Targeted cytosine deaminase-uracil phosphoribosyl transferase suicide gene therapy induces small cell lung cancer-specific cytotoxicity and tumor growth delay
Christensen, Camilla L, Gjetting, Torben, Poulsen, Thomas T, Cramer, Frederik, Roth, Jack A, Poulsen, Hans S
Published in Clinical cancer research (15.04.2010)
Published in Clinical cancer research (15.04.2010)
Get full text
Journal Article
Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity
Jacobsen, Helle J, Poulsen, Thomas T, Dahlman, Anna, Kjær, Ida, Koefoed, Klaus, Sen, Jette W, Weilguny, Dietmar, Bjerregaard, Bolette, Andersen, Christina R, Horak, Ivan D, Pedersen, Mikkel W, Kragh, Michael, Lantto, Johan
Published in Clinical cancer research (15.09.2015)
Published in Clinical cancer research (15.09.2015)
Get full text
Journal Article
CD4 + and CD8a + PET imaging predicts response to novel PD-1 checkpoint inhibitor: studies of Sym021 in syngeneic mouse cancer models
Kristensen, Lotte K, Fröhlich, Camilla, Christensen, Camilla, Melander, Maria C, Poulsen, Thomas T, Galler, Gunther R, Lantto, Johan, Horak, Ivan D, Kragh, Michael, Nielsen, Carsten H, Kjaer, Andreas
Published in Theranostics (01.01.2019)
Published in Theranostics (01.01.2019)
Get full text
Journal Article
Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses: A Phase 2 Randomized Clinical Trial
Montagut, Clara, Argilés, Guillem, Ciardiello, Fortunato, Poulsen, Thomas T, Dienstmann, Rodrigo, Kragh, Michael, Kopetz, Scott, Lindsted, Trine, Ding, Cliff, Vidal, Joana, Clausell-Tormos, Jenifer, Siravegna, Giulia, Sánchez-Martín, Francisco J, Koefoed, Klaus, Pedersen, Mikkel W, Grandal, Michael M, Dvorkin, Mikhail, Wyrwicz, Lucjan, Rovira, Ana, Cubillo, Antonio, Salazar, Ramon, Desseigne, Françoise, Nadal, Cristina, Albanell, Joan, Zagonel, Vittorina, Siena, Salvatore, Fumi, Guglielmo, Rospo, Giuseppe, Nadler, Paul, Horak, Ivan D, Bardelli, Alberto, Tabernero, Josep
Published in JAMA oncology (01.04.2018)
Published in JAMA oncology (01.04.2018)
Get more information
Journal Article
Targeting Three Distinct HER2 Domains with a Recombinant Antibody Mixture Overcomes Trastuzumab Resistance
Pedersen, Mikkel W, Jacobsen, Helle J, Koefoed, Klaus, Dahlman, Anna, Kjær, Ida, Poulsen, Thomas T, Meijer, Per-Johan, Nielsen, Lars S, Horak, Ivan D, Lantto, Johan, Kragh, Michael
Published in Molecular cancer therapeutics (01.03.2015)
Published in Molecular cancer therapeutics (01.03.2015)
Get full text
Journal Article
Simultaneous Targeting of Two Distinct Epitopes on MET Effectively Inhibits MET- and HGF-Driven Tumor Growth by Multiple Mechanisms
Grandal, Michael M, Havrylov, Serhiy, Poulsen, Thomas T, Koefoed, Klaus, Dahlman, Anna, Galler, Gunther R, Conrotto, Paolo, Collins, Sara, Eriksen, Karsten W, Kaufman, Dafna, Woude, George F Vande, Jacobsen, Helle J, Horak, Ivan D, Kragh, Michael, Lantto, Johan, Bouquin, Thomas, Park, Morag, Pedersen, Mikkel W
Published in Molecular cancer therapeutics (01.12.2017)
Published in Molecular cancer therapeutics (01.12.2017)
Get full text
Journal Article
Abstract 1218: A novel synergistic antibody pair targeting non-overlapping epitopes of MET effectively inhibits MET-driven cancer models
Grandal, Michael M., Poulsen, Thomas T., Koefoed, Klaus, Eriksen, Karsten W., Dahlman, Anna, Conrotto, Paolo, Bouquin, Thomas, Jacobsen, Helle, Horak, Ivan D., Kragh, Michael, Lantto, Johan, Pedersen, Mikkel W.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Get full text
Journal Article
Abstract 1219: Sym015, a novel antibody mixture targeting non-overlapping epitopes of MET, effectively inhibits growth of MET dependent tumors and overcomes resistance to a single monoclonal antibody
Poulsen, Thomas T., Grandal, Michael M., Jacobsen, Helle J., Hansen, Dorte S., Lindsted, Trine, Pedersen, Mikkel W., Horak, Ivan D., Kragh, Michael, Lantto, Johan
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Get full text
Journal Article
In vivo imaging of therapy response to a novel pan-HER antibody mixture using FDG and FLT positron emission tomography
Nielsen, Carsten H, Jensen, Mette M, Kristensen, Lotte K, Dahlman, Anna, Fröhlich, Camilla, Jacobsen, Helle J, Poulsen, Thomas T, Lantto, Johan, Horak, Ivan D, Kragh, Michael, Kjaer, Andreas
Published in Oncotarget (10.11.2015)
Published in Oncotarget (10.11.2015)
Get full text
Journal Article
Single agent- and combination treatment with two targeted suicide gene therapy systems is effective in chemoresistant small cell lung cancer cells
Michaelsen, Signe R., Christensen, Camilla L., Sehested, Maxwell, Cramer, Frederik, Poulsen, Thomas T., Patterson, Adam V., Poulsen, Hans S.
Published in The journal of gene medicine (01.07.2012)
Published in The journal of gene medicine (01.07.2012)
Get full text
Journal Article
328. Transcriptionally Targeted Cancer Gene Therapy for Small Cell Lung Cancer
Pedersen, Nina, Poulsen, Thomas T., Pedersen, Mikkel W., Lan, Michael S., Breslin, Mary B., Poulsen, Hans S.
Published in Molecular therapy (01.05.2006)
Published in Molecular therapy (01.05.2006)
Get full text
Journal Article
New Targets for Detection and Treatment of Small Cell Lung Cancer
Pedersen, Nina, Pedersen, Mikkel W., Poulsen, Thomas T., Mortensen, Shila, Sørensen, Susanne B., Rieneck, Klaus, Bovin, Lone F., Poulsen, Hans Skovgaard
Published in Chest (01.05.2004)
Published in Chest (01.05.2004)
Get full text
Journal Article
Abstract LB-216: Protein pathway activation analysis of a panel of patient-derived epithelial tumor models identifies signatures of response to ErbB1-3 co-targeting
Calvert, Valerie S., Fröhlich, Camilla, Poulsen, Thomas T., Pedersen, Mikkel W., Kragh, Michael, Horak, Ivan D., Petricoin, Emanuel F.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Abstract 1723: CD4+ and CD8a+ PET imaging in syngeneic mouse models for prediction of immuno-therapeutic response
Kristensen, Lotte K., Fröhlich, Camilla, Christensen, Camilla, Melander, Maria C., Poulsen, Thomas T., Galler, Gunther R., Lantto, Johan, Horak, Ivan D., Kragh, Michael, Nielsen, Carsten H., Kjaer, Andreas
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Abstract 655: Effect of antibody mixtures on HER-family heterodimerization
Ellebæk, Sofie, Bouquin, Thomas, Grandal, Michael V., Kragh, Michael, Poulsen, Thomas T.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Get full text
Journal Article
Abstract 657: Simultaneous inhibition of HER-family receptors by Pan-HER antibody mixture prevents compensatory HER-family receptor upregulation and induces cell death in a broad range of tumor models
Dahlman, Anna, Jacobsen, Helle J., Poulsen, Thomas T., Conrotto, Paolo, Pedersen, Mikkel W., Horak, Ivan D., Kragh, Michael, Lantto, Johan
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Get full text
Journal Article
Abstract 2070: In vivo imaging of therapy response to novel antibody mixtures targeted at the human epidermal growth factor receptor family using FDG and FLT positron emission tomography
Nielsen, Carsten H., Jensen, Mette M., Jacobsen, Helle J., Poulsen, Thomas T., Horak, Ivan D., Lantto, Johan, Kragh, Michael, Kjaer, Andreas
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Get full text
Journal Article