Infant cynomolgus monkeys exposed to denosumab in utero exhibit an osteoclast-poor osteopetrotic-like skeletal phenotype at birth and in the early postnatal period
Boyce, Rogely W, Varela, Aurore, Chouinard, Luc, Bussiere, Jeanine L, Chellman, Gary J, Ominsky, Michael S, Pyrah, Ian T
Published in Bone (New York, N.Y.) (01.07.2014)
Published in Bone (New York, N.Y.) (01.07.2014)
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Dose-related differences in the pharmacodynamic and toxicologic response to a novel hyperglycosylated analog of recombinant human erythropoietin in Sprague-Dawley rats with similarly high hematocrit
Andrews, Dina A, Boren, Babette M, Turk, James R, Boyce, Rogely W, He, Yudong D, Hamadeh, Hisham K, Mytych, Daniel T, Barger, Troy E, Salimi-Moosavi, Hossein, Sloey, Bethlyn, Elliott, Steve, McElroy, Patricia, Sinclair, Angus M, Shimamoto, Grant, Pyrah, Ian T G, Lightfoot-Dunn, Ruth M
Published in Toxicologic pathology (01.04.2014)
Published in Toxicologic pathology (01.04.2014)
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Cytokines associated with increased erythropoiesis in Sprague-Dawley rats administered a novel hyperglycosylated analog of recombinant human erythropoietin
Andrews, Dina A, Hamadeh, Hisham K, He, Yudong D, Boren, Babette M, Turk, James R, Boyce, Rogely W, Mytych, Daniel T, Barger, Troy E, Salimi-Moosavi, Hossein, Sloey, Bethlyn, Elliott, Steve, McElroy, Patricia, Sinclair, Angus M, Shimamoto, Grant, Pyrah, Ian T G, Lightfoot-Dunn, Ruth M
Published in Toxicologic pathology (01.04.2014)
Published in Toxicologic pathology (01.04.2014)
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Investigation of maternal and fetal exposure to an IgG2 monoclonal antibody following biweekly intravaginal administration to cynomolgus monkeys throughout pregnancy
Moffat, Graeme J., Davies, Rhian, Kwon, Gayle, Retter, Marc W., Chellman, Gary J., Kanapuram, Sekhar, Moore, Meghan, Loomis, Mark, Wang, Wei, Pyrah, Ian T.G.
Published in Reproductive toxicology (Elmsford, N.Y.) (01.09.2014)
Published in Reproductive toxicology (Elmsford, N.Y.) (01.09.2014)
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High hematocrit resulting from administration of erythropoiesis-stimulating agents is not fully predictive of mortality or toxicities in preclinical species
Andrews, Dina A, Pyrah, Ian T G, Boren, Babette M, Tannehill-Gregg, Sarah H, Lightfoot-Dunn, Ruth M
Published in Toxicologic pathology (01.04.2014)
Published in Toxicologic pathology (01.04.2014)
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Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice
Alferez, Denis, Wilkinson, Robert W, Watkins, Jim, Poulsom, Richard, Mandir, Nikki, Wedge, Stephen R, Pyrah, Ian T, Smith, Neil R, Jackson, Lynsay, Ryan, Anderson J, Goodlad, Robert A
Published in Molecular cancer therapeutics (01.03.2008)
Published in Molecular cancer therapeutics (01.03.2008)
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Toxicologic lesions associated with two related inhibitors of oxidosqualene cyclase in the dog and mouse
Pyrah, I T, Kalinowski, A, Jackson, D, Davies, W, Davis, S, Aldridge, A, Greaves, P
Published in Toxicologic pathology (01.03.2001)
Published in Toxicologic pathology (01.03.2001)
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Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc Min/+ mice
Alferez, Denis, Wilkinson, Robert W., Watkins, Jim, Poulsom, Richard, Mandir, Nikki, Wedge, Stephen R., Pyrah, Ian T., Smith, Neil R., Jackson, Lynsay, Ryan, Anderson J., Goodlad, Robert A.
Published in Molecular cancer therapeutics (01.03.2008)
Published in Molecular cancer therapeutics (01.03.2008)
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Expression of the Immediate-Early Genes, c-fos, c-jun, and c-myc: A Comparison in Rats of Nongenotoxic Hepatocarcinogens with Noncarcinogenic Liver Mitogens
Hasmall, Susan C., Pyrah, Ian T. G., Soames, Anthony R., Roberts, Ruth A.
Published in Toxicological sciences (01.11.1997)
Published in Toxicological sciences (01.11.1997)
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