Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target
Lechner, Severin, Malgapo, Martin Ian P., Grätz, Christian, Steimbach, Raphael R., Baron, Agnes, Rüther, Patrick, Nadal, Simon, Stumpf, Carmen, Loos, Christina, Ku, Xin, Prokofeva, Polina, Lautenbacher, Ludwig, Heimburg, Tino, Würf, Vivian, Meng, Chen, Wilhelm, Mathias, Sippl, Wolfgang, Kleigrewe, Karin, Pauling, Josch K., Kramer, Karl, Miller, Aubry K., Pfaffl, Michael W., Linder, Maurine E., Kuster, Bernhard, Médard, Guillaume
Published in Nature chemical biology (01.08.2022)
Published in Nature chemical biology (01.08.2022)
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Journal Article
Thieno3,2-bpyridine: Attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode
Moyano, Paula Martín, Kubina, Tadeáš, Paruch, Štěpán Owen, Jarošková, Aneta, Novotný, Jan, Skočková, Veronika, Ovesná, Petra, Suchánková, Tereza, Prokofeva, Polina, Kuster, Bernhard, Šmída, Michal, Chaikuad, Apirat, Krämer, Andreas, Knapp, Stefan, Souček, Karel, Paruch, Kamil
Published in Angewandte Chemie International Edition (06.11.2024)
Published in Angewandte Chemie International Edition (06.11.2024)
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Journal Article
Decrypting drug actions and protein modifications by dose- and time-resolved proteomics
Zecha, Jana, Bayer, Florian P, Wiechmann, Svenja, Woortman, Julia, Berner, Nicola, Müller, Julian, Schneider, Annika, Kramer, Karl, Abril-Gil, Mar, Hopf, Thomas, Reichart, Leonie, Chen, Lin, Hansen, Fynn M, Lechner, Severin, Samaras, Patroklos, Eckert, Stephan, Lautenbacher, Ludwig, Reinecke, Maria, Hamood, Firas, Prokofeva, Polina, Vornholz, Larsen, Falcomatà, Chiara, Dorsch, Madeleine, Schröder, Ayla, Venhuizen, Anton, Wilhelm, Stephanie, Médard, Guillaume, Stoehr, Gabriele, Ruland, Jürgen, Grüner, Barbara M, Saur, Dieter, Buchner, Maike, Ruprecht, Benjamin, Hahne, Hannes, The, Matthew, Wilhelm, Mathias, Kuster, Bernhard
Published in Science (American Association for the Advancement of Science) (07.04.2023)
Published in Science (American Association for the Advancement of Science) (07.04.2023)
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Journal Article
Thieno[3,2-b]pyridine: Attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode
Martín Moyano, Paula, Kubina, Tadeáš, Paruch, Štěpán Owen, Jarošková, Aneta, Novotný, Jan, Skočková, Veronika, Ovesná, Petra, Suchánková, Tereza, Prokofeva, Polina, Kuster, Bernhard, Šmída, Michal, Chaikuad, Apirat, Kramer, Andreas, Knapp, Stefan, Souček, Karel, Paruch, Kamil
Published in Angewandte Chemie International Edition (21.11.2024)
Published in Angewandte Chemie International Edition (21.11.2024)
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Journal Article
Development of selective inhibitors of phosphatidylinositol 3-kinase C2α
Lo, Wen-Ting, Belabed, Hassane, Kücükdisli, Murat, Metag, Juliane, Roske, Yvette, Prokofeva, Polina, Ohashi, Yohei, Horatscheck, André, Cirillo, Davide, Krauss, Michael, Schmied, Christopher, Neuenschwander, Martin, von Kries, Jens Peter, Médard, Guillaume, Kuster, Bernhard, Perisic, Olga, Williams, Roger L., Daumke, Oliver, Payrastre, Bernard, Severin, Sonia, Nazaré, Marc, Haucke, Volker
Published in Nature chemical biology (01.01.2023)
Published in Nature chemical biology (01.01.2023)
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Journal Article
Targeting cancer with small-molecule pan-KRAS degraders
Popow, Johannes, Farnaby, William, Gollner, Andreas, Kofink, Christiane, Fischer, Gerhard, Wurm, Melanie, Zollman, David, Wijaya, Andre, Mischerikow, Nikolai, Hasenoehrl, Carina, Prokofeva, Polina, Arnhof, Heribert, Arce-Solano, Silvia, Bell, Sammy, Boeck, Georg, Diers, Emelyne, Frost, Aileen B, Goodwin-Tindall, Jake, Karolyi-Oezguer, Jale, Khan, Shakil, Klawatsch, Theresa, Koegl, Manfred, Kousek, Roland, Kratochvil, Barbara, Kropatsch, Katrin, Lauber, Arnel A, McLennan, Ross, Olt, Sabine, Peter, Daniel, Petermann, Oliver, Roessler, Vanessa, Stolt-Bergner, Peggy, Strack, Patrick, Strauss, Eva, Trainor, Nicole, Vetma, Vesna, Whitworth, Claire, Zhong, Siying, Quant, Jens, Weinstabl, Harald, Kuster, Bernhard, Ettmayer, Peter, Ciulli, Alessio
Published in Science (American Association for the Advancement of Science) (20.09.2024)
Published in Science (American Association for the Advancement of Science) (20.09.2024)
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Journal Article
Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition
Kücükdisli, Murat, Bel-Abed, Hassen, Cirillo, Davide, Lo, Wen-Ting, Efrém, Nina-Louisa, Horatscheck, André, Perepelittchenko, Liudmila, Prokofeva, Polina, Ehret, Theresa A. L., Radetzki, Silke, Neuenschwander, Martin, Specker, Edgar, Médard, Guillaume, Müller, Susanne, Wilhelm, Stephanie, Kuster, Bernhard, von Kries, Jens Peter, Haucke, Volker, Nazaré, Marc
Published in Journal of medicinal chemistry (26.10.2023)
Published in Journal of medicinal chemistry (26.10.2023)
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Journal Article
Author Correction: Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target
Lechner, Severin, Malgapo, Martin Ian P., Grätz, Christian, Steimbach, Raphael R., Baron, Agnes, Rüther, Patrick, Nadal, Simon, Stumpf, Carmen, Loos, Christina, Ku, Xin, Prokofeva, Polina, Lautenbacher, Ludwig, Heimburg, Tino, Würf, Vivian, Meng, Chen, Wilhelm, Mathias, Sippl, Wolfgang, Kleigrewe, Karin, Pauling, Josch K., Kramer, Karl, Miller, Aubry K., Pfaffl, Michael W., Linder, Maurine E., Kuster, Bernhard, Médard, Guillaume
Published in Nature chemical biology (01.08.2022)
Published in Nature chemical biology (01.08.2022)
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Journal Article
Thieno[3,2‐ b ]pyridine: Attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode
Moyano, Paula Martín, Kubina, Tadeáš, Paruch, Štěpán Owen, Jarošková, Aneta, Novotný, Jan, Skočková, Veronika, Ovesná, Petra, Suchánková, Tereza, Prokofeva, Polina, Kuster, Bernhard, Šmída, Michal, Chaikuad, Apirat, Krämer, Andreas, Knapp, Stefan, Souček, Karel, Paruch, Kamil
Published in Angewandte Chemie (21.11.2024)
Published in Angewandte Chemie (21.11.2024)
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Journal Article
Beyond Local Interactions: Revisiting Spatial Evolutionary Prisoner's Dilemma
Malikov, Maxim, Prokof'Eva, Polina
Published in 2024 Annual Modeling and Simulation Conference (ANNSIM) (20.05.2024)
Published in 2024 Annual Modeling and Simulation Conference (ANNSIM) (20.05.2024)
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Conference Proceeding