AcrB: a mean, keen, drug efflux machine
Kobylka, Jessica, Kuth, Miriam S., Müller, Reinke T., Geertsma, Eric R., Pos, Klaas M.
Published in Annals of the New York Academy of Sciences (01.01.2020)
Published in Annals of the New York Academy of Sciences (01.01.2020)
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Journal Article
Allosteric drug transport mechanism of multidrug transporter AcrB
Tam, Heng-Keat, Foong, Wuen Ee, Oswald, Christine, Herrmann, Andrea, Zeng, Hui, Pos, Klaas M.
Published in Nature communications (29.06.2021)
Published in Nature communications (29.06.2021)
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Journal Article
Structure, mechanism and cooperation of bacterial multidrug transporters
Du, Dijun, van Veen, Hendrik W, Murakami, Satoshi, Pos, Klaas M, Luisi, Ben F
Published in Current opinion in structural biology (01.08.2015)
Published in Current opinion in structural biology (01.08.2015)
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Journal Article
Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives
Sjuts, Hanno, Vargiu, Attilio V., Kwasny, Steven M., Nguyen, Son T., Kim, Hong-Suk, Ding, Xiaoyuan, Ornik, Alina R., Ruggerone, Paolo, Bowlin, Terry L., Nikaido, Hiroshi, Pos, Klaas M., Opperman, Timothy J.
Published in Proceedings of the National Academy of Sciences - PNAS (29.03.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (29.03.2016)
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Journal Article
Tripartite assembly of RND multidrug efflux pumps
Daury, Laetitia, Orange, François, Taveau, Jean-Christophe, Verchère, Alice, Monlezun, Laura, Gounou, Céline, Marreddy, Ravi K. R., Picard, Martin, Broutin, Isabelle, Pos, Klaas M., Lambert, Olivier
Published in Nature communications (12.02.2016)
Published in Nature communications (12.02.2016)
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Journal Article
Binding and Transport of Carboxylated Drugs by the Multidrug Transporter AcrB
Tam, Heng-Keat, Malviya, Viveka N., Foong, Wuen-Ee, Herrmann, Andrea, Malloci, Giuliano, Ruggerone, Paolo, Vargiu, Attilio V., Pos, Klaas M.
Published in Journal of molecular biology (14.02.2020)
Published in Journal of molecular biology (14.02.2020)
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Journal Article
Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop
Eicher, Thomas, Cha, Hi-jea, Seeger, Markus A, Brandstätter, Lorenz, El-Delik, Jasmin, Bohnert, Jürgen A, Kern, Winfried V, Verrey, François, Grütter, Markus G, Diederichs, Kay, Pos, Klaas M
Published in Proceedings of the National Academy of Sciences - PNAS (10.04.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (10.04.2012)
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Journal Article
Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms
Ornik-Cha, Alina, Wilhelm, Julia, Kobylka, Jessica, Sjuts, Hanno, Vargiu, Attilio V., Malloci, Giuliano, Reitz, Julian, Seybert, Anja, Frangakis, Achilleas S., Pos, Klaas M.
Published in Nature communications (25.11.2021)
Published in Nature communications (25.11.2021)
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Journal Article
Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps
Plé, Coline, Tam, Heng-Keat, Vieira Da Cruz, Anais, Compagne, Nina, Jiménez-Castellanos, Juan-Carlos, Müller, Reinke T., Pradel, Elizabeth, Foong, Wuen Ee, Malloci, Giuliano, Ballée, Alexia, Kirchner, Moritz A., Moshfegh, Parisa, Herledan, Adrien, Herrmann, Andrea, Deprez, Benoit, Willand, Nicolas, Vargiu, Attilio Vittorio, Pos, Klaas M., Flipo, Marion, Hartkoorn, Ruben C.
Published in Nature communications (10.01.2022)
Published in Nature communications (10.01.2022)
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Journal Article
Structural characterization of the EmrAB-TolC efflux complex from E. coli
Yousefian, Narek, Ornik-Cha, Alina, Poussard, Sylvie, Decossas, Marion, Berbon, Melanie, Daury, Laetitia, Taveau, Jean-Christophe, Dupuy, Jean-William, Đorđević-Marquardt, Selena, Lambert, Olivier, Pos, Klaas M.
Published in Biochimica et biophysica acta. Biomembranes (01.01.2021)
Published in Biochimica et biophysica acta. Biomembranes (01.01.2021)
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Journal Article
Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB
Eicher, Thomas, Seeger, Markus A, Anselmi, Claudio, Zhou, Wenchang, Brandstätter, Lorenz, Verrey, François, Diederichs, Kay, Faraldo-Gómez, José D, Pos, Klaas M
Published in eLife (19.09.2014)
Published in eLife (19.09.2014)
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Journal Article
A natural prodrug activation mechanism in nonribosomal peptide synthesis
Reimer, Daniela, Pos, Klaas M, Thines, Marco, Grün, Peter, Bode, Helge B
Published in Nature chemical biology (18.09.2011)
Published in Nature chemical biology (18.09.2011)
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Journal Article
Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP
Nöll, Anne, Thomas, Christoph, Herbring, Valentina, Zollmann, Tina, Barth, Katja, Mehdipour, Ahmad Reza, Tomasiak, Thomas M., Brüchert, Stefan, Joseph, Benesh, Abele, Rupert, Oliéric, Vincent, Wang, Meitian, Diederichs, Kay, Hummer, Gerhard, Stroud, Robert M., Pos, Klaas M., Tampé, Robert
Published in Proceedings of the National Academy of Sciences - PNAS (24.01.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (24.01.2017)
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Journal Article
Dynamics of Intact MexAB-OprM Efflux Pump: Focusing on the MexA-OprM Interface
López, Cesar A., Travers, Timothy, Pos, Klaas M., Zgurskaya, Helen I., Gnanakaran, S.
Published in Scientific reports (28.11.2017)
Published in Scientific reports (28.11.2017)
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Journal Article
Switch Loop Flexibility Affects Substrate Transport of the AcrB Efflux Pump
Müller, Reinke T., Travers, Timothy, Cha, Hi-jea, Phillips, Joshua L., Gnanakaran, S., Pos, Klaas M.
Published in Journal of molecular biology (08.12.2017)
Published in Journal of molecular biology (08.12.2017)
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Journal Article