Randomized Trial of C5a Receptor Inhibitor Avacopan in ANCA-Associated Vasculitis
Jayne, David R W, Bruchfeld, Annette N, Harper, Lorraine, Schaier, Matthias, Venning, Michael C, Hamilton, Patrick, Burst, Volker, Grundmann, Franziska, Jadoul, Michel, Szombati, István, Tesař, Vladimír, Segelmark, Mårten, Potarca, Antonia, Schall, Thomas J, Bekker, Pirow
Published in Journal of the American Society of Nephrology (01.09.2017)
Published in Journal of the American Society of Nephrology (01.09.2017)
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Journal Article
The effect of CCR2 inhibitor CCX140-B on residual albuminuria in patients with type 2 diabetes and nephropathy: a randomised trial
de Zeeuw, Dick, Prof, Bekker, Pirow, MBChB, Henkel, Elena, MD, Hasslacher, Christopher, MD, Gouni-Berthold, Ioanna, MD, Mehling, Heidrun, MD, Potarca, Antonia, MSc, Tesar, Vladimir, Prof, Heerspink, Hiddo J Lambers, PharmD, Schall, Thomas J, PhD
Published in The lancet. Diabetes & endocrinology (01.09.2015)
Published in The lancet. Diabetes & endocrinology (01.09.2015)
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Journal Article
Adjunctive Treatment With Avacopan, an Oral C5a Receptor Inhibitor, in Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis
Merkel, Peter A., Niles, John, Jimenez, Richard, Spiera, Robert F., Rovin, Brad H., Bomback, Andrew, Pagnoux, Christian, Potarca, Antonia, Schall, Thomas J., Bekker, Pirow, Girard, Louis‐Philippe, Lin, Yih Chang Chen, Marder, Galina, Murphy, Jennifer, Shergy, William, Charles Striebich, Christopher, Swarup, Areena, Tumlin, James
Published in ACR open rheumatology (01.11.2020)
Published in ACR open rheumatology (01.11.2020)
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Journal Article
Orally administered CCR2 selective inhibitor CCX872-b clinical trial in pancreatic cancer
Noel, Marcus Smith, Hezel, Aram F., Linehan, David, Wang-Gillam, Andrea, Eskens, Ferry, Sleijfer, Stefan, Desar, Ingrid, Erdkamp, Frans, Wilmink, Johanna, Diehl, Janet, Potarca, Antonia, Zhao, Niky, Deng, Jun, Lohr, Lisa, Miao, Shichang, Charo, Israel, Singh, Rajinder, Schall, Thomas J., Bekker, Pirow
Published in Journal of clinical oncology (01.02.2017)
Published in Journal of clinical oncology (01.02.2017)
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Journal Article
FP167ADVERSE EVENTS WITH GLUCOCORTICOID STANDARD OF CARE VERSUS AVACOPAN IN ANCA-ASSOCIATED VASCULITIS: OBSERVATIONS FROM THE CLEAR TRIAL
Jayne, David, Potarca, Antonia, Schall, Thomas, Hilson, Jan, Becker, Pirow
Published in Nephrology, dialysis, transplantation (01.05.2018)
Published in Nephrology, dialysis, transplantation (01.05.2018)
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Journal Article
C5a receptor inhibitor avacopan in immunoglobulin A nephropathy—an open-label pilot study
Bruchfeld, Annette, Magin, Hasan, Nachman, Patrick, Parikh, Samir, Lafayette, Richard, Potarca, Antonia, Miao, Shichang, Bekker, Pirow
Published in Clinical kidney journal (01.05.2022)
Published in Clinical kidney journal (01.05.2022)
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Journal Article
326. A RANDOMIZED PHASE 3 TRIAL EVALUATING THE SAFETY AND EFFICACY OF AVACOPAN IN PATIENTS WITH NEW OR RELAPSING ANCA-ASSOCIATED VASCULITIS
Merkel, Peter, Jayne, David, Harigai, Masayoshi, Schall, Thomas, Bekker, Pirow, Potarca, Antonia, Hillson, Jan
Published in Rheumatology (Oxford, England) (01.03.2019)
Published in Rheumatology (Oxford, England) (01.03.2019)
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Journal Article
TO012C5A RECEPTOR INHIBITOR AVACOPAN IN IGA NEPHROPATHY STUDY
Bruchfeld, Annette, Nachman, Patrick, Parikh, Samir, Lafayette, Richard, Potarca, Antonia, Diehl, Janet, Lohr, Lisa, Miao, Shichang, Schall, Thomas, Bekker, Pirow
Published in Nephrology, dialysis, transplantation (01.05.2017)
Published in Nephrology, dialysis, transplantation (01.05.2017)
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Journal Article
Overall survival in a trial of orally administered CCR2 inhibitor CCX872 in locally advanced/metastatic pancreatic cancer: Correlation with blood monocyte counts
Linehan, David, Noel, Marcus Smith, Hezel, Aram F., Wang-Gillam, Andrea, Eskens, Ferry, Sleijfer, Stefan, Desar, Ingrid M.E., Erdkamp, Frans, Wilmink, Johanna, Diehl, Janet, Potarca, Antonia, Zhao, Niky, Miao, Shichang, Deng, Jun, Hillson, Jan, Bekker, Pirow, Schall, Thomas J., Singh, Rajinder
Published in Journal of clinical oncology (10.02.2018)
Published in Journal of clinical oncology (10.02.2018)
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Journal Article
The inhibition of CCR2 to modify the microenvironment in pancreatic cancer mouse model and to support the profiling of the CCR2 inhibitor CCX872-B in patients
Wang-Gillam, Andrea, Noel, Marcus Smith, Sleijfer, Stefan, Jung, Heiyoun, Lohr, Lisa, Zhao, Niky, Miao, Shichang, Potarca, Antonia, Charo, Israel, Bekker, Petrus, Schall, Thomas J.
Published in Journal of clinical oncology (20.05.2016)
Published in Journal of clinical oncology (20.05.2016)
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Journal Article
SP457CCR2 INHIBITOR CCX140 EFFECTIVE IN PHASE 2 CLINICAL TRIAL IN DIABETIC NEPHROPATHY
de Zeeuw, Dick, Henkel, Elena, Psottova, Jana, Paragh, Gyorgy, Mehling, Heidrun, Hasslacher, Christopher, Potarca, Antonia, Bekker, Pirow, Schall, Thomas J
Published in Nephrology, dialysis, transplantation (01.05.2015)
Published in Nephrology, dialysis, transplantation (01.05.2015)
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Journal Article
Abstract B24: Pharmacokinetic and pharmacodynamic profile of the novel, oral and selective CCR2 inhibitor CCX872-B in a Phase 1B pancreatic cancer trial
Hezel, Aram, Eskens, Ferry, Sleijfer, Stefan, Noel, Marcus, Wang-Gillam, Andrea, Cheng, Sabrina, Potarca, Antonia, Zhao, Bin, Lohr, Lisa, Miao, Shichang, Charo, Israel, Bekker, Pirow, Schall, Thomas J.
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Journal Article
MO039SUCCESSFUL STEROID REPLACEMENT IN ANCA-ASSOCIATED VASCULITIS WITH C5A RECEPTOR INHIBITOR CCX168 IN PHASE 2 RANDOMISED TRIAL (CLEAR)
Jayne, David, Bruchfeld, Annette, Harper, Lorraine, Schaier, Matthias, Venning, Michael, Hamilton, Patrick, Burst, Volker, Grundman, Franziska, Jadoul, Michel, Szombati, Istvan, Tesar, Vladimir, Segelmark, Mårten, Potarca, Antonia, Schall, Thomas J, Bekker, Pirow
Published in Nephrology, dialysis, transplantation (01.05.2016)
Published in Nephrology, dialysis, transplantation (01.05.2016)
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Journal Article
Orally Administered CCR9 Inhibitor CCX507 Effectively Blocks CCR9 in Circulating Human Leukocytes: 1678
Seitz, Lisa, Lohr, Lisa, Tan, Joanne, Potarca, Antonia, Miao, Shichang, Dairaghi, Daniel, Charvat, Trevor, Pennell, Andrew, Zhang, Penglie, Schall, Thomas, Bekker, Pirow
Published in The American journal of gastroenterology (01.10.2014)
Published in The American journal of gastroenterology (01.10.2014)
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Journal Article
GLOMERULONEPHRITIDES
Jayne, D. R. W., Bruchfeld, A., Schaier, M., Ciechanowski, K., Harper, L., Jadoul, M., Segelmark, M., Selga, D., Szombati, I., Venning, M., Hamilton, P., Hugo, C., Van Daele, P. L. A., Viklicky, O., Potarca, A., Schall, T. J., Bekker, P., Loirat, C., Legendre, C. M., Ogawa, M., Bedrosian, C. L., Kincaid, J. F., Fakhouri, F., Guillevin, L., Karras, A., Pagnoux, C., Carron, P.-L., Quemeneur, T., Gobert, P., Daugas, E., Mouthon, L., Whatmough, S., Fernandez, S., Sweeney, N., Dhaygude, A., Rathi, M., Goyal, A., Gupta, P. K., Jaryal, A., Sharma, A., Jha, V., Ramachandran, R., Kumar, V., Kohli, H. S., Gupta, K. L., Sakhuja, V.
Published in Nephrology, dialysis, transplantation (01.05.2014)
Published in Nephrology, dialysis, transplantation (01.05.2014)
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Conference Proceeding