Reversing tozasertib resistance in glioma through inhibition of pyruvate dehydrogenase kinases
Jane, Esther P., Premkumar, Daniel R., Rajasundaram, Dhivyaa, Thambireddy, Swetha, Reslink, Matthew C., Agnihotri, Sameer, Pollack, Ian F.
Published in Molecular oncology (01.01.2022)
Published in Molecular oncology (01.01.2022)
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Journal Article
Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells
Premkumar, Daniel R, Jane, Esther P, Pollack, Ian F
Published in Cancer biology & therapy (01.02.2015)
Published in Cancer biology & therapy (01.02.2015)
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Journal Article
Targeting mitochondrial energetics reverses panobinostat- and marizomib-induced resistance in pediatric and adult high-grade gliomas
Jane, Esther P, Reslink, Matthew C, Gatesman, Taylor A, Halbert, Matthew E, Miller, Tracy A, Golbourn, Brian J, Casillo, Stephanie M, Mullett, Steven J, Wendell, Stacy G, Obodo, Udochukwu, Mohanakrishnan, Dinesh, Dange, Riya, Michealraj, Antony, Brenner, Charles, Agnihotri, Sameer, Premkumar, Daniel R, Pollack, Ian F
Published in Molecular oncology (01.09.2023)
Published in Molecular oncology (01.09.2023)
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Journal Article
Inhibition of phosphatidylinositol 3-kinase/AKT signaling by NVP-BKM120 promotes ABT-737-induced toxicity in a caspase-dependent manner through mitochondrial dysfunction and DNA damage response in established and primary cultured glioblastoma cells
Jane, Esther P, Premkumar, Daniel R, Morales, Alejandro, Foster, Kimberly A, Pollack, Ian F
Published in The Journal of pharmacology and experimental therapeutics (01.07.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2014)
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Journal Article
Survivin inhibitor YM155 induces mitochondrial dysfunction, autophagy, DNA damage and apoptosis in Bcl‐xL silenced glioma cell lines
Jane, Esther P., Premkumar, Daniel R., Sutera, Philip A., Cavaleri, Jonathon M., Pollack, Ian F.
Published in Molecular carcinogenesis (01.04.2017)
Published in Molecular carcinogenesis (01.04.2017)
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Journal Article
Targeting NAD + Biosynthesis Overcomes Panobinostat and Bortezomib-Induced Malignant Glioma Resistance
Jane, Esther P, Premkumar, Daniel R, Thambireddy, Swetha, Golbourn, Brian, Agnihotri, Sameer, Bertrand, Kelsey C, Mack, Stephen C, Myers, Max I, Chattopadhyay, Ansuman, Taylor, D Lansing, Schurdak, Mark E, Stern, Andrew M, Pollack, Ian F
Published in Molecular cancer research (01.07.2020)
Published in Molecular cancer research (01.07.2020)
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Journal Article
Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome
Golbourn, Brian J, Halbert, Matthew E, Halligan, Katharine, Varadharajan, Srinidhi, Krug, Brian, Mbah, Nneka E, Kabir, Nisha, Stanton, Ann-Catherine J, Locke, Abigail L, Casillo, Stephanie M, Zhao, Yanhua, Sanders, Lauren M, Cheney, Allison, Mullett, Steven J, Chen, Apeng, Wassell, Michelle, Andren, Anthony, Perez, Jennifer, Jane, Esther P, Premkumar, Daniel R David, Koncar, Robert F, Mirhadi, Shideh, McCarl, Lauren H, Chang, Yue-Fang, Wu, Yijen L, Gatesman, Taylor A, Cruz, Andrea F, Zapotocky, Michal, Hu, Baoli, Kohanbash, Gary, Wang, Xiuxing, Vartanian, Alenoush, Moran, Michael F, Lieberman, Frank, Amankulor, Nduka M, Wendell, Stacy G, Vaske, Olena M, Panigrahy, Ashok, Felker, James, Bertrand, Kelsey C, Kleinman, Claudia L, Rich, Jeremy N, Friedlander, Robert M, Broniscer, Alberto, Lyssiotis, Costas, Jabado, Nada, Pollack, Ian F, Mack, Stephen C, Agnihotri, Sameer
Published in Nature cancer (01.05.2022)
Published in Nature cancer (01.05.2022)
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Journal Article
Dinaciclib, a Cyclin-Dependent Kinase Inhibitor Promotes Proteasomal Degradation of Mcl-1 and Enhances ABT-737-Mediated Cell Death in Malignant Human Glioma Cell Lines
Jane, Esther P, Premkumar, Daniel R, Cavaleri, Jonathon M, Sutera, Philip A, Rajasekar, Thatchana, Pollack, Ian F
Published in The Journal of pharmacology and experimental therapeutics (01.02.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2016)
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Journal Article
An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma
Casillo, Stephanie M., Gatesman, Taylor A., Chilukuri, Akanksha, Varadharajan, Srinidhi, Johnson, Brenden J., David Premkumar, Daniel R., Jane, Esther P., Plute, Tritan J., Koncar, Robert F., Stanton, Ann-Catherine J., Biagi-Junior, Carlos A.O., Barber, Callie S., Halbert, Matthew E., Golbourn, Brian J., Halligan, Katharine, Cruz, Andrea F., Mansi, Neveen M., Cheney, Allison, Mullett, Steven J., Land, Clinton Van’t, Perez, Jennifer L., Myers, Max I., Agrawal, Nishant, Michel, Joshua J., Chang, Yue-Fang, Vaske, Olena M., MichaelRaj, Antony, Lieberman, Frank S., Felker, James, Shiva, Sruti, Bertrand, Kelsey C., Amankulor, Nduka, Hadjipanayis, Costas G., Abdullah, Kalil G., Zinn, Pascal O., Friedlander, Robert M., Abel, Taylor J., Nazarian, Javad, Venneti, Sriram, Filbin, Mariella G., Gelhaus, Stacy L., Mack, Stephen C., Pollack, Ian F., Agnihotri, Sameer
Published in Cell reports (Cambridge) (23.01.2024)
Published in Cell reports (Cambridge) (23.01.2024)
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Journal Article
Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage
Premkumar, Daniel R., Jane, Esther P., Agostino, Naomi R., DiDomenico, Joseph D., Pollack, Ian F.
Published in Molecular carcinogenesis (01.02.2013)
Published in Molecular carcinogenesis (01.02.2013)
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Journal Article
Survivin inhibitor YM-155 sensitizes tumor necrosis factor- related apoptosis-inducing ligand-resistant glioma cells to apoptosis through Mcl-1 downregulation and by engaging the mitochondrial death pathway
Premkumar, Daniel R, Jane, Esther P, Foster, Kimberly A, Pollack, Ian F
Published in The Journal of pharmacology and experimental therapeutics (01.08.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2013)
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Journal Article
Mitochondrial dysfunction RAD51, and Ku80 proteolysis promote apoptotic effects of Dinaciclib in Bcl‐xL silenced cells
Premkumar, Daniel R., Jane, Esther P., Thambireddy, Swetha, Sutera, Philip A., Cavaleri, Jonathon M., Pollack, Ian F.
Published in Molecular carcinogenesis (01.04.2018)
Published in Molecular carcinogenesis (01.04.2018)
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Journal Article
ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines
Premkumar, Daniel R, Jane, Esther P, DiDomenico, Joseph D, Vukmer, Natalie A, Agostino, Naomi R, Pollack, Ian F
Published in The Journal of pharmacology and experimental therapeutics (01.06.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2012)
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Journal Article
NVP-BKM120 potentiates apoptosis in tumor necrosis factor-related apoptosis-inducing ligand-resistant glioma cell lines via upregulation of Noxa and death receptor 5
FOSTER, KIMBERLY A, JANE, ESTHER P, PREMKUMAR, DANIEL R, MORALES, ALEJANDRO, POLLACK, IAN F
Published in International journal of oncology (01.08.2015)
Published in International journal of oncology (01.08.2015)
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Journal Article
YM-155 potentiates the effect of ABT-737 in malignant human glioma cells via survivin and Mcl-1 downregulation in an EGFR-dependent context
Jane, Esther P, Premkumar, Daniel R, DiDomenico, Joseph D, Hu, Bo, Cheng, Shi-Yuan, Pollack, Ian F
Published in Molecular cancer therapeutics (01.03.2013)
Published in Molecular cancer therapeutics (01.03.2013)
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Journal Article
Co-administration of ABT-737 and SAHA induces apoptosis, mediated by Noxa upregulation, Bax activation and mitochondrial dysfunction in PTEN-intact malignant human glioma cell lines
Foster, Kimberly A., Jane, Esther P., Premkumar, Daniel R., Morales, Alejandro, Pollack, Ian F.
Published in Journal of neuro-oncology (01.12.2014)
Published in Journal of neuro-oncology (01.12.2014)
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Journal Article
Abrogation of Mitogen-Activated Protein Kinase and Akt Signaling by Vandetanib Synergistically Potentiates Histone Deacetylase Inhibitor-Induced Apoptosis in Human Glioma Cells
Jane, Esther P, Premkumar, Daniel R, Addo-Yobo, Steven O, Pollack, Ian F
Published in The Journal of pharmacology and experimental therapeutics (01.10.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2009)
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