Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases
Pruneda, Jonathan N., Littlefield, Peter J., Soss, Sarah E., Nordquist, Kyle A., Chazin, Walter J., Brzovic, Peter S., Klevit, Rachel E.
Published in Molecular cell (28.09.2012)
Published in Molecular cell (28.09.2012)
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Journal Article
Bacterial usurpation of the OTU deubiquitinase fold
Pruneda, Jonathan N., Nguyen, Justine V., Nagai, Hiroki, Kubori, Tomoko
Published in The FEBS journal (01.08.2024)
Published in The FEBS journal (01.08.2024)
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Journal Article
Assembly and Specific Recognition of K29- and K33-Linked Polyubiquitin
Michel, Martin A., Elliott, Paul R., Swatek, Kirby N., Simicek, Michal, Pruneda, Jonathan N., Wagstaff, Jane L., Freund, Stefan M.V., Komander, David
Published in Molecular cell (02.04.2015)
Published in Molecular cell (02.04.2015)
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Journal Article
Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis
Wauer, Tobias, Swatek, Kirby N, Wagstaff, Jane L, Gladkova, Christina, Pruneda, Jonathan N, Michel, Martin A, Gersch, Malte, Johnson, Christopher M, Freund, Stefan MV, Komander, David
Published in The EMBO journal (03.02.2015)
Published in The EMBO journal (03.02.2015)
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Journal Article
Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal
DaRosa, Paul A., Wang, Zhizhi, Jiang, Xiaomo, Pruneda, Jonathan N., Cong, Feng, Klevit, Rachel E., Xu, Wenqing
Published in Nature (London) (08.01.2015)
Published in Nature (London) (08.01.2015)
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Journal Article
A cascading activity-based probe sequentially targets E1–E2–E3 ubiquitin enzymes
Mulder, Monique P C, Witting, Katharina, Berlin, Ilana, Pruneda, Jonathan N, Wu, Kuen-Phon, Chang, Jer-Gung, Merkx, Remco, Bialas, Johanna, Groettrup, Marcus, Vertegaal, Alfred C O, Schulman, Brenda A, Komander, David, Neefjes, Jacques, El Oualid, Farid, Ovaa, Huib
Published in Nature chemical biology (01.07.2016)
Published in Nature chemical biology (01.07.2016)
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Journal Article
Identification and characterization of diverse OTU deubiquitinases in bacteria
Schubert, Alexander F, Nguyen, Justine V, Franklin, Tyler G, Geurink, Paul P, Roberts, Cameron G, Sanderson, Daniel J, Miller, Lauren N, Ovaa, Huib, Hofmann, Kay, Pruneda, Jonathan N, Komander, David
Published in The EMBO journal (03.08.2020)
Published in The EMBO journal (03.08.2020)
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Journal Article
Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis
Starita, Lea M., Pruneda, Jonathan N., Lo, Russell S., Fowler, Douglas M., Kim, Helen J., Hiatt, Joseph B., Shendure, Jay, Brzovic, Peter S., Fields, Stanley, Klevit, Rachel E.
Published in Proceedings of the National Academy of Sciences - PNAS (02.04.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (02.04.2013)
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Journal Article
Ubiquitin in Motion: Structural Studies of the Ubiquitin-Conjugating Enzyme∼Ubiquitin Conjugate
Pruneda, Jonathan N, Stoll, Kate E, Bolton, Laura J, Brzovic, Peter S, Klevit, Rachel E
Published in Biochemistry (Easton) (15.03.2011)
Published in Biochemistry (Easton) (15.03.2011)
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Journal Article
The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protecting Chlamydia effectors from degradation
Bastidas, Robert J, Kędzior, Mateusz, Davidson, Robert K, Walsh, Stephen C, Dolat, Lee, Sixt, Barbara S, Pruneda, Jonathan N, Coers, Jörn, Valdivia, Raphael H
Published in eLife (15.02.2024)
Published in eLife (15.02.2024)
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Journal Article
Allelic strengths of encephalopathy-associated UBA5 variants correlate between in vivo and in vitro assays
Pan, Xueyang, Alvarez, Albert N, Ma, Mengqi, Lu, Shenzhao, Crawford, Michael W, Briere, Lauren C, Kanca, Oguz, Yamamoto, Shinya, Sweetser, David A, Wilson, Jenny L, Napier, Ruth J, Pruneda, Jonathan N, Bellen, Hugo J
Published in eLife (11.12.2023)
Published in eLife (11.12.2023)
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Journal Article
A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation
Pruneda, Jonathan N., Bastidas, Robert J., Bertsoulaki, Erithelgi, Swatek, Kirby N., Santhanam, Balaji, Clague, Michael J., Valdivia, Raphael H., Urbé, Sylvie, Komander, David
Published in Nature microbiology (01.12.2018)
Published in Nature microbiology (01.12.2018)
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Journal Article
OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function
Juang, Yu-Chi, Landry, Marie-Claude, Sanches, Mario, Vittal, Vinayak, Leung, Charles C.Y., Ceccarelli, Derek F., Mateo, Abigail-Rachele F., Pruneda, Jonathan N., Mao, Daniel Y.L., Szilard, Rachel K., Orlicky, Stephen, Munro, Meagan, Brzovic, Peter S., Klevit, Rachel E., Sicheri, Frank, Durocher, Daniel
Published in Molecular cell (10.02.2012)
Published in Molecular cell (10.02.2012)
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