Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists
Gomtsyan, Arthur, Schmidt, Robert G, Bayburt, Erol K, Gfesser, Gregory A, Voight, Eric A, Daanen, Jerome F, Schmidt, Diana L, Cowart, Marlon D, Liu, Huaqing, Altenbach, Robert J, Kort, Michael E, Clapham, Bruce, Cox, Phil B, Shrestha, Anurupa, Henry, Rodger, Whittern, David N, Reilly, Regina M, Puttfarcken, Pamela S, Brederson, Jill-Desiree, Song, Ping, Li, Bin, Huang, Susan M, McDonald, Heath A, Neelands, Torben R, McGaraughty, Steve P, Gauvin, Donna M, Joshi, Shailen K, Banfor, Patricia N, Segreti, Jason A, Shebley, Mohamad, Faltynek, Connie R, Dart, Michael J, Kym, Philip R
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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High content screen microscopy analysis of Aβ1–42 -induced neurite outgrowth reduction in rat primary cortical neurons: Neuroprotective effects of α7 neuronal nicotinic acetylcholine receptor ligands
Hu, Min, Schurdak, Mark E, Puttfarcken, Pamela S, El Kouhen, Rachid, Gopalakrishnan, Murali, Li, Jinhe
Published in Brain research (04.09.2007)
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TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells
Vos, Melissa H., Neelands, Torben R., McDonald, Heath A., Choi, Won, Kroeger, Paul E., Puttfarcken, Pamela S., Faltynek, Connie R., Moreland, Robert B., Han, Ping
Published in Journal of neurochemistry (01.11.2006)
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Characterization of A-425619 at native TRPV1 receptors: A comparison between dorsal root ganglia and trigeminal ganglia
McDonald, Heath A., Neelands, Torben R., Kort, Michael, Han, Ping, Vos, Melissa H., Faltynek, Connie R., Moreland, Robert B., Puttfarcken, Pamela S.
Published in European journal of pharmacology (31.10.2008)
Published in European journal of pharmacology (31.10.2008)
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Modulation of human TRPV1 receptor activity by extracellular protons and host cell expression system
Bianchi, Bruce R., Lee, Chih-Hung, Jarvis, Michael F., El Kouhen, Rachid, Moreland, Robert B., Faltynek, Connie R., Puttfarcken, Pamela S.
Published in European journal of pharmacology (10.05.2006)
Published in European journal of pharmacology (10.05.2006)
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[3H]A-778317 [1-((R)-5-tert-Butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a Novel, Stereoselective, High-Affinity Antagonist Is a Useful Radioligand for the Human Transient Receptor Potential Vanilloid-1 (TRPV1) Receptor
Bianchi, Bruce R, El Kouhen, Rachid, Neelands, Torben R, Lee, Chih-Hung, Gomtsyan, Arthur, Raja, Shirish N, Vaidyanathan, Sriajan N, Surber, Bruce, McDonald, Heath A, Surowy, Carol S, Faltynek, Connie R, Moreland, Robert B, Jarvis, Michael F, Puttfarcken, Pamela S
Published in The Journal of pharmacology and experimental therapeutics (01.10.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2007)
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Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature
Reilly, Regina M, McDonald, Heath A, Puttfarcken, Pamela S, Joshi, Shailen K, Lewis, LaGeisha, Pai, Madhavi, Franklin, Pamela H, Segreti, Jason A, Neelands, Torben R, Han, Ping, Chen, Jun, Mantyh, Patrick W, Ghilardi, Joseph R, Turner, Teresa M, Voight, Eric A, Daanen, Jerome F, Schmidt, Robert G, Gomtsyan, Arthur, Kort, Michael E, Faltynek, Connie R, Kym, Philip R
Published in The Journal of pharmacology and experimental therapeutics (01.08.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2012)
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Discovery of (R)‑1-(7-Chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): A Temperature-Neutral Transient Receptor Potential Vanilloid‑1 (TRPV1) Antagonist with Analgesic Efficacy
Voight, Eric A, Gomtsyan, Arthur R, Daanen, Jerome F, Perner, Richard J, Schmidt, Robert G, Bayburt, Erol K, DiDomenico, Stanley, McDonald, Heath A, Puttfarcken, Pamela S, Chen, Jun, Neelands, Torben R, Bianchi, Bruce R, Han, Ping, Reilly, Regina M, Franklin, Pamela H, Segreti, Jason A, Nelson, Richard A, Su, Zhi, King, Andrew J, Polakowski, James S, Baker, Scott J, Gauvin, Donna M, Lewis, LaGeisha R, Mikusa, Joseph P, Joshi, Shailen K, Faltynek, Connie R, Kym, Philip R, Kort, Michael E
Published in Journal of medicinal chemistry (11.09.2014)
Published in Journal of medicinal chemistry (11.09.2014)
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A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model
Puttfarcken, Pamela S., Han, Ping, Joshi, Shailen K., Neelands, Torben R., Gauvin, Donna M., Baker, Scott J., Lewis, La Geisha R., Bianchi, Bruce R., Mikusa, Joseph P., Koenig, John R., Perner, Richard J., Kort, Michael E., Honore, Prisca, Faltynek, Connie R., Kym, Philip R., Reilly, Regina M.
Published in Pain (Amsterdam) (01.08.2010)
Published in Pain (Amsterdam) (01.08.2010)
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TRPV1 ligands with hyperthermic, hypothermic and no temperature effects in rats
Gomtsyan, Arthur, McDonald, Heath A, Schmidt, Robert G, Daanen, Jerome F, Voight, Eric A, Segreti, Jason A, Puttfarcken, Pamela S, Reilly, Regina M, Kort, Michael E, Dart, Michael J, Kym, Philip R
Published in Temperature (Austin) (30.06.2015)
Published in Temperature (Austin) (30.06.2015)
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Discovery of TRPV1 antagonist ABT-116
Brown, Brian S, Keddy, Ryan, Perner, Richard J, DiDomenico, Stanley, Koenig, John R, Jinkerson, Tammie K, Hannick, Steven M, McDonald, Heath A, Bianchi, Bruce R, Honore, Prisca, Puttfarcken, Pamela S, Moreland, Robert B, Marsh, Kennan C, Faltynek, Connie R, Lee, Chih-Hung
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
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In Vitro Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107
Malysz, John, Anderson, David J., Grønlien, Jens H., Ji, Jianguo, Bunnelle, William H., Håkerud, Monika, Thorin-Hagene, Kirten, Ween, Hilde, Helfrich, Rosalind, Hu, Min, Gubbins, Earl, Gopalakrishnan, Sujatha, Puttfarcken, Pamela S., Briggs, Clark A., Li, Jinhe, Meyer, Michael D., Dyhring, Tino, Ahring, Philip K., Nielsen, Elsebet Ø., Peters, Dan, Timmermann, Daniel B., Gopalakrishnan, Murali
Published in The Journal of pharmacology and experimental therapeutics (01.09.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2010)
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Preclinical Characterization of A-582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties
Tietje, Karin R., Anderson, David J., Bitner, R. Scott, Blomme, Eric A., Brackemeyer, Paul J., Briggs, Clark A., Browman, Kaitlin E., Bury, Dagmar, Curzon, Peter, Drescher, Karla U., Frost, Jennifer M., Fryer, Ryan M., Fox, Gerard B., Gronlien, Jens Halvard, Håkerud, Monika, Gubbins, Earl J., Halm, Sabine, Harris, Richard, Helfrich, Rosalind J., Kohlhaas, Kathy L., Law, Devalina, Malysz, John, Marsh, Kennan C., Martin, Ruth L., Meyer, Michael D., Molesky, Angela L., Nikkel, Arthur L., Otte, Stephani, Pan, Liping, Puttfarcken, Pamela S., Radek, Richard J., Robb, Holly M., Spies, Eva, Thorin-Hagene, Kirsten, Waring, Jeffrey F., Ween, Hilde, Xu, Hongyu, Gopalakrishnan, Murali, Bunnelle, William H.
Published in CNS neuroscience & therapeutics (01.03.2008)
Published in CNS neuroscience & therapeutics (01.03.2008)
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