Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity
Petrilli, Alejandra, Bossy-Wetzel, Ella, Song, Wenjun, Ellisman, Mark, Rouiller, Isabelle, Klinglmayr, Eva, Chen, Jin, Zhou, Yue, Poquiz, Patrick, Masliah, Eliezer, Tjong, Jonathan, Perkins, Guy, Liot, Geraldine, Hayden, Michael R, Pouladi, Mahmoud A, Schwarzenbacher, Robert, Bossy, Blaise
Published in Nature medicine (01.03.2011)
Published in Nature medicine (01.03.2011)
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A thiol probe for measuring unfolded protein load and proteostasis in cells
Chen, Moore Z., Moily, Nagaraj S., Bridgford, Jessica L., Wood, Rebecca J., Radwan, Mona, Smith, Trevor A., Song, Zhegang, Tang, Ben Zhong, Tilley, Leann, Xu, Xiaohong, Reid, Gavin E., Pouladi, Mahmoud A., Hong, Yuning, Hatters, Danny M.
Published in Nature communications (07.09.2017)
Published in Nature communications (07.09.2017)
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Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes
Maillet, Agnes, Tan, Kim, Chai, Xiaoran, Sadananda, Singh N., Mehta, Ashish, Ooi, Jolene, Hayden, Michael R., Pouladi, Mahmoud A., Ghosh, Sujoy, Shim, Winston, Brunham, Liam R.
Published in Scientific reports (04.05.2016)
Published in Scientific reports (04.05.2016)
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Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice
Milnerwood, Austen J., Gladding, Clare M., Pouladi, Mahmoud A., Kaufman, Alexandra M., Hines, Rochelle M., Boyd, Jamie D., Ko, Rebecca W.Y., Vasuta, Oana C., Graham, Rona K., Hayden, Michael R., Murphy, Timothy H., Raymond, Lynn A.
Published in Neuron (Cambridge, Mass.) (28.01.2010)
Published in Neuron (Cambridge, Mass.) (28.01.2010)
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Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells
Xu, Xiaohong, Tay, Yilin, Sim, Bernice, Yoon, Su-In, Huang, Yihui, Ooi, Jolene, Utami, Kagistia Hana, Ziaei, Amin, Ng, Bryan, Radulescu, Carola, Low, Donovan, Ng, Alvin Yu Jin, Loh, Marie, Venkatesh, Byrappa, Ginhoux, Florent, Augustine, George J., Pouladi, Mahmoud A.
Published in Stem cell reports (14.03.2017)
Published in Stem cell reports (14.03.2017)
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Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
Talantova, Maria, Kaul, Marcus, Yao, Dongdong, Xia, Peng, Ehrnhoefer, Dagmar E, Zaidi, Rameez, Lipton, Stuart A, Graham, Rona K, Tong, Gary, Zhang, Dongxian, Clemente, Arjay, Okamoto, Shu-ichi, Hayden, Michael R, Pouladi, Mahmoud A, Vincent Chen, H-S
Published in Nature medicine (01.12.2009)
Published in Nature medicine (01.12.2009)
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A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease
Björkqvist, Maria, Wild, Edward J, Thiele, Jenny, Silvestroni, Aurelio, Andre, Ralph, Lahiri, Nayana, Raibon, Elsa, Lee, Richard V, Benn, Caroline L, Soulet, Denis, Magnusson, Anna, Woodman, Ben, Landles, Christian, Pouladi, Mahmoud A, Hayden, Michael R, Khalili-Shirazi, Azadeh, Lowdell, Mark W, Brundin, Patrik, Bates, Gillian P, Leavitt, Blair R, Möller, Thomas, Tabrizi, Sarah J
Published in The Journal of experimental medicine (04.08.2008)
Published in The Journal of experimental medicine (04.08.2008)
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Generation of three isogenic gene-edited Huntington’s disease human embryonic stem cell lines with DOX-inducible NGN2 expression cassette in the AAVS1 safe locus
Villegas, Luisana Duque, Chandrasekaran, Abinaya, Andersen, Sofie Amalie Flintholm, Nørremølle, Anne, Schmid, Benjamin, Pouladi, Mahmoud A., Freude, Kristine
Published in Stem cell research (01.06.2024)
Published in Stem cell research (01.06.2024)
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Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity
Lemarié, Fanny L., Caron, Nicholas S., Sanders, Shaun S., Schmidt, Mandi E., Nguyen, Yen T.N., Ko, Seunghyun, Xu, Xiaohong, Pouladi, Mahmoud A., Martin, Dale D.O., Hayden, Michael R.
Published in Neurobiology of disease (01.10.2021)
Published in Neurobiology of disease (01.10.2021)
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Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease
Southwell, Amber L, Franciosi, Sonia, Villanueva, Erika B, Xie, Yuanyun, Winter, Laurie A, Veeraraghavan, Janaki, Jonason, Alan, Felczak, Boguslaw, Zhang, Weining, Kovalik, Vlad, Waltl, Sabine, Hall, George, Pouladi, Mahmoud A, Smith, Ernest S, Bowers, William J, Zauderer, Maurice, Hayden, Michael R
Published in Neurobiology of disease (01.04.2015)
Published in Neurobiology of disease (01.04.2015)
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Manipulation of microbiota reveals altered callosal myelination and white matter plasticity in a model of Huntington disease
Radulescu, Carola I., Garcia-Miralles, Marta, Sidik, Harwin, Bardile, Costanza Ferrari, Yusof, Nur Amirah Binte Mohammad, Lee, Hae Ung, Ho, Eliza Xin Pei, Chu, Collins Wenhan, Layton, Emma, Low, Donovan, De Sessions, Paola Florez, Pettersson, Sven, Ginhoux, Florent, Pouladi, Mahmoud A.
Published in Neurobiology of disease (01.07.2019)
Published in Neurobiology of disease (01.07.2019)
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CHCHD2 up-regulation in Huntington disease mediates a compensatory protective response against oxidative stress
Liu, Xuanzhuo, Wang, Fang, Fan, Xinman, Chen, Mingyi, Xu, Xiaoxin, Xu, Qiuhong, Zhu, Huili, Xu, Anding, Pouladi, Mahmoud A., Xu, Xiaohong
Published in Cell death & disease (10.02.2024)
Published in Cell death & disease (10.02.2024)
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Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes
Valenza, Marta, Leoni, Valerio, Karasinska, Joanna M, Petricca, Lara, Fan, Jianjia, Carroll, Jeffrey, Pouladi, Mahmoud A, Fossale, Elisa, Nguyen, Huu Phuc, Riess, Olaf, MacDonald, Marcy, Wellington, Cheryl, DiDonato, Stefano, Hayden, Michael, Cattaneo, Elena
Published in The Journal of neuroscience (11.08.2010)
Published in The Journal of neuroscience (11.08.2010)
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A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability
Chia, Poh Hui, Zhong, Franklin Lei, Niwa, Shinsuke, Bonnard, Carine, Utami, Kagistia Hana, Zeng, Ruizhu, Lee, Hane, Eskin, Ascia, Nelson, Stanley F, Xie, William H, Al-Tawalbeh, Samah, El-Khateeb, Mohammad, Shboul, Mohammad, Pouladi, Mahmoud A, Al-Raqad, Mohammed, Reversade, Bruno
Published in eLife (22.05.2018)
Published in eLife (22.05.2018)
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Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity
Sorek, Matan, Oweis, Walaa, Nissim-Rafinia, Malka, Maman, Moria, Simon, Shahar, Hession, Cynthia C, Adiconis, Xian, Simmons, Sean K, Sanjana, Neville E, Shi, Xi, Lu, Congyi, Pan, Jen Q, Xu, Xiaohong, Pouladi, Mahmoud A, Ellerby, Lisa M, Zhang, Feng, Levin, Joshua Z, Meshorer, Eran
Published in Genome Biology (04.03.2021)
Published in Genome Biology (04.03.2021)
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Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle
Julien, Sofi G, Kim, Sun-Yee, Brunmeir, Reinhard, Sinnakannu, Joanna R, Ge, Xiaojia, Li, Hongyu, Ma, Wei, Yaligar, Jadegoud, Kn, Bhanu Prakash, Velan, Sendhil S, Röder, Pia V, Zhang, Qiongyi, Sim, Choon Kiat, Wu, Jingyi, Garcia-Miralles, Marta, Pouladi, Mahmoud A, Xie, Wei, McFarlane, Craig, Han, Weiping, Xu, Feng
Published in PLoS biology (16.02.2017)
Published in PLoS biology (16.02.2017)
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Elevated de novo protein synthesis in FMRP-deficient human neurons and its correction by metformin treatment
Utami, Kagistia Hana, Yusof, Nur Amirah Binte Mohammad, Kwa, Jing Eugene, Peteri, Ulla-Kaisa, Castrén, Maija L, Pouladi, Mahmoud A
Published in Molecular autism (27.05.2020)
Published in Molecular autism (27.05.2020)
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Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease
Simpson, Jessica M, Gil-Mohapel, Joana, Pouladi, Mahmoud A, Ghilan, Mohamed, Xie, Yuanyun, Hayden, Michael R, Christie, Brian R
Published in Neurobiology of disease (01.02.2011)
Published in Neurobiology of disease (01.02.2011)
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Journal Article
Reprint of: Manipulation of microbiota reveals altered callosal myelination and white matter plasticity in a model of Huntington disease
Radulescu, Carola I., Garcia-Miralles, Marta, Sidik, Harwin, Bardile, Costanza Ferrari, Yusof, Nur Amirah Binte Mohammad, Lee, Hae Ung, Ho, Eliza Xin Pei, Chu, Collins Wenhan, Layton, Emma, Low, Donovan, De Sessions, Paola Florez, Pettersson, Sven, Ginhoux, Florent, Pouladi, Mahmoud A.
Published in Neurobiology of disease (01.02.2020)
Published in Neurobiology of disease (01.02.2020)
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