Concise and Practical Asymmetric Synthesis of a Challenging Atropisomeric HIV Integrase Inhibitor
Fandrick, Keith R., Li, Wenjie, Zhang, Yongda, Tang, Wenjun, Gao, Joe, Rodriguez, Sonia, Patel, Nitinchandra D., Reeves, Diana C., Wu, Jiang-Ping, Sanyal, Sanjit, Gonnella, Nina, Qu, Bo, Haddad, Nizar, Lorenz, Jon C., Sidhu, Kanwar, Wang, June, Ma, Shengli, Grinberg, Nelu, Lee, Heewon, Tsantrizos, Youla, Poupart, Marc-André, Busacca, Carl A., Yee, Nathan K., Lu, Bruce Z., Senanayake, Chris H.
Published in Angewandte Chemie International Edition (08.06.2015)
Published in Angewandte Chemie International Edition (08.06.2015)
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Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor
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Published in Antimicrobial agents and chemotherapy (01.06.2014)
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Discovery of a Potent and Selective Noncovalent Linear Inhibitor of the Hepatitis C Virus NS3 Protease (BI 201335)
Llinàs-Brunet, Montse, Bailey, Murray D, Goudreau, Nathalie, Bhardwaj, Punit K, Bordeleau, Josée, Bös, Michael, Bousquet, Yves, Cordingley, Michael G, Duan, Jiamin, Forgione, Pat, Garneau, Michel, Ghiro, Elise, Gorys, Vida, Goulet, Sylvie, Halmos, Ted, Kawai, Stephen H, Naud, Julie, Poupart, Marc-André, White, Peter W
Published in Journal of medicinal chemistry (09.09.2010)
Published in Journal of medicinal chemistry (09.09.2010)
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Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV‑1
Fader, Lee D, Malenfant, Eric, Parisien, Mathieu, Carson, Rebekah, Bilodeau, François, Landry, Serge, Pesant, Marc, Brochu, Christian, Morin, Sébastien, Chabot, Catherine, Halmos, Ted, Bousquet, Yves, Bailey, Murray D, Kawai, Stephen H, Coulombe, René, LaPlante, Steven, Jakalian, Araz, Bhardwaj, Punit K, Wernic, Dominik, Schroeder, Patricia, Amad, Ma’an, Edwards, Paul, Garneau, Michel, Duan, Jianmin, Cordingley, Michael, Bethell, Richard, Mason, Stephen W, Bös, Michael, Bonneau, Pierre, Poupart, Marc-André, Faucher, Anne-Marie, Simoneau, Bruno, Fenwick, Craig, Yoakim, Christiane, Tsantrizos, Youla
Published in ACS medicinal chemistry letters (10.04.2014)
Published in ACS medicinal chemistry letters (10.04.2014)
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An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
Lamarre, Daniel, Anderson, Paul C, Bailey, Murray, Beaulieu, Pierre, Bolger, Gordon, Bonneau, Pierre, Bös, Michael, Cameron, Dale R, Cartier, Mireille, Cordingley, Michael G, Faucher, Anne-Marie, Goudreau, Nathalie, Kawai, Stephen H, Kukolj, George, Lagacé, Lisette, LaPlante, Steven R, Narjes, Hans, Poupart, Marc-André, Rancourt, Jean, Sentjens, Roel E, St George, Roger, Simoneau, Bruno, Steinmann, Gerhard, Thibeault, Diane, Tsantrizos, Youla S, Weldon, Steven M, Yong, Chan-Loi, Llinàs-Brunet, Montse
Published in Nature (13.11.2003)
Published in Nature (13.11.2003)
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Cleavage of Cohesin by the CD Clan Protease Separin Triggers Anaphase in Yeast
Uhlmann, Frank, Wernic, Dominik, Poupart, Marc-André, Koonin, Eugene V, Nasmyth, Kim
Published in Cell (27.10.2000)
Published in Cell (27.10.2000)
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Discovery of BI 207524, an Indole Diamide NS5B Thumb Pocket 1 Inhibitor with Improved Potency for the Potential Treatment of Chronic Hepatitis C Virus Infection
Beaulieu, Pierre L, Anderson, Paul C, Bethell, Richard, Bös, Michael, Bousquet, Yves, Brochu, Christian, Cordingley, Michael G, Fazal, Gulrez, Garneau, Michel, Gillard, James R, Kawai, Stephen, Marquis, Martin, McKercher, Ginette, Poupart, Marc-André, Stammers, Timothy, Thavonekham, Bounkham, Wernic, Dominik, Duan, Jianmin, Kukolj, George
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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Binding Site Characterization and Resistance to a Class of Non-nucleoside Inhibitors of the Hepatitis C Virus NS5B Polymerase
Kukolj, George, McGibbon, Graham A., McKercher, Ginette, Marquis, Martin, Lefèbvre, Sylvain, Thauvette, Louise, Gauthier, Jean, Goulet, Sylvie, Poupart, Marc-André, Beaulieu, Pierre L.
Published in The Journal of biological chemistry (25.11.2005)
Published in The Journal of biological chemistry (25.11.2005)
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Phosphorylation of the Cohesin Subunit Scc1 by Polo/Cdc5 Kinase Regulates Sister Chromatid Separation in Yeast
Alexandru, Gabriela, Uhlmann, Frank, Mechtler, Karl, Poupart, Marc-André, Nasmyth, Kim
Published in Cell (18.05.2001)
Published in Cell (18.05.2001)
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N-Acetamideindolecarboxylic acid allosteric ‘finger-loop’ inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies
Beaulieu, Pierre L., Jolicoeur, Eric, Gillard, James, Brochu, Christian, Coulombe, René, Dansereau, Nathalie, Duan, Jianmin, Garneau, Michel, Jakalian, Araz, Kühn, Peter, Lagacé, Lisette, LaPlante, Steven, McKercher, Ginette, Perrault, Stéphane, Poirier, Martin, Poupart, Marc-André, Stammers, Timothy, Thauvette, Louise, Thavonekham, Bounkham, Kukolj, George
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Journal Article
Concise and Practical Asymmetric Synthesis of a Challenging Atropisomeric HIV Integrase Inhibitor
Fandrick, Keith R., Li, Wenjie, Zhang, Yongda, Tang, Wenjun, Gao, Joe, Rodriguez, Sonia, Patel, Nitinchandra D., Reeves, Diana C., Wu, Jiang-Ping, Sanyal, Sanjit, Gonnella, Nina, Qu, Bo, Haddad, Nizar, Lorenz, Jon C., Sidhu, Kanwar, Wang, June, Ma, Shengli, Grinberg, Nelu, Lee, Heewon, Tsantrizos, Youla, Poupart, Marc-André, Busacca, Carl A., Yee, Nathan K., Lu, Bruce Z., Senanayake, Chris H.
Published in Angewandte Chemie (08.06.2015)
Published in Angewandte Chemie (08.06.2015)
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Discovery of the First Thumb Pocket 1 NS5B Polymerase Inhibitor (BILB 1941) with Demonstrated Antiviral Activity in Patients Chronically Infected with Genotype 1 Hepatitis C Virus (HCV)
Beaulieu, Pierre L, Bös, Michael, Cordingley, Michael G, Chabot, Catherine, Fazal, Gulrez, Garneau, Michel, Gillard, James R, Jolicoeur, Eric, LaPlante, Steven, McKercher, Ginette, Poirier, Martin, Poupart, Marc-André, Tsantrizos, Youla S, Duan, Jianmin, Kukolj, George
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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Peptidomimetic Inhibitors of the Human Cytomegalovirus Protease
Ogilvie, William, Bailey, Murray, Poupart, Marc-André, Abraham, Bhavsar, Amit, Bonneau, Pierre, Bordeleau, Josée, Bousquet, Yves, Chabot, Catherine, Duceppe, Jean-Simon, Fazal, Gulrez, Goulet, Sylvie, Grand-Maître, Chantal, Guse, Ingrid, Halmos, Ted, Lavallée, Pierre, Leach, Michael, Malenfant, Eric, O'Meara, Jeff, Plante, Raymond, Plouffe, Céline, Poirier, Martin, Soucy, François, Yoakim, Christiane, Déziel, Robert
Published in Journal of medicinal chemistry (05.12.1997)
Published in Journal of medicinal chemistry (05.12.1997)
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From benzimidazole to indole-5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase. Part 1: Indole C-2 SAR and discovery of diamide derivatives with nanomolar potency in cell-based subgenomic replicons
Beaulieu, Pierre L., Gillard, James, Jolicoeur, Eric, Duan, Jianmin, Garneau, Michel, Kukolj, George, Poupart, Marc-André
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
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Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors
Stammers, Timothy A., Coulombe, René, Rancourt, Jean, Thavonekham, Bounkham, Fazal, Gulrez, Goulet, Sylvie, Jakalian, Araz, Wernic, Dominic, Tsantrizos, Youla, Poupart, Marc-André, Bös, Michael, McKercher, Ginette, Thauvette, Louise, Kukolj, George, Beaulieu, Pierre L.
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
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Discovery of benzimidazole-diamide finger loop (Thumb Pocket I) allosteric inhibitors of HCV NS5B polymerase: Implementing parallel synthesis for rapid linker optimization
Goulet, Sylvie, Poupart, Marc-André, Gillard, James, Poirier, Martin, Kukolj, George, Beaulieu, Pierre L.
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives
Beaulieu, Pierre L, Bös, Michael, Bousquet, Yves, Fazal, Gulrez, Gauthier, Jean, Gillard, James, Goulet, Sylvie, LaPlante, Steven, Poupart, Marc-André, Lefebvre, Sylvain, McKercher, Ginette, Pellerin, Charles, Austel, Volkhard, Kukolj, George
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
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Discovery of the First Thumb Pocket 1 NS5B Polymerase Inhibitor (BILB 1941) with Demonstrated Antiviral Activity in Patients Chronically Infected with Genotype 1 Hepatitis C Virus (HCV)
Beaulieu, Pierre L, Bös, Michael, Cordingley, Michael G, Chabot, Catherine, Fazal, Gulrez, Garneau, Michel, Gillard, James R, Jolicoeur, Eric, LaPlante, Steven, McKercher, Ginette, Poirier, Martin, Poupart, Marc-André, Tsantrizos, Youla S, Duan, Jianmin, Kukolj, George
Published in Journal of medicinal chemistry (28.08.2014)
Published in Journal of medicinal chemistry (28.08.2014)
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Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency
BEAULIEU, Pierre L, BÖS, Michael, VALOIS, Serge, KUKOLJ, George, BOUSQUET, Yves, DEROY, Patrick, FAZAL, Gulrez, GAUTHIER, Jean, GILLARD, James, GOULET, Sylvie, MCKERCHER, Ginette, POUPART, Marc-André
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
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Indole 5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase with nanomolar potency in cell-based subgenomic replicons (part 2): Central amino acid linker and right-hand-side SAR studies
Beaulieu, Pierre L., Chabot, Catherine, Duan, Jianmin, Garneau, Michel, Gillard, James, Jolicoeur, Eric, Poirier, Martin, Poupart, Marc-André, Stammers, Timothy A., Kukolj, George, Tsantrizos, Youla S.
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
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