Pyrrolamide DNA Gyrase Inhibitors: Fragment-Based Nuclear Magnetic Resonance Screening To Identify Antibacterial Agents
Eakin, Ann E, Green, Oluyinka, Hales, Neil, Walkup, Grant K, Bist, Shanta, Singh, Alok, Mullen, George, Bryant, Joanna, Embrey, Kevin, Gao, Ning, Breeze, Alex, Timms, Dave, Andrews, Beth, Uria-Nickelsen, Maria, Demeritt, Julie, Loch, James T., III, Hull, Ken, Blodgett, April, Illingworth, Ruth N, Prince, Bryan, Boriack-Sjodin, P. Ann, Hauck, Sheila, MacPherson, Lawrence J, Ni, Haihong, Sherer, Brian
Published in Antimicrobial Agents and Chemotherapy (01.03.2012)
Published in Antimicrobial Agents and Chemotherapy (01.03.2012)
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Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome
Olivier, Nelson B., Altman, Roger B., Noeske, Jonas, Basarab, Gregory S., Code, Erin, Ferguson, Andrew D., Gao, Ning, Huang, Jian, Juette, Manuel F., Livchak, Stephania, Miller, Matthew D., Prince, D. Bryan, Cate, Jamie H. D., Buurman, Ed T., Blanchard, Scott C.
Published in Proceedings of the National Academy of Sciences - PNAS (18.11.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (18.11.2014)
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Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human β-Secretase
Maillard, Michel C, Hom, Roy K, Benson, Timothy E, Moon, Joseph B, Mamo, Shumeye, Bienkowski, Michael, Tomasselli, Alfredo G, Woods, Danielle D, Prince, D. Bryan, Paddock, Donna J, Emmons, Thomas L, Tucker, John A, Dappen, Michael S, Brogley, Louis, Thorsett, Eugene D, Jewett, Nancy, Sinha, Sukanto, John, Varghese
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
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Journal Article
Exploring the UDP pocket of LpxC through amino acid analogs
Hale, Michael R., Hill, Pamela, Lahiri, Sushmita, Miller, Matthew D., Ross, Philip, Alm, Richard, Gao, Ning, Kutschke, Amy, Johnstone, Michele, Prince, Bryan, Thresher, Jason, Yang, Wei
Published in Bioorganic & medicinal chemistry letters (15.04.2013)
Published in Bioorganic & medicinal chemistry letters (15.04.2013)
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Journal Article
Overexpression of Pseudomonas aeruginosa LpxC with its inhibitors in an acrB-deficient Escherichia coli strain
Gao, Ning, McLeod, Sarah M., Hajec, Laurel, Olivier, Nelson B., Lahiri, Sushmita D., Bryan Prince, D., Thresher, Jason, Ross, Philip L., Whiteaker, James D., Doig, Peter, Li, Amanda Haixi, Hill, Pamela J., Cornebise, Mark, Reck, Folkert, Hale, Michael R.
Published in Protein expression and purification (01.12.2014)
Published in Protein expression and purification (01.12.2014)
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Journal Article
Design of potent inhibitors of human β-secretase. Part 1
Freskos, John N., Fobian, Yvette M., Benson, Timothy E., Bienkowski, Michael J., Brown, David L., Emmons, Thomas L., Heintz, Robert, Laborde, Alice, McDonald, Joseph J., Mischke, Brent V., Molyneaux, John M., Moon, Joseph B., Mullins, Patrick B., Bryan Prince, D., Paddock, Donna J., Tomasselli, Alfredo G., Winterrowd, Gregory
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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Journal Article
Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1
KORTUM, Steven W, BENSON, Timothy E, BIENKOWSKI, Michael J, EMMONS, Thomas L, PRINCE, D. Bryan, PADDOCK, Donna J, TOMASSELLI, Alfredo G, MOON, Joseph B, LABORDE, Alice, TENBRINK, Ruth E
Published in Bioorganic & medicinal chemistry letters (15.06.2007)
Published in Bioorganic & medicinal chemistry letters (15.06.2007)
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Journal Article
Design of potent inhibitors of human β-secretase. Part 2
Freskos, John N., Fobian, Yvette M., Benson, Timothy E., Moon, Joseph B., Bienkowski, Michael J., Brown, David L., Emmons, Thomas L., Heintz, Robert, Laborde, Alice, McDonald, Joseph J., Mischke, Brent V., Molyneaux, John M., Mullins, Patrick B., Bryan Prince, D., Paddock, Donna J., Tomasselli, Alfredo G., Winterrowd, Greg
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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Journal Article
Discovery of Pyrazolo[1,5‑a]pyrimidine B‑Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors
McCoull, William, Abrams, Roman D, Anderson, Erica, Blades, Kevin, Barton, Peter, Box, Matthew, Burgess, Jonathan, Byth, Kate, Cao, Qing, Chuaqui, Claudio, Carbajo, Rodrigo J, Cheung, Tony, Code, Erin, Ferguson, Andrew D, Fillery, Shaun, Fuller, Nathan O, Gangl, Eric, Gao, Ning, Grist, Matthew, Hargreaves, David, Howard, Martin R, Hu, Jun, Kemmitt, Paul D, Nelson, Jennifer E, O’Connell, Nichole, Prince, D. Bryan, Raubo, Piotr, Rawlins, Philip B, Robb, Graeme R, Shi, Junjie, Waring, Michael J, Whittaker, David, Wylot, Marta, Zhu, Xiahui
Published in Journal of medicinal chemistry (25.05.2017)
Published in Journal of medicinal chemistry (25.05.2017)
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Journal Article
Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors
Cocozaki, Alexis I., Altman, Roger B., Huang, Jian, Buurman, Ed T., Kazmirski, Steven L., Doig, Peter, Prince, D. Bryan, Blanchard, Scott C., Cate, Jamie H. D., Ferguson, Andrew D.
Published in Proceedings of the National Academy of Sciences - PNAS (19.07.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (19.07.2016)
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Journal Article
Structure‐Based Design of Selective Noncovalent CDK12 Inhibitors
Johannes, Jeffrey W., Denz, Christopher R., Su, Nancy, Wu, Allan, Impastato, Anna C., Mlynarski, Scott, Varnes, Jeffrey G., Prince, D. Bryan, Cidado, Justin, Gao, Ning, Haddrick, Malcolm, Jones, Natalie H., Li, Shaobin, Li, Xiuwei, Liu, Yang, Nguyen, Toan B., O'Connell, Nichole, Rivers, Emma, Robbins, Daniel W., Tomlinson, Ronald, Yao, Tieguang, Zhu, Xiahui, Ferguson, Andrew D., Lamb, Michelle L., Manchester, John I., Guichard, Sylvie
Published in ChemMedChem (06.02.2018)
Published in ChemMedChem (06.02.2018)
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Journal Article
The Role of a Novel Auxiliary Pocket in Bacterial Phenylalanyl-tRNA Synthetase Druggability
Abibi, Ayome, Ferguson, Andrew D., Fleming, Paul R., Gao, Ning, Hajec, Laurel I., Hu, Jun, Laganas, Valerie A., McKinney, David C., McLeod, Sarah M., Prince, D.Bryan, Shapiro, Adam B., Buurman, Ed T.
Published in The Journal of biological chemistry (01.08.2014)
Published in The Journal of biological chemistry (01.08.2014)
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Journal Article
Correction to Discovery of Pyrazolo[1,5‑a]pyrimidine B‑Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors
McCoull, William, Abrams, Roman D, Anderson, Erica, Blades, Kevin, Barton, Peter, Box, Matthew, Burgess, Jonathan, Byth, Kate, Cao, Qing, Chuaqui, Claudio, Carbajo, Rodrigo J, Cheung, Tony, Code, Erin, Ferguson, Andrew D, Fillery, Shaun, Fuller, Nathan O, Gangl, Eric, Gao, Ning, Grist, Matthew, Hargreaves, David, Howard, Martin R, Hu, Jun, Kemmitt, Paul D, Nelson, Jennifer E, O’Connell, Nichole, Prince, D. Bryan, Raubo, Piotr, Rawlins, Philip B, Robb, Graeme R, Shi, Junjie, Waring, Michael J, Whittaker, David, Wylot, Marta, Zhu, Xiahui
Published in Journal of medicinal chemistry (27.07.2017)
Published in Journal of medicinal chemistry (27.07.2017)
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Journal Article
Identification through structure-based methods of a bacterial NAD(+)-dependent DNA ligase inhibitor that avoids known resistance mutations
Murphy-Benenato, Kerry, Wang, Hongming, McGuire, Helen M., Davis, Hajnalka E., Gao, Ning, Prince, D. Bryan, Jahic, Haris, Stokes, Suzanne S., Boriack-Sjodin, P. Ann
Published in Bioorganic & medicinal chemistry letters (01.01.2014)
Published in Bioorganic & medicinal chemistry letters (01.01.2014)
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Journal Article
4,5-Disubstituted 6‑Aryloxy-1,3-dihydrobenzo[c][1,2]oxaboroles Are Broad-Spectrum Serine β‑Lactamase Inhibitors
McKinney, David C, Zhou, Fei, Eyermann, Charles J, Ferguson, Andrew D, Prince, D. Bryan, Breen, John, Giacobbe, Robert A, Lahiri, Sushmita, Verheijen, Jeroen C
Published in ACS infectious diseases (10.07.2015)
Published in ACS infectious diseases (10.07.2015)
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Journal Article
A growing codependency: compounding pharmacy and safety
Prince, Bryan, Lundevall, Jeremy
Published in International journal of pharmaceutical compounding (01.11.2013)
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Published in International journal of pharmaceutical compounding (01.11.2013)
Journal Article
X-Ray Crystal Structure of Staphylococcus aureus FemA
Benson, Timothy E., Prince, D.Bryan, Mutchler, Veronica T., Curry, Kimberly A., Ho, Andrea M., Sarver, Ronald W., Hagadorn, Jeanne C., Choi, Gil H., Garlick, Robert L.
Published in Structure (London) (01.08.2002)
Published in Structure (London) (01.08.2002)
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Journal Article
Corrigendum to “Identification through structure-based methods of a bacterial NAD+-dependent DNA ligase inhibitor that avoids known resistance mutations” [Bioorg. Med. Chem. Lett. 24 (2014) 360–366]
Murphy-Benenato, Kerry, Wang, Hongming, McGuire, Helen M., Davis, Hajnalka E., Gao, Ning, Bryan Prince, D., Jahic, Haris, Stokes, Suzanne S., Ann Boriack-Sjodin, P.
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
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