BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity
RUDOLPH, Dorothea, STEEGMAIER, Martin, HOFFMANN, Matthias, GRAUERT, Matthias, BAUM, Anke, QUANT, Jens, HASLINGER, Christian, GARIN-CHESA, Pilar, ADOLF, Gunther R
Published in Clinical cancer research (01.05.2009)
Published in Clinical cancer research (01.05.2009)
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Journal Article
BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo
Steegmaier, Martin, Hoffmann, Matthias, Baum, Anke, Lénárt, Péter, Petronczki, Mark, Krššák, Martin, Gürtler, Ulrich, Garin-Chesa, Pilar, Lieb, Simone, Quant, Jens, Grauert, Matthias, Adolf, Günther R., Kraut, Norbert, Peters, Jan-Michael, Rettig, Wolfgang J.
Published in Current biology (20.02.2007)
Published in Current biology (20.02.2007)
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Journal Article
Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype
Hirt, Ulrich A., Waizenegger, Irene C., Schweifer, Norbert, Haslinger, Christian, Gerlach, Daniel, Braunger, Jürgen, Weyer-Czernilofsky, Ulrike, Stadtmüller, Heinz, Sapountzis, Ioannis, Bader, Gerd, Zoephel, Andreas, Bister, Bojan, Baum, Anke, Quant, Jens, Kraut, Norbert, Garin-Chesa, Pilar, Adolf, Günther R.
Published in Oncogenesis (New York, NY) (23.02.2018)
Published in Oncogenesis (New York, NY) (23.02.2018)
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Journal Article
BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
Hilberg, Frank, Roth, Gerald J, Krssak, Martin, Kautschitsch, Susanna, Sommergruber, Wolfgang, Tontsch-Grunt, Ulrike, Garin-Chesa, Pilar, Bader, Gerd, Zoephel, Andreas, Quant, Jens, Heckel, Armin, Rettig, Wolfgang J
Published in Cancer research (Chicago, Ill.) (15.06.2008)
Published in Cancer research (Chicago, Ill.) (15.06.2008)
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Journal Article
Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2-p53 Antagonist Suitable for Intermittent Dose Schedules
Gollner, Andreas, Rudolph, Dorothea, Weyer-Czernilofsky, Ulrike, Baumgartinger, Rosa, Jung, Peter, Weinstabl, Harald, Ramharter, Jürgen, Grempler, Rolf, Quant, Jens, Rinnenthal, Jörg, Pérez Pitarch, Alejandro, Golubovic, Bojana, Gerlach, Daniel, Bader, Gerd, Wetzel, Kristiane, Otto, Sebastian, Mandl, Christian, Boehmelt, Guido, McConnell, Darryl B, Kraut, Norbert, Sini, Patrizia
Published in Molecular cancer therapeutics (03.12.2024)
Published in Molecular cancer therapeutics (03.12.2024)
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Journal Article
Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis
Weinstabl, Harald, Treu, Matthias, Rinnenthal, Joerg, Zahn, Stephan K, Ettmayer, Peter, Bader, Gerd, Dahmann, Georg, Kessler, Dirk, Rumpel, Klaus, Mischerikow, Nikolai, Savarese, Fabio, Gerstberger, Thomas, Mayer, Moriz, Zoephel, Andreas, Schnitzer, Renate, Sommergruber, Wolfgang, Martinelli, Paola, Arnhof, Heribert, Peric-Simov, Biljana, Hofbauer, Karin S, Garavel, Géraldine, Scherbantin, Yvonne, Mitzner, Sophie, Fett, Thomas N, Scholz, Guido, Bruchhaus, Jens, Burkard, Michelle, Kousek, Roland, Ciftci, Tuncay, Sharps, Bernadette, Schrenk, Andreas, Harrer, Christoph, Haering, Daniela, Wolkerstorfer, Bernhard, Zhang, Xuechun, Lv, Xiaobing, Du, Alicia, Li, Dongyang, Li, Yali, Quant, Jens, Pearson, Mark, McConnell, Darryl B
Published in Journal of medicinal chemistry (12.09.2019)
Published in Journal of medicinal chemistry (12.09.2019)
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Journal Article
Targeting cancer with small-molecule pan-KRAS degraders
Popow, Johannes, Farnaby, William, Gollner, Andreas, Kofink, Christiane, Fischer, Gerhard, Wurm, Melanie, Zollman, David, Wijaya, Andre, Mischerikow, Nikolai, Hasenoehrl, Carina, Prokofeva, Polina, Arnhof, Heribert, Arce-Solano, Silvia, Bell, Sammy, Boeck, Georg, Diers, Emelyne, Frost, Aileen B, Goodwin-Tindall, Jake, Karolyi-Oezguer, Jale, Khan, Shakil, Klawatsch, Theresa, Koegl, Manfred, Kousek, Roland, Kratochvil, Barbara, Kropatsch, Katrin, Lauber, Arnel A, McLennan, Ross, Olt, Sabine, Peter, Daniel, Petermann, Oliver, Roessler, Vanessa, Stolt-Bergner, Peggy, Strack, Patrick, Strauss, Eva, Trainor, Nicole, Vetma, Vesna, Whitworth, Claire, Zhong, Siying, Quant, Jens, Weinstabl, Harald, Kuster, Bernhard, Ettmayer, Peter, Ciulli, Alessio
Published in Science (American Association for the Advancement of Science) (20.09.2024)
Published in Science (American Association for the Advancement of Science) (20.09.2024)
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Journal Article
Abstract 4868: BI 907828: A novel, potent MDM2 inhibitor that is suitable for high-dose intermittent schedules
Rudolph, Dorothea, Gollner, Andreas, Blake, Sophia, Rinnenthal, Jörg, Wernitznig, Andreas, Weyer-Czernilofsky, Ulrike, Haslinger, Christian, Garin-Chesa, Pilar, Quant, Jens, McConnell, Darryl B., Moll, Jürgen, Norbert, Kraut
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 4865: BI 907828: A highly potent MDM2 inhibitor with low human dose estimation, designed for high-dose intermittent schedules in the clinic
Rinnenthal, Joerg, Rudolph, Dorothea, Blake, Sophia, Gollner, Andreas, Wernitznig, Andreas, Weyer-Czernilofsky, Ulrike, Haslinger, Christian, Garin-Chesa, Pilar, Moll, Jürgen, Kraut, Norbert, McConnell, Darryl, Quant, Jens
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases
Sini, Patrizia, Gürtler, Ulrich, Zahn, Stephan K, Baumann, Christoph, Rudolph, Dorothea, Baumgartinger, Rosa, Strauss, Eva, Haslinger, Christian, Tontsch-Grunt, Ulrike, Waizenegger, Irene C, Solca, Flavio, Bader, Gerd, Zoephel, Andreas, Treu, Matthias, Reiser, Ulrich, Garin-Chesa, Pilar, Boehmelt, Guido, Kraut, Norbert, Quant, Jens, Adolf, Günther R
Published in Molecular cancer therapeutics (01.10.2016)
Published in Molecular cancer therapeutics (01.10.2016)
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Journal Article
Abstract 4866: BI 907828: A novel, potent MDM2 inhibitor that induces antitumor immunologic memory and acts synergistically with an anti-PD-1 antibody in syngeneic mouse models of cancer
Rudolph, Dorothea, Reschke, Markus, Blake, Sophia, Rinnenthal, Jörg, Wernitznig, Andreas, Weyer-Czernilofsky, Ulrike, Gollner, Andreas, Haslinger, Christian, Garin-Chesa, Pilar, Quant, Jens, McConnell, Darryl B., Norbert, Kraut, Moll, Jürgen
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 2330: BI5: a novel SMAC mimetic that triggers tumor cell death and potentiates PD-1 mediated cancer therapy
Reschke, Markus, Impagnatiello, Maria Antonietta, Reiser, Ulrich, Scharn, Dirk, Spevak, Walter, Savchenko, Alexander, Wernitznig, Andreas, Sykora, Martina, Langlois, Rebecca, Zier, Elisabeth, Zach, Daniel, Kallenda, Sabine, Garin-Chesa, Pilar, Quant, Jens, Pearson, Mark, McConnell, Darryl, Kraut, Norbert, Moll, Juergen
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis
Sanderson, Michael P, Apgar, Joshua, Garin-Chesa, Pilar, Hofmann, Marco H, Kessler, Dirk, Quant, Jens, Savchenko, Alexander, Schaaf, Otmar, Treu, Matthias, Tye, Heather, Zahn, Stephan K, Zoephel, Andreas, Haaksma, Eric, Adolf, Günther R, Kraut, Norbert
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Journal Article
An allometric pharmacokinetic/pharmacodynamics model for BI 893923, a novel IGF-1 receptor inhibitor
Titze, Melanie I., Schaaf, Otmar, Hofmann, Marco H., Sanderson, Michael P., Zahn, Stephan K., Quant, Jens, Lehr, Thorsten
Published in Cancer chemotherapy and pharmacology (01.03.2017)
Published in Cancer chemotherapy and pharmacology (01.03.2017)
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Journal Article
A comprehensive pharmacokinetic/pharmacodynamics analysis of the novel IGF1R/INSR inhibitor BI 893923 applying in vitro, in vivo and in silico modeling techniques
Titze, Melanie I., Schaaf, Otmar, Hofmann, Marco H., Sanderson, Michael P., Zahn, Stephan K., Quant, Jens, Lehr, Thorsten
Published in Cancer chemotherapy and pharmacology (01.06.2016)
Published in Cancer chemotherapy and pharmacology (01.06.2016)
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Journal Article
Abstract 1082: BI 811283, a potent inhibitor of the mitotic kinase Aurora B, shows dose- and schedule-dependent efficacy in human cancer xenograft models
Gürtler, Ulrich, Tontsch-Grunt, Ulrike, Zahn, Stephan K., Quant, Jens, Adolf, Guenther R., Solca, Flavio
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Journal Article
DIHYDROPTERIDINONES, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRUGS
HOFFMANN MATTHIAS, QUANT JENS JÜRGEN, EICKMEIER CHRISTIAN, BRANDL TRIXI, SCHNAPP GISELA, GRAUERT MATTHIAS, STEEGMAIER MARTIN, BREITFELDER STEFFEN, BAUM ANKE, COLBATZKY FLORIAN, SOLCA FLAVIO
Year of Publication 31.07.2017
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Year of Publication 31.07.2017
Patent
2,4-DI(AMINOPHENYL)PYRIMIDINE DERIVATIVES AS PLK INHIBITORS
QUANT, Jens, Juergen, ENGELHARDT, Harald, STEEGMAIER, Martin, REISER, Ulrich, SCHOOP, Andreas, HERFURTH, Lars, SOLCA, Flavio, STADTMUELLER, Heinz, BAUM, Anke, GUERTLER, Ulrich, HAUPTMANN, Rudolf, ZAHN, Stephan Karl
Year of Publication 29.03.2016
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Year of Publication 29.03.2016
Patent
NEW COMPOUNDS
ZAHN, STEPHAN KARL, BOEHMELT, GUIDO, ENGELHARDT, HARALD, BAUM, ANKE, QUANT, JENS, STEEGMAIER, MARTIN, SOLCA, FLAVIO, STADTMUELLER, HEINZ
Year of Publication 08.07.2014
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Year of Publication 08.07.2014
Patent