Discovery of 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDC-101) as a Potent Multi-Acting HDAC, EGFR, and HER2 Inhibitor for the Treatment of Cancer
Cai, Xiong, Zhai, Hai-Xiao, Wang, Jing, Forrester, Jeffrey, Qu, Hui, Yin, Ling, Lai, Cheng-Jung, Bao, Rudi, Qian, Changgeng
Published in Journal of medicinal chemistry (11.03.2010)
Published in Journal of medicinal chemistry (11.03.2010)
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Cancer Network Disruption by a Single Molecule Inhibitor Targeting Both Histone Deacetylase Activity and Phosphatidylinositol 3-Kinase Signaling
CHANGGENG QIAN, LAI, Cheng-Jung, ZIFCAK, Brian, ANNA WAI SEE MA, DELLAROCCA, Steven, BOREK, Mylissa, ZHAI, Hai-Xiao, XIONG CAI, VOI, Maurizio, RUDI BAO, WANG, Da-Gong, JING WANG, XU, Guang-Xin, ATOYAN, Ruzanna, HUI QU, LING YIN, SAMSON, Maria
Published in Clinical cancer research (01.08.2012)
Published in Clinical cancer research (01.08.2012)
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GDC-0449—A potent inhibitor of the hedgehog pathway
Robarge, Kirk D., Brunton, Shirley A., Castanedo, Georgette M., Cui, Yong, Dina, Michael S., Goldsmith, Richard, Gould, Stephen E., Guichert, Oivin, Gunzner, Janet L., Halladay, Jason, Jia, Wei, Khojasteh, Cyrus, Koehler, Michael F.T., Kotkow, Karen, La, Hank, LaLonde, Rebecca L., Lau, Kevin, Lee, Leslie, Marshall, Derek, Marsters, James C., Murray, Lesley J., Qian, Changgeng, Rubin, Lee L., Salphati, Laurent, Stanley, Mark S., Stibbard, John H.A., Sutherlin, Daniel P., Ubhayaker, Savita, Wang, Shumei, Wong, Susan, Xie, Minli
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
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CUDC-101, a Multitargeted Inhibitor of Histone Deacetylase, Epidermal Growth Factor Receptor, and Human Epidermal Growth Factor Receptor 2, Exerts Potent Anticancer Activity
LAI, Cheng-Jung, RUDI BAO, ZIFCAK, Brian, XU, Guang-Xin, DELLAROCCA, Steven, ZHAI, Hai-Xiao, XIONG CAI, MUNGER, William E, KEEGAN, Mitchell, PEPICELLI, Carmen V, CHANGGENG QIAN, XU TAO, JING WANG, ATOYAN, Ruzanna, HUI QU, WANG, Da-Gong, LING YIN, SAMSON, Maria, FORRESTER, Jeffrey
Published in Cancer research (Chicago, Ill.) (01.05.2010)
Published in Cancer research (Chicago, Ill.) (01.05.2010)
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CUDC-305, a Novel Synthetic HSP90 Inhibitor with Unique Pharmacologic Properties for Cancer Therapy
Bao, Rudi, Lai, Cheng-Jung, Qu, Hui, Wang, Dagong, Yin, Ling, Zifcak, Brian, Atoyan, Ruzanna, Wang, Jing, Samson, Maria, Forrester, Jeffrey, DellaRocca, Steven, Xu, Guang-Xin, Tao, Xu, Zhai, Hai-Xiao, Cai, Xiong, Qian, Changgeng
Published in Clinical cancer research (15.06.2009)
Published in Clinical cancer research (15.06.2009)
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BEBT-109, a pan-mutant-selective EGFR inhibitor with potent antitumor activity in EGFR-mutant non-small cell lung cancer
Fan, Fushun, Zhou, Minhua, Ye, Xiaolan, Mo, Zhenxian, Ma, Yaru, Luo, Liying, Liang, Xiaotong, Liu, Haiqi, Weng, Yunwo, Lin, Mingsheng, Liu, Xinjian, Cai, Xiong, Qian, Changgeng
Published in Translational oncology (01.02.2021)
Published in Translational oncology (01.02.2021)
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Targeting heat shock protein 90 with CUDC-305 overcomes erlotinib resistance in non–small cell lung cancer
Bao, Rudi, Lai, Cheng-Jung, Wang, Da-Gong, Qu, Hui, Yin, Ling, Zifcak, Brian, Tao, Xu, Wang, Jing, Atoyan, Ruzanna, Samson, Maria, Forrester, Jeffrey, Xu, Guang-Xin, DellaRocca, Steven, Borek, Mylissa, Zhai, Hai-Xiao, Cai, Xiong, Qian, Changgeng
Published in Molecular cancer therapeutics (01.12.2009)
Published in Molecular cancer therapeutics (01.12.2009)
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A Dual PI3K/HDAC Inhibitor Induces Immunogenic Ferroptosis to Potentiate Cancer Immune Checkpoint Therapy
Fan, Fushun, Liu, Pei, Bao, Rudi, Chen, Jian, Zhou, Minhua, Mo, Zhenxian, Ma, Yaru, Liu, Haiqi, Zhou, Yiping, Cai, Xiong, Qian, Changgeng, Liu, Xinjian
Published in Cancer research (Chicago, Ill.) (15.12.2021)
Published in Cancer research (Chicago, Ill.) (15.12.2021)
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Impurities from Hydroxyproline Derivatives in the Synthesis of Modified Oligonucleotides
Liang, Hao, Hou, Dalong, Li, Siming, Chen, Simin, Ma, Yaru, Liu, Haiqi, Fan, Fushun, Wang, Yuqiang, Qian, Changgeng, Liu, Xinjian
Published in Organic process research & development (18.10.2024)
Published in Organic process research & development (18.10.2024)
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Retraction notice to “BEBT-908: A novel potent PI3K/HDAC inhibitor against diffuse large B-cell lymphoma” [Biochem. Biophys. Res. Commun. 491 (2017) 939-945]
Li, Jin, Qian, Changgeng, Zhou, Qianqian, Li, Jiwei, Li, Kunlun, Yi, Pingyong
Published in Biochemical and biophysical research communications (18.03.2018)
Published in Biochemical and biophysical research communications (18.03.2018)
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BEBT-908: A novel potent PI3K/HDAC inhibitor against diffuse large B-cell lymphoma
Li, Jin, Qian, Changgeng, Zhou, Qianqian, Li, Jiwei, Li, Kunlun, Yi, Pingyong
Published in Biochemical and biophysical research communications (30.09.2017)
Published in Biochemical and biophysical research communications (30.09.2017)
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Dual PI3K/HDAC Inhibitor BEBT-908 Exhibits Potent Efficacy as Monotherapy for Primary Central Nervous System Lymphoma
Wang, Ning, Mo, Zhenxian, Pan, Lu, Zhou, Minhua, Ye, Xiaolan, Liu, Xinjian, Cai, Xiong, Qian, Changgeng, Chen, Feili, Xiong, Yan, Fan, Fushun, Li, Wenyu
Published in Targeted oncology (01.11.2023)
Published in Targeted oncology (01.11.2023)
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(±)-trans-2-[3-Methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N- hydroxyureidyl)methylphenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a Potent Dual 5-Lipoxygenase Inhibitor and Platelet-Activating Factor Receptor Antagonist
Cai, Xiong, Scannell, Ralph T, Yaeger, David, Hussoin, Md. Sajjat, Killian, David B, Qian, Changgeng, Eckman, Joseph, Hwang, San-Bao, Libertine-Garahan, Lynn, Yeh, C. Grace, Ip, Stephen H, Shen, T. Y
Published in Journal of medicinal chemistry (21.05.1998)
Published in Journal of medicinal chemistry (21.05.1998)
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The analgesic effect of epibatidine and isomers
Li, Tongchuan, Qian, Changgeng, Eckman, Joseph, Huang, Dao Fei, Shen, T.Y.
Published in Bioorganic & medicinal chemistry letters (01.12.1993)
Published in Bioorganic & medicinal chemistry letters (01.12.1993)
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