Pyridine and pyridinone-based factor XIa inhibitors
Corte, James R., Fang, Tianan, Hangeland, Jon J., Friends, Todd J., Rendina, Alan R., Luettgen, Joseph M., Bozarth, Jeffrey M., Barbera, Frank A., Rossi, Karen A., Wei, Anzhi, Ramamurthy, Vidhyashankar, Morin, Paul E., Seiffert, Dietmar A., Wexler, Ruth R., Quan, Mimi L.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
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Design and Synthesis of Isoxazoline Derivatives as Factor Xa Inhibitors. 1
Quan, Mimi L, Liauw, Ann Y, Ellis, Christopher D, Pruitt, James R, Carini, David J, Bostrom, Lori L, Huang, Peggy P, Harrison, Kimberly, Knabb, Robert M, Thoolen, Martin J, Wong, Pancras C, Wexler, Ruth R
Published in Journal of medicinal chemistry (29.07.1999)
Published in Journal of medicinal chemistry (29.07.1999)
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Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)‑one as the P2′ Moiety
Hu, Zilun, Wong, Pancras C, Gilligan, Paul J, Han, Wei, Pabbisetty, Kumar B, Bozarth, Jeffrey M, Crain, Earl J, Harper, Timothy, Luettgen, Joseph M, Myers, Joseph E, Ramamurthy, Vidhyashankar, Rossi, Karen A, Sheriff, Steven, Watson, Carol A, Wei, Anzi, Zheng, Joanna J, Seiffert, Dietmar A, Wexler, Ruth R, Quan, Mimi L
Published in ACS medicinal chemistry letters (14.05.2015)
Published in ACS medicinal chemistry letters (14.05.2015)
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Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa
Pinto, Donald J. P, Orwat, Michael J, Wang, Shuaige, Fevig, John M, Quan, Mimi L, Amparo, Eugene, Cacciola, Joseph, Rossi, Karen A, Alexander, Richard S, Smallwood, Angela M, Luettgen, Joseph M, Liang, Li, Aungst, Bruce J, Wright, Matthew R, Knabb, Robert M, Wong, Pancras C, Wexler, Ruth R, Lam, Patrick Y. S
Published in Journal of medicinal chemistry (15.02.2001)
Published in Journal of medicinal chemistry (15.02.2001)
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1-[3-Aminobenzisoxazol-5′-yl]-3-trifluoromethyl-6-[2′-(3-( R)-hydroxy- N-pyrrolidinyl)methyl-[1,1′]-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4- c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa
Pinto, Donald J.P., Orwat, Michael J., Quan, Mimi L., Han, Qi, Galemmo, Robert A., Amparo, Eugene, Wells, Brian, Ellis, Christopher, He, Ming Y., Alexander, Richard S., Rossi, Karen A., Smallwood, Angela, Wong, Pancras C., Luettgen, Joseph M., Rendina, Alan R., Knabb, Robert M., Mersinger, Lawrence, Kettner, Charles, Bai, Steven, He, Kan, Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
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Journal Article
Phenyltriazolinones as potent factor Xa inhibitors
Quan, Mimi L., Pinto, Donald J.P., Rossi, Karen A., Sheriff, Steven, Alexander, Richard S., Amparo, Eugene, Kish, Kevin, Knabb, Robert M., Luettgen, Joseph M., Morin, Paul, Smallwood, Angela, Woerner, Francis J., Wexler, Ruth R.
Published in Bioorganic & medicinal chemistry letters (15.02.2010)
Published in Bioorganic & medicinal chemistry letters (15.02.2010)
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Journal Article
Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits
Wong, Pancras C, Crain, Earl J, Watson, Carol A, Wexler, Ruth R, Lam, Patrick Y S, Quan, Mimi L, Knabb, Robert M
Published in Journal of thrombosis and thrombolysis (01.08.2007)
Published in Journal of thrombosis and thrombolysis (01.08.2007)
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Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moieties
Pinto, Donald J.P., Galemmo, Robert A., Quan, Mimi L., Orwat, Michael J., Clark, Charles, Li, Renhua, Wells, Brian, Woerner, Francis, Alexander, Richard S., Rossi, Karen A., Smallwood, Angela, Wong, Pancras C., Luettgen, Joseph M., Rendina, Alan R., Knabb, Robert M., He, Kan, Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (01.11.2006)
Published in Bioorganic & medicinal chemistry letters (01.11.2006)
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Sulfonamidolactam inhibitors of coagulation factor Xa
Smallheer, Joanne M., Wang, Shuaige, Laws, Mia L., Nakajima, Suanne, Hu, Zilun, Han, Wei, Jacobson, Irina, Luettgen, Joseph M., Rossi, Karen A., Rendina, Alan R., Knabb, Robert M., Wexler, Ruth R., Lam, Patrick Y.S., Quan, Mimi L.
Published in Bioorganic & medicinal chemistry (01.04.2008)
Published in Bioorganic & medicinal chemistry (01.04.2008)
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Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors
Quan, Mimi L., Han, Qi, Fevig, John M., Lam, Patrick Y.S., Bai, Steve, Knabb, Robert M., Luettgen, Joseph M., Wong, Pancras C., Wexler, Ruth R.
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
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Nonbenzamidine tetrazole derivatives as factor Xa inhibitors
Quan, Mimi L, Ellis, Christopher D, He, Ming Y, Liauw, Ann Y, Woerner, Francis J, Alexander, Richard S, Knabb, Robert M, Lam, Patrick Y.S, Luettgen, Joseph M, Wong, Pancras C, Wright, Matthew R, Wexler, Ruth R
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
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Nonpeptide Factor Xa Inhibitors II. Antithrombotic Evaluation in a Rabbit Model of Electrically Induced Carotid Artery Thrombosis
Wong, P C, Crain, E J, Knabb, R M, Meade, R P, Quan, M L, Watson, C A, Wexler, R R, Wright, M R, Slee, A M
Published in The Journal of pharmacology and experimental therapeutics (01.10.2000)
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Published in The Journal of pharmacology and experimental therapeutics (01.10.2000)
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Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core
Fevig, John M., Pinto, Donald J., Han, Qi, Quan, Mimi L., Pruitt, James R., Jacobson, Irina C., Galemmo, Jr, Robert A., Wang, Shuaige, Orwat, Michael J., Bostrom, Lori L., Knabb, Robert M., Wong, Pancras C., Lam, Patrick Y.S., Wexler, Ruth R.
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
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Journal Article
Nonbenzamidine isoxazoline derivatives as factor Xa inhibitors
Quan, Mimi L., Ellis, Christopher D., He, Ming Y., Liauw, Ann Y., Lam, Patrick Y.S., Rossi, Karen A., Knabb, Robert M., Luettgen, Joseph M., Wright, Matthew R., Wong, Pancras C., Wexler, Ruth R.
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
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MACROCYCLES AS FACTOR XIA INHIBITORS
PINTO DONALD J. P, FANG TIANAN, WANG YUFENG, SMALLHEER JOANNE M, JEON YOON, ROSSI KAREN A, CORTE JAMES R, HU ZILUN, QUAN MIMI L, YANG WU, DECICCO CARL P
Year of Publication 08.12.2017
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Year of Publication 08.12.2017
Patent
Discovery of a Parenteral Small Molecule Coagulation Factor Xla Inhibitor Clinical Candidate (BMS-962212)
Pinto, Donald J. P., Orwat, Michael J., Smith, Leon M., Quan, Mimi L., Lam, Patrick Y. S., Rossi, Karen A., Apedo, Atsu, Bozarth, Jeffrey M., Wu, Yiming, Zheng, Joanna J., Xin, Baomin, Toussaint, Nathalie, Stetsko, Paul, Gudmundsson, Olafur, Maxwell, Brad, Crain, Earl J., Wong, Pancras C., Lou, Zhen, Harper, Timothy W., Chacko, Silvi A., Myers, Joseph E., Sheriff, Steven, Zhang, Huiping, Hou, Xiaoping, Mathur, Arvind, Seiffert, Dietmar A., Wexler, Ruth R., Luettgen, Joseph M., Ewing, William R.
Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
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DIPEPTIDE ANALOGS AS COAGULATION FACTOR INHIBITORS
PINTO DONALD J. P, SMITH II LEON M, ORWAT MICHAEL J, QUAN MIMI L, GILLIGAN PAUL J
Year of Publication 09.04.2010
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Year of Publication 09.04.2010
Patent