Biological and chemical approaches to diseases of proteostasis deficiency
Powers, Evan T, Morimoto, Richard I, Dillin, Andrew, Kelly, Jeffery W, Balch, William E
Published in Annual review of biochemistry (01.01.2009)
Published in Annual review of biochemistry (01.01.2009)
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Journal Article
The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory-Agency-Approved Drug
Johnson, Steven M., Connelly, Stephen, Fearns, Colleen, Powers, Evan T., Kelly, Jeffery W.
Published in Journal of molecular biology (10.08.2012)
Published in Journal of molecular biology (10.08.2012)
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Journal Article
The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis
Hebert, Daniel N, Lamriben, Lydia, Powers, Evan T, Kelly, Jeffery W
Published in Nature chemical biology (01.11.2014)
Published in Nature chemical biology (01.11.2014)
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Journal Article
Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade
Bulawa, Christine E, Connelly, Stephen, DeVit, Michael, Wang, Lan, Weigel, Charlotte, Fleming, James A, Packman, Jeff, Powers, Evan T, Wiseman, R. Luke, Foss, Theodore R, Wilson, Ian A, Kelly, Jeffery W, Labaudinière, Richard
Published in Proceedings of the National Academy of Sciences - PNAS (12.06.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (12.06.2012)
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Journal Article
Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity
Madhavan, Aparajita, Kok, Bernard P., Rius, Bibiana, Grandjean, Julia M. D., Alabi, Adekunle, Albert, Verena, Sukiasyan, Ara, Powers, Evan T., Galmozzi, Andrea, Saez, Enrique, Wiseman, R. Luke
Published in Nature communications (01.02.2022)
Published in Nature communications (01.02.2022)
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Journal Article
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation
Plate, Lars, Cooley, Christina B, Chen, John J, Paxman, Ryan J, Gallagher, Ciara M, Madoux, Franck, Genereux, Joseph C, Dobbs, Wesley, Garza, Dan, Spicer, Timothy P, Scampavia, Louis, Brown, Steven J, Rosen, Hugh, Powers, Evan T, Walter, Peter, Hodder, Peter, Wiseman, R Luke, Kelly, Jeffery W
Published in eLife (20.07.2016)
Published in eLife (20.07.2016)
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Journal Article
Protein Native-State Stabilization by Placing Aromatic Side Chains in N-Glycosylated Reverse Turns
Culyba, Elizabeth K, Price, Joshua L, Hanson, Sarah R, Dhar, Apratim, Wong, Chi-Huey, Gruebele, Martin, Powers, Evan T, Kelly, Jeffery W
Published in Science (American Association for the Advancement of Science) (04.02.2011)
Published in Science (American Association for the Advancement of Science) (04.02.2011)
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Journal Article
Translation efficiency is maintained at elevated temperature in Escherichia coli
Morgan, Gareth J., Burkhardt, David H., Kelly, Jeffery W., Powers, Evan T.
Published in The Journal of biological chemistry (19.01.2018)
Published in The Journal of biological chemistry (19.01.2018)
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Journal Article
AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin
Penchala, Sravan C., Connelly, Stephen, Wang, Yu, Park, Miki S., Zhao, Lei, Baranczak, Aleksandra, Rappley, Irit, Vogel, Hannes, Liedtke, Michaela, Witteles, Ronald M., Powers, Evan T., Reixach, Natàlia, Chan, William K., Wilson, Ian A., Kelly, Jeffery W., Graef, Isabella A., Alhamadsheh, Mamoun M.
Published in Proceedings of the National Academy of Sciences - PNAS (11.06.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (11.06.2013)
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Journal Article
Structural and Energetic Basis of Carbohydrate–Aromatic Packing Interactions in Proteins
Chen, Wentao, Enck, Sebastian, Price, Joshua L, Powers, David L, Powers, Evan T, Wong, Chi-Huey, Dyson, H. Jane, Kelly, Jeffery W
Published in Journal of the American Chemical Society (03.07.2013)
Published in Journal of the American Chemical Society (03.07.2013)
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Journal Article
core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability
Hanson, Sarah R, Culyba, Elizabeth K, Hsu, Tsui-Ling, Wong, Chi-Huey, Kelly, Jeffery W, Powers, Evan T
Published in Proceedings of the National Academy of Sciences - PNAS (03.03.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (03.03.2009)
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Journal Article
Quantification of Transthyretin Kinetic Stability in Human Plasma Using Subunit Exchange
Rappley, Irit, Monteiro, Cecília, Novais, Marta, Baranczak, Aleksandra, Solis, Gregory, Wiseman, R. Luke, Helmke, Stephen, Maurer, Mathew S, Coelho, Teresa, Powers, Evan T, Kelly, Jeffery W
Published in Biochemistry (Easton) (01.04.2014)
Published in Biochemistry (Easton) (01.04.2014)
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Journal Article
The Dependence of Carbohydrate–Aromatic Interaction Strengths on the Structure of the Carbohydrate
Hsu, Che-Hsiung, Park, Sangho, Mortenson, David E, Foley, B. Lachele, Wang, Xiaocong, Woods, Robert J, Case, David A, Powers, Evan T, Wong, Chi-Huey, Dyson, H. Jane, Kelly, Jeffery W
Published in Journal of the American Chemical Society (22.06.2016)
Published in Journal of the American Chemical Society (22.06.2016)
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Journal Article
Characterising diflunisal as a transthyretin kinetic stabilizer at relevant concentrations in human plasma using subunit exchange
Tsai, Felix J., Nelson, Luke T., Kline, Gabriel M., Jäger, Marcus, Berk, John L., Sekijima, Yoshiki, Powers, Evan T., Kelly, Jeffery W.
Published in Amyloid (03.04.2023)
Published in Amyloid (03.04.2023)
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Journal Article
The endoplasmic reticulum HSP40 co‐chaperone ERdj3/DNAJB11 assembles and functions as a tetramer
Chen, Kai‐Chun, Qu, Song, Chowdhury, Saikat, Noxon, Isabelle C, Schonhoft, Joseph D, Plate, Lars, Powers, Evan T, Kelly, Jeffery W, Lander, Gabriel C, Wiseman, R Luke
Published in The EMBO journal (01.08.2017)
Published in The EMBO journal (01.08.2017)
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