Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells
Alotaibi, Moureq, Sharma, Khushboo, Saleh, Tareq, Povirk, Lawrence F., Hendrickson, Eric A., Gewirtz, David A.
Published in Radiation research (01.03.2016)
Published in Radiation research (01.03.2016)
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Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
Golding, Sarah E, Rosenberg, Elizabeth, Valerie, Nicholas, Hussaini, Isa, Frigerio, Mark, Cockcroft, Xiaoling F, Chong, Wei Yee, Hummersone, Marc, Rigoreau, Laurent, Menear, Keith A, O'Connor, Mark J, Povirk, Lawrence F, van Meter, Timothy, Valerie, Kristoffer
Published in Molecular cancer therapeutics (01.10.2009)
Published in Molecular cancer therapeutics (01.10.2009)
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Persistent 3′-phosphate termini and increased cytotoxicity of radiomimetic DNA double-strand breaks in cells lacking polynucleotide kinase/phosphatase despite presence of an alternative 3′-phosphatase
Chalasani, Sri Lakshmi, Kawale, Ajinkya S., Akopiants, Konstantin, Yu, Yaping, Fanta, Mesfin, Weinfeld, Michael, Povirk, Lawrence F.
Published in DNA repair (01.08.2018)
Published in DNA repair (01.08.2018)
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Tumor Cell Recovery from Senescence Induced by Radiation with PARP Inhibition
Gewirtz, David A., Alotaibi, Moureq, Yakovlev, Vasily A., Povirk, Lawrence F.
Published in Radiation research (01.10.2016)
Published in Radiation research (01.10.2016)
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Journal Article
Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response
Golding, Sarah E, Rosenberg, Elizabeth, Neill, Steven, Dent, Paul, Povirk, Lawrence F, Valerie, Kristoffer
Published in Cancer research (Chicago, Ill.) (01.02.2007)
Published in Cancer research (Chicago, Ill.) (01.02.2007)
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ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response
Sule, Amrita, Golding, Sarah E., Ahmad, Syed F., Watson, James, Ahmed, Mostafa H., Kellogg, Glen E., Bernas, Tytus, Koebley, Sean, Reed, Jason C., Povirk, Lawrence F., Valerie, Kristoffer
Published in Cellular and molecular life sciences : CMLS (01.12.2022)
Published in Cellular and molecular life sciences : CMLS (01.12.2022)
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TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining
Kawale, Ajinkya S, Akopiants, Konstantin, Valerie, Kristoffer, Ruis, Brian, Hendrickson, Eric A, Huang, Shar-yin N, Pommier, Yves, Povirk, Lawrence F
Published in Nucleic acids research (28.09.2018)
Published in Nucleic acids research (28.09.2018)
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Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells
Golding, Sarah E., Morgan, Rhiannon N, Adams, Bret R, Hawkins, Amy J, Povirk, Lawrence F, Valerie, Kristoffer
Published in Cancer biology & therapy (15.04.2009)
Published in Cancer biology & therapy (15.04.2009)
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Tracking the processing of damaged DNA double-strand break ends by ligation-mediated PCR: increased persistence of 3'-phosphoglycolate termini in SCAN1 cells
Akopiants, Konstantin, Mohapatra, Susovan, Menon, Vijay, Zhou, Tong, Valerie, Kristoffer, Povirk, Lawrence F
Published in Nucleic acids research (01.03.2014)
Published in Nucleic acids research (01.03.2014)
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Nucleolar Targeting by Platinum: p53-Independent Apoptosis Follows rRNA Inhibition, Cell-Cycle Arrest, and DNA Compaction
Peterson, Erica J, Menon, Vijay R, Gatti, Laura, Kipping, Ralph, Dewasinghe, Dilhara, Perego, Paola, Povirk, Lawrence F, Farrell, Nicholas P
Published in Molecular pharmaceutics (05.01.2015)
Published in Molecular pharmaceutics (05.01.2015)
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ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks
Khalil, Ashraf, Morgan, Rhiannon N., Adams, Bret R., Golding, Sarah E., Dever, Seth M., Rosenberg, Elizabeth, Povirk, Lawrence F., Valerie, Kristoffer
Published in Cell cycle (Georgetown, Tex.) (01.02.2011)
Published in Cell cycle (Georgetown, Tex.) (01.02.2011)
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Ligand modulation of a dinuclear platinum compound leads to mechanistic differences in cell cycle progression and arrest
Menon, Vijay R., Peterson, Erica J., Valerie, Kristoffer, Farrell, Nicholas P., Povirk, Lawrence F.
Published in Biochemical pharmacology (15.12.2013)
Published in Biochemical pharmacology (15.12.2013)
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