Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells
Smalley, Joshua P, Baker, India M, Pytel, Wiktoria A, Lin, Li-Ying, Bowman, Karen J, Schwabe, John W R, Cowley, Shaun M, Hodgkinson, James T
Published in Journal of medicinal chemistry (14.04.2022)
Published in Journal of medicinal chemistry (14.04.2022)
Get full text
Journal Article
A 'click' chemistry approach to novel entinostat (MS-275) based class I histone deacetylase proteolysis targeting chimeras
Cross, Jasmine M, Coulson, Megan E, Smalley, Joshua P, Pytel, Wiktoria A, Ismail, Ozair, Trory, Justin S, Cowley, Shaun M, Hodgkinson, James T
Published in MedChemComm (14.12.2022)
Published in MedChemComm (14.12.2022)
Get full text
Journal Article
Optimization of Class I Histone Deacetylase PROTACs Reveals thatHDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells
Smalley, Joshua P., Baker, India M., Pytel, Wiktoria A., Lin, Li-Ying, Bowman, Karen J., Schwabe, John W. R., Cowley, Shaun M., Hodgkinson, James T.
Published in Journal of medicinal chemistry (14.04.2022)
Published in Journal of medicinal chemistry (14.04.2022)
Get full text
Journal Article