MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53
Hines, John, Lartigue, Schan, Dong, Hanqing, Qian, Yimin, Crews, Craig M
Published in Cancer research (Chicago, Ill.) (01.01.2019)
Published in Cancer research (Chicago, Ill.) (01.01.2019)
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Journal Article
PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer
Raina, Kanak, Lu, Jing, Qian, Yimin, Altieri, Martha, Gordon, Deborah, Rossi, Ann Marie K., Wang, Jing, Chen, Xin, Dong, Hanqing, Siu, Kam, Winkler, James D., Crew, Andrew P., Crews, Craig M., Coleman, Kevin G.
Published in Proceedings of the National Academy of Sciences - PNAS (28.06.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (28.06.2016)
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Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1
Crew, Andrew P, Raina, Kanak, Dong, Hanqing, Qian, Yimin, Wang, Jing, Vigil, Dominico, Serebrenik, Yevgeniy V, Hamman, Brian D, Morgan, Alicia, Ferraro, Caterina, Siu, Kam, Neklesa, Taavi K, Winkler, James D, Coleman, Kevin G, Crews, Craig M
Published in Journal of medicinal chemistry (25.01.2018)
Published in Journal of medicinal chemistry (25.01.2018)
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Journal Article
RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1
Mill, Christopher P., Fiskus, Warren, DiNardo, Courtney D., Qian, Yimin, Raina, Kanak, Rajapakshe, Kimal, Perera, Dimuthu, Coarfa, Cristian, Kadia, Tapan M., Khoury, Joseph D., Saenz, Dyana T., Saenz, David N., Illendula, Anuradha, Takahashi, Koichi, Kornblau, Steven M., Green, Michael R., Futreal, Andrew P., Bushweller, John H., Crews, Craig M., Bhalla, Kapil N.
Published in Blood (04.07.2019)
Published in Blood (04.07.2019)
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A 90-day Sub-chronic Oral Toxicity Assessment of Mulberry Extract in Sprague Dawley Rats
Hong, Min, Lu, Min, Qian, Yimin, Wei, Liping, Zhang, Yaqun, Pan, Xueying, Li, Hua, Chen, Huaying, Tang, Naping
Published in Inquiry (Chicago) (12.11.2021)
Published in Inquiry (Chicago) (12.11.2021)
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Journal Article
Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4
Lu, Jing, Qian, Yimin, Altieri, Martha, Dong, Hanqing, Wang, Jing, Raina, Kanak, Hines, John, Winkler, James D., Crew, Andrew P., Coleman, Kevin, Crews, Craig M.
Published in Chemistry & biology (18.06.2015)
Published in Chemistry & biology (18.06.2015)
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Journal Article
A Comprehensive Assessment of Drought and Climate Change
Qian, yimin, Yao, Shuiping, Yan, Kun, Tang, Wenjia
Published in MATEC Web of Conferences (01.01.2018)
Published in MATEC Web of Conferences (01.01.2018)
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Conference Proceeding
Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors
Qian, Yimin, Ahmad, Mushtaq, Chen, Shaoqing, Gillespie, Paul, Le, Nam, Mennona, Frank, Mischke, Steven, So, Sung-Sau, Wang, Hong, Burghardt, Charles, Tannu, Shahid, Conde-Knape, Karin, Kochan, Jarema, Bolin, David
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
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Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors
Yun, Weiya, Ahmad, Mushtaq, Chen, Yingsi, Gillespie, Paul, Conde-Knape, Karin, Kazmer, Sonja, Li, Shiming, Qian, Yimin, Taub, Rebecca, Wertheimer, Stanley J., Whittard, Toni, Bolin, David
Published in Bioorganic & medicinal chemistry letters (01.12.2011)
Published in Bioorganic & medicinal chemistry letters (01.12.2011)
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Comparing the differential effects of LPA on the barrier function of human pulmonary endothelial cells
Ren, Yonglin, Guo, Liang, Tang, Xiaoyan, Apparsundaram, Subramaniam, Kitson, Christopher, Deguzman, Jeremy, Fuentes, Maria E., Coyle, Luke, Majmudar, Rupal, Allard, John, Truitt, Theresa, Hamid, Rachid, Chen, Yun, Qian, Yimin, Budd, David C.
Published in Microvascular research (01.01.2013)
Published in Microvascular research (01.01.2013)
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Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I : Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine
JIAZHI SUN, BLASKOVICH, M. A, KNOWLES, D, YIMIN QIAN, OHKANDA, J, BAILEY, R. D, HAMILTON, A. D, SEBTI, S. M
Published in Cancer research (Chicago, Ill.) (01.10.1999)
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Published in Cancer research (Chicago, Ill.) (01.10.1999)
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Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines
LERNER, E. C, ZHANG, T.-T, KNOWLES, D. B, QIAN, Y, HAMILTON, A. D, SEBTI, S. M
Published in Oncogene (01.09.1997)
Published in Oncogene (01.09.1997)
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Inhibiting ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes
BERNHARD, E. J, MCKENNA, W. G, HAMILTON, A. D, SEBTI, S. M, YIMIN QIAN, JUNMIN WU, MUSCHEL, R. J
Published in Cancer research (Chicago, Ill.) (15.04.1998)
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Published in Cancer research (Chicago, Ill.) (15.04.1998)
Journal Article
Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes ()
Lerner, Edwina C., Qian, Yimin, Blaskovich, Michelle A., Fossum, Renae D., Vogt, Andreas, Sun, Jiazhi, Cox, Adrienne D., Der, Channing J., Hamilton, Andrew D., Sebti, Saïd M.
Published in The Journal of biological chemistry (10.11.1995)
Published in The Journal of biological chemistry (10.11.1995)
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