Comparison of the cancer gene targeting and biochemical selectivities of all targeted kinase inhibitors approved for clinical use
Uitdehaag, Joost C M, de Roos, Jeroen A D M, van Doornmalen, Antoon M, Prinsen, Martine B W, de Man, Jos, Tanizawa, Yoshinori, Kawase, Yusuke, Yoshino, Kohichiro, Buijsman, Rogier C, Zaman, Guido J R
Published in PloS one (20.03.2014)
Published in PloS one (20.03.2014)
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TTK Inhibitors as a Targeted Therapy for CTNNB1 ( β -catenin) Mutant Cancers
Zaman, Guido J R, de Roos, Jeroen A D M, Libouban, Marion A A, Prinsen, Martine B W, de Man, Jos, Buijsman, Rogier C, Uitdehaag, Joost C M
Published in Molecular cancer therapeutics (01.11.2017)
Published in Molecular cancer therapeutics (01.11.2017)
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Journal Article
Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance
Willemsen-Seegers, Nicole, Uitdehaag, Joost C.M., Prinsen, Martine B.W., de Vetter, Judith R.F., de Man, Jos, Sawa, Masaaki, Kawase, Yusuke, Buijsman, Rogier C., Zaman, Guido J.R.
Published in Journal of molecular biology (17.02.2017)
Published in Journal of molecular biology (17.02.2017)
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Journal Article
Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity
Uitdehaag, Joost C.M., de Man, Jos, Willemsen-Seegers, Nicole, Prinsen, Martine B.W., Libouban, Marion A.A., Sterrenburg, Jan Gerard, de Wit, Joeri J.P., de Vetter, Judith R.F., de Roos, Jeroen A.D.M., Buijsman, Rogier C., Zaman, Guido J.R.
Published in Journal of molecular biology (07.07.2017)
Published in Journal of molecular biology (07.07.2017)
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Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells
The, Inge, Ruijtenberg, Suzan, Bouchet, Benjamin P., Cristobal, Alba, Prinsen, Martine B. W., van Mourik, Tim, Koreth, John, Xu, Huihong, Heck, Albert J. R., Akhmanova, Anna, Cuppen, Edwin, Boxem, Mike, Muñoz, Javier, van den Heuvel, Sander
Published in Nature communications (06.01.2015)
Published in Nature communications (06.01.2015)
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Caenorhabditis elegans cyclin D/CDK4 and cyclin E/CDK2 induce distinct cell cycle re-entry programs in differentiated muscle cells
Korzelius, Jerome, The, Inge, Ruijtenberg, Suzan, Prinsen, Martine B W, Portegijs, Vincent, Middelkoop, Teije C, Groot Koerkamp, Marian J, Holstege, Frank C P, Boxem, Mike, van den Heuvel, Sander
Published in PLoS genetics (01.11.2011)
Published in PLoS genetics (01.11.2011)
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Targeting Indoleamine 2,3-Dioxygenase in Cancer Models Using the Novel Small Molecule Inhibitor NTRC 3883-0
Grobben, Yvonne, de Man, Jos, van Doornmalen, Antoon M, Muller, Michelle, Willemsen-Seegers, Nicole, Vu-Pham, Diep, Mulder, Winfried R, Prinsen, Martine B W, de Wit, Joeri, Sterrenburg, Jan Gerard, van Cauter, Freek, den Ouden, Judith E, van Altena, Anne M, Massuger, Leon F, Uitdehaag, Joost C M, Buijsman, Rogier C, Zaman, Guido J R
Published in Frontiers in immunology (28.01.2021)
Published in Frontiers in immunology (28.01.2021)
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Combined Cellular and Biochemical Profiling to Identify Predictive Drug Response Biomarkers for Kinase Inhibitors Approved for Clinical Use between 2013 and 2017
Uitdehaag, Joost C M, Kooijman, Jeffrey J, de Roos, Jeroen A D M, Prinsen, Martine B W, Dylus, Jelle, Willemsen-Seegers, Nicole, Kawase, Yusuke, Sawa, Masaaki, de Man, Jos, van Gerwen, Suzanne J C, Buijsman, Rogier C, Zaman, Guido J R
Published in Molecular cancer therapeutics (01.02.2019)
Published in Molecular cancer therapeutics (01.02.2019)
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Comparative kinase and cancer cell panel profiling of kinase inhibitors approved for clinical use from 2018 to 2020
Kooijman, Jeffrey J, van Riel, Wilhelmina E, Dylus, Jelle, Prinsen, Martine B W, Grobben, Yvonne, de Bitter, Tessa J J, van Doornmalen, Antoon M, Melis, Janneke J T M, Uitdehaag, Joost C M, Narumi, Yugo, Kawase, Yusuke, de Roos, Jeroen A D M, Willemsen-Seegers, Nicole, Zaman, Guido J R
Published in Frontiers in oncology (14.09.2022)
Published in Frontiers in oncology (14.09.2022)
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Journal Article
Selective Targeting of CTNNB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs
Uitdehaag, Joost C. M., de Roos, Jeroen A. D. M., van Doornmalen, Antoon M., Prinsen, Martine B. W., Spijkers-Hagelstein, Jill A. P., de Vetter, Judith R. F., de Man, Jos, Buijsman, Rogier C., Zaman, Guido J. R.
Published in PloS one (01.05.2015)
Published in PloS one (01.05.2015)
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Cell Panel Profiling Reveals Conserved Therapeutic Clusters and Differentiates the Mechanism of Action of Different PI3K/mTOR, Aurora Kinase and EZH2 Inhibitors
Uitdehaag, Joost C M, de Roos, Jeroen A D M, Prinsen, Martine B W, Willemsen-Seegers, Nicole, de Vetter, Judith R F, Dylus, Jelle, van Doornmalen, Antoon M, Kooijman, Jeffrey, Sawa, Masaaki, van Gerwen, Suzanne J C, de Man, Jos, Buijsman, Rogier C, Zaman, Guido J R
Published in Molecular cancer therapeutics (01.12.2016)
Published in Molecular cancer therapeutics (01.12.2016)
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Journal Article
Selective Targeting of CTNBB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs
Uitdehaag, Joost C M, de Roos, Jeroen A D M, van Doornmalen, Antoon M, Prinsen, Martine B W, Spijkers-Hagelstein, Jill A P, de Vetter, Judith R F, de Man, Jos, Buijsman, Rogier C, Zaman, Guido J R
Published in PloS one (27.05.2015)
Published in PloS one (27.05.2015)
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Journal Article
Abstract 2646: The unique binding mode of NTRC 0066-0, a novel inhibitor of the spindle assembly checkpoint kinase TTK (Mps1), leads to long target residence time and potent antitumor activity
de Man, Jos, Uitdehaag, Joost C.M., Willemsen-Seegers, Nicole, Sterrenburg, Jan Gerard, de Wit, Joeri J.P., de Roos, Jeroen A.D.M., Prinsen, Martine B.W., Buijsman, Rogier C., Zaman, Guido J.R.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract 1480: Comparative cancer cell panel profiling of kinase inhibitors approved for clinical use from 2018 to 2020
Kooijman, Jeffrey J., van Riel, Wilhelmina E., Prinsen, Martine B., Dylus, Jelle, de Roos, Jeroen A., Grobben, Yvonne, Willemsen-Seegers, Nicole, Muller, Michelle, de Man, Jos, Narumi, Yugo, Kawase, Yusuke, Buijsman, Rogier C., van Gerwen, Suzanne J., Zaman, Guido J.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Abstract A153: Novel synergistic drug combinations of PARP, bromodomain, and spindle assembly checkpoint kinase inhibitors by large-scale screen of 150 anticancer agents
van Gerwen, Suzanne, Prinsen, Martine, Dylus, Jelle, Buijsman, Rogier, Uitdehaag, Joost, Zaman, Guido
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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Journal Article
Abstract B065: TTK inhibitors as a targeted therapy for β-catenin mutant cancers
Zaman, Guido, de Roos, Jeroen, Libouban, Marion, Prinsen, Martine, de Man, Jos, Buijsman, Rogier, Uitdehaag, Joost
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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Journal Article
Abstract 279A: Cell panel profiling of 162 small molecule therapeutics identifies response biomarkers for PARP, BET-family and proteasome inhibitors
Uitdehaag, Joost C., Kooijman, Jeffrey J., Roos, Jeroen A.D.M. de, Prinsen, Martine B.W., Dylus, Jelle, Willemsen-Seegers, Nicole, Man, Jos de, Gerwen, Suzanne J.C. van, Buijsman, Rogier C., Zaman, Guido J.R.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract 2158: Combining cell panel profiling and synthetic lethality data to efficiently screen for synergistic combinations
Uitdehaag, Joost C., Tilborg, Derek W. van, Prinsen, Martine B.W., Kooijman, Jeffrey J., Dylus, Jelle, Roos, Jeroen A.D.M. de, Gerwen, Suzanne J.C. van, Man, Jos de, Buijsman, Rogier C., Zaman, Guido J.R.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract A141: Computational models of synergy contribute to efficient combination screening
Uitdehaag, Joost C.M., Prinsen, Martine B.W., Tilborg, Derek W. van, Kooijman, Jeffrey J., Dylus, Jelle, Roos, Jeroen A.D.M. de, Gerwen, Suzanne J.C. van, Man, Jos de, Buijsman, Rogier C., Zaman, Guido J.R.
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Abstract B155: Combining cell panel screening with analysis of gene expression levels reveals features of drug response and resistance
Uitdehaag, Joost C.M., Kooijman, Jeffrey, de Roos, Jeroen A.D.M., Prinsen, Martine B.W., Dylus, Jelle, van Gerwen, Suzanne J.C., Buijsman, Rogier C., Zaman, Guido J.R.
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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