Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss
Fedoriw, Andrew, Rajapurkar, Satyajit R., O'Brien, Shane, Gerhart, Sarah V., Mitchell, Lorna H., Adams, Nicholas D., Rioux, Nathalie, Lingaraj, Trupti, Ribich, Scott A., Pappalardi, Melissa B., Shah, Niyant, Laraio, Jenny, Liu, Yan, Butticello, Michael, Carpenter, Chris L., Creasy, Caretha, Korenchuk, Susan, McCabe, Michael T., McHugh, Charles F., Nagarajan, Raman, Wagner, Craig, Zappacosta, Francesca, Annan, Roland, Concha, Nestor O., Thomas, Roberta A., Hart, Timothy K., Smith, Jesse J., Copeland, Robert A., Moyer, Mikel P., Campbell, John, Stickland, Kim, Mills, James, Jacques-O’Hagan, Suzanne, Allain, Christina, Johnston, Danielle, Raimondi, Alejandra, Porter Scott, Margaret, Waters, Nigel, Swinger, Kerren, Boriack-Sjodin, Ann, Riera, Tom, Shapiro, Gideon, Chesworth, Richard, Prinjha, Rabinder K., Kruger, Ryan G., Barbash, Olena, Mohammad, Helai P.
Published in Cancer cell (08.07.2019)
Published in Cancer cell (08.07.2019)
Get full text
Journal Article
Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all- trans retinoic acid in acute myeloid leukemia across subtypes
Smitheman, Kimberly N, Severson, Tesa M, Rajapurkar, Satyajit R, McCabe, Michael T, Karpinich, Natalie, Foley, James, Pappalardi, Melissa B, Hughes, Ashley, Halsey, Wendy, Thomas, Elizabeth, Traini, Christopher, Federowicz, Kelly E, Laraio, Jenny, Mobegi, Fredrick, Ferron-Brady, Geraldine, Prinjha, Rabinder K, Carpenter, Christopher L, Kruger, Ryan G, Wessels, Lodewyk, Mohammad, Helai P
Published in Haematologica (Roma) (01.06.2019)
Published in Haematologica (Roma) (01.06.2019)
Get full text
Journal Article
Phase 1 Study of Molibresib (GSK525762), a Bromodomain and Extra-Terminal Domain Protein Inhibitor, in NUT Carcinoma and Other Solid Tumors
Piha-Paul, Sarina A, Hann, Christine L, French, Christopher A, Cousin, Sophie, Braña, Irene, Cassier, Phillippe A, Moreno, Victor, de Bono, Johann S, Harward, Sara Duckworth, Ferron-Brady, Geraldine, Barbash, Olena, Wyce, Anastasia, Wu, Yuehui, Horner, Thierry, Annan, Meg, Parr, Nigel J, Prinjha, Rabinder K, Carpenter, Christopher L, Hilton, John, Hong, David S, Haas, Naomi B, Markowski, Mark C, Dhar, Arindam, O'Dwyer, Peter J, Shapiro, Geoffrey I
Published in JNCI cancer spectrum (01.04.2020)
Published in JNCI cancer spectrum (01.04.2020)
Get full text
Journal Article
Signaling function of PRC2 is essential for TCR-driven T cell responses
Dobenecker, Marc-Werner, Park, Joon Seok, Marcello, Jonas, McCabe, Michael T, Gregory, Richard, Knight, Steven D, Rioja, Inmaculada, Bassil, Anna K, Prinjha, Rabinder K, Tarakhovsky, Alexander
Published in The Journal of experimental medicine (02.04.2018)
Published in The Journal of experimental medicine (02.04.2018)
Get full text
Journal Article
The Commonly Used PI3-Kinase Probe LY294002 Is an Inhibitor of BET Bromodomains
Dittmann, Antje, Werner, Thilo, Chung, Chun-Wa, Savitski, Mikhail M, Fälth Savitski, Maria, Grandi, Paola, Hopf, Carsten, Lindon, Matthew, Neubauer, Gitte, Prinjha, Rabinder K, Bantscheff, Marcus, Drewes, Gerard
Published in ACS chemical biology (21.02.2014)
Published in ACS chemical biology (21.02.2014)
Get full text
Journal Article
A randomized study of the safety and pharmacokinetics of GSK3358699, a mononuclear myeloid‐targeted bromodomain and extra‐terminal domain inhibitor
Brown, Jack A., Bal, Joanne, Simeoni, Monica, Williams, Peter, Mander, Palwinder K., Soden, Peter E., Daga, Shruti, Fahy, William A., Wong, Gabriel K., Bloomer, Jackie C., Erwig, Lars, Cui, Yi, Fernando, Disala, Carnaghan, Helen, Banham‐Hall, Edward J., Hopkins, Sarah, Davis, Bill G., Oliveira, Joao J. D., Prinjha, Rabinder K.
Published in British journal of clinical pharmacology (01.05.2022)
Published in British journal of clinical pharmacology (01.05.2022)
Get full text
Journal Article
Tyrosine Kinase 2 Signalling Drives Pathogenic T cells in Colitis
De Vries, Leonie C S, Ghiboub, Mohammed, van Hamersveld, Patricia H P, Welting, Olaf, Verseijden, Caroline, Bell, Matthew J, Rioja, Inmaculada, Prinjha, Rabinder K, Koelink, Pim J, Strobl, Birgit, Müller, Mathias, D’Haens, Geert R, Wildenberg, Manon E, De Jonge, Wouter J
Published in Journal of Crohn's and colitis (06.04.2021)
Published in Journal of Crohn's and colitis (06.04.2021)
Get full text
Journal Article
Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins
Giger, R J, Cloutier, J F, Sahay, A, Prinjha, R K, Levengood, D V, Moore, S E, Pickering, S, Simmons, D, Rastan, S, Walsh, F S, Kolodkin, A L, Ginty, D D, Geppert, M
Published in Neuron (Cambridge, Mass.) (01.01.2000)
Published in Neuron (Cambridge, Mass.) (01.01.2000)
Get full text
Journal Article
Nogo Provides a Molecular Marker for Diagnosis of Amyotrophic Lateral Sclerosis
Dupuis, Luc, Gonzalez de Aguilar, Jose-Luis, di Scala, Franck, Rene, Frédérique, de Tapia, Marc, Pradat, Pierre-François, Lacomblez, Lucette, Seihlan, Danielle, Prinjha, Rabinder, Walsh, Frank S., Meininger, Vincent, Loeffler, Jean-Philippe
Published in Neurobiology of disease (01.08.2002)
Published in Neurobiology of disease (01.08.2002)
Get full text
Journal Article
The catalytic domain of the histone methyltransferase NSD2/MMSET is required for the generation of B1 cells in mice
Dobenecker, Marc‐Werner, Marcello, Jonas, Becker, Annette, Rudensky, Eugene, Bhanu, Natarajan V., Carrol, Thomas, Garcia, Benjamin A., Prinjha, Rabinder, Yurchenko, Vyacheslav, Tarakhovsky, Alexander
Published in FEBS letters (01.10.2020)
Published in FEBS letters (01.10.2020)
Get full text
Journal Article
3122 – SUMOYLATION OF DNMT1 REGULATES RESPONSE TO CATALYTIC INHIBITION OF DNMT1 IN ACUTE MYELOID LEUKAEMIA
Liddicoat, Brian, Jia, Wendy, Garcia-Bediaga, Naiara, Das, Andrew, Scolamiero, Laura, Gillespie, Andrea, Maarel, Christa, Guirguis, Andrew, Lam, Enid, Litchfield, Cassie, Talarmain, Laure, Wang, Tao, Zappacosta, Francesca, Annan, Roland, Prinjha, Rabinder, Dawson, Sarah-Jane, McCabe, Michael, Pappalardi, Melissa, Ang, Ching-Seng, Dawson, Mark
Published in Experimental hematology (2022)
Published in Experimental hematology (2022)
Get full text
Journal Article
Inhibitor of neurite outgrowth in humans
PRINJHA, R, MOORE, S. E, VINSON, M, BLAKE, S, MORROW, R, CHRISTIE, G, MICHALOVICH, D, SIMMONS, D. L, WALSH, F. S
Published in Nature (London) (27.01.2000)
Published in Nature (London) (27.01.2000)
Get full text
Journal Article
Neurobiology Inhibitor of neurite outgrowth in humans
Walsh, Frank S, Prinjha, Rabinder, Moore, Stephen E, Vinson, Mary, Blake, Sian, Morrow, Rachel, Christie, Gary, Michalovich, David, Simmons, David L
Published in Nature (London) (27.01.2000)
Published in Nature (London) (27.01.2000)
Get full text
Journal Article
PTEN couples Sema3A signalling to growth cone collapse
Chadborn, Neil H, Ahmed, Aminul I, Holt, Mark R, Prinjha, Rabinder, Dunn, Graham A, Jones, Gareth E, Eickholt, Britta J
Published in Journal of cell science (01.03.2006)
Published in Journal of cell science (01.03.2006)
Get full text
Journal Article
Non-clinical development of ozanezumab: a humanised antibody targeting the amino terminus of neurite outgrowth inhibitor A (Nogo-A)Electronic supplementary information (ESI) available. See DOI: 10.1039/c5tx00179j
Lynch, Anthony M, Cleveland, Matthew, Prinjha, Rabinder, Kumar, Umesh, Stubbs, Robert, Wuerthner, Jens
Year of Publication 18.08.2015
Year of Publication 18.08.2015
Get full text
Journal Article
Non-clinical development of ozanezumab: a humanised antibody targeting the amino terminus of neurite outgrowth inhibitor A (Nogo-A)
Lynch, Anthony M., Cleveland, Matthew, Prinjha, Rabinder, Kumar, Umesh, Stubbs, Robert, Wuerthner, Jens
Published in Toxicology research (Cambridge) (01.01.2015)
Published in Toxicology research (Cambridge) (01.01.2015)
Get full text
Journal Article
Treatment with an antibody directed against Nogo-A delays disease progression in the SOD1G93A mouse model of Amyotrophic lateral sclerosis
Bros-Facer, Virginie, Krull, David, Taylor, Adam, Dick, James R T, Bates, Stewart A, Cleveland, Matthew S, Prinjha, Rabinder K, Greensmith, Linda
Published in Human molecular genetics (15.08.2014)
Published in Human molecular genetics (15.08.2014)
Get full text
Journal Article
Proteomic identification and early validation of complement 1 inhibitor and pigment epithelium-derived factor: Two novel biomarkers of Alzheimer's disease in human plasma
Cutler, Paul, Akuffo, Emma L., Bodnar, Wanda M., Briggs, Deborah M., Davis, John B., Debouck, Christine M., Fox, Steven M., Gibson, Rachel A., Gormley, Darren A., Holbrook, Joanna D., Hunter, A. Jacqueline, Kinsey, Emma E., Prinjha, Rabinder, Richardson, Jill C., Roses, Allen D., Smith, Marjorie A., Tsokanas, Nikos, Willé, David R., Wu, Wen, Yates, John W., Gloger, Israel S.
Published in Proteomics. Clinical applications (01.04.2008)
Published in Proteomics. Clinical applications (01.04.2008)
Get full text
Journal Article