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Apixaban, an oral, direct factor Xa inhibitor: single dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects
Frost, Charles, Wang, Jessie, Nepal, Sunil, Schuster, Alan, Barrett, Yu Chen, Mosqueda‐Garcia, Rogelio, Reeves, Richard A., LaCreta, Frank
Published in British journal of clinical pharmacology (01.02.2013)
Published in British journal of clinical pharmacology (01.02.2013)
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Pharmacokinetics, pharmacodynamics, and safety of apixaban in subjects with end-stage renal disease on hemodialysis
Wang, Xiaoli, Tirucherai, Giridhar, Marbury, Thomas C, Wang, Jessie, Chang, Ming, Zhang, Donglu, Song, Yan, Pursley, Janice, Boyd, Rebecca A, Frost, Charles
Published in Journal of clinical pharmacology (01.05.2016)
Published in Journal of clinical pharmacology (01.05.2016)
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Safety, pharmacokinetics and pharmacodynamics of multiple oral doses of apixaban, a factor Xa inhibitor, in healthy subjects
Frost, Charles, Nepal, Sunil, Wang, Jessie, Schuster, Alan, Byon, Wonkyung, Boyd, Rebecca A., Yu, Zhigang, Shenker, Andrew, Barrett, Yu Chen, Mosqueda‐Garcia, Rogelio, LaCreta, Frank
Published in British journal of clinical pharmacology (01.11.2013)
Published in British journal of clinical pharmacology (01.11.2013)
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Apixaban: A Clinical Pharmacokinetic and Pharmacodynamic Review
Byon, Wonkyung, Garonzik, Samira, Boyd, Rebecca A., Frost, Charles E.
Published in Clinical pharmacokinetics (01.10.2019)
Published in Clinical pharmacokinetics (01.10.2019)
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Effect of extremes of body weight on the pharmacokinetics, pharmacodynamics, safety and tolerability of apixaban in healthy subjects
Upreti, Vijay V., Wang, Jessie, Barrett, Yu Chen, Byon, Wonkyung, Boyd, Rebecca A., Pursley, Janice, LaCreta, Frank P., Frost, Charles E.
Published in British journal of clinical pharmacology (01.12.2013)
Published in British journal of clinical pharmacology (01.12.2013)
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Quantification of cerebral cannabinoid receptors subtype 1 (CB1) in healthy subjects and schizophrenia by the novel PET radioligand [11C]OMAR
Wong, Dean F., Kuwabara, Hiroto, Horti, Andrew G., Raymont, Vanessa, Brasic, James, Guevara, Maria, Ye, Weiguo, Dannals, Robert F., Ravert, Hayden T., Nandi, Ayon, Rahmim, Arman, Ming, Jeffrey E., Grachev, Igor, Roy, Christine, Cascella, Nicola
Published in NeuroImage (Orlando, Fla.) (01.10.2010)
Published in NeuroImage (Orlando, Fla.) (01.10.2010)
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Clinical Pharmacokinetics of the Androgen Receptor Inhibitor Darolutamide in Healthy Subjects and Patients with Hepatic or Renal Impairment
Zurth, Christian, Nykänen, Pirjo, Wilkinson, Gary, Taavitsainen, Päivi, Vuorela, Annamari, Huang, Funan, Reschke, Susanne, Koskinen, Mikko
Published in Clinical pharmacokinetics (01.04.2022)
Published in Clinical pharmacokinetics (01.04.2022)
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Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans
Raghavan, Nirmala, Frost, Charles E., Yu, Zhigang, He, Kan, Zhang, Haiying, Humphreys, W. Griffith, Pinto, Donald, Chen, Shiangyuan, Bonacorsi, Samuel, Wong, Pancras C., Zhang, Donglu
Published in Drug metabolism and disposition (01.01.2009)
Published in Drug metabolism and disposition (01.01.2009)
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Effect of renal impairment on the pharmacokinetics, pharmacodynamics, and safety of apixaban
Chang, Ming, Yu, Zhigang, Shenker, Andrew, Wang, Jessie, Pursley, Janice, Byon, Wonkyung, Boyd, Rebecca A, LaCreta, Frank, Frost, Charles E
Published in Journal of clinical pharmacology (01.05.2016)
Published in Journal of clinical pharmacology (01.05.2016)
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Evaluation of Bruton’s Tyrosine Kinase (BTK) inhibition with alternative doses of ibrutinib in subjects with Chronic Lymphocytic Leukemia (CLL)
Ouerdani, Aziz, Valenzuela, Belén, Treijtel, Nicoline, Haddish-Berhane, Nahor, Desphande, Sanjay, Srinivasan, Srimathi, Smith, Emma, Perez Ruixo, Juan José
Published in Cancer chemotherapy and pharmacology (01.12.2025)
Published in Cancer chemotherapy and pharmacology (01.12.2025)
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Reversal of apixaban anticoagulation by four‐factor prothrombin complex concentrates in healthy subjects: a randomized three‐period crossover study
Song, Y., Wang, Z., Perlstein, I., Wang, J., LaCreta, F., Frost, R. J. A., Frost, C.
Published in Journal of thrombosis and haemostasis (01.11.2017)
Published in Journal of thrombosis and haemostasis (01.11.2017)
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Effect of Activated Charcoal on Apixaban Pharmacokinetics in Healthy Subjects
Wang, Xiaoli, Mondal, Sabiha, Wang, Jessie, Tirucherai, Giridhar, Zhang, Donglu, Boyd, Rebecca A., Frost, Charles
Published in American journal of cardiovascular drugs : drugs, devices, and other interventions (01.04.2014)
Published in American journal of cardiovascular drugs : drugs, devices, and other interventions (01.04.2014)
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Pharmacokinetics, safety, and bioequivalence of apixaban tablets in healthy Chinese subjects under fasting and fed conditions
Luo, Hong-Yu, Yao, Zhen-Jiang, Long, Hui-Zhi, Zhou, Zi-Wei, Xu, Shuo-Guo, Li, Feng-Jiao, Cheng, Yan, Wen, Dan-Dan, Deng, Ping, Guan, Yue-Qing, Gao, Li-Chen
Published in International journal of clinical pharmacology and therapeutics (01.03.2023)
Published in International journal of clinical pharmacology and therapeutics (01.03.2023)
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Effect of rifampin and itraconazole on the pharmacokinetics of zanubrutinib (a Bruton's tyrosine kinase inhibitor) in Asian and non-Asian healthy subjects
Mu, Song, Tang, Zhiyu, Novotny, William, Tawashi, Manal, Li, Ta-Kai, Ou, Ying, Sahasranaman, Srikumar
Published in Cancer chemotherapy and pharmacology (01.02.2020)
Published in Cancer chemotherapy and pharmacology (01.02.2020)
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Effect of ketoconazole and diltiazem on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor
Frost, Charles E., Byon, Wonkyung, Song, Yan, Wang, Jessie, Schuster, Alan E., Boyd, Rebecca A., Zhang, Donglu, Yu, Zhigang, Dias, Clapton, Shenker, Andrew, LaCreta, Frank
Published in British journal of clinical pharmacology (01.05.2015)
Published in British journal of clinical pharmacology (01.05.2015)
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Effects of Age and Sex on the Single-Dose Pharmacokinetics and Pharmacodynamics of Apixaban
Frost, Charles E., Song, Yan, Shenker, Andrew, Wang, Jessie, Barrett, Yu Chen, Schuster, Alan, Harris, Stuart I., LaCreta, Frank
Published in Clinical pharmacokinetics (01.06.2015)
Published in Clinical pharmacokinetics (01.06.2015)
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Investigation of absorption, metabolism, and excretion of [14C]pruxelutamide (GT0918), an androgen receptor antagonist in humans
Zheng, Yuan‐dong, Ma, Sheng, Yuan, Ya‐li, Zhang, Hua, Yang, Ying, Ye, Feng‐zhi, Wang, Mei‐yu, Chen, Jie, Tong, You‐zhi, Hu, Tao, He, Yi‐fei, Zhang, Yi‐fan, Zhong, Da‐fang, Miao, Li‐yan, Diao, Xing‐xing
Published in British journal of clinical pharmacology (01.07.2025)
Published in British journal of clinical pharmacology (01.07.2025)
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Bioequivalence of generic and branded ibrutinib capsules in healthy Chinese volunteers under fasting and fed conditions: a randomized, four-period, fully replicated, crossover study
Zhang, Rong, Chong, Rui, Yang, Shaomei, He, Kun, Wen, Qing
Published in Expert opinion on drug metabolism & toxicology (03.07.2025)
Published in Expert opinion on drug metabolism & toxicology (03.07.2025)
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Impact of ABCB1, ABCG2, and CYP3A5 polymorphisms on plasma trough concentrations of apixaban in Japanese patients with atrial fibrillation
Ueshima, Satoshi, Hira, Daiki, Fujii, Ryo, Kimura, Yuuma, Tomitsuka, Chiho, Yamane, Takuya, Tabuchi, Yohei, Ozawa, Tomoya, Itoh, Hideki, Horie, Minoru, Terada, Tomohiro, Katsura, Toshiya
Published in Pharmacogenetics and genomics (01.09.2017)
Published in Pharmacogenetics and genomics (01.09.2017)
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Metabolism, excretion and pharmacokinetics of [14C]crizotinib following oral administration to healthy subjects
Johnson, Theodore R., Tan, Weiwei, Goulet, Lance, Smith, Evan B., Yamazaki, Shinji, Walker, Gregory S., O'Gorman, Melissa T., Bedarida, Gabriella, Zou, Helen Y., Christensen, James G., Nguyen, Leslie N., Shen, Zhongzhou, Dalvie, Deepak, Bello, Akintunde, Smith, Bill J.
Published in Xenobiotica (01.01.2015)
Published in Xenobiotica (01.01.2015)
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