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A Clinical PET Imaging Tracer ([18F]DASA-23) to Monitor Pyruvate Kinase M2–Induced Glycolytic Reprogramming in Glioblastoma
Beinat, Corinne, Patel, Chirag B., Haywood, Tom, Murty, Surya, Naya, Lewis, Castillo, Jessa B., Reyes, Samantha T., Phillips, Megan, Buccino, Pablo, Shen, Bin, Park, Jun Hyung, Koran, Mary Ellen I., Alam, Israt S., James, Michelle L., Holley, Dawn, Halbert, Kim, Gandhi, Harsh, He, Joy Q., Granucci, Monica, Johnson, Eli, Liu, Daniel Dan, Uchida, Nobuko, Sinha, Rahul, Chu, Pauline, Born, Donald E., Warnock, Geoffrey I., Weissman, Irving, Hayden-Gephart, Melanie, Khalighi, Mehdi, Massoud, Tarik F., Iagaru, Andrei, Davidzon, Guido, Thomas, Reena, Nagpal, Seema, Recht, Lawrence D., Gambhir, Sanjiv Sam
Published in Clinical cancer research (01.12.2021)
Published in Clinical cancer research (01.12.2021)
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Human biodistribution and radiation dosimetry of [18F]DASA-23, a PET probe targeting pyruvate kinase M2
Beinat, Corinne, Patel, Chirag B., Haywood, Tom, Shen, Bin, Naya, Lewis, Gandhi, Harsh, Holley, Dawn, Khalighi, Mehdi, Iagaru, Andrei, Davidzon, Guido, Gambhir, Sanjiv Sam
Published in European journal of nuclear medicine and molecular imaging (01.08.2020)
Published in European journal of nuclear medicine and molecular imaging (01.08.2020)
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Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease
Schroeder, Patricia, Fulzele, Keertik, Forsyth, Sanjeev, Ribadeneira, Maria D., Guichard, Sylvie, Wilker, Erik, Marshall, C. Gary, Drake, Adam, Fessler, Rose, Konstantinidis, Diamantis G., Seu, Katie G., Kalfa, Theodosia A.
Published in The Journal of pharmacology and experimental therapeutics (01.03.2022)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2022)
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A phase 1 dose escalation study of the pyruvate kinase activator mitapivat (AG-348) in sickle cell disease
Xu, Julia Z., Conrey, Anna, Frey, Ingrid, Gwaabe, Eveline, Menapace, Laurel A., Tumburu, Laxminath, Lundt, Maureen, Lequang, Timothy, Li, Quan, Glass, Kristen, Dunkelberger, Emily B., Iyer, Varsha, Mangus, Heidi, Kung, Charles, Dang, Lenny, Kosinski, Penelope A., Hawkins, Peter, Jeffries, Neal, Eaton, William A., Lay Thein, Swee
Published in Blood (10.11.2022)
Published in Blood (10.11.2022)
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Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis
Zhang, Hui, Wang, Daren, Li, Min, Plecitá-Hlavatá, Lydie, D’Alessandro, Angelo, Tauber, Jan, Riddle, Suzette, Kumar, Sushil, Flockton, Amanda, McKeon, B. Alexandre, Frid, Maria G., Reisz, Julie A., Caruso, Paola, El Kasmi, Karim C., Ježek, Petr, Morrell, Nicholas W., Hu, Cheng-Jun, Stenmark, Kurt R.
Published in Circulation (New York, N.Y.) (19.12.2017)
Published in Circulation (New York, N.Y.) (19.12.2017)
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Red Blood Cell Metabolism in Pyruvate Kinase Deficient Patients
Roy, Micaela K., Cendali, Francesca, Ooyama, Gabrielle, Gamboni, Fabia, Morton, Holmes, D’Alessandro, Angelo
Published in Frontiers in physiology (21.10.2021)
Published in Frontiers in physiology (21.10.2021)
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Pyruvate Kinase Deficiency and Malaria
Ayi, Kodjo, Min-Oo, Gundula, Serghides, Lena, Crockett, Maryanne, Kirby-Allen, Melanie, Quirt, Ian, Gros, Philippe, Kain, Kevin C
Published in The New England journal of medicine (24.04.2008)
Published in The New England journal of medicine (24.04.2008)
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Effects of Pyruvate Kinase M2 (PKM2) Gene Deletion on Astrocyte-Specific Glycolysis and Global Cerebral Ischemia-Induced Neuronal Death
Kang, Beom-Seok, Choi, Bo-Young, Kho, A-Ra, Lee, Song-Hee, Hong, Dae-Ki, Park, Min-Kyu, Lee, Si-Hyun, Lee, Chang-Juhn, Yang, Hyeun-Wook, Woo, Seo-Young, Park, Se-Wan, Kim, Dong-Yeon, Park, Jae-Bong, Chung, Won-Suk, Suh, Sang-Won
Published in Antioxidants (15.02.2023)
Published in Antioxidants (15.02.2023)
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Red Blood Cell Pyruvate Kinase Properties in Sickle Cell Disease - of Mice and Men
Traets, Marissa J.M., van Oirschot, Brigitte A., Ruiter, Titine J.J., Levine, Charles, Rijneveld, Anita W., Jans, Judith J.M., Rab, Minke A.E., Chen, Yu-Wei, van Wijk, Richard
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Voxelotor and Red Blood Cell Pyruvate Kinase Activator Affect Clot Strength in Sickle Cell Disease
Sekyonda, Zoe, Abonga, Calvin, Delianides, Christopher A., Oshabaheebwa, Solomon, Little, Jane A., Suster, Michael A., Mohseni, Pedram, Gurkan, Umut A.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Safety and Efficacy of Mitapivat (AG-348), an Oral Activator of Pyruvate Kinase R, in Subjects with Sickle Cell Disease: A Phase 2, Open-Label Study (ESTIMATE)
van Dijk, Myrthe J., Rab, Minke A.E., Rijneveld, Anita W., Nur, Erfan, Bartels, Marije, Jans, Judith J.M., van Solinge, Wouter W., Schutgens, Roger E.G., Wijk, Richard van, Van Beers, Eduard J.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Increased Plasma Pyruvate Kinase M2 (PK‐M2) in Heart Failure: A Novel Biomarker Related to Cardiac Function and its Clinical Implications
Cao, Lu, Dong, Xiaoyu, Chen, Fuzhong, Li, Guangjuan, Fang, Jiale, Han, Zhijun, Wang, Junhong
Published in Journal of the American Heart Association (21.01.2025)
Published in Journal of the American Heart Association (21.01.2025)
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T lymphocyte-derived extracellular vesicles aggravate abdominal aortic aneurysm by promoting macrophage lipid peroxidation and migration via pyruvate kinase muscle isozyme 2
Dang, Guohui, Li, Tianrun, Yang, Dongmin, Yang, Guangxin, Du, Xing, Yang, Juan, Miao, Yutong, Han, Lulu, Ma, Xiaolong, Song, Yuwei, Liu, Bo, Li, Xuan, Wang, Xian, Feng, Juan
Published in Redox biology (01.04.2022)
Published in Redox biology (01.04.2022)
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Safety, Pharmacokinetics, and Pharmacodynamics of Etavopivat (FT‐4202), an Allosteric Activator of Pyruvate Kinase‐R, in Healthy Adults: A Randomized, Placebo‐Controlled, Double‐Blind, First‐in‐Human Phase 1 Trial
Forsyth, Sanjeev, Schroeder, Patricia, Geib, James, Vrishabhendra, Leela, Konstantinidis, Diamantis G., LaSalvia, Kari, Ribadeneira, Maria D., Wu, Eric, Kelly, Patrick, Kalfa, Theodosia A.
Published in Clinical pharmacology in drug development (01.05.2022)
Published in Clinical pharmacology in drug development (01.05.2022)
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Results Update from the DRIVE PK Study: Effects of AG-348, a Pyruvate Kinase Activator, in Patients with Pyruvate Kinase Deficiency
Grace, Rachael F., Layton, D. Mark, Galactéros, Frédéric, Rose, Christian, Barcellini, Wilma, Morton, D. Holmes, Van Beers, Eduard J., Yaish, Hassan M., Ravindranath, Yaddanapudi, Kuo, Kevin H.M., Sheth, Sujit, Kwiatkowski, Janet L., Silver, Bruce, Kung, Charles, Cohen, Marvin, Yang, Hua, Kosinski, Penelope A., Hua, Lei, Barbier, Ann, Glader, Bertil
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Phase 1 Single‐ and Multiple‐Ascending‐Dose Randomized Studies of the Safety, Pharmacokinetics, and Pharmacodynamics of AG‐348, a First‐in‐Class Allosteric Activator of Pyruvate Kinase R, in Healthy Volunteers
Yang, Hua, Merica, Elizabeth, Chen, Yue, Cohen, Marvin, Goldwater, Ronald, Kosinski, Penelope A., Kung, Charles, Yuan, Zheng (Jason), Silverman, Lee, Goldwasser, Meredith, Silver, Bruce A., Agresta, Sam, Barbier, Ann J.
Published in Clinical pharmacology in drug development (01.02.2019)
Published in Clinical pharmacology in drug development (01.02.2019)
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