Year of Publication 19.10.2023
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Year of Publication 19.10.2023
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Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof
Miyong Yong, Bruce R Diebold, Sang-ae Seung, So Young Hwang, Yan Liu, Wongil Lee, William G Devine, Jaekyoo Lee, Sewon Kim, Yunggeun Choi, Sung Jong Koh
Year of Publication 18.10.2023
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Year of Publication 18.10.2023
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