Siltuximab for multicentric Castleman's disease: a randomised, double-blind, placebo-controlled trial
van Rhee, Frits, Prof, Wong, Raymond S, Prof, Munshi, Nikhil, Prof, Rossi, Jean-Francois, Prof, Ke, Xiao-Yan, Prof, Fosså, Alexander, MD, Simpson, David, MD, Capra, Marcelo, MD, Liu, Ting, MD, Hsieh, Ruey Kuen, MD, Goh, Yeow Tee, MD, Zhu, Jun, MD, Cho, Seok-Goo, MD, Ren, Hanyun, MD, Cavet, James, MD, Bandekar, Rajesh, PhD, Rothman, Margaret, PhD, Puchalski, Thomas A, PharmD, Reddy, Manjula, MSc, van de Velde, Helgi, MD, Vermeulen, Jessica, MD, Casper, Corey, Prof
Published in The lancet oncology (01.08.2014)
Published in The lancet oncology (01.08.2014)
Get full text
Journal Article
Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer
Pienta, Kenneth J., Machiels, Jean-Pascal, Schrijvers, Dirk, Alekseev, Boris, Shkolnik, Mikhail, Crabb, Simon J., Li, Susan, Seetharam, Shobha, Puchalski, Thomas A., Takimoto, Chris, Elsayed, Yusri, Dawkins, Fitzroy, de Bono, Johann S.
Published in Investigational new drugs (01.06.2013)
Published in Investigational new drugs (01.06.2013)
Get full text
Journal Article
Phase I Clinical Study of AZD2171, an Oral Vascular Endothelial Growth Factor Signaling Inhibitor, in Patients With Advanced Solid Tumors
DREVS, Joachim, SIEGERT, Patrizia, PUCHALSKI, Thomas A, YOUNG, Helen, SAUNDERS, Owain, UNGER, Clemens, MEDINGER, Michael, MROSS, Klaus, STRECKER, Ralph, ZIRRGIEBEL, Ute, HARDER, Jan, BLUM, Hubert, ROBERTSON, Jane, JÜRGENSMEIER, Juliane M
Published in Journal of clinical oncology (20.07.2007)
Published in Journal of clinical oncology (20.07.2007)
Get full text
Journal Article
Phase I and Pharmacokinetic Study of Daily Oral AZD2171, an Inhibitor of Vascular Endothelial Growth Factor Tyrosine Kinases, in Combination With Carboplatin and Paclitaxel in Patients With Advanced Non–Small-Cell Lung Cancer: The National Cancer Institute of Canada Clinical Trials Group
LAURIE, Scott A, GAUTHIER, Isabelle, ROBERTSON, Jane, PUCHALSKI, Thomas A, SEYMOUR, Lesley, ARNOLD, Andrew, SHEPHERD, Frances A, ELLIS, Peter M, CHEN, Eric, GOSS, Glenwood, POWERS, Jean, WALSH, Wendy, DONGSHENG TU
Published in Journal of clinical oncology (10.04.2008)
Published in Journal of clinical oncology (10.04.2008)
Get full text
Journal Article
Utilizing pharmacokinetics/pharmacodynamics modeling to simultaneously examine free CCL2, total CCL2 and carlumab (CNTO 888) concentration time data
Fetterly, Gerald J, Aras, Urvi, Meholick, Patricia D, Takimoto, Chris, Seetharam, Shobha, McIntosh, Thomas, de Bono, Johann S, Sandhu, Shahneen K, Tolcher, Anthony, Davis, Hugh M, Zhou, Honghui, Puchalski, Thomas A
Published in Journal of clinical pharmacology (01.10.2013)
Published in Journal of clinical pharmacology (01.10.2013)
Get more information
Journal Article
Phase I Clinical Trial of Recombinant Human Endostatin Administered as a Short Intravenous Infusion Repeated Daily
EDER, Joseph P, SUPKO, Jeffrey G, CONNORS, Susan, KEOGAN, Mary T, JANICEK, Milos J, FOGLER, William E, SCHNIPPER, Lowell, KINCHLA, Nancy, SIDOR, Carolyn, PHILLIPS, Eric, FOLKMAN, Judah, KUFE, Donald W, CLARK, Jeffrey W, PUCHALSKI, Thomas A, GARCIA-CARBONERO, Rocio, RYAN, David P, SHULMAN, Lawrence N, PROPER, Joann, KIRVAN, Moira, RATTNER, Barbara
Published in Journal of clinical oncology (15.09.2002)
Published in Journal of clinical oncology (15.09.2002)
Get full text
Journal Article
A Phase I, Open-Label Study of Siltuximab, an Anti―IL-6 Monoclonal Antibody, in Patients with B-cell Non-Hodgkin Lymphoma, Multiple Myeloma, or Castleman Disease
KURZROCK, Razelle, VOORHEES, Peter M, DE VELDE, Helgi Van, XIANG QIN, PUCHALSKI, Thomas A, HALL, Brett, REDDY, Manjula, MING QI, RHEE, Frits Van, CASPER, Corey, FURMAN, Richard R, FAYAD, Luis, LONIAL, Sagar, BORGHAEI, Hossein, JAGANNATH, Sundar, SOKOL, Lubomir, USMANI, Saad Z
Published in Clinical cancer research (01.07.2013)
Published in Clinical cancer research (01.07.2013)
Get full text
Journal Article
A Phase I/II, Multiple-Dose, Dose-Escalation Study of Siltuximab, an Anti-Interleukin-6 Monoclonal Antibody, in Patients with Advanced Solid Tumors
ANGEVIN, Eric, TABERNERO, Josep, RAY-COQUARD, Isabelle, DIRIX, Luc, MACHIELS, Jean-Pascal, STEVEN, Neil, REDDY, Manjula, HALL, Brett, PUCHALSKI, Thomas A, BANDEKAR, Rajesh, VAN DE VELDE, Helgi, TROMP, Brenda, ELEZ, Elena, VERMEULEN, Jessica, KURZROCK, Razelle, COHEN, Steven J, BAHLEDA, Rastilav, VAN LAETHEM, Jean-Luc, OTTENSMEIER, Christian, LOPEZ-MARTIN, Jose A, CLIVE, Sally, JOLY, Florence
Published in Clinical cancer research (15.04.2014)
Published in Clinical cancer research (15.04.2014)
Get full text
Journal Article
A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors
Sandhu, Shahneen K., Papadopoulos, Kyri, Fong, Peter C., Patnaik, Amita, Messiou, Christina, Olmos, David, Wang, George, Tromp, Brenda J., Puchalski, Thomas A., Balkwill, Frances, Berns, Birge, Seetharam, Shobha, de Bono, Johann S., Tolcher, Anthony W.
Published in Cancer chemotherapy and pharmacology (01.04.2013)
Published in Cancer chemotherapy and pharmacology (01.04.2013)
Get full text
Journal Article
Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors: an open-label, multicenter phase 1b study
Brana, Irene, Calles, Antonio, LoRusso, Patricia M., Yee, Lorrin K., Puchalski, Thomas A., Seetharam, Shobha, Zhong, Bob, de Boer, Carla J., Tabernero, Josep, Calvo, Emiliano
Published in Targeted oncology (01.03.2015)
Published in Targeted oncology (01.03.2015)
Get full text
Journal Article
A phase 2, randomized, double‐blind, placebo‐controlled study of siltuximab (anti‐IL‐6 mAb) and bortezomib versus bortezomib alone in patients with relapsed or refractory multiple myeloma
Orlowski, Robert Z., Gercheva, Liana, Williams, Cathy, Sutherland, Heather, Robak, Tadeusz, Masszi, Tamás, Goranova‐Marinova, Vesselina, Dimopoulos, Meletios A., Cavenagh, James D., Špička, Ivan, Maiolino, Angelo, Suvorov, Alexander, Bladé, Joan, Samoylova, Olga, Puchalski, Thomas A., Reddy, Manjula, Bandekar, Rajesh, van de Velde, Helgi, Xie, Hong, Rossi, Jean‐Franςois
Published in American journal of hematology (01.01.2015)
Published in American journal of hematology (01.01.2015)
Get full text
Journal Article
A phase 1 study of a chimeric monoclonal antibody against interleukin-6, siltuximab, combined with docetaxel in patients with metastatic castration-resistant prostate cancer
Hudes, Gary, Tagawa, Scott T., Whang, Young E., Qi, Ming, Qin, Xiang, Puchalski, Thomas A., Reddy, Manjula, Cornfeld, Mark, Eisenberger, Mario
Published in Investigational new drugs (01.06.2013)
Published in Investigational new drugs (01.06.2013)
Get full text
Journal Article
Dose selection of siltuximab for multicentric Castleman’s disease
Mayer, Christina L., Xie, Lanyi, Bandekar, Rajesh, Qi, Ming, van de Velde, Helgi, Reddy, Manjula, Qin, Xiang, Davis, Hugh M., Puchalski, Thomas A.
Published in Cancer chemotherapy and pharmacology (01.05.2015)
Published in Cancer chemotherapy and pharmacology (01.05.2015)
Get full text
Journal Article
Phase I, dose escalation and pharmacokinetic study of cediranib (RECENTIN™), a highly potent and selective VEGFR signaling inhibitor, in Japanese patients with advanced solid tumors
Yamamoto, Noboru, Tamura, Tomohide, Yamamoto, Nobuyuki, Yamada, Kazuhiko, Yamada, Yasuhide, Nokihara, Hiroshi, Fujiwara, Yutaka, Takahashi, Toshiaki, Murakami, Haruyasu, Boku, Narikazu, Yamazaki, Kentaro, Puchalski, Thomas A., Shin, Eisei
Published in Cancer chemotherapy and pharmacology (01.11.2009)
Published in Cancer chemotherapy and pharmacology (01.11.2009)
Get full text
Journal Article
Phase I evaluation of cediranib, a selective VEGFR signalling inhibitor, in combination with gefitinib in patients with advanced tumours
van Cruijsen, Hester, Voest, Emile E, Punt, Cornelis J.A, Hoekman, Klaas, Witteveen, Petronella O, Meijerink, Martijn R, Puchalski, Thomas A, Robertson, Jane, Saunders, Owain, Jürgensmeier, Juliane M, van Herpen, Carla M.L, Giaccone, Giuseppe
Published in European journal of cancer (1990) (01.03.2010)
Published in European journal of cancer (1990) (01.03.2010)
Get full text
Journal Article
Evaluation of the QTc prolongation potential of a monoclonal antibody, siltuximab, in patients with monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, or low-volume multiple myeloma
Thomas, Sheeba K., Suvorov, Alexander, Noens, Lucien, Rukavitsin, Oleg, Fay, Joseph, Wu, Ka Lung, Zimmerman, Todd M., van de Velde, Helgi, Bandekar, Rajesh, Puchalski, Thomas A., Qi, Ming, Uhlar, Clarissa, Samoylova, Olga S.
Published in Cancer chemotherapy and pharmacology (2014)
Published in Cancer chemotherapy and pharmacology (2014)
Get full text
Journal Article
Pharmacodynamic modeling of lansoprazole using an indirect irreversible response model
Puchalski, T A, Krzyzanski, W, Blum, R A, Jusko, W J
Published in Journal of clinical pharmacology (01.03.2001)
Published in Journal of clinical pharmacology (01.03.2001)
Get more information
Journal Article
A Novel Approach to Evaluate the Pharmacokinetic Biocomparability of a Monoclonal Antibody Derived from Two Different Cell Lines Using Simultaneous Crossover Design
Han, Chao, McIntosh, Thomas S., Geist, Brian J., Jiao, Trina, Puchalski, Thomas A., Goldberg, Kenneth M., Yang, Tong-Yuan, Pendley, Charles E., Zhou, Honghui, Davis, Hugh M.
Published in The AAPS journal (01.01.2014)
Published in The AAPS journal (01.01.2014)
Get full text
Journal Article
A phase 1, randomized study to assess the pharmacokinetic comparability of siltuximab derived from two different cell lines in healthy subjects
Xu, Chao, Han, Chao, Marini, Joseph, Ford, Joyce, Marciniak, Stanley, Lopez Jr, Manny, Frederick, Bart, de Vries, Dick, Bandekar, Rajesh, Davis, Hugh M., Zhou, Honghui, Puchalski, Thomas A.
Published in Clinical pharmacology in drug development (01.07.2014)
Published in Clinical pharmacology in drug development (01.07.2014)
Get full text
Journal Article