Rationally Designed Amanitins Achieve Enhanced Cytotoxicity
Todorovic, Mihajlo, Rivollier, Paul, Wong, Antonio A. W. L., Wang, Zhou, Pryyma, Alla, Nguyen, Tuan Trung, Newell, Kayla C., Froelich, Juliette, Perrin, David M.
Published in Journal of medicinal chemistry (11.08.2022)
Published in Journal of medicinal chemistry (11.08.2022)
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Synthesis and Activation of Bench-Stable 3a-Fluoropyrroloindolines as Latent Electrophiles for the Synthesis of C‑2-Thiol-Substituted Tryptophans and C‑3a-Substituted Pyrroloindolines
Pryyma, Alla, Bu, Yong Jia, Wai, Yonnie, Patrick, Brian O, Perrin, David M
Published in Organic letters (18.10.2019)
Published in Organic letters (18.10.2019)
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Synthesis of a Cytotoxic Amanitin for Biorthogonal Conjugation
Zhao, Liang, May, Jonathan P., Blanc, Antoine, Dietrich, David J., Loonchanta, Anastak, Matinkhoo, Kaveh, Pryyma, Alla, Perrin, David M.
Published in Chembiochem : a European journal of chemical biology (06.07.2015)
Published in Chembiochem : a European journal of chemical biology (06.07.2015)
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Journal Article
Synthesis of the Death-Cap Mushroom Toxin α‑Amanitin
Matinkhoo, Kaveh, Pryyma, Alla, Todorovic, Mihajlo, Patrick, Brian O, Perrin, David M
Published in Journal of the American Chemical Society (30.05.2018)
Published in Journal of the American Chemical Society (30.05.2018)
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Diphenylphosphinylhydroxylamine (DPPH) Affords Late‐Stage S‐imination to access free‐NH Sulfilimines and Sulfoximines
Gunasekera, Shanal, Pryyma, Alla, Jung, Jimin, Greenwood, Rebekah, Patrick, Brian O., Perrin, David M.
Published in Angewandte Chemie International Edition (22.03.2024)
Published in Angewandte Chemie International Edition (22.03.2024)
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Scaling Amatoxin Synthesis with an Improved Route to (2S,3R,4R)‑Dihydroxyisoleucine Exemplified by a Toxic, Clickable α‑Amanitin Analogue
Hambira, Chido M, Matinkhoo, Kaveh, Pryyma, Alla, Patrick, Brian O, Perrin, David M
Published in Journal of organic chemistry (02.04.2021)
Published in Journal of organic chemistry (02.04.2021)
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Synthesis and evaluation of "Ama-Flash", a photocaged amatoxin prodrug for light-activated RNA Pol II inhibition and cell death
Matinkhoo, Kaveh, Pryyma, Alla, Wong, Antonio A. W. L., Perrin, David M.
Published in Chemical communications (Cambridge, England) (25.09.2021)
Published in Chemical communications (Cambridge, England) (25.09.2021)
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One-Step 18 F-Labeling and Preclinical Evaluation of Prostate-Specific Membrane Antigen Trifluoroborate Probes for Cancer Imaging
Kuo, Hsiou-Ting, Lepage, Mathieu L, Lin, Kuo-Shyan, Pan, Jinhe, Zhang, Zhengxing, Liu, Zhibo, Pryyma, Alla, Zhang, Chengcheng, Merkens, Helen, Roxin, Aron, Perrin, David M, Bénard, François
Published in Journal of Nuclear Medicine (01.08.2019)
Published in Journal of Nuclear Medicine (01.08.2019)
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Journal Article
One-Step 18F-Labeling and Preclinical Evaluation of Prostate-Specific Membrane Antigen Trifluoroborate Probes for Cancer Imaging
Kuo, Hsiou-Ting, Lepage, Mathieu L, Lin, Kuo-Shyan, Pan, Jinhe, Zhang, Zhengxing, Liu, Zhibo, Pryyma, Alla, Zhang, Chengcheng, Merkens, Helen, Roxin, Aron, Perrin, David M, Bénard, François
Published in The Journal of nuclear medicine (1978) (01.08.2019)
Published in The Journal of nuclear medicine (1978) (01.08.2019)
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Synthesis and preliminary evaluation of octreotate conjugates of bioactive synthetic amatoxins for targeting somatostatin receptor (sstr2) expressing cells
Pryyma, Alla, Matinkhoo, Kaveh, Bu, Yong Jia, Merkens, Helen, Zhang, Zhengxing, Bénard, Francois, Perrin, David M
Published in RSC chemical biology (05.01.2022)
Published in RSC chemical biology (05.01.2022)
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