Functional characterization of a PROTAC directed against BRAF mutant V600E
Posternak, Ganna, Tang, Xiaojing, Maisonneuve, Pierre, Jin, Ting, Lavoie, Hugo, Daou, Salima, Orlicky, Stephen, Goullet de Rugy, Theo, Caldwell, Lauren, Chan, Kin, Aman, Ahmed, Prakesch, Michael, Poda, Gennady, Mader, Pavel, Wong, Cassandra, Maier, Stefan, Kitaygorodsky, Julia, Larsen, Brett, Colwill, Karen, Yin, Zhe, Ceccarelli, Derek F., Batey, Robert A., Taipale, Mikko, Kurinov, Igor, Uehling, David, Wrana, Jeff, Durocher, Daniel, Gingras, Anne-Claude, Al-Awar, Rima, Therrien, Marc, Sicheri, Frank
Published in Nature chemical biology (01.11.2020)
Published in Nature chemical biology (01.11.2020)
Get full text
Journal Article
Design, Synthesis, and Characterization of 4‑Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma
Uehling, David E, Joseph, Babu, Chung, Kim Chan, Zhang, Andrew X, Ler, Spencer, Prakesch, Michael A, Poda, Gennady, Grouleff, Julie, Aman, Ahmed, Kiyota, Taira, Leung-Hagesteijn, Chungyee, Konda, John David, Marcellus, Richard, Griffin, Carly, Subramaniam, Ratheesh, Abibi, Ayome, Strathdee, Craig A, Isaac, Methvin B, Al-awar, Rima, Tiedemann, Rodger E
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
Get full text
Journal Article
Correction to “Design, Synthesis, and Characterization of 4‑Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma”
Uehling, David E, Joseph, Babu, Chung, Kim Chan, Zhang, Andrew X, Ler, Spencer, Prakesch, Michael A, Poda, Gennady, Grouleff, Julie, Aman, Ahmed, Kiyota, Taira, Leung-Hagesteijn, Chungyee, Konda, John David, Marcellus, Richard, Griffin, Carly, Subramaniam, Ratheesh, Abibi, Ayome, Strathdee, Craig A, Isaac, Methvin B, Al-awar, Rima, Tiedemann, Rodger E
Published in Journal of medicinal chemistry (13.01.2022)
Published in Journal of medicinal chemistry (13.01.2022)
Get full text
Journal Article
Small Molecule Kinase Inhibitor Screen Identifies Polo-Like Kinase 1 as a Target for Neuroblastoma Tumor-Initiating Cells
GRINSHTEIN, Natalie, DATTI, Alessandro, FUJITANI, Mayumi, UEHLING, David, PRAKESCH, Michael, ISAAC, Methvin, IRWIN, Meredith S, WRANA, Jeffrey L, AI-AWAR, Rima, KAPLAN, David R
Published in Cancer research (Chicago, Ill.) (15.02.2011)
Published in Cancer research (Chicago, Ill.) (15.02.2011)
Get full text
Journal Article
Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor
Mamai, Ahmed, Chau, Anh M., Wilson, Brian J., Watson, Iain D., Joseph, Babu B., Subramanian, Pandiaraju R., Morshed, Monzur M., Morin, Justin A., Prakesch, Michael A., Lu, Tianbao, Connolly, Pete, Kuntz, Douglas A., Pomroy, Neil C., Poda, Gennady, Nguyen, Kong, Marcellus, Richard, Strathdee, Graig, Theriault, Brigitte, Subramaniam, Ratheesh, Mohammed, Mohammed, Abibi, Ayome, Chan, Manuel, Winston, Jeffrey, Kiyota, Taira, Undzys, Elijus, Aman, Ahmed, Austin, Nigel, Du Jardin, Marc, Packman, Kathryn, Phillippar, Ulrike, Attar, Riccardo, Edwards, James, O’Meara, Jeff, Uehling, David E., Al-awar, Rima, Privé, Gilbert G., Isaac, Methvin B.
Published in ACS medicinal chemistry letters (09.02.2023)
Published in ACS medicinal chemistry letters (09.02.2023)
Get full text
Journal Article
Size Reduction of CdSe/ZnS Quantum Dots by a Peptidic Amyloid Supergelator
Zaman, Md. Badruz, Bardelang, David, Prakesch, Michaël, Leek, Donald M, Naubron, Jean-Valère, Chan, Gordon, Wu, Xiaohua, Ripmeester, John A, Ratcliffe, Christopher I, Yu, Kui
Published in ACS applied materials & interfaces (01.03.2012)
Published in ACS applied materials & interfaces (01.03.2012)
Get full text
Journal Article
The PKN1- TRAF1 signaling axis as a potential new target for chronic lymphocytic leukemia
Edilova, Maria I., Law, Jaclyn C., Zangiabadi, Safoura, Ting, Kenneth, Mbanwi, Achire N., Arruda, Andrea, Uehling, David, Isaac, Methvin, Prakesch, Michael, Al-awar, Rima, Minden, Mark D., Abdul-Sater, Ali A., Watts, Tania H.
Published in Oncoimmunology (01.01.2021)
Published in Oncoimmunology (01.01.2021)
Get full text
Journal Article
Sorafenib as an Inhibitor of RUVBL2
Nano, Nardin, Ugwu, Francisca, Seraphim, Thiago V, Li, Tangzhi, Azer, Gina, Isaac, Methvin, Prakesch, Michael, Barbosa, Leandro R S, Ramos, Carlos H I, Datti, Alessandro, Houry, Walid A
Published in Biomolecules (Basel, Switzerland) (14.04.2020)
Published in Biomolecules (Basel, Switzerland) (14.04.2020)
Get full text
Journal Article
The discovery of small molecule chemical probes of Bcl-XL and Mcl-1
Prakesch, Michael, Denisov, Alexey Yu, Naim, Marwen, Gehring, Kalle, Arya, Prabhat
Published in Bioorganic & medicinal chemistry (01.08.2008)
Published in Bioorganic & medicinal chemistry (01.08.2008)
Get full text
Journal Article
The Propargylic Route as a Short and Versatile Entry to Optically Active Monofluorinated Compounds
Prakesch, Michaël, Grée, Danielle, Grée, René
Published in Accounts of chemical research (01.03.2002)
Published in Accounts of chemical research (01.03.2002)
Get full text
Journal Article
Synthesis of Fluoro Analogues of Unsaturated Fatty Acids and Corresponding Acyclic Metabolites
Prakesch, Michaël, Grée, Danielle, Chandrasekhar, Srivari, Grée, René
Published in European Journal of Organic Chemistry (01.04.2005)
Published in European Journal of Organic Chemistry (01.04.2005)
Get full text
Book Review
Journal Article
A kinome drug screen identifies multi-TKI synergies and ERBB2 signaling as a therapeutic vulnerability in MYC/TYR subgroup atypical teratoid rhabdoid tumors
Golbourn, Brian, Ho, Ben, Bondoc, Andrew, Luck, Amanda, Fan, Xiaolian, Richardson, Elizabeth, Marcellus, Richard, Prakesch, Michael, Halbert, Mathew, Agrawal, Nishant, Smith, Christian, Huang, Annie, Rutka, James T
Published in Neuro-oncology (Charlottesville, Va.) (03.10.2024)
Published in Neuro-oncology (Charlottesville, Va.) (03.10.2024)
Get full text
Journal Article
Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors
Sanches, Mario, Duffy, Nicole M., Talukdar, Manisha, Thevakumaran, Nero, Chiovitti, David, Canny, Marella D., Lee, Kenneth, Kurinov, Igor, Uehling, David, Al-awar, Rima, Poda, Gennadiy, Prakesch, Michael, Wilson, Brian, Tam, Victor, Schweitzer, Colleen, Toro, Andras, Lucas, Julie L., Vuga, Danka, Lehmann, Lynn, Durocher, Daniel, Zeng, Qingping, Patterson, John B., Sicheri, Frank
Published in Nature communications (28.08.2014)
Published in Nature communications (28.08.2014)
Get full text
Journal Article
A drug discovery platform to identify compounds that inhibit EGFR triple mutants
Saraon, Punit, Snider, Jamie, Kalaidzidis, Yannis, Wybenga-Groot, Leanne E., Weiss, Konstantin, Rai, Ankit, Radulovich, Nikolina, Drecun, Luka, Vučković, Nika, Vučetić, Adriana, Wong, Victoria, Thériault, Brigitte, Pham, Nhu-An, Park, Jin H., Datti, Alessandro, Wang, Jenny, Pathmanathan, Shivanthy, Aboualizadeh, Farzaneh, Lyakisheva, Anna, Yao, Zhong, Wang, Yuhui, Joseph, Babu, Aman, Ahmed, Moran, Michael F., Prakesch, Michael, Poda, Gennady, Marcellus, Richard, Uehling, David, Samaržija, Miroslav, Jakopović, Marko, Tsao, Ming-Sound, Shepherd, Frances A., Sacher, Adrian, Leighl, Natasha, Akhmanova, Anna, Al-awar, Rima, Zerial, Marino, Stagljar, Igor
Published in Nature chemical biology (01.05.2020)
Published in Nature chemical biology (01.05.2020)
Get full text
Journal Article
Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells
Saraon, Punit, Snider, Jamie, Schormann, Wiebke, Rai, Ankit, Radulovich, Nikolina, Sánchez-Osuna, Maria, Coulombe-Huntington, Jasmin, Huard, Caroline, Mohammed, Mohammed, Lima-Fernandes, Evelyne, Thériault, Brigitte, Halabelian, Levon, Chan, Manuel, Joshi, Dhananjay, Drecun, Luka, Yao, Zhong, Pathmanathan, Shivanthy, Wong, Victoria, Lyakisheva, Anna, Aboualizadeh, Farzaneh, Niu, Li, Li, Fengling, Kiyota, Taira, Subramanian, Ratheesh, Joseph, Babu, Aman, Ahmed, Prakesch, Michael, Isaac, Methvin, Mamai, Ahmed, Poda, Gennady, Vedadi, Masoud, Marcellus, Richard, Uehling, David, Leighl, Natasha, Sacher, Adrian, Samaržija, Miroslav, Jakopović, Marko, Arrowsmith, Cheryl, Tyers, Mike, Tsao, Ming-Sound, Andrews, David, Al-awar, Rima, Stagljar, Igor
Published in Journal of molecular biology (19.11.2021)
Published in Journal of molecular biology (19.11.2021)
Get full text
Journal Article
Abstract 2377: Design, synthesis, and characterization of 4-aminopyrazole quinazolines as potent inhibitors of G protein-coupled receptor kinase GRK6 for the potential treatment of multiple myeloma
Uehling, David, Joseph, Babu, Griffin, Carly, Subramaniam, Ratheesh, Abibi, Ayome, Marcellus, Richard, Prakesch, Michael, Poda, Gennadiy, Isaac, Methvin, Leung-Hagesteijn, Chungyee, Tiedemann, Rodger, Al-awar, Rima
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma
Babichev, Yael, Kabaroff, Leah, Datti, Alessandro, Uehling, David, Isaac, Methvin, Al-Awar, Rima, Prakesch, Michael, Sun, Ren X, Boutros, Paul C, Venier, Rosemarie, Dickson, Brendan C, Gladdy, Rebecca A
Published in Journal of translational medicine (08.03.2016)
Published in Journal of translational medicine (08.03.2016)
Get full text
Journal Article