2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity
Sulkowski, Parker L, Corso, Christopher D, Robinson, Nathaniel D, Scanlon, Susan E, Purshouse, Karin R, Bai, Hanwen, Liu, Yanfeng, Sundaram, Ranjini K, Hegan, Denise C, Fons, Nathan R, Breuer, Gregory A, Song, Yuanbin, Mishra-Gorur, Ketu, De Feyter, Henk M, de Graaf, Robin A, Surovtseva, Yulia V, Kachman, Maureen, Halene, Stephanie, Günel, Murat, Glazer, Peter M, Bindra, Ranjit S
Published in Science translational medicine (01.02.2017)
Published in Science translational medicine (01.02.2017)
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Journal Article
Challenges to DNA replication in hypoxic conditions
Ng, Natalie, Purshouse, Karin, Foskolou, Iosifina P., Olcina, Monica M., Hammond, Ester M.
Published in The FEBS journal (01.05.2018)
Published in The FEBS journal (01.05.2018)
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Journal Article
Oncogene expression from extrachromosomal DNA is driven by copy number amplification and does not require spatial clustering in glioblastoma stem cells
Purshouse, Karin, Friman, Elias T, Boyle, Shelagh, Dewari, Pooran Singh, Grant, Vivien, Hamdan, Alhafidz, Morrison, Gillian M, Brennan, Paul M, Beentjes, Sjoerd V, Pollard, Steven M, Bickmore, Wendy A
Published in eLife (07.12.2022)
Published in eLife (07.12.2022)
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Journal Article
Characterisation and outcomes of patients referred to a regional cancer of unknown primary team: a 10-year analysis
Stares, Mark, Purshouse, Karin, Knowles, Gillian, Haigh, Rachel, Irvine, Jenny, Gatenby, Aoife, Patton, Rebekah, McGinty, Jo, Christie, Alan, MacLennan, Marjory, Barrie, Colin, Clive, Sally
Published in British journal of cancer (23.11.2021)
Published in British journal of cancer (23.11.2021)
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Immune checkpoint blockade: releasing the breaks or a protective barrier to COVID-19 severe acute respiratory syndrome?
Pickles, Oliver J., Lee, Lennard Y. W., Starkey, Thomas, Freeman-Mills, Luke, Olsson-Brown, Anna, Cheng, Vinton, Hughes, Daniel J., Lee, Alvin, Purshouse, Karin, Middleton, Gary
Published in British journal of cancer (01.09.2020)
Published in British journal of cancer (01.09.2020)
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Journal Article
The Scottish COVID Cancer Immunity Prevalence Study: A Longitudinal Study of SARS-CoV-2 Immune Response in Patients Receiving Anti–Cancer Treatment
Purshouse, Karin, Thomson, John P, Vallet, Mahéva, Alexander, Lorna, Bonisteel, Isaac, Brennan, Maree, Cameron, David A, Figueroa, Jonine D, Furrie, Elizabeth, Haig, Pamela, Heck, Mattea, McCaughan, Hugh, Mitchell, Paul, McVicars, Heather, Primrose, Lorraine, Silva, Ines, Templeton, Kate, Wilson, Natalie, Hall, Peter S
Published in The oncologist (Dayton, Ohio) (17.03.2023)
Published in The oncologist (Dayton, Ohio) (17.03.2023)
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Case report of oxalate nephropathy in a patient with pancreatic metastases from renal carcinoma
Purshouse, Karin, Chamberlain, Sarah, Soares, Maria, Tuthill, Mark, Protheroe, Andrew, Mole, David R
Published in BMC cancer (17.10.2019)
Published in BMC cancer (17.10.2019)
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Abstract 4277: Development and validation of a novel IDH1-mutant astrocyte cell line as a model for high-grade gliomas
Robinson, Nathaniel D., Purshouse, Karin R., Fons, Nathan R., Breuer, Gregory A., Pusch, Stefan, von Deimling, Andreas, Sundaram, Ranjini K., Bindra, Ranjit S.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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PemBla: A Phase 1 study of intravesical pembrolizumab in recurrent non‐muscle‐invasive bladder cancer
Woodcock, Victoria K., Chen, Ji‐Li, Purshouse, Karin, Butcher, Chrissie, Collins, Linda, Haddon, Caroline, Verrall, Gillian, Elhussein, Leena, Roberts, Corran, Tarlton, Andrea, Rei, Margarida, Napolitani, Giorgio, Salio, Mariolina, Middleton, Mark R., Cerundolo, Vincenzo, Crew, Jeremy, Protheroe, Andrew S.
Published in BJUI compass (01.05.2023)
Published in BJUI compass (01.05.2023)
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COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study
Lee, Lennard YW, Cazier, Jean-Baptiste, Angelis, Vasileios, Arnold, Roland, Bisht, Vartika, Campton, Naomi A, Chackathayil, Julia, Cheng, Vinton WT, Curley, Helen M, Fittall, Matthew W, Freeman-Mills, Luke, Gennatas, Spyridon, Goel, Anshita, Hartley, Simon, Hughes, Daniel J, Kerr, David, Lee, Alvin JX, Lee, Rebecca J, McGrath, Sophie E, Middleton, Christopher P, Murugaesu, Nirupa, Newsom-Davis, Thomas, Okines, Alicia FC, Olsson-Brown, Anna C, Palles, Claire, Pan, Yi, Pettengell, Ruth, Powles, Thomas, Protheroe, Emily A, Purshouse, Karin, Sharma-Oates, Archana, Sivakumar, Shivan, Smith, Ashley J, Starkey, Thomas, Turnbull, Chris D, Várnai, Csilla, Yousaf, Nadia, Kerr, Rachel, Middleton, Gary
Published in The Lancet (20.06.2020)
Published in The Lancet (20.06.2020)
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Imaging extrachromosomal DNA (ecDNA) in cancer
Purshouse, Karin, Pollard, Steven M., Bickmore, Wendy A.
Published in Histochemistry and cell biology (01.07.2024)
Published in Histochemistry and cell biology (01.07.2024)
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Journal Article
The UK Coronavirus Cancer Monitoring Project: protecting patients with cancer in the era of COVID-19
Anil, Iris, Arnold, Roland, Benkwitz-Beford, Sam, Branford, Simon, Campton, Naomi, Cazier, Jean-Baptiste, Cheng, Vinton, Curley, Helen, D'Costa, Jamie, Edmondson, Andrew, Goel, Anshita, Hartley, Simon, Hughes, Daniel J, Kerr, Rachel, Lee, Alvin, Lee, Lennard YW, Longworth, Naomi, Middleton, Christopher, Middleton, Gary, Naksukpaiboon, Piangfan, Olsson-Brown, Anna, Palles, Claire, Purshouse, Karin, Sandys, Carol, Sharma-Oates, Archana, Sivakumar, Shivan, Smith, Ashley, Starkey, Thomas, Thompson, Simon, Varnai, Csilla
Published in The Lancet Oncology (01.05.2020)
Published in The Lancet Oncology (01.05.2020)
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Scottish COVID CAncer iMmunity Prevalence (SCCAMP): A longitudinal study of patients with cancer receiving active anti-cancer treatment during the COVID-19 pandemic
Purshouse, Karin, Thomson, John P, Vallet, Mahéva, Alexander, Lorna, Bonisteel, Isaac, Brennan, Maree, Cameron, David A., Figueroa, Jonine, Furrie, Elizabeth, Haig, Pamela, Heck, Mattea, McCaughan, Hugh, Mitchell, Paul, McVicars, Heather, Primrose, Lorraine, Templeton, Kate, Wilson, Natalie, Hall, Peter S.
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
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Key findings from the UKCCMP cohort of 877 patients with haematological malignancy and COVID‐19: disease control as an important factor relative to recent chemotherapy or anti‐CD20 therapy
Booth, Stephen, Curley, Helen M., Varnai, Csilla, Arnold, Roland, Lee, Lennard Y. W., Campton, Naomi A., Cook, Gordon, Purshouse, Karin, Aries, James, Innes, Andrew, Cook, Lucy B., Tomkins, Oliver, Oram, Helen S., Tilby, Michael, Kulasekararaj, Austin, Wrench, David, Dolly, Saoirse, Newsom‐Davies, Tom, Pettengell, Ruth, Gault, Abigail, Moody, Sam, Mittal, Sajjan, Altohami, Mohammed, Tillet, Tania, Illingworth, Jack, Mukherjee, Leena, Apperly, Jane, Ashcroft, John, Rabin, Neil, Carmichael, Jonathan, Cazier, Jean‐Baptiste, Kerr, Rachel, Middleton, Gary, Collins, Graham P., Palles, Claire
Published in British Journal of Haematology (01.02.2022)
Published in British Journal of Haematology (01.02.2022)
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