Single intravenous administration of oncolytic adenovirus TILT-123 results in systemic tumor transduction and immune response in patients with advanced solid tumors
Jirovec, Elise, Quixabeira, Dafne C. A, Clubb, James H. A, Pakola, Santeri A, Kudling, Tatiana, Arias, Victor, Haybout, Lyna, Jalkanen, Katriina, Alanko, Tuomo, Monberg, Tine, Khammari, Amir, Dreno, Brigitte, Svane, Inge Marie, Block, Matthew S, Adamo, Daniel A, Mäenpää, Johanna, Kistler, Claudia, Sorsa, Suvi, Hemminki, Otto, Kanerva, Anna, Santos, João M, Cervera-Carrascon, Victor, Hemminki, Akseli
Published in Journal of experimental & clinical cancer research (06.11.2024)
Published in Journal of experimental & clinical cancer research (06.11.2024)
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Oncolytic Adenovirus Coding for a Variant Interleukin 2 (vIL-2) Cytokine Re-Programs the Tumor Microenvironment and Confers Enhanced Tumor Control
Quixabeira, Dafne C. A., Zafar, Sadia, Santos, Joao M., Cervera-Carrascon, Victor, Havunen, Riikka, Kudling, Tatiana V., Basnet, Saru, Anttila, Marjukka, Kanerva, Anna, Hemminki, Akseli
Published in Frontiers in immunology (18.05.2021)
Published in Frontiers in immunology (18.05.2021)
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Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer
Clubb, James H A, Kudling, Tatiana V, Heiniö, Camilla, Basnet, Saru, Pakola, Santeri, Cervera Carrascón, Víctor, Santos, João Manuel, Quixabeira, Dafne C A, Havunen, Riikka, Sorsa, Suvi, Zheng, Vincent, Salo, Tuula, Bäck, Leif, Aro, Katri, Tulokas, Sanni, Loimu, Venla, Hemminki, Akseli
Published in Frontiers in immunology (07.03.2022)
Published in Frontiers in immunology (07.03.2022)
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Local therapy with an engineered oncolytic adenovirus enables antitumor response in non-injected melanoma tumors in mice treated with aPD-1
Quixabeira, Dafne C. A., Cervera-Carrascon, Victor, Santos, Joao M., Clubb, James H.A., Kudling, Tatiana V., Basnet, Saru, Heiniö, Camilla, Grönberg-Vähä-Koskela, Susanna, Anttila, Marjukka, Havunen, Riikka, Kanerva, Anna, Hemminki, Akseli
Published in Oncoimmunology (31.12.2022)
Published in Oncoimmunology (31.12.2022)
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Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity
Santos, João Manuel, Heiniö, Camilla, Cervera-Carrascon, Victor, Quixabeira, Dafne C A, Siurala, Mikko, Havunen, Riikka, Butzow, Ralf, Zafar, Sadia, de Gruijl, Tanja, Lassus, Heini, Kanerva, Anna, Hemminki, Akseli
Published in Journal for immunotherapy of cancer (01.01.2020)
Published in Journal for immunotherapy of cancer (01.01.2020)
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Adenovirus Armed With TNFa and IL2 Added to aPD-1 Regimen Mediates Antitumor Efficacy in Tumors Refractory to aPD-1
Cervera-Carrascon, Victor, Quixabeira, Dafne C A, Santos, Joao M, Havunen, Riikka, Milenova, Ioanna, Verhoeff, Jan, Heiniö, Camilla, Zafar, Sadia, Garcia-Vallejo, Juan J, van Beusechem, Victor W, de Gruijl, Tanja D, Kalervo, Aino, Sorsa, Suvi, Kanerva, Anna, Hemminki, Akseli
Published in Frontiers in immunology (23.07.2021)
Published in Frontiers in immunology (23.07.2021)
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Journal Article
An oncolytic adenovirus coding for a variant interleukin 2 cytokine improves response to chemotherapy through enhancement of effector lymphocyte cytotoxicity, fibroblast compartment modulation and mitotic slippage
Pakola, Santeri, Quixabeira, Dafne C A, Kudling, Tatiana V, Clubb, James H A, Grönberg-Vähä-Koskela, Susanna, Basnet, Saru, Jirovec, Elise, Arias, Victor, Haybout, Lyna, Heiniö, Camilla, Santos, Joao M, Cervera-Carrascon, Victor, Havunen, Riikka, Anttila, Marjukka, Hemminki, Akseli
Published in Frontiers in immunology (05.07.2023)
Published in Frontiers in immunology (05.07.2023)
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Journal Article
Oncolytic adenovirus decreases the proportion of TIM-3+ subset of tumor-infiltrating CD8+ T cells with correlation to improved survival in patients with cancer
Liikanen, Ilkka, Basnet, Saru, Quixabeira, Dafne C A, Taipale, Kristian, Hemminki, Otto, Oksanen, Minna, Kankainen, Matti, Juhila, Juuso, Kanerva, Anna, Joensuu, Timo, Tähtinen, Siri, Hemminki, Akseli
Published in Journal for immunotherapy of cancer (01.02.2022)
Published in Journal for immunotherapy of cancer (01.02.2022)
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Journal Article
Safety, Efficacy, and Biological Data of T-Cell-Enabling Oncolytic Adenovirus TILT-123 in Advanced Solid Cancers from the TUNIMO Monotherapy Phase I Trial
Pakola, Santeri A, Peltola, Katriina J, Clubb, James H A, Jirovec, Elise, Haybout, Lyna, Kudling, Tatiana V, Alanko, Tuomo, Korpisaari, Riitta, Juteau, Susanna, Jaakkola, Marjut, Sormunen, Jorma, Kemppainen, Jukka, Hemmes, Annabrita, Pellinen, Teijo, van der Heijden, Mirte, Quixabeira, Dafne C A, Kistler, Claudia, Sorsa, Suvi, Havunen, Riikka, Santos, Joao M, Cervera-Carrascon, Victor, Hemminki, Akseli
Published in Clinical cancer research (03.09.2024)
Published in Clinical cancer research (03.09.2024)
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Journal Article
Overcoming effector T cell exhaustion in ovarian cancer ascites with a novel adenovirus encoding for a MUC1 bispecific antibody engager and IL-2 cytokine
Basnet, Saru, Van der Heijden, Mirte, Quixabeira, Dafne C.A., Jirovec, Elise, Grönberg-Vähä-Koskela, Susanna A.M., Clubb, James H.A., Kanerva, Anna, Pakola, Santeri, Haybout, Lyna, Arias, Victor, Hemminki, Otto, Kudling, Tatiana, Zafar, Sadia, Cervera-Carrascon, Victor, Santos, Joao M., Hemminki, Akseli
Published in Molecular therapy (04.09.2024)
Published in Molecular therapy (04.09.2024)
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Journal Article
Overcoming effector T cell exhaustion in ovarian cancer ascites with a novel adenovirus encoding for a MUC1 bispecific antibody engager and IL-2 cytokine
Basnet, Saru, Van der Heijden, Mirte, Quixabeira, Dafne C.A., Jirovec, Elise, Grönberg-Vähä-Koskela, Susanna A.M., Clubb, James H.A., Kanerva, Anna, Pakola, Santeri, Haybout, Lyna, Arias, Victor, Hemminki, Otto, Kudling, Tatiana, Zafar, Sadia, Cervera-Carrascon, Victor, Santos, Joao M., Hemminki, Akseli
Published in Molecular therapy (07.08.2024)
Published in Molecular therapy (07.08.2024)
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Journal Article
Oncolytic Adenovirus ORCA-010 Activates Proinflammatory Myeloid Cells and Facilitates T Cell Recruitment and Activation by PD-1 Blockade in Melanoma
Milenova, Ioanna, Lopez Gonzalez, Marta, Quixabeira, Dafne C A, Santos, Joao Manuel, Cervera-Carrascon, Victor, Dong, Wenliang, Hemminki, Akseli, van Beusechem, Victor W, van de Ven, Rieneke, de Gruijl, Tanja D
Published in Human gene therapy (01.02.2021)
Published in Human gene therapy (01.02.2021)
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Local delivery of interleukin 7 with an oncolytic adenovirus activates tumor-infiltrating lymphocytes and causes tumor regression
Kudling, Tatiana V., Clubb, James H.A., Quixabeira, Dafne C.A., Santos, Joao M., Havunen, Riikka, Kononov, Alexander, Heiniö, Camilla, Cervera-Carrascon, Victor, Pakola, Santeri, Basnet, Saru, Grönberg-Vähä-Koskela, Susanna, Arias, Victor, Gladwyn-Ng, Ivan, Aro, Katri, Bäck, Leif, Räsänen, Jari, Ilonen, Ilkka, Borenius, Kristian, Räsänen, Mikko, Hemminki, Otto, Rannikko, Antti, Kanerva, Anna, Tapper, Johanna, Hemminki, Akseli
Published in Oncoimmunology (31.12.2022)
Published in Oncoimmunology (31.12.2022)
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Journal Article
Effective intravenous delivery of adenovirus armed with TNFα and IL-2 improves anti-PD-1 checkpoint blockade in non-small cell lung cancer
Kudling, Tatiana V., Clubb, James H.A., Pakola, Santeri, Quixabeira, Dafne C.A., Lähdeniemi, Iris A.K., Heiniö, Camilla, Arias, Victor, Havunen, Riikka, Cervera-Carrascon, Victor, Santos, Joao M., Sutinen, Eva, Räsänen, Jari, Borenius, Kristian, Mäyränpää, Mikko I., Aaltonen, Eero, Sorsa, Suvi, Hemminki, Otto, Kanerva, Anna, Verschuren, Emmy W., Ilonen, Ilkka, Hemminki, Akseli
Published in Oncoimmunology (31.12.2023)
Published in Oncoimmunology (31.12.2023)
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Journal Article
Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting
Clubb, James H A, Kudling, Tatiana V, Girych, Mykhailo, Haybout, Lyna, Pakola, Santeri, Hamdan, Firas, Cervera-Carrascon, Víctor, Hemmes, Annabrita, Grönberg-Vähä-Koskela, Susanna, Santos, João Manuel, Quixabeira, Dafne C A, Basnet, Saru, Heiniö, Camilla, Arias, Victor, Jirovec, Elise, Kaptan, Shreyas, Havunen, Riikka, Sorsa, Suvi, Erikat, Abdullah, Schwartz, Joel, Anttila, Marjukka, Aro, Katri, Viitala, Tapani, Vattulainen, Ilpo, Cerullo, Vincenzo, Kanerva, Anna, Hemminki, Akseli
Published in Frontiers in immunology (03.02.2023)
Published in Frontiers in immunology (03.02.2023)
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Journal Article
Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition
Cervera-Carrascon, Victor, Quixabeira, Dafne C.A., Santos, Joao Manuel, Havunen, Riikka, Zafar, Sadia, Hemminki, Otto, Heiniö, Camilla, Munaro, Eleonora, Siurala, Mikko, Sorsa, Suvi, Mirtti, Tuomas, Järvinen, Petrus, Mildh, Markus, Nisen, Harry, Rannikko, Antti, Anttila, Marjukka, Kanerva, Anna, Hemminki, Akseli
Published in Oncoimmunology (01.01.2020)
Published in Oncoimmunology (01.01.2020)
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Journal Article
Comparison of Clinically Relevant Oncolytic Virus Platforms for Enhancing T Cell Therapy of Solid Tumors
Cervera-Carrascon, Victor, Quixabeira, Dafne C.A., Havunen, Riikka, Santos, Joao M., Kutvonen, Emma, Clubb, James H.A., Siurala, Mikko, Heiniö, Camilla, Zafar, Sadia, Koivula, Teija, Lumen, Dave, Vaha, Marjo, Garcia-Horsman, Arturo, Airaksinen, Anu J., Sorsa, Suvi, Anttila, Marjukka, Hukkanen, Veijo, Kanerva, Anna, Hemminki, Akseli
Published in Molecular therapy. Oncolytics (26.06.2020)
Published in Molecular therapy. Oncolytics (26.06.2020)
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Journal Article
Oncolytic adenovirus coding for bispecific T cell engager against human MUC-1 potentiates T cell response against solid tumors
Basnet, Saru, Santos, Joao M., Quixabeira, Dafne C.A., Clubb, James H.A., Grönberg-Vähä-Koskela, Susanna A.M., Arias, Victor, Pakola, Santeri, Kudling, Tatiana V., Heiniö, Camilla, Havunen, Riikka, Cervera-Carrascon, Victor, Sorsa, Suvi, Anttila, Marjukka, Kanerva, Anna, Hemminki, Akseli
Published in Molecular therapy. Oncolytics (16.03.2023)
Published in Molecular therapy. Oncolytics (16.03.2023)
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Journal Article
739 Emerging proteomic and safety analysis of blood from solid tumor patients receiving TILT-123 (Ad5/3-E2F-d24-hTNFa-IRES-hIL2) monotherapy in TUNIMO phase 1 clinical trial
Pakola, Santeri A, Cervera-Carrascon, Victor, Peltola, Katriina, Alanko, Tuomo, Korpisaari, Riitta, Jaakkola, Marjut, Sormunen, Jorma, Kononen, Juha, Clubb, James, Jirovec, Elise, Kudling, Tatiana, Haybout, Lyna, Quixabeira, Dafne CA, Kistler, Claudia, Santos, Joao, Sorsa, Suvi, Havunen, Riikka, Hemminki, Akseli
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
805 Oncolytic adenovirus encoding human interleukin-7 in combination with ICIs as a treatment strategy against renal cell carcinoma (RCC)
Arias, Victor, Kudling, Tatiana, Clubb, James, Haybout, Lyna, Jirovec, Elise, Pakola, Santeri A, Basnet, Saru, Quixabeira, Dafne CA, Hemminki, Otto, Grönberg-Vähä-Koskela, Susanna AM, Santos, Joao Manuel, Cervera-Carrascon, Victor, Hemminki, Akseli
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article