Design and Synthesis of Orally Bioavailable 4‑Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors
Qiu, Zongxing, Lin, Xianfeng, Zhou, Mingwei, Liu, Yongfu, Zhu, Wei, Chen, Wenming, Zhang, Weixing, Guo, Lei, Liu, Haixia, Wu, Guolong, Huang, Mengwei, Jiang, Min, Xu, Zhiheng, Zhou, Zheng, Qin, Ning, Ren, Shuang, Qiu, Hongxia, Zhong, Sheng, Zhang, Yuxia, Zhang, Yi, Wu, Xiaoyue, Shi, Liping, Shen, Fang, Mao, Yi, Zhou, Xue, Yang, Wengang, Wu, Jim Z, Yang, Guang, Mayweg, Alexander V, Shen, Hong C, Tang, Guozhi
Published in Journal of medicinal chemistry (25.08.2016)
Published in Journal of medicinal chemistry (25.08.2016)
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Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors
Qiu, Zongxing, Kuhn, Bernd, Aebi, Johannes, Lin, Xianfeng, Ding, Haiyuan, Zhou, Zheng, Xu, Zhiheng, Xu, Danqing, Han, Li, Liu, Cheng, Qiu, Hongxia, Zhang, Yuxia, Haap, Wolfgang, Riemer, Claus, Stahl, Martin, Qin, Ning, Shen, Hong C, Tang, Guozhi
Published in ACS medicinal chemistry letters (11.08.2016)
Published in ACS medicinal chemistry letters (11.08.2016)
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Inhibition of influenza A virus (H1N1) fusion by benzenesulfonamide derivatives targeting viral hemagglutinin
Zhu, Lei, Li, Yuhuan, Li, Shaohua, Li, Haodong, Qiu, Zongxing, Lee, Chichang, Lu, Henry, Lin, Xianfeng, Zhao, Rong, Chen, Li, Wu, Jim Z, Tang, Guozhi, Yang, Wengang
Published in PloS one (15.12.2011)
Published in PloS one (15.12.2011)
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Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Benzyl derivatives with broad potency against resistant mutant viruses
Kertesz, Denis J., Brotherton-Pleiss, Christine, Yang, Minmin, Wang, Zhanguo, Lin, Xianfeng, Qiu, Zongxing, Hirschfeld, Donald R., Gleason, Shelley, Mirzadegan, Taraneh, Dunten, Pete W., Harris, Seth F., Villaseñor, Armando G., Hang, Julie Qi, Heilek, Gabrielle M., Klumpp, Klaus
Published in Bioorganic & medicinal chemistry letters (15.07.2010)
Published in Bioorganic & medicinal chemistry letters (15.07.2010)
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Identification of New ATG4B Inhibitors Based on a Novel High-Throughput Screening Platform
Xu, Danqing, Xu, Zhiheng, Han, Li, Liu, Cheng, Zhou, Zheng, Qiu, Zongxing, Lin, Xianfeng, Tang, Guozhi, Shen, Hong, Aebi, Johannes, Riemer, Claus, Kuhn, Bernd, Stahl, Martin, Mark, David, Qin, Ning, Ding, Haiyuan
Published in SLAS discovery (01.04.2017)
Published in SLAS discovery (01.04.2017)
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Exploration of piperidine-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses
Tang, Guozhi, Kertesz, Denis J., Yang, Minmin, Lin, Xianfeng, Wang, Zhanguo, Li, Wentao, Qiu, Zongxing, Chen, Junli, Mei, Jianghua, Chen, Li, Mirzadegan, Taraneh, Harris, Seth F., Villaseñor, Armando G., Fretland, Jennifer, Fitch, William L., Hang, Julie Qi, Heilek, Gabrielle, Klumpp, Klaus
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
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Discovery of novel 1-phenyl-cycloalkane carbamides as potent and selective influenza fusion inhibitors
Tang, Guozhi, Qiu, Zongxing, Lin, Xianfeng, Li, Wentao, Zhu, Lei, Li, Shaohua, Li, Haodong, Wang, Lisha, Chen, Li, Wu, Jim Z., Yang, Wengang
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Journal Article
A New Approach of Mitigating CYP3A4 Induction Led to the Discovery of Potent Hepatitis B Virus (HBV) Capsid Inhibitor with Optimal ADMET Profiles
Lin, Xianfeng, Shi, Houguang, Zhang, Weixing, Qiu, Zongxing, Zhou, Zheng, Dey, Fabian, Zhong, Sheng, Qiu, Hongxia, Xie, Jianxun, Zhou, Xue, Yang, Guang, Tang, Guozhi, Shen, Hong C, Zhu, Wei
Published in Journal of medicinal chemistry (27.11.2019)
Published in Journal of medicinal chemistry (27.11.2019)
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Discovery and Pre-Clinical Characterization of Third-Generation 4‑H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors
Qiu, Zongxing, Lin, Xianfeng, Zhang, Weixing, Zhou, Mingwei, Guo, Lei, Kocer, Buelent, Wu, Guolong, Zhang, Zhisen, Liu, Haixia, Shi, Houguang, Kou, Buyu, Hu, Taishan, Hu, Yimin, Huang, Mengwei, Yan, S. Frank, Xu, Zhiheng, Zhou, Zheng, Qin, Ning, Wang, Yue Fen, Ren, Shuang, Qiu, Hongxia, Zhang, Yuxia, Zhang, Yi, Wu, Xiaoyue, Sun, Kai, Zhong, Sheng, Xie, Jianxun, Ottaviani, Giorgio, Zhou, Yuan, Zhu, Lina, Tian, Xiaojun, Shi, Liping, Shen, Fang, Mao, Yi, Zhou, Xue, Gao, Lu, Young, John A. T, Wu, Jim Zhen, Yang, Guang, Mayweg, Alexander V, Shen, Hong C, Tang, Guozhi, Zhu, Wei
Published in Journal of medicinal chemistry (27.04.2017)
Published in Journal of medicinal chemistry (27.04.2017)
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Design and Synthesis of Orally Bioavailable Aminopyrrolidinone Histone Deacetylase 6 Inhibitors
Lin, Xianfeng, Chen, Wenming, Qiu, Zongxing, Guo, Lei, Zhu, Wei, Li, Wentao, Wang, Zhanguo, Zhang, Weixing, Zhang, Zhenshan, Rong, Yiping, Zhang, Meifang, Yu, Lingjie, Zhong, Sheng, Zhao, Rong, Wu, Xihan, Wong, Jason C, Tang, Guozhi
Published in Journal of medicinal chemistry (26.03.2015)
Published in Journal of medicinal chemistry (26.03.2015)
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Inhibition of Influenza A Virus
Zhu, Lei, Li, Yuhuan, Li, Shaohua, Li, Haodong, Qiu, Zongxing, Lee, Chichang, Lu, Henry, Lin, Xianfeng, Zhao, Rong, Chen, Li, Wu, Jim Z, Tang, Guozhi, Yang, Wengang
Published in PloS one (15.12.2011)
Published in PloS one (15.12.2011)
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Journal Article
Design and Synthesis of Benzenesulfonamide Derivatives as Potent Anti-Influenza Hemagglutinin Inhibitors
Tang, Guozhi, Lin, Xianfeng, Qiu, Zongxing, Li, Wentao, Zhu, Lei, Wang, Lisha, Li, Shaohua, Li, Haodong, Lin, Wenbin, Yang, Mei, Guo, Tao, Chen, Li, Lee, Daniel, Wu, Jim Z., Yang, Wengang
Published in ACS medicinal chemistry letters (11.08.2011)
Published in ACS medicinal chemistry letters (11.08.2011)
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NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER
ZHANG ZHENSHAN, WONG JASON CHRISTOPHER, TANG GUOZHI, LIN XIANFENG, QIU ZONGXING
Year of Publication 04.11.2013
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Year of Publication 04.11.2013
Patent
NOVEL 4-METHYL-DIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
ZHU WEI, TANG GUOZHI, GUO LEI, LIU HAIXIA, LIN XIANFENG, QIU ZONGXING, ZHANG WEIXING, SHEN HONG, WU GUOLONG
Year of Publication 15.12.2014
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Year of Publication 15.12.2014
Patent
6-AMINO ACID HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
KOCER BUELENT, MAYWEG ALEXANDER V, ZHOU MINGWEI, WANG LISHA, YAN SHIXIANG, LIN XIANFENG, QIU ZONGXING, SHEN HONG, HU YIMIN, ZHU WEI, TANG GUOZHI, GUO LEI, LIU HAIXIA, ZHANG WEIXING, HU TAISHAN, WU GUOLONG
Year of Publication 20.05.2015
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Year of Publication 20.05.2015
Patent