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Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial
Fitzgerald, Kevin, Frank-Kamenetsky, Maria, Shulga-Morskaya, Svetlana, Liebow, Abigail, Bettencourt, Brian R, Sutherland, Jessica E, Hutabarat, Renta M, Clausen, Valerie A, Karsten, Verena, Cehelsky, Jeffrey, Nochur, Saraswathy V, Kotelianski, Victor, Horton, Jay, Mant, Timothy, Chiesa, Joseph, Ritter, James, Munisamy, Malathy, Vaishnaw, Akshay K, Gollob, Jared A, Simon, Amy
Published in The Lancet (British edition) (04.01.2014)
Published in The Lancet (British edition) (04.01.2014)
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Molecular Lipids Identify Cardiovascular Risk and Are Efficiently Lowered by Simvastatin and PCSK9 Deficiency
Tarasov, Kirill, Ekroos, Kim, Suoniemi, Matti, Kauhanen, Dimple, Sylvänne, Tuulia, Hurme, Reini, Gouni-Berthold, Ioanna, Berthold, Heiner K., Kleber, Marcus E., Laaksonen, Reijo, März, Winfried
Published in The journal of clinical endocrinology and metabolism (01.01.2014)
Published in The journal of clinical endocrinology and metabolism (01.01.2014)
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Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial
Bjermo, Helena, Iggman, David, Kullberg, Joel, Dahlman, Ingrid, Johansson, Lars, Persson, Lena, Berglund, Johan, Pulkki, Kari, Basu, Samar, Uusitupa, Matti, Rudling, Mats, Arner, Peter, Cederholm, Tommy, Ahlström, Håkan, Risérus, Ulf
Published in The American journal of clinical nutrition (01.05.2012)
Published in The American journal of clinical nutrition (01.05.2012)
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Spectrum of mutations and phenotypic expression in patients with autosomal dominant hypercholesterolemia identified in Italy
Bertolini, Stefano, Pisciotta, Livia, Rabacchi, Claudio, Cefalù, Angelo B., Noto, Davide, Fasano, Tommaso, Signori, Alessio, Fresa, Raffaele, Averna, Maurizio, Calandra, Sebastiano
Published in Atherosclerosis (01.04.2013)
Published in Atherosclerosis (01.04.2013)
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Potential role of milk fat globule membrane in modulating plasma lipoproteins, gene expression, and cholesterol metabolism in humans: a randomized study
Rosqvist, Fredrik, Smedman, Annika, Lindmark-Månsson, Helena, Paulsson, Marie, Petrus, Paul, Straniero, Sara, Rudling, Mats, Dahlman, Ingrid, Risåérus, Ulf
Published in The American journal of clinical nutrition (01.07.2015)
Published in The American journal of clinical nutrition (01.07.2015)
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Intestinal Lipid Handling: Evidence and Implication of Insulin Signaling Abnormalities in Human Obese Subjects
Veilleux, Alain, Grenier, Émilie, Marceau, Picard, Carpentier, André C., Richard, Denis, Levy, Emile
Published in Arteriosclerosis, thrombosis, and vascular biology (01.03.2014)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.03.2014)
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Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody
Hopkins, Paul N., Defesche, Joep, Fouchier, Sigrid W., Bruckert, Eric, Luc, Gérald, Cariou, Bertrand, Sjouke, Barbara, Leren, Trond P., Harada-Shiba, Mariko, Mabuchi, Hiroshi, Rabès, Jean-Pierre, Carrié, Alain, van Heyningen, Charles, Carreau, Valérie, Farnier, Michel, Teoh, Yee P., Bourbon, Mafalda, Kawashiri, Masa-aki, Nohara, Atsushi, Soran, Handrean, Marais, A. David, Tada, Hayato, Abifadel, Marianne, Boileau, Catherine, Chanu, Bernard, Katsuda, Shoji, Kishimoto, Ichiro, Lambert, Gilles, Makino, Hisashi, Miyamoto, Yoshihiro, Pichelin, Matthieu, Yagi, Kunimasa, Yamagishi, Masakazu, Zair, Yassine, Mellis, Scott, Yancopoulos, George D., Stahl, Neil, Mendoza, Johanna, Du, Yunling, Hamon, Sara, Krempf, Michel, Swergold, Gary D.
Published in Circulation. Cardiovascular genetics (01.12.2015)
Published in Circulation. Cardiovascular genetics (01.12.2015)
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PCSK9 R46L, Lower LDL, and Cardiovascular Disease Risk in Familial Hypercholesterolemia: A Cross-Sectional Cohort Study
Luna Saavedra, Yascara Grisel, Dufour, Robert, Davignon, Jean, Baass, Alexis
Published in Arteriosclerosis, thrombosis, and vascular biology (01.12.2014)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.12.2014)
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Genetic diagnosis of familial hypercholesterolaemia by targeted next‐generation sequencing
Maglio, C., Mancina, R. M., Motta, B. M., Stef, M., Pirazzi, C., Palacios, L., Askaryar, N., Borén, J., Wiklund, O., Romeo, S.
Published in Journal of internal medicine (01.10.2014)
Published in Journal of internal medicine (01.10.2014)
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Characterization of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Trafficking Reveals a Novel Lysosomal Targeting Mechanism via Amyloid Precursor-like Protein 2 (APLP2)
DeVay, Rachel M., Shelton, David L., Liang, Hong
Published in The Journal of biological chemistry (12.04.2013)
Published in The Journal of biological chemistry (12.04.2013)
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G-Protein Estrogen Receptor as a Regulator of Low-Density Lipoprotein Cholesterol Metabolism: Cellular and Population Genetic Studies
Hussain, Yasin, Ding, Qingming, Connelly, Philip W., Brunt, J. Howard, Ban, Matthew R., McIntyre, Adam D., Huff, Murray W., Gros, Robert, Hegele, Robert A., Feldman, Ross D.
Published in Arteriosclerosis, thrombosis, and vascular biology (01.01.2015)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.01.2015)
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Clinical features of familial hypercholesterolemia in Korea: Predictors of pathogenic mutations and coronary artery disease – A study supported by the Korean Society of Lipidology and Atherosclerosis
Shin, Dong Geum, Han, Soo Min, Kim, Doo Il, Rhee, Moo-Yong, Lee, Byoung-Kwon, Ahn, Young Keun, Cho, Byung Ryul, Woo, Jeong-Taek, Hur, Seung-Ho, Jeong, Jin-Ok, Jang, Yangsoo, Lee, Ji Hyun, Lee, Sang-Hak
Published in Atherosclerosis (01.11.2015)
Published in Atherosclerosis (01.11.2015)
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The effect of insulin on circulating PCSK9 in postmenopausal obese women
Awan, Zuhier, Dubuc, Geneviève, Faraj, May, Dufour, Robert, Seidah, Nabil G., Davignon, Jean, Rabasa-Lhoret, Rémi, Baass, Alexis
Published in Clinical biochemistry (01.08.2014)
Published in Clinical biochemistry (01.08.2014)
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AAV Vectors Expressing LDLR Gain-of-Function Variants Demonstrate Increased Efficacy in Mouse Models of Familial Hypercholesterolemia
Somanathan, Suryanarayan, Jacobs, Frank, Wang, Qiang, Hanlon, Alexandra L., Wilson, James M., Rader, Daniel J.
Published in Circulation research (29.08.2014)
Published in Circulation research (29.08.2014)
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Familial hypercholesterolemia: PCSK9 InsLEU genetic variant and prediabetes/diabetes risk
Saavedra, Yascara G. Luna, Dufour, Robert, Baass, Alexis
Published in Journal of clinical lipidology (01.11.2015)
Published in Journal of clinical lipidology (01.11.2015)
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The genetic spectrum of familial hypercholesterolemia in south-eastern Poland
Sharifi, Mahtab, Walus-Miarka, Małgorzata, Idzior-Waluś, Barbara, Malecki, Maciej T., Sanak, Marek, Whittall, Ros, Li, Ka Wah, Futema, Marta, Humphries, Steve E.
Published in Metabolism, clinical and experimental (01.03.2016)
Published in Metabolism, clinical and experimental (01.03.2016)
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Plasma proprotein convertase subtilisin kexin type 9 is not altered in subjects with impaired glucose metabolism and type 2 diabetes mellitus, but its relationship with non-HDL cholesterol and apolipoprotein B may be modified by type 2 diabetes mellitus: The CODAM study
Brouwers, M.C.G.J., Troutt, J.S., van Greevenbroek, M.M.J., Ferreira, I., Feskens, E.J., van der Kallen, C.J.H., Schaper, N.C., Schalkwijk, C.G., Konrad, R.J., Stehouwer, C.D.A.
Published in Atherosclerosis (01.07.2011)
Published in Atherosclerosis (01.07.2011)
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The contribution of PCSK9 levels to the phenotypic severity of familial hypercholesterolemia is independent of LDL receptor genotype
Drouin-Chartier, Jean-Philippe, Tremblay, André J., Hogue, Jean-Charles, Ooi, Teik C., Lamarche, Benoît, Couture, Patrick
Published in Metabolism, clinical and experimental (01.11.2015)
Published in Metabolism, clinical and experimental (01.11.2015)
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