Combining RAS(ON) G12C-selective inhibitor with SHP2 inhibition sensitises lung tumours to immune checkpoint blockade
Anastasiou, Panayiotis, Moore, Christopher, Rana, Sareena, Tomaschko, Mona, Pillsbury, Claire E., de Castro, Andrea, Boumelha, Jesse, Mugarza, Edurne, de Carné Trécesson, Sophie, Mikolajczak, Ania, Blaj, Cristina, Goldstone, Robert, Smith, Jacqueline A. M., Quintana, Elsa, Molina-Arcas, Miriam, Downward, Julian
Published in Nature communications (25.09.2024)
Published in Nature communications (25.09.2024)
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Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma
Eskiocak, Ugur, Ramesh, Vijayashree, Gill, Jennifer G., Zhao, Zhiyu, Yuan, Stacy W., Wang, Meng, Vandergriff, Travis, Shackleton, Mark, Quintana, Elsa, Frankel, Arthur E., Johnson, Timothy M., DeBerardinis, Ralph J., Morrison, Sean J.
Published in Nature communications (22.08.2016)
Published in Nature communications (22.08.2016)
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Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity
Myers, Darienne R, Abram, Clare L, Wildes, David, Belwafa, Amira, Welsh, Alia M N, Schulze, Christopher J, Choy, Tiffany J, Nguyen, Tram, Omaque, Neil, Hu, Yongmei, Singh, Mallika, Hansen, Rich, Goldsmith, Mark A, Quintana, Elsa, Smith, Jacqueline A M, Lowell, Clifford A
Published in Frontiers in immunology (29.09.2020)
Published in Frontiers in immunology (29.09.2020)
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214 The KRASG12D(ON) covalent tricomplex inhibitor RM-044 increases tumor antigen presentation and TCR repertoire diversity to promote anti-tumor immunity in a preclinical model of KRASG12D mutant cancer
Shifrin, Nataliya Tovbis, Menard, Marie, Courtney, Haley, Ganesh, Swetha, Kumamoto, Alice, Seu, Lillian, Smith, Jacqueline AM, Quintana, Elsa
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Erratum: Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma
Eskiocak, Ugur, Ramesh, Vijayashree, Gill, Jennifer G., Zhao, Zhiyu, Yuan, Stacy W., Wang, Meng, Vandergriff, Travis, Shackleton, Mark, Quintana, Elsa, Frankel, Arthur E., Johnson, Timothy M., DeBerardinis, Ralph J., Morrison, Sean J.
Published in Nature communications (29.09.2016)
Published in Nature communications (29.09.2016)
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Efficient tumour formation by single human melanoma cells
Quintana, Elsa, Shackleton, Mark, Sabel, Michael S., Fullen, Douglas R., Johnson, Timothy M., Morrison, Sean J.
Published in Nature (04.12.2008)
Published in Nature (04.12.2008)
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Phenotypic Heterogeneity among Tumorigenic Melanoma Cells from Patients that Is Reversible and Not Hierarchically Organized
Quintana, Elsa, Shackleton, Mark, Foster, Hannah R., Fullen, Douglas R., Sabel, Michael S., Johnson, Timothy M., Morrison, Sean J.
Published in Cancer cell (16.11.2010)
Published in Cancer cell (16.11.2010)
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Allosteric Inhibition of SHP2 Stimulates Antitumor Immunity by Transforming the Immunosuppressive Environment
Quintana, Elsa, Schulze, Christopher J., Myers, Darienne R., Choy, Tiffany J., Mordec, Kasia, Wildes, David, Shifrin, Nataliya Tobvis, Belwafa, Amira, Koltun, Elena S., Gill, Adrian L., Singh, Mallika, Kelsey, Stephen, Goldsmith, Mark A., Nichols, Robert, Smith, Jacqueline A.M.
Published in Cancer research (Chicago, Ill.) (01.07.2020)
Published in Cancer research (Chicago, Ill.) (01.07.2020)
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Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy
Holderfield, Matthew, Lee, Bianca J., Jiang, Jingjing, Tomlinson, Aidan, Seamon, Kyle J., Mira, Alessia, Patrucco, Enrico, Goodhart, Grace, Dilly, Julien, Gindin, Yevgeniy, Dinglasan, Nuntana, Wang, Yingyun, Lai, Lick Pui, Cai, Shurui, Jiang, Lingyan, Nasholm, Nicole, Shifrin, Nataliya, Blaj, Cristina, Shah, Harshit, Evans, James W., Montazer, Nilufar, Lai, Oliver, Shi, Jade, Ahler, Ethan, Quintana, Elsa, Chang, Stephanie, Salvador, Anthony, Marquez, Abby, Cregg, Jim, Liu, Yang, Milin, Anthony, Chen, Anqi, Ziv, Tamar Bar, Parsons, Dylan, Knox, John E., Klomp, Jennifer E., Roth, Jennifer, Rees, Matthew, Ronan, Melissa, Cuevas-Navarro, Antonio, Hu, Feng, Lito, Piro, Santamaria, David, Aguirre, Andrew J., Waters, Andrew M., Der, Channing J., Ambrogio, Chiara, Wang, Zhengping, Gill, Adrian L., Koltun, Elena S., Smith, Jacqueline A. M., Wildes, David, Singh, Mallika
Published in Nature (London) (23.05.2024)
Published in Nature (London) (23.05.2024)
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Journal Article
Human melanoma metastasis in NSG mice correlates with clinical outcome in patients
Quintana, Elsa, Piskounova, Elena, Shackleton, Mark, Weinberg, Daniel, Eskiocak, Ugur, Fullen, Douglas R, Johnson, Timothy M, Morrison, Sean J
Published in Science translational medicine (07.11.2012)
Published in Science translational medicine (07.11.2012)
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Journal Article
A cerebral nitrergic pathway modulates endotoxin‐induced changes in gastric motility
Quintana, Elsa, García‐Zaragozá, Eugenia, Angeles Martínez‐Cuesta, M, Calatayud, Sara, Esplugues, Juan V, Barrachina, María Dolores
Published in British journal of pharmacology (01.09.2001)
Published in British journal of pharmacology (01.09.2001)
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Abstract 2837: Dual inhibition of SHP2 and CDK4/6 leads to immunological memory and immune-mediated anti-tumor activity in a mouse syngeneic model of breast cancer
Shifrin, Nataliya Tovbis, Lee, Grace J., Omaque, Neil, Nguyen, Tram, Belwafa, Amira, Lorenzana, Edward G., Nichols, Robert J., Smith, Jacqueline A., Singh, Mallika, Quintana, Elsa
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer
Wasko, Urszula N., Jiang, Jingjing, Dalton, Tanner C., Curiel-Garcia, Alvaro, Edwards, A. Cole, Wang, Yingyun, Lee, Bianca, Orlen, Margo, Tian, Sha, Stalnecker, Clint A., Drizyte-Miller, Kristina, Menard, Marie, Dilly, Julien, Sastra, Stephen A., Palermo, Carmine F., Hasselluhn, Marie C., Decker-Farrell, Amanda R., Chang, Stephanie, Jiang, Lingyan, Wei, Xing, Yang, Yu C., Helland, Ciara, Courtney, Haley, Gindin, Yevgeniy, Muonio, Karl, Zhao, Ruiping, Kemp, Samantha B., Clendenin, Cynthia, Sor, Rina, Vostrejs, William P., Hibshman, Priya S., Amparo, Amber M., Hennessey, Connor, Rees, Matthew G., Ronan, Melissa M., Roth, Jennifer A., Brodbeck, Jens, Tomassoni, Lorenzo, Bakir, Basil, Socci, Nicholas D., Herring, Laura E., Barker, Natalie K., Wang, Junning, Cleary, James M., Wolpin, Brian M., Chabot, John A., Kluger, Michael D., Manji, Gulam A., Tsai, Kenneth Y., Sekulic, Miroslav, Lagana, Stephen M., Califano, Andrea, Quintana, Elsa, Wang, Zhengping, Smith, Jacqueline A. M., Holderfield, Matthew, Wildes, David, Lowe, Scott W., Badgley, Michael A., Aguirre, Andrew J., Vonderheide, Robert H., Stanger, Ben Z., Baslan, Timour, Der, Channing J., Singh, Mallika, Olive, Kenneth P.
Published in Nature (London) (23.05.2024)
Published in Nature (London) (23.05.2024)
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Journal Article
Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Jiang, Jingjing, Jiang, Lingyan, Maldonato, Benjamin J, Wang, Yingyun, Holderfield, Matthew, Aronchik, Ida, Winters, Ian P, Salman, Zeena, Blaj, Cristina, Menard, Marie, Brodbeck, Jens, Chen, Zhe, Wei, Xing, Rosen, Michael J, Gindin, Yevgeniy, Lee, Bianca J, Evans, James W, Chang, Stephanie, Wang, Zhican, Seamon, Kyle J, Parsons, Dylan, Cregg, James, Marquez, Abby, Tomlinson, Aidan C A, Yano, Jason K, Knox, John E, Quintana, Elsa, Aguirre, Andrew J, Arbour, Kathryn C, Reed, Abby, Gustafson, W Clay, Gill, Adrian L, Koltun, Elena S, Wildes, David, Smith, Jacqueline A M, Wang, Zhengping, Singh, Mallika
Published in Cancer discovery (09.04.2024)
Published in Cancer discovery (09.04.2024)
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Author Correction: Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer
Wasko, Urszula N., Jiang, Jingjing, Dalton, Tanner C., Curiel-Garcia, Alvaro, Edwards, A. Cole, Wang, Yingyun, Lee, Bianca, Orlen, Margo, Tian, Sha, Stalnecker, Clint A., Drizyte-Miller, Kristina, Menard, Marie, Dilly, Julien, Sastra, Stephen A., Palermo, Carmine F., Hasselluhn, Marie C., Decker-Farrell, Amanda R., Chang, Stephanie, Jiang, Lingyan, Wei, Xing, Yang, Yu C., Helland, Ciara, Courtney, Haley, Gindin, Yevgeniy, Muonio, Karl, Zhao, Ruiping, Kemp, Samantha B., Clendenin, Cynthia, Sor, Rina, Vostrejs, William P., Hibshman, Priya S., Amparo, Amber M., Hennessey, Connor, Rees, Matthew G., Ronan, Melissa M., Roth, Jennifer A., Brodbeck, Jens, Tomassoni, Lorenzo, Bakir, Basil, Socci, Nicholas D., Herring, Laura E., Barker, Natalie K., Wang, Junning, Cleary, James M., Wolpin, Brian M., Chabot, John A., Kluger, Michael D., Manji, Gulam A., Tsai, Kenneth Y., Sekulic, Miroslav, Lagana, Stephen M., Califano, Andrea, Quintana, Elsa, Wang, Zhengping, Smith, Jacqueline A. M., Holderfield, Matthew, Wildes, David, Lowe, Scott W., Badgley, Michael A., Aguirre, Andrew J., Vonderheide, Robert H., Stanger, Ben Z., Baslan, Timour, Der, Channing J., Singh, Mallika, Olive, Kenneth P.
Published in Nature (London) (12.11.2024)
Published in Nature (London) (12.11.2024)
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