Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death
Balsa, Eduardo, Perry, Elizabeth A., Bennett, Christopher F., Jedrychowski, Mark, Gygi, Steven P., Doench, John G., Puigserver, Pere
Published in Nature communications (01.06.2020)
Published in Nature communications (01.06.2020)
Get full text
Journal Article
Targeting hepatic glucose metabolism in the treatment of type 2 diabetes
Rines, Amy K, Sharabi, Kfir, Tavares, Clint D J, Puigserver, Pere
Published in Nature reviews. Drug discovery (01.11.2016)
Published in Nature reviews. Drug discovery (01.11.2016)
Get full text
Journal Article
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1
Rodgers, Joseph T, Puigserver, Pere
Published in Proceedings of the National Academy of Sciences - PNAS (31.07.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (31.07.2007)
Get full text
Journal Article
The sirtuin family's role in aging and age-associated pathologies
Hall, Jessica A, Dominy, John E, Lee, Yoonjin, Puigserver, Pere
Published in The Journal of clinical investigation (01.03.2013)
Published in The Journal of clinical investigation (01.03.2013)
Get full text
Journal Article
Molecular pathophysiology of hepatic glucose production
Sharabi, Kfir, Tavares, Clint D.J., Rines, Amy K., Puigserver, Pere
Published in Molecular aspects of medicine (01.12.2015)
Published in Molecular aspects of medicine (01.12.2015)
Get full text
Journal Article
A Hypoxia-Induced Positive Feedback Loop Promotes Hypoxia-Inducible Factor 1α Stability through miR-210 Suppression of Glycerol-3-Phosphate Dehydrogenase 1-Like
Kelly, Timothy J., Souza, Amanda L., Clish, Clary B., Puigserver, Pere
Published in Molecular and Cellular Biology (01.07.2011)
Published in Molecular and Cellular Biology (01.07.2011)
Get full text
Journal Article
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity
Kraus, Daniel, Yang, Qin, Kong, Dong, Banks, Alexander S, Zhang, Lin, Rodgers, Joseph T, Pirinen, Eija, Pulinilkunnil, Thomas C, Gong, Fengying, Wang, Ya-chin, Cen, Yana, Sauve, Anthony A, Asara, John M, Peroni, Odile D, Monia, Brett P, Bhanot, Sanjay, Alhonen, Leena, Puigserver, Pere, Kahn, Barbara B
Published in Nature (London) (10.04.2014)
Published in Nature (London) (10.04.2014)
Get full text
Journal Article
Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression
Lee, Yoonjin, Dominy, John E, Choi, Yoon Jong, Jurczak, Michael, Tolliday, Nicola, Camporez, Joao Paulo, Chim, Helen, Lim, Ji-Hong, Ruan, Hai-Bin, Yang, Xiaoyong, Vazquez, Francisca, Sicinski, Piotr, Shulman, Gerald I, Puigserver, Pere
Published in Nature (London) (26.06.2014)
Published in Nature (London) (26.06.2014)
Get full text
Journal Article
Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread
Yu, Deyang, Liang, Jiaxin, Widlund, Hans R., Puigserver, Pere
Published in Cell reports (Cambridge) (23.07.2024)
Published in Cell reports (Cambridge) (23.07.2024)
Get full text
Journal Article
The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD
Gerhart-Hines, Zachary, Dominy, John E., Blättler, Sharon M., Jedrychowski, Mark P., Banks, Alexander S., Lim, Ji-Hong, Chim, Helen, Gygi, Steven P., Puigserver, Pere
Published in Molecular cell (23.12.2011)
Published in Molecular cell (23.12.2011)
Get full text
Journal Article
The SLC25A47 locus controls gluconeogenesis and energy expenditure
Yook, Jin-Seon, Taxin, Zachary H, Yuan, Bo, Oikawa, Satoshi, Auger, Christopher, Mutlu, Beste, Puigserver, Pere, Hui, Sheng, Kajimura, Shingo
Published in Proceedings of the National Academy of Sciences - PNAS (28.02.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (28.02.2023)
Get full text
Journal Article
Epigenetic suppression of PGC1α (PPARGC1A) causes collateral sensitivity to HMGCR-inhibitors within BRAF-treatment resistant melanomas
Liang, Jiaxin, Yu, Deyang, Luo, Chi, Bennett, Christopher, Jedrychowski, Mark, Gygi, Steve P, Widlund, Hans R, Puigserver, Pere
Published in Nature communications (05.06.2023)
Published in Nature communications (05.06.2023)
Get full text
Journal Article
The Deacetylase Sirt6 Activates the Acetyltransferase GCN5 and Suppresses Hepatic Gluconeogenesis
Dominy, John E., Lee, Yoonjin, Jedrychowski, Mark P., Chim, Helen, Jurczak, Michael J., Camporez, Joao Paulo, Ruan, Hai-Bin, Feldman, Jessica, Pierce, Kerry, Mostoslavsky, Raul, Denu, John M., Clish, Clary B., Yang, Xiaoyong, Shulman, Gerald I., Gygi, Steven P., Puigserver, Pere
Published in Molecular cell (28.12.2012)
Published in Molecular cell (28.12.2012)
Get full text
Journal Article
A metabolic prosurvival role for PML in breast cancer
Carracedo, Arkaitz, Weiss, Dror, Leliaert, Amy K, Bhasin, Manoj, de Boer, Vincent C J, Laurent, Gaelle, Adams, Andrew C, Sundvall, Maria, Song, Su Jung, Ito, Keisuke, Finley, Lydia S, Egia, Ainara, Libermann, Towia, Gerhart-Hines, Zachary, Puigserver, Pere, Haigis, Marcia C, Maratos-Flier, Elefteria, Richardson, Andrea L, Schafer, Zachary T, Pandolfi, Pier P
Published in The Journal of clinical investigation (01.09.2012)
Published in The Journal of clinical investigation (01.09.2012)
Get full text
Journal Article
TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis
Ye, Li, Kleiner, Sandra, Wu, Jun, Sah, Rajan, Gupta, Rana K, Banks, Alexander S, Cohen, Paul, Khandekar, Melin J, Boström, Pontus, Mepani, Rina J, Laznik, Dina, Kamenecka, Theodore M, Song, Xinyi, Liedtke, Wolfgang, Mootha, Vamsi K, Puigserver, Pere, Griffin, Patrick R, Clapham, David E, Spiegelman, Bruce M
Published in Cell (28.09.2012)
Published in Cell (28.09.2012)
Get full text
Journal Article
Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction
Qin, Weiping, Yang, Tianle, Ho, Lap, Zhao, Zhong, Wang, Jun, Chen, Linghong, Zhao, Wei, Thiyagarajan, Meenakshisundaram, MacGrogan, Donal, Rodgers, Joseph T., Puigserver, Pere, Sadoshima, Junichi, Deng, Haiteng, Pedrini, Steven, Gandy, Samuel, Sauve, Anthony A., Pasinetti, Giulio M.
Published in The Journal of biological chemistry (04.08.2006)
Published in The Journal of biological chemistry (04.08.2006)
Get full text
Journal Article
Adipose Tissue CLK2 Promotes Energy Expenditure during High-Fat Diet Intermittent Fasting
Hatting, Maximilian, Rines, Amy K., Luo, Chi, Tabata, Mitsuhisa, Sharabi, Kfir, Hall, Jessica A., Verdeguer, Francisco, Trautwein, Christian, Puigserver, Pere
Published in Cell metabolism (07.02.2017)
Published in Cell metabolism (07.02.2017)
Get full text
Journal Article
ERRα Maintains Mitochondrial Oxidative Metabolism and Constitutes an Actionable Target in PGC1α-Elevated Melanomas
Luo, Chi, Balsa, Eduardo, Thomas, Ajith, Hatting, Maximilian, Jedrychowski, Mark, Gygi, Steven P, Widlund, Hans R, Puigserver, Pere
Published in Molecular cancer research (01.10.2017)
Published in Molecular cancer research (01.10.2017)
Get full text
Journal Article
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP
Walker, Amy K, Yang, Fajun, Jiang, Karen, Ji, Jun-Yuan, Watts, Jennifer L, Purushotham, Aparna, Boss, Olivier, Hirsch, Michael L, Ribich, Scott, Smith, Jesse J, Israelian, Kristine, Westphal, Christoph H, Rodgers, Joseph T, Shioda, Toshi, Elson, Sarah L, Mulligan, Peter, Najafi-Shoushtari, Hani, Black, Josh C, Thakur, Jitendra K, Kadyk, Lisa C, Whetstine, Johnathan R, Mostoslavsky, Raul, Puigserver, Pere, Li, Xiaoling, Dyson, Nicholas J, Hart, Anne C, Näär, Anders M
Published in Genes & development (01.07.2010)
Published in Genes & development (01.07.2010)
Get full text
Journal Article