14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
Nichols, R Jeremy, Dzamko, Nicolas, Morrice, Nicholas A, Campbell, David G, Deak, Maria, Ordureau, Alban, Macartney, Thomas, Tong, Youren, Shen, Jie, Prescott, Alan R, Alessi, Dario R
Published in Biochemical journal (15.09.2010)
Published in Biochemical journal (15.09.2010)
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Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase
Bago, Ruzica, Malik, Nazma, Munson, Michael J, Prescott, Alan R, Davies, Paul, Sommer, Eeva, Shpiro, Natalia, Ward, Richard, Cross, Darren, Ganley, Ian G, Alessi, Dario R
Published in Biochemical journal (01.11.2014)
Published in Biochemical journal (01.11.2014)
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Journal Article
Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand
McWilliams, Thomas G., Prescott, Alan R., Montava-Garriga, Lambert, Ball, Graeme, Singh, François, Barini, Erica, Muqit, Miratul M.K., Brooks, Simon P., Ganley, Ian G.
Published in Cell metabolism (06.02.2018)
Published in Cell metabolism (06.02.2018)
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Journal Article
Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader
Tovell, Hannah, Testa, Andrea, Maniaci, Chiara, Zhou, Houjiang, Prescott, Alan R, Macartney, Thomas, Ciulli, Alessio, Alessi, Dario R
Published in ACS chemical biology (17.05.2019)
Published in ACS chemical biology (17.05.2019)
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Journal Article
Antibody RING-Mediated Destruction of Endogenous Proteins
Ibrahim, Adel F.M., Shen, Linnan, Tatham, Michael H., Dickerson, David, Prescott, Alan R., Abidi, Naima, Xirodimas, Dimitris P., Hay, Ronald T.
Published in Molecular cell (02.07.2020)
Published in Molecular cell (02.07.2020)
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Journal Article
BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm
Hobley, Laura, Ostrowski, Adam, Rao, Francesco V., Bromley, Keith M., Porter, Michael, Prescott, Alan R., MacPhee, Cait E., van Aalten, Daan M. F., Stanley-Wall, Nicola R.
Published in Proceedings of the National Academy of Sciences - PNAS (13.08.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (13.08.2013)
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Pharmacological rescue of impaired mitophagy in Parkinson's disease-related LRRK2 G2019S knock-in mice
Singh, Francois, Prescott, Alan R, Rosewell, Philippa, Ball, Graeme, Reith, Alastair D, Ganley, Ian G
Published in eLife (03.08.2021)
Published in eLife (03.08.2021)
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Journal Article
IKKβ is required for the formation of the NLRP3 inflammasome
Nanda, Sambit K, Prescott, Alan R, Figueras-Vadillo, Clara, Cohen, Philip
Published in EMBO reports (05.10.2021)
Published in EMBO reports (05.10.2021)
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Journal Article
Why are the phenotypes of TRAF6 knock-in and TRAF6 knock-out mice so different?
Petrova, Tsvetana, Bennett, Kyle, Nanda, Sambit, Strickson, Sam, Scudamore, Cheryl L, Prescott, Alan R, Cohen, Philip
Published in PloS one (14.02.2022)
Published in PloS one (14.02.2022)
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Journal Article
A conserved ATG2‐GABARAP family interaction is critical for phagophore formation
Bozic, Mihaela, van den Bekerom, Luuk, Milne, Beth A, Goodman, Nicola, Roberston, Lisa, Prescott, Alan R, Macartney, Thomas J, Dawe, Nina, McEwan, David G
Published in EMBO reports (04.03.2020)
Published in EMBO reports (04.03.2020)
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Journal Article
A comparative map of macroautophagy and mitophagy in the vertebrate eye
McWilliams, Thomas G., Prescott, Alan R., Villarejo-Zori, Beatriz, Ball, Graeme, Boya, Patricia, Ganley, Ian G.
Published in Autophagy (03.07.2019)
Published in Autophagy (03.07.2019)
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Journal Article
Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization
Dzamko, Nicolas, Deak, Maria, Hentati, Faycal, Reith, Alastair D, Prescott, Alan R, Alessi, Dario R, Nichols, R Jeremy
Published in Biochemical journal (15.09.2010)
Published in Biochemical journal (15.09.2010)
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Journal Article
Publisher's Note: ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase
Hoxhaj, Gerta, Najafov, Ayaz, Toth, Rachel, Campbell, David G, Prescott, Alan R, MacKintosh, Carol
Published in Journal of cell science (15.03.2022)
Published in Journal of cell science (15.03.2022)
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Journal Article
High-resolution quantitative proteome analysis reveals substantial differences between phagosomes of RAW 264.7 and bone marrow derived macrophages
Guo, Manman, Härtlova, Anetta, Dill, Brian D., Prescott, Alan R., Gierliński, Marek, Trost, Matthias
Published in Proteomics (Weinheim) (01.09.2015)
Published in Proteomics (Weinheim) (01.09.2015)
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Journal Article
Biochemical analysis of TssK, a core component of the bacterial Type VI secretion system, reveals distinct oligomeric states of TssK and identifies a TssK-TssFG subcomplex
English, Grant, Byron, Olwyn, Cianfanelli, Francesca R, Prescott, Alan R, Coulthurst, Sarah J
Published in Biochemical journal (15.07.2014)
Published in Biochemical journal (15.07.2014)
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Journal Article
Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding
Kalogeropulou, Alexia F, Purlyte, Elena, Tonelli, Francesca, Lange, Sven M, Wightman, Melanie, Prescott, Alan R, Padmanabhan, Shalini, Sammler, Esther, Alessi, Dario R
Published in Biochemical journal (16.09.2022)
Published in Biochemical journal (16.09.2022)
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Journal Article
Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation
Kazlauskaite, Agne, Martínez-Torres, R Julio, Wilkie, Scott, Kumar, Atul, Peltier, Julien, Gonzalez, Alba, Johnson, Clare, Zhang, Jinwei, Hope, Anthony G, Peggie, Mark, Trost, Matthias, van Aalten, Daan MF, Alessi, Dario R, Prescott, Alan R, Knebel, Axel, Walden, Helen, Muqit, Miratul MK
Published in EMBO reports (01.08.2015)
Published in EMBO reports (01.08.2015)
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