A Practical Approach for Enantio- and Diastereocontrol in the Synthesis of 2,3-Disubstituted Succinic Acid Esters: Synthesis of the pan-Notch Inhibitor BMS-906024
Quesnelle, Claude A., Gill, Patrice, Kim, Soong-Hoon, Chen, Libing, Zhao, Yufen, Fink, Brian E., Saulnier, Mark, Frennesson, David, DeMartino, Michael P., Baran, Phil S., Gavai, Ashvinikumar V.
Published in Synlett (19.09.2016)
Published in Synlett (19.09.2016)
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Journal Article
Sordaricin antifungal agents
Quesnelle, Claude A, Gill, Patrice, Dodier, Marco, St. Laurent, Denis, Serrano-Wu, Michael, Marinier, Anne, Martel, Alain, Mazzucco, Charles E, Stickle, Terry M, Barrett, John F, Vyas, Dolatrai M, Balasubramanian, Balu N
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
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Journal Article
Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials
Snyder, Lawrence B., Meng, Zhaoxing, Mate, Robert, D’Andrea, Stanley V., Marinier, Anne, Quesnelle, Claude A., Gill, Patrice, DenBleyker, Kenneth L., Fung-Tomc, Joan C., Frosco, MaryBeth, Martel, Alain, Barrett, John F., Bronson, Joanne J.
Published in Bioorganic & medicinal chemistry letters (20.09.2004)
Published in Bioorganic & medicinal chemistry letters (20.09.2004)
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Journal Article
Biaryl isoxazolinone antibacterial agents
Quesnelle, Claude A., Gill, Patrice, Roy, Stephan, Dodier, Marco, Marinier, Anne, Martel, Alain, Snyder, Lawrence B., D’Andrea, Stanley V., Bronson, Joanne J., Frosco, MaryBeth, Beaulieu, Danielle, Warr, Glen A., DenBleyker, Ken L., Stickle, Terry M., Yang, Hyekyung, Chaniewski, Susan E., Ferraro, Cheryl A., Taylor, Dennis, Russell, John W., Santone, Kenneth S., Clarke, Junius, Drain, Rebecca L., Knipe, Jay O., Mosure, Kathleen, Barrett, John F.
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
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Journal Article
Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization
Cherney, Emily C, Zhang, Liping, Lo, Julian, Huynh, Tram, Wei, Donna, Ahuja, Vijay, Quesnelle, Claude, Schieven, Gary L, Futran, Alan, Locke, Gregory A, Lin, Zeyu, Monereau, Laura, Chaudhry, Charu, Blum, Jordan, Li, Sha, Fereshteh, Mark, Li-Wang, Bifang, Gangwar, Sanjeev, Pan, Chin, Chong, Colin, Zhu, Xiao, Posy, Shana L, Sack, John S, Zhang, Ping, Ruzanov, Max, Harner, Mary, Akhtar, Fahad, Schroeder, Gretchen M, Vite, Gregory, Fink, Brian
Published in Journal of medicinal chemistry (24.02.2022)
Published in Journal of medicinal chemistry (24.02.2022)
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Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design
Gavai, Ashvinikumar V, Norris, Derek, Delucca, George, Tortolani, David, Tokarski, John S, Dodd, Dharmpal, O’Malley, Daniel, Zhao, Yufen, Quesnelle, Claude, Gill, Patrice, Vaccaro, Wayne, Huynh, Tram, Ahuja, Vijay, Han, Wen-Ching, Mussari, Christopher, Harikrishnan, Lalgudi, Kamau, Muthoni, Poss, Michael, Sheriff, Steven, Yan, Chunhong, Marsilio, Frank, Menard, Krista, Wen, Mei-Li, Rampulla, Richard, Wu, Dauh-Rurng, Li, Jianqing, Zhang, Huiping, Li, Peng, Sun, Dawn, Yip, Henry, Traeger, Sarah C, Zhang, Yingru, Mathur, Arvind, Zhang, Haiying, Huang, Christine, Yang, Zheng, Ranasinghe, Asoka, Everlof, Gerry, Raghavan, Nirmala, Tye, Ching Kim, Wee, Susan, Hunt, John T, Vite, Gregory, Westhouse, Richard, Lee, Francis Y
Published in Journal of medicinal chemistry (14.10.2021)
Published in Journal of medicinal chemistry (14.10.2021)
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Journal Article
Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype
Hill, Matthew D., Quesnelle, Claude, Tokarski, John, Fang, Haiquan, Fanslau, Carolynn, Haarhoff, Zuzana, Kramer, Melissa, Madari, Shilpa, Wiebesiek, Amy, Morrison, John, Simmermacher-Mayer, Jean, Sinz, Michael, Westhouse, Richard, Xie, Chunshan, Zhao, Jiuqiao, Huang, Lisa, Sheriff, Steven, Yan, Chunhong, Marsilio, Frank, Everlof, Gerry, Zvyaga, Tatyana, Lee, Francis, Gavai, Ashvinikumar V., Degnan, Andrew P.
Published in Bioorganic & medicinal chemistry letters (01.11.2021)
Published in Bioorganic & medicinal chemistry letters (01.11.2021)
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Journal Article
마크로시클릭 면역조정제
ZHANG YUNHUI, POSS MICHAEL A, WANG TAMMY C, MAPELLI CLAUDIO, ALLEN MARTIN PATRICK, QIAO JENNIFER X, QUESNELLE CLAUDE
Year of Publication 18.03.2024
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Year of Publication 18.03.2024
Patent
마크로시클릭 면역조정제
ZHANG YUNHUI, WANG TAO, POSS MICHAEL A, WANG TAMMY C, QUESNELLE CLAUDE A, TORTOLANI DAVID R, ZHANG YONG, MAPELLI CLAUDIO, ALLEN MARTIN PATRICK, QIAO JENNIFER X, ZHANG ZHONGXING
Year of Publication 17.07.2024
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Year of Publication 17.07.2024
Patent
Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties
Hill, Matthew D., Fang, Haiquan, Norris, Derek, Delucca, George V., Huang, Hong, DeBenedetto, Mikkel, Quesnelle, Claude, Schmitz, William D., Tokarski, John S., Sheriff, Steven, Yan, Chunhong, Fanslau, Caroline, Haarhoff, Zuzana, Huang, Christine, Kramer, Melissa, Madari, Shilpa, Menard, Krista, Monereau, Laura, Morrison, John, Raghavan, Nirmala, Shields, Eric E., Simmermacher-Mayer, Jean, Sinz, Michael, Tye, Ching Kim, Westhouse, Richard, Xie, Chunshan, Zhang, Haiying, Zhang, Lisa, Zvyaga, Tatyana, Lee, Francis, Gavai, Ashvinikumar V., Degnan, Andrew P.
Published in ACS medicinal chemistry letters (14.07.2022)
Published in ACS medicinal chemistry letters (14.07.2022)
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Journal Article
Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors
Gavai, Ashvinikumar V, Quesnelle, Claude, Norris, Derek, Han, Wen-Ching, Gill, Patrice, Shan, Weifang, Balog, Aaron, Chen, Ke, Tebben, Andrew, Rampulla, Richard, Wu, Dauh-Rurng, Zhang, Yingru, Mathur, Arvind, White, Ronald, Rose, Anne, Wang, Haiqing, Yang, Zheng, Ranasinghe, Asoka, D’Arienzo, Celia, Guarino, Victor, Xiao, Lan, Su, Ching, Everlof, Gerry, Arora, Vinod, Shen, Ding Ren, Cvijic, Mary Ellen, Menard, Krista, Wen, Mei-Li, Meredith, Jere, Trainor, George, Lombardo, Louis J, Olson, Richard, Baran, Phil S, Hunt, John T, Vite, Gregory D, Fischer, Bruce S, Westhouse, Richard A, Lee, Francis Y
Published in ACS medicinal chemistry letters (14.05.2015)
Published in ACS medicinal chemistry letters (14.05.2015)
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Journal Article
Abstract 5789: Discovery of clinical candidate BMS-986158, an oral BET inhibitor, for the treatment of cancer
Gavai, Ashvinikumar V., Norris, Derek, Tortolani, David, O'Malley, Daniel, Zhao, Yufen, Quesnelle, Claude, Gill, Patrice, Vaccaro, Wayne, Huynh, Tram, Ahuja, Vijay, Dodd, Dharmpal, Mussari, Christopher, Harikrishnan, Lalgudi, Kamau, Muthoni, Tokarski, John S., Sheriff, Steven, Rampulla, Richard, Wu, Dauh-Rurng, Li, Jianqing, Zhang, Huiping, Li, Peng, Sun, Dawn, Yip, Henry, Zhang, Yingru, Mathur, Arvind, Zhang, Haiying, Huang, Christine, Yang, Zheng, Ranasinghe, Asoka, D'Arienzo, Celia, Su, Ching, Everlof, Gerry, Zhang, Lisa, Raghavan, Nirmala, Hunt, John T., Poss, Michael, Vite, Gregory D., Westhouse, Richard A., Wee, Susan
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Symmetrical alkoxysilyl ethers. A new class of alcohol-protecting groups. Preparation of tert-butoxydiphenylsilyl ethers
Gillard, John W, Fortin, Rejean, Morton, Howard E, Yoakim, Christiane, Quesnelle, Claude A, Daignault, Sylvain, Guindon, Yvan
Published in Journal of organic chemistry (01.05.1988)
Published in Journal of organic chemistry (01.05.1988)
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Journal Article
BMS-871: A novel orally active pan-Notch inhibitor as an anticancer agent
Shan, Weifang, Balog, Aaron, Quesnelle, Claude, Gill, Patrice, Han, Wen-Ching, Norris, Derek, Mandal, Sunilkumar, Thiruvenkadam, Raja, Gona, Kiran Babu, Thiyagarajan, Kamalraj, Kandula, Sathiah, McGlinchey, Kelly, Menard, Krista, Wen, Mei-Li, Rose, Anne, White, Ronald, Guarino, Victor, Shen, Ding Ren, Cvijic, Mary Ellen, Ranasinghe, Asoka, Dai, Jun, Zhang, Yingru, Wu, Dauh-Rurng, Mathur, Arvind, Rampulla, Richard, Trainor, George, Hunt, John T., Vite, Gregory D., Westhouse, Richard, Lee, Francis Y., Gavai, Ashvinikumar V.
Published in Bioorganic & medicinal chemistry letters (01.05.2015)
Published in Bioorganic & medicinal chemistry letters (01.05.2015)
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Journal Article
Abstract 1643: BMS-983970, an oral pan-Notch inhibitor for the treatment of cancer
Gavai, Ashvinikumar V., Zhao, Yufen, O'Malley, Daniel, Fink, Brian, Quesnelle, Claude, Norris, Derek, Chen, Libing, Kim, Soong-Hoon, Han, Wen-Ching, Gill, Patrice, Shan, Weifang, Balog, Aaron, Tebben, Andrew, Rampulla, Richard, Wu, Dauh-Rurng, Zhang, Yingru, Mathur, Arvind, Wang, Haiqing, Yang, Zheng, Ruan, Qian, Moore, Robin, Rodrigues, David, Ranasinghe, Asoka, D'Arienzo, Celia, Tye, Ching Kim, Su, Ching, Everlof, Gerry, Yarde, Melissa, Cvijic, Mary Ellen, Menard, Krista, Wen, Mei-Li, Trainor, George, Fischer, Bruce, Hunt, John, Vite, Gregory, Westhouse, Richard, Lee, Francis
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Novel Tricyclic Inhibitors of IκB Kinase
Kempson, James, Spergel, Steven H, Guo, Junqing, Quesnelle, Claude, Gill, Patrice, Belanger, Dominique, Dyckman, Alaric J, Li, Tianle, Watterson, Scott H, Langevine, Charles M, Das, Jagabandhu, Moquin, Robert V, Furch, Joseph A, Marinier, Anne, Dodier, Marco, Martel, Alain, Nirschl, David, Van Kirk, Katy, Burke, James R, Pattoli, Mark A, Gillooly, Kathleen, McIntyre, Kim W, Chen, Laishun, Yang, Zheng, Marathe, Punit H, Wang-Iverson, David, Dodd, John H, McKinnon, Murray, Barrish, Joel C, Pitts, William J
Published in Journal of medicinal chemistry (09.04.2009)
Published in Journal of medicinal chemistry (09.04.2009)
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Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: Synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis
Dyckman, Alaric J., Langevine, Charles M., Quesnelle, Claude, Kempson, James, Guo, Junqing, Gill, Patrice, Spergel, Steven H., Watterson, Scott H., Li, Tianle, Nirschl, David S., Gillooly, Kathleen M., Pattoli, Mark A., McIntyre, Kim W., Chen, Laishun, McKinnon, Murray, Dodd, John H., Barrish, Joel C., Burke, James R., Pitts, William J.
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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