Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic
Bird, Gregory H., Madani, Navid, Perry, Alisa F., Princiotto, Amy M., Supko, Jeffrey G., He, Xiaoying, Gavathiotis, Evripidis, Sodroski, Joseph G., Walensky, Loren D., Snyder, Solomon H.
Published in Proceedings of the National Academy of Sciences - PNAS (10.08.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (10.08.2010)
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Journal Article
Activation and Inactivation of Primary Human Immunodeficiency Virus Envelope Glycoprotein Trimers by CD4-Mimetic Compounds
Madani, Navid, Princiotto, Amy M, Zhao, Connie, Jahanbakhshsefidi, Fatemeh, Mertens, Max, Herschhorn, Alon, Melillo, Bruno, Smith, 3rd, Amos B, Sodroski, Joseph
Published in Journal of virology (01.02.2017)
Published in Journal of virology (01.02.2017)
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Journal Article
A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge
Madani, Navid, Princiotto, Amy M., Mach, Linh, Ding, Shilei, Prevost, Jérémie, Richard, Jonathan, Hora, Bhavna, Sutherland, Laura, Zhao, Connie A., Conn, Brandon P., Bradley, Todd, Moody, M. Anthony, Melillo, Bruno, Finzi, Andrés, Haynes, Barton F., Smith III, Amos B., Santra, Sampa, Sodroski, Joseph
Published in Nature communications (18.06.2018)
Published in Nature communications (18.06.2018)
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Journal Article
Structure-Based Design, Synthesis, and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors
LaLonde, Judith M, Kwon, Young Do, Jones, David M, Sun, Alexander W, Courter, Joel R, Soeta, Takahiro, Kobayashi, Toyoharu, Princiotto, Amy M, Wu, Xueling, Schön, Arne, Freire, Ernesto, Kwong, Peter D, Mascola, John R, Sodroski, Joseph, Madani, Navid, Smith, Amos B
Published in Journal of medicinal chemistry (10.05.2012)
Published in Journal of medicinal chemistry (10.05.2012)
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Journal Article
Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV‑1 Entry Inhibition
Melillo, Bruno, Liang, Shuaiyi, Park, Jongwoo, Schön, Arne, Courter, Joel R, LaLonde, Judith M, Wendler, Daniel J, Princiotto, Amy M, Seaman, Michael S, Freire, Ernesto, Sodroski, Joseph, Madani, Navid, Hendrickson, Wayne A, Smith, Amos B
Published in ACS medicinal chemistry letters (10.03.2016)
Published in ACS medicinal chemistry letters (10.03.2016)
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Journal Article
CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies
Madani, Navid, Princiotto, Amy M, Schön, Arne, LaLonde, Judith, Feng, Yu, Freire, Ernesto, Park, Jongwoo, Courter, Joel R, Jones, David M, Robinson, James, Liao, Hua-Xin, Moody, M Anthony, Permar, Sallie, Haynes, Barton, Smith, 3rd, Amos B, Wyatt, Richard, Sodroski, Joseph
Published in Journal of virology (01.06.2014)
Published in Journal of virology (01.06.2014)
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Journal Article
Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds
Madani, Navid, Princiotto, Amy M, Easterhoff, David, Bradley, Todd, Luo, Kan, Williams, Wilton B, Liao, Hua-Xin, Moody, M Anthony, Phad, Ganesh E, Vázquez Bernat, Néstor, Melillo, Bruno, Santra, Sampa, Smith, 3rd, Amos B, Karlsson Hedestam, Gunilla B, Haynes, Barton, Sodroski, Joseph
Published in Journal of virology (15.05.2016)
Published in Journal of virology (15.05.2016)
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Journal Article
Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening
LaLonde, Judith M., Elban, Mark A., Courter, Joel R., Sugawara, Akihiro, Soeta, Takahiro, Madani, Navid, Princiotto, Amy M., Kwon, Young Do, Kwong, Peter D., Schön, Arne, Freire, Ernesto, Sodroski, Joseph, Smith, Amos B.
Published in Bioorganic & medicinal chemistry (01.01.2011)
Published in Bioorganic & medicinal chemistry (01.01.2011)
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Journal Article
Structure-Based Design and Synthesis of an HIV‑1 Entry Inhibitor Exploiting X‑ray and Thermodynamic Characterization
LaLonde, Judith M., Le-Khac, Matthew, Jones, David M., Courter, Joel R., Park, Jongwoo, Schön, Arne, Princiotto, Amy M., Wu, Xueling, Mascola, John R., Freire, Ernesto, Sodroski, Joseph, Madani, Navid, Hendrickson, Wayne A., Smith, Amos B.
Published in ACS medicinal chemistry letters (14.03.2013)
Published in ACS medicinal chemistry letters (14.03.2013)
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Journal Article
A Small-Molecule CD4-Mimetic Compound Protects Bone Marrow-Liver-Thymus Humanized Mice From HIV-1 Infection
Princiotto, Amy M, Vrbanac, Vladimir D, Melillo, Bruno, Park, Jongwoo, Tager, Andrew M, Smith, 3rd, Amos B, Sodroski, Joseph, Madani, Navid
Published in The Journal of infectious diseases (02.07.2018)
Published in The Journal of infectious diseases (02.07.2018)
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Journal Article
Small-Molecule CD4 Mimics Interact with a Highly Conserved Pocket on HIV-1 gp120
Madani, Navid, Schön, Arne, Princiotto, Amy M., LaLonde, Judith M., Courter, Joel R., Soeta, Takahiro, Ng, Danny, Wang, Liping, Brower, Evan T., Xiang, Shi-Hua, Do Kwon, Young, Huang, Chih-chin, Wyatt, Richard, Kwong, Peter D., Freire, Ernesto, Smith, Amos B., Sodroski, Joseph
Published in Structure (London) (12.11.2008)
Published in Structure (London) (12.11.2008)
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Journal Article
Strain-Dependent Activation and Inhibition of Human Immunodeficiency Virus Entry by a Specific PF-68742 Stereoisomer
Zhao, Connie, Princiotto, Amy M, Nguyen, Hanh T, Zou, Shitao, Zhao, Meiqing Lily, Zhang, Shijian, Herschhorn, Alon, Farrell, Mark, Pahil, Karanbir, Melillo, Bruno, Sambasivarao, Somisetti V, Abrams, Cameron, Smith, 3rd, Amos B, Madani, Navid, Sodroski, Joseph
Published in Journal of virology (01.11.2019)
Published in Journal of virology (01.11.2019)
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Journal Article
Liposomes for HIV prophylaxis
Malavia, Nikita K, Zurakowski, David, Schroeder, Avi, Princiotto, Amy M, Laury, Anna R, Barash, Hila E, Sodroski, Joseph, Langer, Robert, Madani, Navid, Kohane, Daniel S
Published in Biomaterials (01.11.2011)
Published in Biomaterials (01.11.2011)
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Journal Article
Inhibitors of HIV-1 entry and methods of use thereof
Sodroski, Joseph, Princiotto, Amy M, Madani, Navid, LaLonde, Judith M, Smith, III, Amos B, Melillo, Bruno
Year of Publication 22.05.2018
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Year of Publication 22.05.2018
Patent
INHIBITORS OF HIV-1 ENTRY AND METHODS OF USE THEREOF
SODROSKI Joseph, MELILLO Bruno, SMITH,, III Amos B, PRINCIOTTO Amy M, MADANI Navid, LALONDE Judith M
Year of Publication 17.08.2017
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Year of Publication 17.08.2017
Patent
Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic
Bird, Gregory H, Madani, Navid, Perry, Alisa F, Princiotto, Amy M, Supko, Jeffrey G, He, Xiaoying, Gavathiotis, Evripidis, Sodroski, Joseph G, Walensky, Loren D
Year of Publication 2015
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Year of Publication 2015
Journal Article
Small molecule CD4 mimetics and uses thereof
Ng Danny, Hendrickson Wayne A, Soeta Takahiro, Freire Ernesto, Le-Khac Matthew, Courter Joel R, Madani Navid, Smith, III Amos B, Sodroski Joseph G, Schön Arne, LaLonde Judith M, Princiotto Amy M
Year of Publication 03.10.2017
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Year of Publication 03.10.2017
Patent
CD4-MIMETIC SMALL MOLECULES SENSITIZE HUMAN IMMUNODEFICIENCY VIRUS TO VACCINE-ELICITED ANTIBODIES
JONES, DAVID, M, WYATT, RICHARD, T, PARK, JONGWOO, MADANI, NAVID, LALONDE, JUDITH, M, FREIRE, ERNESTO, SCHON, AME, PRINCIOTTO, AMY, M, COURTER, JOEL, R, SODROSKI, JOSEPH, SMITH, AMOS, B., III
Year of Publication 12.11.2015
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Year of Publication 12.11.2015
Patent
CD4-MIMETIC SMALL MOLECULES SENSITIZE HUMAN IMMUNODEFICIENCY VIRUS TO VACCINE-ELICITED ANTIBODIES
WYATT Richard T, KWONG Peter D, SODROSKI Joseph, COURTER Joel R, HENDRICKSON Wayne A, MADANI Navid, SMITH Amos B, MASCOLA John R, PARK Jongwoo, LaLONDE Judith M, WU Xueling, JONES David M, SCHON Arne, PRINCIOTTO Amy M, LE-KHAC Matthew, KWON Young Do, FREIRE Ernesto
Year of Publication 15.12.2016
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Year of Publication 15.12.2016
Patent
CD4-MIMETIC SMALL MOLECULES SENSITIZE HUMAN IMMUNODEFICIENCY VIRUS TO VACCINE-ELICITED ANTIBODIES
JONES, DAVID, M, WYATT, RICHARD, T, PARK, JONGWOO, MADANI, NAVID, LALONDE, JUDITH, M, FREIRE, ERNESTO, SCHON, AME, PRINCIOTTO, AMY, M, COURTER, JOEL, R, SODROSKI, JOSEPH, SMITH, AMOS, B., III
Year of Publication 13.08.2015
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Year of Publication 13.08.2015
Patent