Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport
Liu, Ming, Haataja, Leena, Wright, Jordan, Wickramasinghe, Nalinda P, Hua, Qing-Xin, Phillips, Nelson F, Barbetti, Fabrizio, Weiss, Michael A, Arvan, Peter
Published in PloS one (11.10.2010)
Published in PloS one (11.10.2010)
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Design and Folding of [GluA4(OβThrB30)]Insulin ("Ester Insulin"): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insulin
Sohma, Youhei, Hua, Qing-Xin, Whittaker, Jonathan, Weiss, Michael A., Kent, Stephen B. H.
Published in Angewandte Chemie (International ed.) (26.07.2010)
Published in Angewandte Chemie (International ed.) (26.07.2010)
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A Protein Caught in a Kinetic Trap: Structures and Stabilities of Insulin Disulfide Isomers
Hua, Qing-Xin, Jia, Wenhua, Frank, Bruce H, Phillips, Nelson F. B, Weiss, Michael A
Published in Biochemistry (Easton) (17.12.2002)
Published in Biochemistry (Easton) (17.12.2002)
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Achilles' Heel in an Amyloidogenic Protein and Its Repair: INSULIN FIBRILLATION AND THERAPEUTIC DESIGN
Yang, Yanwu, Petkova, Aneta, Huang, Kun, Xu, Bin, Hua, Qing-xin, Ye, I. Ju, Chu, Ying-Chi, Hu, Shi-Quan, Phillips, Nelson B, Whittaker, Jonathan, Ismail-Beigi, Faramarz, Mackin, Robert B, Katsoyannis, Panayotis G, Tycko, Robert, Weiss, Michael A
Published in The Journal of biological chemistry (02.04.2010)
Published in The Journal of biological chemistry (02.04.2010)
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Design of an Active Ultrastable Single-chain Insulin Analog: SYNTHESIS, STRUCTURE, AND THERAPEUTIC IMPLICATIONS
Hua, Qing-xin, Nakagawa, Satoe H, Jia, Wenhua, Huang, Kun, Phillips, Nelson B, Hu, Shi-quan, Weiss, Michael A
Published in The Journal of biological chemistry (23.05.2008)
Published in The Journal of biological chemistry (23.05.2008)
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Activities of Monomeric Insulin Analogs at Position A8 Are Uncorrelated with Their Thermodynamic Stabilities
Weiss, Michael A., Hua, Qing-Xin, Jia, Wenhua, Nakagawa, Satoe H., Chu, Ying-Chi, Hu, Shi-Quan, Katsoyannis, Panayotis G.
Published in The Journal of biological chemistry (26.10.2001)
Published in The Journal of biological chemistry (26.10.2001)
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Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS
Hua, Qing-xin, Xu, Bin, Huang, Kun, Hu, Shi-Quan, Nakagawa, Satoe, Jia, Wenhua, Wang, Shuhua, Whittaker, Jonathan, Katsoyannis, Panayotis G, Weiss, Michael A
Published in The Journal of biological chemistry (22.05.2009)
Published in The Journal of biological chemistry (22.05.2009)
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Supramolecular Protein Engineering: DESIGN OF ZINC-STAPLED INSULIN HEXAMERS AS A LONG ACTING DEPOT
Phillips, Nelson B, Wan, Zhu-li, Whittaker, Linda, Hu, Shi-Quan, Huang, Kun, Hua, Qing-xin, Whittaker, Jonathan, Ismail-Beigi, Faramarz, Weiss, Michael A
Published in The Journal of biological chemistry (16.04.2010)
Published in The Journal of biological chemistry (16.04.2010)
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Diabetes-Associated Mutations in a β -Cell Transcription Factor Destabilize an Antiparallel "Mini-Zipper" in a Dimerization Interface
Hua, Qing-Xin, Zhao, Ming, Narayana, Narendra, Nakagawa, Satoe H., Jia, Wenhua, Weiss, Michael A.
Published in Proceedings of the National Academy of Sciences - PNAS (29.02.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (29.02.2000)
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Crystal structure of a "nonfoldable" insulin: impaired folding efficiency despite native activity
Liu, Ming, Wan, Zhu-Li, Chu, Ying-Chi, Aladdin, Hassan, Klaproth, Birgit, Choquette, Meredith, Hua, Qing-Xin, Mackin, Robert B, Rao, J Sunil, De Meyts, Pierre, Katsoyannis, Panayotis G, Arvan, Peter, Weiss, Michael A
Published in The Journal of biological chemistry (11.12.2009)
Published in The Journal of biological chemistry (11.12.2009)
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Deciphering the Hidden Informational Content of Protein Sequences: FOLDABILITY OF PROINSULIN HINGES ON A FLEXIBLE ARM THAT IS DISPENSABLE IN THE MATURE HORMONE
Liu, Ming, Hua, Qing-xin, Hu, Shi-Quan, Jia, Wenhua, Yang, Yanwu, Saith, Sunil Evan, Whittaker, Jonathan, Arvan, Peter, Weiss, Michael A
Published in The Journal of biological chemistry (01.10.2010)
Published in The Journal of biological chemistry (01.10.2010)
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A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE
Huang, Kun, Chan, Shu Jin, Hua, Qing-xin, Chu, Ying-Chi, Wang, Run-ying, Klaproth, Birgit, Jia, Wenhua, Whittaker, Jonathan, De Meyts, Pierre, Nakagawa, Satoe H, Steiner, Donald F, Katsoyannis, Panayotis G, Weiss, Michael A
Published in The Journal of biological chemistry (30.11.2007)
Published in The Journal of biological chemistry (30.11.2007)
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Cover Picture: Design and Folding of [GluA4(OβThrB30)]Insulin ("Ester Insulin"): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insulin (Angew. Chem. Int. Ed. 32/2010)
Sohma, Youhei, Hua, Qing-Xin, Whittaker, Jonathan, Weiss, Michael A., Kent, Stephen B. H.
Published in Angewandte Chemie (International ed.) (26.07.2010)
Published in Angewandte Chemie (International ed.) (26.07.2010)
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Conformational dynamics of insulin
Hua, Qing-Xin, Jia, Wenhua, Weiss, Michael A
Published in Frontiers in endocrinology (Lausanne) (2011)
Published in Frontiers in endocrinology (Lausanne) (2011)
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Contribution of Residue B5 to the Folding and Function of Insulin and IGF-I: CONSTRAINTS AND FINE-TUNING IN THE EVOLUTION OF A PROTEIN FAMILY
Sohma, Youhei, Hua, Qing-xin, Liu, Ming, Phillips, Nelson B, Hu, Shi-Quan, Whittaker, Jonathan, Whittaker, Linda J, Ng, Aubree, Roberts, Charles T. Jr, Arvan, Peter, Kent, Stephen B.H, Weiss, Michael A
Published in The Journal of biological chemistry (12.02.2010)
Published in The Journal of biological chemistry (12.02.2010)
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Chiral Mutagenesis of Insulin: CONTRIBUTION OF THE B20-B23 β-TURN TO ACTIVITY AND STABILITY
Nakagawa, Satoe H, Hua, Qing-xin, Hu, Shi-Quan, Jia, Wenhua, Wang, Shuhua, Katsoyannis, Panayotis G, Weiss, Michael A
Published in The Journal of biological chemistry (04.08.2006)
Published in The Journal of biological chemistry (04.08.2006)
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