Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting
Huard, Kim, Smith, Aaron C, Cappon, Gregg, Dow, Robert L, Edmonds, David J, El-Kattan, Ayman, Esler, William P, Fernando, Dilinie P, Griffith, David A, Kalgutkar, Amit S, Ross, Trenton T, Bagley, Scott W, Beebe, David, Bi, Yi-An, Cabral, Shawn, Crowley, Collin, Doran, Shawn D, Dowling, Matthew S, Liras, Spiros, Mascitti, Vincent, Niosi, Mark, Pfefferkorn, Jeffrey A, Polivkova, Jana, Préville, Cathy, Price, David A, Shavnya, Andre, Shirai, Norimitsu, Smith, Andrew H, Southers, James R, Tess, David A, Thuma, Benjamin A, Varma, Manthena V, Yang, Xiaojing
Published in Journal of medicinal chemistry (08.10.2020)
Published in Journal of medicinal chemistry (08.10.2020)
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Journal Article
Discovery of a Clinical Candidate from the Structurally Unique Dioxa-bicyclo[3.2.1]octane Class of Sodium-Dependent Glucose Cotransporter 2 Inhibitors
Mascitti, Vincent, Maurer, Tristan S, Robinson, Ralph P, Bian, Jianwei, Boustany-Kari, Carine M, Brandt, Thomas, Collman, Benjamin M, Kalgutkar, Amit S, Klenotic, Michelle K, Leininger, Michael T, Lowe, André, Maguire, Robert J, Masterson, Victoria M, Miao, Zhuang, Mukaiyama, Emi, Patel, Jigna D, Pettersen, John C, Préville, Cathy, Samas, Brian, She, Li, Sobol, Zhanna, Steppan, Claire M, Stevens, Benjamin D, Thuma, Benjamin A, Tugnait, Meera, Zeng, Dongxiang, Zhu, Tong
Published in Journal of medicinal chemistry (28.04.2011)
Published in Journal of medicinal chemistry (28.04.2011)
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Journal Article
Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation
Bonaventure, Pascal, Dugovic, Christine, Shireman, Brock, Preville, Cathy, Yun, Sujin, Lord, Brian, Nepomuceno, Diane, Wennerholm, Michelle, Lovenberg, Timothy, Carruthers, Nicolas, Fitz, Stephanie D, Shekhar, Anantha, Johnson, Philip L
Published in Frontiers in pharmacology (09.06.2017)
Published in Frontiers in pharmacology (09.06.2017)
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Journal Article
Regioselective Hydroarylations and Parallel Kinetic Resolution of Vince Lactam
Kamlet, Adam S., Préville, Cathy, Farley, Kathleen A., Piotrowski, David W.
Published in Angewandte Chemie International Edition (27.09.2013)
Published in Angewandte Chemie International Edition (27.09.2013)
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Journal Article
C-Aryl glycoside inhibitors of SGLT2: Exploration of sugar modifications including C-5 spirocyclization
Robinson, Ralph P., Mascitti, Vincent, Boustany-Kari, Carine M., Carr, Christopher L., Foley, Patrick M., Kimoto, Emi, Leininger, Michael T., Lowe, Andre, Klenotic, Michelle K., MacDonald, James I., Maguire, Robert J., Masterson, Victoria M., Maurer, Tristan S., Miao, Zhuang, Patel, Jigna D., Préville, Cathy, Reese, Matthew R., She, Li, Steppan, Claire M., Thuma, Benjamin A., Zhu, Tong
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
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Journal Article
Syntheses of C-5-spirocyclic C-glycoside SGLT2 inhibitors
Mascitti, Vincent, Robinson, Ralph P., Préville, Cathy, Thuma, Benjamin A., Carr, Christopher L., Reese, Matthew R., Maguire, Robert J., Leininger, Michael T., Lowe, André, Steppan, Claire M.
Published in Tetrahedron letters (07.04.2010)
Published in Tetrahedron letters (07.04.2010)
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Journal Article
Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor
Sanhueza, Carlos A, Baksh, Michael M, Thuma, Benjamin, Roy, Marc D, Dutta, Sanjay, Préville, Cathy, Chrunyk, Boris A, Beaumont, Kevin, Dullea, Robert, Ammirati, Mark, Liu, Shenping, Gebhard, David, Finley, James E, Salatto, Christopher T, King-Ahmad, Amanda, Stock, Ingrid, Atkinson, Karen, Reidich, Benjamin, Lin, Wen, Kumar, Rajesh, Tu, Meihua, Menhaji-Klotz, Elnaz, Price, David A, Liras, Spiros, Finn, M. G, Mascitti, Vincent
Published in Journal of the American Chemical Society (08.03.2017)
Published in Journal of the American Chemical Society (08.03.2017)
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Journal Article
Glycomimetic Ligands for the Human Asialoglycoprotein Receptor
Mamidyala, Sreeman K, Dutta, Sanjay, Chrunyk, Boris A, Préville, Cathy, Wang, Hong, Withka, Jane M, McColl, Alexander, Subashi, Timothy A, Hawrylik, Steven J, Griffor, Matthew C, Kim, Sung, Pfefferkorn, Jeffrey A, Price, David A, Menhaji-Klotz, Elnaz, Mascitti, Vincent, Finn, M.G
Published in Journal of the American Chemical Society (01.02.2012)
Published in Journal of the American Chemical Society (01.02.2012)
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Journal Article
Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin‑1 Antagonists: Discovery of JNJ-54717793
Préville, Cathy, Bonaventure, Pascal, Koudriakova, Tatiana, Lord, Brian, Nepomuceno, Diane, Rizzolio, Michele, Mani, Neelakandha, Coe, Kevin J, Ndifor, Anthony, Dugovic, Christine, Dvorak, Curt A, Coate, Heather, Pippel, Daniel J, Fitzgerald, Anne, Allison, Brett, Lovenberg, Timothy W, Carruthers, Nicholas I, Shireman, Brock T
Published in ACS medicinal chemistry letters (08.10.2020)
Published in ACS medicinal chemistry letters (08.10.2020)
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Journal Article
Spirolactam-Based Acetyl-CoA Carboxylase Inhibitors: Toward Improved Metabolic Stability of a Chromanone Lead Structure
Griffith, David A, Dow, Robert L, Huard, Kim, Edmonds, David J, Bagley, Scott W, Polivkova, Jana, Zeng, Dongxiang, Garcia-Irizarry, Carmen N, Southers, James A, Esler, William, Amor, Paul, Loomis, Kathrine, McPherson, Kirk, Bahnck, Kevin B, Préville, Cathy, Banks, Tereece, Moore, Dianna E, Mathiowetz, Alan M, Menhaji-Klotz, Elnaz, Smith, Aaron C, Doran, Shawn D, Beebe, David A, Dunn, Matthew F
Published in Journal of medicinal chemistry (12.09.2013)
Published in Journal of medicinal chemistry (12.09.2013)
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Journal Article
Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors
Huard, Kim, Bagley, Scott W, Menhaji-Klotz, Elnaz, Préville, Cathy, Southers, James A, Smith, Aaron C, Edmonds, David J, Lucas, John C, Dunn, Matthew F, Allanson, Nigel M, Blaney, Emma L, Garcia-Irizarry, Carmen N, Kohrt, Jeffrey T, Griffith, David A, Dow, Robert L
Published in Journal of organic chemistry (16.11.2012)
Published in Journal of organic chemistry (16.11.2012)
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Journal Article
Regioselective Hydroarylations and Parallel Kinetic Resolution of Vince Lactam
Kamlet, Adam S., Préville, Cathy, Farley, Kathleen A., Piotrowski, David W.
Published in Angewandte Chemie (27.09.2013)
Published in Angewandte Chemie (27.09.2013)
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Journal Article
X-ray Structures and Thermodynamics of the Interaction of PA-IIL from Pseudomonas aeruginosa with Disaccharide Derivatives
Marotte, Karine, Sabin, Charles, Préville, Cathy, Moumé-Pymbock, Myriam, Wimmerová, Michaela, Mitchell, Edward P., Imberty, Anne, Roy, René
Published in ChemMedChem (10.09.2007)
Published in ChemMedChem (10.09.2007)
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Journal Article
카제인 키나아제 1 델타 조절제
PATRICK KELSEY, HANNA LUKE EDWARD, SEIERSTAD MARK, SWIFT ELIZABETH, SAMANT ANDREW V, WU DONGPEI, MCCARVER STEFAN, LEBOLD TERRY PATRICK, PREVILLE CATHY, SHIREMAN BROCK T
Year of Publication 19.05.2023
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Year of Publication 19.05.2023
Patent
카제인 키나제 1 델타 조절제
MCCLURE KELLY J, WANG JOCELYN, SEIERSTAD MARK, ZIFF JEANNIE, WU DONGPEI, MCCARVER STEFAN, ZHANG WEI, LEBOLD TERRY PATRICK, PREVILLE CATHY, SHIREMAN BROCK T
Year of Publication 18.05.2023
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Year of Publication 18.05.2023
Patent
2-[4-Chloro-3-(4-ethoxy-benz-yl)phen-yl]-1,3-dithiane
Samas, Brian, Préville, Cathy, Thuma, Benjamin A, Mascitti, Vincent
Published in Acta crystallographica. Section E, Structure reports online (19.05.2010)
Published in Acta crystallographica. Section E, Structure reports online (19.05.2010)
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Journal Article
From partial to full agonism: Identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor
Futatsugi, Kentaro, Mascitti, Vincent, Guimarães, Cristiano R.W., Morishita, Nao, Cai, Cuiman, DeNinno, Michael P., Gao, Hua, Hamilton, Michael D., Hank, Richard, Harris, Anthony R., Kung, Daniel W., Lavergne, Sophie Y., Lefker, Bruce A., Lopaze, Michael G., McClure, Kim F., Munchhof, Michael J., Preville, Cathy, Robinson, Ralph P., Wright, Stephen W., Bonin, Paul D., Cornelius, Peter, Chen, Yue, Kalgutkar, Amit S.
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
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Journal Article
Intrinsic Electrophilicity of a 4-Substituted-5-cyano-6-(2-methylpyridin-3-yloxy)pyrimidine Derivative: Structural Characterization of Glutathione Conjugates in Vitro
Kalgutkar, Amit S, Mascitti, Vincent, Sharma, Raman, Walker, Gregory W, Ryder, Tim, McDonald, Thomas S, Chen, Yue, Preville, Cathy, Basak, Arindrajit, McClure, Kim F, Kohrt, Jeffrey T, Robinson, Ralph P, Munchhof, Michael J, Cornelius, Peter
Published in Chemical research in toxicology (18.02.2011)
Published in Chemical research in toxicology (18.02.2011)
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Journal Article
2- SUBSTITUTED 2-AZABICYCLES AND THEIR USE AS OREXIN RECEPTOR MODULATORS
CHEN GANG, ZIFF JEANNIE M, LEBOLD TERRY P, GELIN CHRISTINE F, DVORAK CURT A, COATE HEATHER R, PREVILLE CATHY, SHIREMAN BROCK T
Year of Publication 08.05.2017
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Year of Publication 08.05.2017
Patent