The immune landscape of common CNS malignancies: implications for immunotherapy
Ott, Martina, Prins, Robert M., Heimberger, Amy B.
Published in Nature reviews. Clinical oncology (01.11.2021)
Published in Nature reviews. Clinical oncology (01.11.2021)
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Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma
Lee, Alexander H., Sun, Lu, Mochizuki, Aaron Y., Reynoso, Jeremy G., Orpilla, Joey, Chow, Frances, Kienzler, Jenny C., Everson, Richard G., Nathanson, David A., Bensinger, Steven J., Liau, Linda M., Cloughesy, Timothy, Hugo, Willy, Prins, Robert M.
Published in Nature communications (26.11.2021)
Published in Nature communications (26.11.2021)
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2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling
Fu, Xudong, Chin, Randall M., Vergnes, Laurent, Hwang, Heejun, Deng, Gang, Xing, Yanpeng, Pai, Melody Y., Li, Sichen, Ta, Lisa, Fazlollahi, Farbod, Chen, Chuo, Prins, Robert M., Teitell, Michael A., Nathanson, David A., Lai, Albert, Faull, Kym F., Jiang, Meisheng, Clarke, Steven G., Cloughesy, Timothy F., Graeber, Thomas G., Braas, Daniel, Christofk, Heather R., Jung, Michael E., Reue, Karen, Huang, Jing
Published in Cell metabolism (01.09.2015)
Published in Cell metabolism (01.09.2015)
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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Bittinger, Mark A, Driggers, Edward M, Ward, Patrick S, Gross, Stefan, Su, Shinsan M, Liau, Linda M, Dang, Lenny, Fantin, Valeria R, Jang, Hyun Gyung, Marks, Kevin M, White, David W, Vander Heiden, Matthew G, Thompson, Craig B, Rabinowitz, Joshua D, Cantley, Lewis C, Keenan, Marie C, Prins, Robert M, Jin, Shengfang, Bennett, Bryson D, Yen, Katharine E
Published in Nature (London) (10.12.2009)
Published in Nature (London) (10.12.2009)
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Detection of immune responses after immunotherapy in glioblastoma using PET and MRI
Antonios, Joseph P., Soto, Horacio, Everson, Richard G., Moughon, Diana L., Wang, Anthony C., Orpilla, Joey, Radu, Caius, Ellingson, Benjamin M., Lee, Jason T., Cloughesy, Timothy, Phelps, Michael E., Czernin, Johannes, Liau, Linda M., Prins, Robert M.
Published in Proceedings of the National Academy of Sciences - PNAS (19.09.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (19.09.2017)
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TLR agonists polarize interferon responses in conjunction with dendritic cell vaccination in malignant glioma: a randomized phase II Trial
Everson, Richard G., Hugo, Willy, Sun, Lu, Antonios, Joseph, Lee, Alexander, Ding, Lizhong, Bu, Melissa, Khattab, Sara, Chavez, Carolina, Billingslea-Yoon, Emma, Salazar, Andres, Ellingson, Benjamin M., Cloughesy, Timothy F., Liau, Linda M., Prins, Robert M.
Published in Nature communications (08.05.2024)
Published in Nature communications (08.05.2024)
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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Marks, Kevin M, Rabinowitz, Joshua D, Dang, Lenny, Gross, Stefan, Fantin, Valeria R, Keenan, Marie C, Driggers, Edward M, Bennett, Bryson D, Jang, Hyun Gyung, Liau, Linda M, Ward, Patrick S, Jin, Shengfang, Yen, Katharine E, Su, Shinsan M, Prins, Robert M, Vander Heiden, Matthew G, White, David W, Cantley, Lewis C, Thompson, Craig B, Bittinger, Mark A
Published in Nature (London) (17.06.2010)
Published in Nature (London) (17.06.2010)
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Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1
Lu, Yue, Ng, Alphonsus H. C., Chow, Frances E., Everson, Richard G., Helmink, Beth A., Tetzlaff, Michael T., Thakur, Rohit, Wargo, Jennifer A., Cloughesy, Timothy F., Prins, Robert M., Heath, James R.
Published in Nature communications (29.06.2021)
Published in Nature communications (29.06.2021)
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Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy
Pope, Whitney B., Prins, Robert M., Albert Thomas, M., Nagarajan, Rajakumar, Yen, Katharine E., Bittinger, Mark A., Salamon, Noriko, Chou, Arthur P., Yong, William H., Soto, Horacio, Wilson, Neil, Driggers, Edward, Jang, Hyun G., Su, Shinsan M., Schenkein, David P., Lai, Albert, Cloughesy, Timothy F., Kornblum, Harley I., Wu, Hong, Fantin, Valeria R., Liau, Linda M.
Published in Journal of neuro-oncology (01.03.2012)
Published in Journal of neuro-oncology (01.03.2012)
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Author Correction: TLR agonists polarize interferon responses in conjunction with dendritic cell vaccination in malignant glioma: a randomized phase II Trial
Everson, Richard G., Hugo, Willy, Sun, Lu, Antonios, Joseph, Lee, Alexander, Ding, Lizhong, Bu, Melissa, Khattab, Sara, Chavez, Carolina, Billingslea-Yoon, Emma, Salazar, Andres, Ellingson, Benjamin M., Cloughesy, Timothy F., Liau, Linda M., Prins, Robert M.
Published in Nature communications (05.06.2024)
Published in Nature communications (05.06.2024)
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pH-weighted molecular imaging of gliomas using amine chemical exchange saturation transfer MRI
Harris, Robert J, Cloughesy, Timothy F, Liau, Linda M, Prins, Robert M, Antonios, Joseph P, Li, Debiao, Yong, William H, Pope, Whitney B, Lai, Albert, Nghiemphu, Phioanh L, Ellingson, Benjamin M
Published in Neuro-oncology (Charlottesville, Va.) (01.11.2015)
Published in Neuro-oncology (Charlottesville, Va.) (01.11.2015)
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Antigen presentation by clonally diverse CXCR5+ B cells to CD4 and CD8 T cells is associated with durable response to immune checkpoint inhibitors
Ding, Lizhong, Sun, Lu, Bu, Melissa T, Zhang, Yanjun, Scott, Lauren N, Prins, Robert M, Su, Maureen A, Lechner, Melissa G, Hugo, Willy
Published in Frontiers in immunology (26.06.2023)
Published in Frontiers in immunology (26.06.2023)
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Immune checkpoint blockade induces distinct alterations in the microenvironments of primary and metastatic brain tumors
Sun, Lu, Kienzler, Jenny C, Reynoso, Jeremy G, Lee, Alexander, Shiuan, Eileen, Li, Shanpeng, Kim, Jiyoon, Ding, Lizhong, Monteleone, Amber J, Owens, Geoffrey C, Phillips, Joanna J, Everson, Richard G, Nathanson, David, Cloughesy, Timothy F, Li, Gang, Liau, Linda M, Hugo, Willy, Kim, Won, Prins, Robert M
Published in The Journal of clinical investigation (01.09.2023)
Published in The Journal of clinical investigation (01.09.2023)
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An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway
Guo, Deliang, Reinitz, Felicia, Youssef, Mary, Hong, Cynthia, Nathanson, David, Akhavan, David, Kuga, Daisuke, Amzajerdi, Ali Nael, Soto, Horacio, Zhu, Shaojun, Babic, Ivan, Tanaka, Kazuhiro, Dang, Julie, Iwanami, Akio, Gini, Beatrice, Dejesus, Jason, Lisiero, Dominique D, Huang, Tiffany T, Prins, Robert M, Wen, Patrick Y, Robins, H Ian, Prados, Michael D, Deangelis, Lisa M, Mellinghoff, Ingo K, Mehta, Minesh P, James, C David, Chakravarti, Arnab, Cloughesy, Timothy F, Tontonoz, Peter, Mischel, Paul S
Published in Cancer discovery (01.10.2011)
Published in Cancer discovery (01.10.2011)
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An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
WILLIAMS, Kevin J, ARGUS, Joseph P, KOMISOPOULOU, Evangelia, HENKIN, Amy H, SOTO, Horacio, CHAMBERLAIN, Brian T, VERGNES, Laurent, JUNG, Michael E, TORRES, Jorge Z, LIAU, Linda M, CHRISTOFK, Heather R, PRINS, Robert M, YUE ZHU, MISCHEL, Paul S, REUE, Karen, GRAEBER, Thomas G, BENSINGER, Steven J, WILKS, Moses Q, MARBOIS, Beth N, YORK, Autumn G, KIDANI, Yoko, POURZIA, Alexandra L, AKHAVAN, David, LISIERO, Dominique N
Published in Cancer research (Chicago, Ill.) (01.05.2013)
Published in Cancer research (Chicago, Ill.) (01.05.2013)
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Monitoring of regulatory T cell frequencies and expression of CTLA-4 on T cells, before and after DC vaccination, can predict survival in GBM patients
Fong, Brendan, Jin, Richard, Wang, Xiaoyan, Safaee, Michael, Lisiero, Dominique N, Yang, Isaac, Li, Gang, Liau, Linda M, Prins, Robert M
Published in PloS one (02.04.2012)
Published in PloS one (02.04.2012)
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AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis
Guo, Deliang, Hildebrandt, Isabel J, Prins, Robert M, Soto, Horacio, Mazzotta, Mary M, Dang, Julie, Czernin, Johannes, Shyy, John Y.-J, Watson, Andrew D, Phelps, Michael, Radu, Caius G, Cloughesy, Timothy F, Mischel, Paul S
Published in Proceedings of the National Academy of Sciences - PNAS (04.08.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (04.08.2009)
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Amine‐weighted chemical exchange saturation transfer magnetic resonance imaging in brain tumors
Cho, Nicholas S., Hagiwara, Akifumi, Yao, Jingwen, Nathanson, David A., Prins, Robert M., Wang, Chencai, Raymond, Catalina, Desousa, Brandon R., Divakaruni, Ajit, Morrow, Danielle H., Nghiemphu, Phioanh L., Lai, Albert, Liau, Linda M., Everson, Richard G., Salamon, Noriko, Pope, Whitney B., Cloughesy, Timothy F., Ellingson, Benjamin M.
Published in NMR in biomedicine (01.06.2023)
Published in NMR in biomedicine (01.06.2023)
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Comparison of glioma-associated antigen peptide-loaded versus autologous tumor lysate-loaded dendritic cell vaccination in malignant glioma patients
Prins, Robert M, Wang, Xiaoyan, Soto, Horacio, Young, Emma, Lisiero, Dominique N, Fong, Brendan, Everson, Richard, Yong, William H, Lai, Albert, Li, Gang, Cloughesy, Timothy F, Liau, Linda M
Published in Journal of immunotherapy (1997) (01.02.2013)
Published in Journal of immunotherapy (1997) (01.02.2013)
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EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy
Guo, Deliang, Prins, Robert M, Dang, Julie, Kuga, Daisuke, Iwanami, Akio, Soto, Horacio, Lin, Kelly Y, Huang, Tiffany T, Akhavan, David, Hock, M Benjamin, Zhu, Shaojun, Kofman, Ava A, Bensinger, Steve J, Yong, William H, Vinters, Harry V, Horvath, Steve, Watson, Andrew D, Kuhn, John G, Robins, H Ian, Mehta, Minesh P, Wen, Patrick Y, DeAngelis, Lisa M, Prados, Michael D, Mellinghoff, Ingo K, Cloughesy, Timothy F, Mischel, Paul S
Published in Science signaling (15.12.2009)
Published in Science signaling (15.12.2009)
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