Senescent cell clearance by the immune system: Emerging therapeutic opportunities
Prata, Larissa G.P. Langhi, Ovsyannikova, Inna G., Tchkonia, Tamara, Kirkland, James L.
Published in Seminars in immunology (01.12.2018)
Published in Seminars in immunology (01.12.2018)
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Epigenetic and senescence markers indicate an accelerated ageing-like state in women with preeclamptic pregnancies
Suvakov, Sonja, Ghamrawi, Ranine, Cubro, Hajrunisa, Tu, Haitao, White, Wendy M., Tobah, Yvonne S. Butler, Milic, Natasa M., Grande, Joseph P., Cunningham, Julie M., Chebib, Fouad T., Prata, Larissa G.P. Langhi, Zhu, Yi, Tchkonia, Tamara, Kirkland, James L., Nath, Karl A., Milosavljevic, Aleksandar, Garovic, Vesna D.
Published in EBioMedicine (01.08.2021)
Published in EBioMedicine (01.08.2021)
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Senolytics reduce coronavirus-related mortality in old mice
Camell, Christina D., Yousefzadeh, Matthew J., Zhu, Yi, Prata, Larissa G. P. Langhi, Huggins, Matthew A., Pierson, Mark, Zhang, Lei, O’Kelly, Ryan D., Pirtskhalava, Tamar, Xun, Pengcheng, Ejima, Keisuke, Xue, Ailing, Tripathi, Utkarsh, Espindola-Netto, Jair Machado, Giorgadze, Nino, Atkinson, Elizabeth J., Inman, Christina L., Johnson, Kurt O., Cholensky, Stephanie H., Carlson, Timothy W., LeBrasseur, Nathan K., Khosla, Sundeep, O’Sullivan, M. Gerard, Allison, David B., Jameson, Stephen C., Meves, Alexander, Li, Ming, Prakash, Y. S., Chiarella, Sergio E., Hamilton, Sara E., Tchkonia, Tamara, Niedernhofer, Laura J., Kirkland, James L., Robbins, Paul D.
Published in Science (16.07.2021)
Published in Science (16.07.2021)
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Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
Hickson, LaTonya J., Langhi Prata, Larissa G.P., Bobart, Shane A., Evans, Tamara K., Giorgadze, Nino, Hashmi, Shahrukh K., Herrmann, Sandra M., Jensen, Michael D., Jia, Qingyi, Jordan, Kyra L., Kellogg, Todd A., Khosla, Sundeep, Koerber, Daniel M., Lagnado, Anthony B., Lawson, Donna K., LeBrasseur, Nathan K., Lerman, Lilach O., McDonald, Kathleen M., McKenzie, Travis J., Passos, João F., Pignolo, Robert J., Pirtskhalava, Tamar, Saadiq, Ishran M., Schaefer, Kalli K., Textor, Stephen C., Victorelli, Stella G., Volkman, Tammie L., Xue, Ailing, Wentworth, Mark A., Wissler Gerdes, Erin O., Zhu, Yi, Tchkonia, Tamara, Kirkland, James L.
Published in EBioMedicine (01.09.2019)
Published in EBioMedicine (01.09.2019)
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Cell senescence, the senescence-associated secretory phenotype, and cancers
Langhi Prata, Larissa G P, Tchkonia, Tamar, Kirkland, James L
Published in PLoS biology (21.09.2023)
Published in PLoS biology (21.09.2023)
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Journal Article
Fisetin for COVID‐19 in skilled nursing facilities: Senolytic trials in the COVID era
Verdoorn, Brandon P., Evans, Tamara K., Hanson, Gregory J., Zhu, Yi, Langhi Prata, Larissa G. P., Pignolo, Robert J., Atkinson, Elizabeth J., Wissler‐Gerdes, Erin O., Kuchel, George A., Mannick, Joan B., Kritchevsky, Stephen B., Khosla, Sundeep, Rizza, Stacey A., Walston, Jeremy D., Musi, Nicolas, Lipsitz, Lewis A., Kiel, Douglas P., Yung, Raymond, LeBrasseur, Nathan K., Singh, Ravinder J., McCarthy, Teresa, Puskarich, Michael A., Niedernhofer, Laura J., Robbins, Paul D., Sorenson, Matthew, Tchkonia, Tamara, Kirkland, James L.
Published in Journal of the American Geriatrics Society (01.11.2021)
Published in Journal of the American Geriatrics Society (01.11.2021)
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Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans
Zhu, Yi, Prata, Larissa G.P. Langhi, Gerdes, Erin O. Wissler, Netto, Jair Machado Espindola, Pirtskhalava, Tamar, Giorgadze, Nino, Tripathi, Utkarsh, Inman, Christina L., Johnson, Kurt O., Xue, Ailing, Palmer, Allyson K., Chen, Tingjun, Schaefer, Kalli, Justice, Jamie N., Nambiar, Anoop M., Musi, Nicolas, Kritchevsky, Stephen B., Chen, Jun, Khosla, Sundeep, Jurk, Diana, Schafer, Marissa J., Tchkonia, Tamar, Kirkland, James L.
Published in EBioMedicine (01.03.2022)
Published in EBioMedicine (01.03.2022)
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Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity
Wang, Lichao, Wang, Binsheng, Gasek, Nathan S., Zhou, Yueying, Cohn, Rachel L., Martin, Dominique E., Zuo, Wulin, Flynn, William F., Guo, Chun, Jellison, Evan R., Kim, Taewan, Langhi Prata, Larissa G.P., Palmer, Allyson K., Li, Ming, Inman, Christina L., Barber, Lauren S., Al-Naggar, Iman M.A., Zhou, Yanjiao, Du, Wenqiang, Kshitiz, Kuchel, George A., Meves, Alexander, Tchkonia, Tamar, Kirkland, James L., Robson, Paul, Xu, Ming
Published in Cell metabolism (04.01.2022)
Published in Cell metabolism (04.01.2022)
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Journal Article
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity
Wang, Lichao, Wang, Binsheng, Gasek, Nathan S., Zhou, Yueying, Cohn, Rachel L., Martin, Dominique E., Zuo, Wulin, Flynn, William F., Guo, Chun, Jellison, Evan R., Kim, Taewan, Prata, Larissa G.P. Langhi, Palmer, Allyson K., Li, Ming, Inman, Christina L., Barber, Lauren S., Al-Naggar, Iman M.A., Zhou, Yanjiao, Du, Wenqiang, Kshitiz, Kuchel, George A., Meves, Alexander, Tchkonia, Tamar, Kirkland, James L., Robson, Paul, Xu, Ming
Published in Cell metabolism (04.01.2022)
Published in Cell metabolism (04.01.2022)
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Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney diseaseResearch in context
LaTonya J. Hickson, Larissa G.P. Langhi Prata, Shane A. Bobart, Tamara K. Evans, Nino Giorgadze, Shahrukh K. Hashmi, Sandra M. Herrmann, Michael D. Jensen, Qingyi Jia, Kyra L. Jordan, Todd A. Kellogg, Sundeep Khosla, Daniel M. Koerber, Anthony B. Lagnado, Donna K. Lawson, Nathan K. LeBrasseur, Lilach O. Lerman, Kathleen M. McDonald, Travis J. McKenzie, João F. Passos, Robert J. Pignolo, Tamar Pirtskhalava, Ishran M. Saadiq, Kalli K. Schaefer, Stephen C. Textor, Stella G. Victorelli, Tammie L. Volkman, Ailing Xue, Mark A. Wentworth, Erin O. Wissler Gerdes, Yi Zhu, Tamara Tchkonia, James L. Kirkland
Published in EBioMedicine (01.09.2019)
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Published in EBioMedicine (01.09.2019)
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