Triggering NETosis via protease-activated receptor (PAR)-2 signaling as a mechanism of hijacking neutrophils function for pathogen benefits
Bryzek, Danuta, Ciaston, Izabela, Dobosz, Ewelina, Gasiorek, Anna, Makarska, Anna, Sarna, Michal, Eick, Sigrun, Puklo, Magdalena, Lech, Maciej, Potempa, Barbara, Potempa, Jan, Koziel, Joanna
Published in PLoS pathogens (01.05.2019)
Published in PLoS pathogens (01.05.2019)
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Journal Article
Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid Arthritis Etiology
Kharlamova, Nastya, Jiang, Xia, Sherina, Natalia, Potempa, Barbara, Israelsson, Lena, Quirke, Anne‐Marie, Eriksson, Kaja, Yucel‐Lindberg, Tülay, Venables, Patrick J., Potempa, Jan, Alfredsson, Lars, Lundberg, Karin
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.03.2016)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.03.2016)
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Structural determinants of inhibition of Porphyromonas gingivalis gingipain K by KYT-36, a potent, selective, and bioavailable peptidase inhibitor
Guevara, Tibisay, Rodríguez-Banqueri, Arturo, Lasica, Anna M., Ksiazek, Miroslaw, Potempa, Barbara A., Potempa, Jan, Gomis-Rüth, F. Xavier
Published in Scientific reports (20.03.2019)
Published in Scientific reports (20.03.2019)
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Journal Article
Structure and Mechanism of Cysteine Peptidase Gingipain K (Kgp), a Major Virulence Factor of Porphyromonas gingivalis in Periodontitis
de Diego, Iñaki, Veillard, Florian, Sztukowska, Maryta N., Guevara, Tibisay, Potempa, Barbara, Pomowski, Anja, Huntington, James A., Potempa, Jan, Gomis-Rüth, F. Xavier
Published in The Journal of biological chemistry (14.11.2014)
Published in The Journal of biological chemistry (14.11.2014)
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Journal Article
Peptidylarginine Deiminase of Porphyromonas gingivalis Modulates the Interactions between Candida albicans Biofilm and Human Plasminogen and High-Molecular-Mass Kininogen
Karkowska-Kuleta, Justyna, Surowiec, Magdalena, Gogol, Mariusz, Koziel, Joanna, Potempa, Barbara, Potempa, Jan, Kozik, Andrzej, Rapala-Kozik, Maria
Published in International journal of molecular sciences (03.04.2020)
Published in International journal of molecular sciences (03.04.2020)
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Journal Article
Proteolytic Activity-Independent Activation of the Immune Response by Gingipains from Porphyromonas gingivalis
Ciaston, Izabela, Budziaszek, Joanna, Satala, Dorota, Potempa, Barbara, Fuchs, Andrew, Rapala-Kozik, Maria, Mizgalska, Danuta, Dobosz, Ewelina, Lamont, Richard J, Potempa, Jan, Koziel, Joanna
Published in mBio (28.06.2022)
Published in mBio (28.06.2022)
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Journal Article
Antibodies against Porphyromonas gingivalis in serum and saliva and their association with rheumatoid arthritis and periodontitis. Data from two rheumatoid arthritis cohorts in Sweden
Svärd, Anna, Kastbom, Alf, Ljungberg, Karin Roos, Potempa, Barbara, Potempa, Jan, Persson, G Rutger, Renvert, Stefan, Berglund, Johan Sanmartin, Söderlin, Maria K
Published in Frontiers in immunology (2023)
Published in Frontiers in immunology (2023)
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Journal Article
Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase
Goulas, Theodoros, Mizgalska, Danuta, Garcia-Ferrer, Irene, Kantyka, Tomasz, Guevara, Tibisay, Szmigielski, Borys, Sroka, Aneta, Millán, Claudia, Usón, Isabel, Veillard, Florian, Potempa, Barbara, Mydel, Piotr, Solà, Maria, Potempa, Jan, Gomis-Rüth, F. Xavier
Published in Scientific reports (01.07.2015)
Published in Scientific reports (01.07.2015)
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Journal Article
Subversion of Lipopolysaccharide Signaling in Gingival Keratinocytes via MCPIP-1 Degradation as a Novel Pathogenic Strategy of Inflammophilic Pathobionts
Gasiorek, Anna, Dobosz, Ewelina, Potempa, Barbara, Ciaston, Izabela, Wilamowski, Mateusz, Oruba, Zuzanna, Lamont, Richard J, Jura, Jolanta, Potempa, Jan, Koziel, Joanna
Published in mBio (29.06.2021)
Published in mBio (29.06.2021)
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Journal Article
Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis
Lasica, Anna M., Goulas, Theodoros, Mizgalska, Danuta, Zhou, Xiaoyan, de Diego, Iñaki, Ksiazek, Mirosław, Madej, Mariusz, Guo, Yonghua, Guevara, Tibisay, Nowak, Magdalena, Potempa, Barbara, Goel, Apoorv, Sztukowska, Maryta, Prabhakar, Apurva T., Bzowska, Monika, Widziolek, Magdalena, Thøgersen, Ida B., Enghild, Jan J., Simonian, Mary, Kulczyk, Arkadiusz W., Nguyen, Ky-Anh, Potempa, Jan, Gomis-Rüth, F. Xavier
Published in Scientific reports (24.11.2016)
Published in Scientific reports (24.11.2016)
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Journal Article
Cleavage of extracellular matrix in periodontitis: gingipains differentially affect cell adhesion activities of fibronectin and tenascin-C
Ruggiero, Sabrina, Cosgarea, Raluca, Potempa, Jan, Potempa, Barbara, Eick, Sigrun, Chiquet, Matthias
Published in Biochimica et biophysica acta (01.04.2013)
Published in Biochimica et biophysica acta (01.04.2013)
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Journal Article
Proteolysis of Gingival Keratinocyte Cell Surface Proteins by Gingipains Secreted From Porphyromonas gingivalis - Proteomic Insights Into Mechanisms Behind Tissue Damage in the Diseased Gingiva
Hočevar, Katarina, Vizovišek, Matej, Wong, Alicia, Kozieł, Joanna, Fonović, Marko, Potempa, Barbara, Lamont, Richard J, Potempa, Jan, Turk, Boris
Published in Frontiers in microbiology (28.04.2020)
Published in Frontiers in microbiology (28.04.2020)
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Journal Article
Inactive Gingipains from P. gingivalis Selectively Skews T Cells toward a Th17 Phenotype in an IL-6 Dependent Manner
Glowczyk, Izabela, Wong, Alicia, Potempa, Barbara, Babyak, Olena, Lech, Maciej, Lamont, Richard J, Potempa, Jan, Koziel, Joanna
Published in Frontiers in cellular and infection microbiology (27.04.2017)
Published in Frontiers in cellular and infection microbiology (27.04.2017)
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Journal Article
Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB
Wichert, Rielana, Ermund, Anna, Schmidt, Stefanie, Schweinlin, Matthias, Ksiazek, Miroslaw, Arnold, Philipp, Knittler, Katharina, Wilkens, Frederike, Potempa, Barbara, Rabe, Björn, Stirnberg, Marit, Lucius, Ralph, Bartsch, Jörg W., Nikolaus, Susanna, Falk-Paulsen, Maren, Rosenstiel, Philip, Metzger, Marco, Rose-John, Stefan, Potempa, Jan, Hansson, Gunnar C., Dempsey, Peter J., Becker-Pauly, Christoph
Published in Cell reports (Cambridge) (21.11.2017)
Published in Cell reports (Cambridge) (21.11.2017)
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Exhaled Nitric Oxide Reflects the Immune Reactions of the Airways in Early Rheumatoid Arthritis
Weitoft, Tomas, Rönnelid, Johan, Lind, Anders, de Vries, Charlotte, Larsson, Anders, Potempa, Barbara, Potempa, Jan, Kastbom, Alf, Martinsson, Klara, Lundberg, Karin, Högman, Marieann
Published in Biomedicines (01.05.2024)
Published in Biomedicines (01.05.2024)
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Journal Article
Porphyromonas gingivalis Virulence Factor Gingipain RgpB Shows a Unique Zymogenic Mechanism for Cysteine Peptidases
de Diego, Iñaki, Veillard, Florian T., Guevara, Tibisay, Potempa, Barbara, Sztukowska, Maryta, Potempa, Jan, Gomis-Rüth, F. Xavier
Published in The Journal of biological chemistry (17.05.2013)
Published in The Journal of biological chemistry (17.05.2013)
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Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors
Dominy, Stephen S, Lynch, Casey, Ermini, Florian, Benedyk, Malgorzata, Marczyk, Agata, Konradi, Andrei, Nguyen, Mai, Haditsch, Ursula, Raha, Debasish, Griffin, Christina, Holsinger, Leslie J, Arastu-Kapur, Shirin, Kaba, Samer, Lee, Alexander, Ryder, Mark I, Potempa, Barbara, Mydel, Piotr, Hellvard, Annelie, Adamowicz, Karina, Hasturk, Hatice, Walker, Glenn D, Reynolds, Eric C, Faull, Richard L M, Curtis, Maurice A, Dragunow, Mike, Potempa, Jan
Published in Science advances (01.01.2019)
Published in Science advances (01.01.2019)
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Journal Article
Concentration of antibodies against Porphyromonas gingivalis is increased before the onset of symptoms of rheumatoid arthritis
Johansson, Linda, Sherina, Natalia, Kharlamova, Nastya, Potempa, Barbara, Larsson, Barbro, Israelsson, Lena, Potempa, Jan, Rantapää-Dahlqvist, Solbritt, Lundberg, Karin
Published in Arthritis research & therapy (07.09.2016)
Published in Arthritis research & therapy (07.09.2016)
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Tethering soluble meprin α in an enzyme complex to the cell surface affects IBD-associated genes
Peters, Florian, Scharfenberg, Franka, Colmorgen, Cynthia, Armbrust, Fred, Wichert, Rielana, Arnold, Philipp, Potempa, Barbara, Potempa, Jan, Pietrzik, Claus U, Häsler, Robert, Rosenstiel, Philip, Becker-Pauly, Christoph
Published in The FASEB journal (01.06.2019)
Published in The FASEB journal (01.06.2019)
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Limited proteolysis of neutrophil granule proteins by the bacterial protease RgpB depletes neutrophil antimicrobial capacity
Cooper, Kelley N, Wielento, Aleksandra, Morris, Savannah C, Terekhova, Marina, Rodriguez-Hernandez, Carlos J, Potempa, Barbara, Carey, Katherine A, Artyomov, Maxim N, Potempa, Jan, Bagaitkar, Juhi
Published in Journal of leukocyte biology (25.09.2024)
Published in Journal of leukocyte biology (25.09.2024)
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