Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease
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Conference Proceeding
Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP
Malherbe, Pari, Kratochwil, Nicole, Mühlemann, Andreas, Zenner, Marie‐Thérèse, Fischer, Christophe, Stahl, Martin, Gerber, Paul R., Jaeschke, Georg, Porter, Richard H. P.
Published in Journal of neurochemistry (01.07.2006)
Published in Journal of neurochemistry (01.07.2006)
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Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity
Porter, Richard H P, Jaeschke, Georg, Spooren, Will, Ballard, Theresa M, Büttelmann, Bernd, Kolczewski, Sabine, Peters, Jens-Uwe, Prinssen, Eric, Wichmann, Jürgen, Vieira, Eric, Mühlemann, Andreas, Gatti, Silvia, Mutel, Vincent, Malherbe, Pari
Published in The Journal of pharmacology and experimental therapeutics (01.11.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2005)
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G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey
Kratochwil, Nicole A, Gatti-McArthur, Silvia, Hoener, Marius C, Lindemann, Lothar, Christ, Andreas D, Green, Luke G, Guba, Wolfgang, Martin, Rainer E, Malherbe, Pari, Porter, Richard H P, Slack, Jay P, Winnig, Marcel, Dehmlow, Henrietta, Grether, Uwe, Hertel, Cornelia, Narquizian, Robert, Panousis, Constantinos G, Kolczewski, Sabine, Steward, Lucinda
Published in Current topics in medicinal chemistry (01.08.2011)
Published in Current topics in medicinal chemistry (01.08.2011)
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Mutational Analysis and Molecular Modeling of the Binding Pocket of the Metabotropic Glutamate 5 Receptor Negative Modulator 2-Methyl-6-(phenylethynyl)-pyridine
Malherbe, Pari, Kratochwil, Nicole, Zenner, Marie-Thérèse, Piussi, Jenny, Diener, Catherine, Kratzeisen, Claudia, Fischer, Christophe, Porter, Richard H P
Published in Molecular pharmacology (01.10.2003)
Published in Molecular pharmacology (01.10.2003)
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Functional characterization of agonists at recombinant human 5‐HT2A, 5‐HT2B and 5‐HT2C receptors in CHO‐K1 cells
Porter, R H P, Benwell, K R, Lamb, H, Malcolm, C S, Allen, N H, Revell, D F, Adams, D R, Sheardown, M J
Published in British journal of pharmacology (01.09.1999)
Published in British journal of pharmacology (01.09.1999)
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Influence of the 5-HT6 Receptor on Acetylcholine Release in the Cortex: Pharmacological Characterization of 4-(2-Bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a Potent and Selective 5-HT6 Receptor Antagonist
Riemer, Claus, Borroni, Edilio, Levet-Trafit, Bernard, Martin, James R, Poli, Sonia, Porter, Richard H. P, Bös, Michael
Published in Journal of medicinal chemistry (27.03.2003)
Published in Journal of medicinal chemistry (27.03.2003)
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An Automated System for the Analysis of G Protein-Coupled Receptor Transmembrane Binding Pockets: Alignment, Receptor-Based Pharmacophores, and Their Application
Kratochwil, Nicole A, Malherbe, Pari, Lindemann, Lothar, Ebeling, Martin, Hoener, Marius C, Mühlemann, Andreas, Porter, Richard H. P, Stahl, Martin, Gerber, Paul R
Published in Journal of chemical information and modeling (01.09.2005)
Published in Journal of chemical information and modeling (01.09.2005)
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3,5-Disubstituted-4-hydroxyphenyls Linked to 3-Hydroxy-2-methyl- 4(1H)-pyridinone: Potent Inhibitors of Lipid Peroxidation and Cell Toxicity
Bebbington, David, Monck, Nathaniel J. T, Gaur, Suneel, Palmer, Alan M, Benwell, Karen, Harvey, Victoria, Malcolm, Craig S, Porter, Richard H. P
Published in Journal of medicinal chemistry (27.07.2000)
Published in Journal of medicinal chemistry (27.07.2000)
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Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists
Büttelmann, Bernd, Peters, Jens-Uwe, Ceccarelli, Simona, Kolczewski, Sabine, Vieira, Eric, Prinssen, Eric P., Spooren, Will, Schuler, Franz, Huwyler, Jörg, Porter, Richard H.P., Jaeschke, Georg
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
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Antagonists of the human adenosine A2A receptor. Part 1 Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives
GILLESPIE, Roger J, ADAMS, David R, JORDAN, Allan M, KNIGHT, Antony R, KNUTSEN, Lars J. S, LAWRENCE, Anthony, LERPINIERE, Joanne, MISRA, Anil, PORTER, Richard H. P, PRATT, Robert M, SHEPHERD, Robin, UPTON, Rebecca, BEBBINGTON, David, WARD, Simon E, WEISS, Scott M, WILLIAMSON, Douglas S, BENWELL, Karen, CLIFFE, Ian A, DAWSON, Claire E, DOURISH, Colin T, FLETCHER, Allan, GAUR, Suneel, GILES, Paul R
Published in Bioorganic & medicinal chemistry letters (01.05.2008)
Published in Bioorganic & medicinal chemistry letters (01.05.2008)
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Determination of key amino acids implicated in the actions of allosteric modulation by 3,3′-difluorobenzaldazine on rat mGlu5 receptors
Mühlemann, Andreas, Ward, Natalie A., Kratochwil, Nicole, Diener, Catherine, Fischer, Christophe, Stucki, Andy, Jaeschke, Georg, Malherbe, Pari, Porter, Richard H.P.
Published in European journal of pharmacology (04.01.2006)
Published in European journal of pharmacology (04.01.2006)
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Metabolite Identification via LC-SPE-NMR-MS of the In vitro Biooxidation Products of a Lead mGlu5 Allosteric Antagonist and Impact on the Improvement of Metabolic Stability in the Series
Ceccarelli, Simona M., Schlotterbeck, Götz, Boissin, Patrick, Binder, Martin, Buettelmann, Bernd, Hanlon, Steven, Jaeschke, Georg, Kolczewski, Sabine, Kupfer, Ernst, Peters, Jens-Uwe, Porter, Richard H. P., Prinssen, Eric P., Rueher, Marianne, Ruf, Iris, Spooren, Will, Stämpfli, Andreas, Vieira, Eric
Published in ChemMedChem (11.01.2008)
Published in ChemMedChem (11.01.2008)
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Characterization of (R,S)‐5,7‐di‐tert‐butyl‐3‐hydroxy‐3‐trifluoromethyl‐3H‐benzofuran‐2‐one as a positive allosteric modulator of GABAB receptors
Malherbe, P, Masciadri, R, Norcross, R D, Knoflach, F, Kratzeisen, C, Zenner, M‐T, Kolb, Y, Marcuz, A, Huwyler, J, Nakagawa, T, Porter, R H P, Thomas, A W, Wettstein, J G, Sleight, A J, Spooren, W, Prinssen, E P
Published in British journal of pharmacology (01.06.2008)
Published in British journal of pharmacology (01.06.2008)
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Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum
Greene, J G, Porter, R H, Eller, R V, Greenamyre, J T
Published in Journal of neurochemistry (01.09.1993)
Published in Journal of neurochemistry (01.09.1993)
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Identification of 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT2C receptor agonists
RÖVER, S, ADAMS, D. R, HEBEISEN, P, KENNETT, G. A, KNIGHT, A. R, MALCOLM, C. S, MATTEI, P, MISRA, A, MIZRAHI, J, MULLER, M, PORTER, R. H. P, RICHTER, H, BENARDEAU, A, TAYLOR, S, VICKERS, S. P, BENTLEY, J. M, BICKERDIKE, M. J, BOURSON, A, CLIFFE, I. A, COASSOLO, P, DAVIDSON, J. E. P, DOURISH, C. T
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
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Fat absorption in bile fistula man. A morphological and biochemical study
Porter, H P, Saunders, D R, Tytgat, G, Brunser, O, Rubin, C E
Published in Gastroenterology (New York, N.Y. 1943) (01.06.1971)
Published in Gastroenterology (New York, N.Y. 1943) (01.06.1971)
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