RNA-seq analyses reveal that cervical spinal cords and anterior motor neurons from amyotrophic lateral sclerosis subjects show reduced expression of mitochondrial DNA-encoded respiratory genes, and rhTFAM may correct this respiratory deficiency
Ladd, Amy C, Brohawn, David G, Thomas, Ravindar R, Keeney, Paula M, Berr, Stuart S, Khan, Shaharyar M, Portell, Francisco R, Shakenov, Meiram Zh, Antkowiak, Patrick F, Kundu, Bijoy, Tustison, Nicholas, Bennett, James P
Published in Brain research (15.07.2017)
Published in Brain research (15.07.2017)
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Mitochondrial gene therapy augments mitochondrial physiology in a Parkinson's disease cell model
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Published in Human gene therapy (01.08.2009)
Published in Human gene therapy (01.08.2009)
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Recombinant human mitochondrial transcription factor A stimulates mitochondrial biogenesis and ATP synthesis, improves motor function after MPTP, reduces oxidative stress and increases survival after endotoxin
Thomas, Ravindar R, Khan, Shaharyar M, Portell, Francisco R, Smigrodzki, Rafal M, Bennett, Jr, James P
Published in Mitochondrion (01.01.2011)
Published in Mitochondrion (01.01.2011)
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Recombinant mitochondrial transcription factor A with N-terminal mitochondrial transduction domain increases respiration and mitochondrial gene expression
Iyer, Shilpa, Thomas, Ravindar R, Portell, Francisco R, Dunham, Lisa D, Quigley, Caitlin K, Bennett, Jr, James P
Published in Mitochondrion (01.06.2009)
Published in Mitochondrion (01.06.2009)
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RhTFAM treatment stimulates mitochondrial oxidative metabolism and improves memory in aged mice
Thomas, Ravindar R, Khan, Shaharyar M, Smigrodzki, Rafal M, Onyango, Isaac G, Dennis, Jameel, Khan, Omer M, Portelli, Francisco R, Bennett, Jr, James P
Published in Aging (Albany, NY.) (30.09.2012)
Published in Aging (Albany, NY.) (30.09.2012)
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Manipulation of the mitochondrial genome to improve bioenergetics in human childhood disease models
Iyer⁎, Shilpa, Berquist, Kristen E., Portell, Francisco R., Miller, Bradley M., Arthur, Charles R., Dunham, Lisa D., Young, Kisha J., Khan, Shaharyar M., Bennett, James P.
Published in Mitochondrion (01.07.2011)
Published in Mitochondrion (01.07.2011)
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FRI-338-Mitochondrial uncoupler HU6 reduces hepatic oxidative stress in the DIAMOND (TM) mouse model, thus abrogating NASH development
Portell, Francisco, Eaton, Stephen, Dennis, Jameel, Caffrey, Rebecca, Marioneaux, Jonathon, Onyango, Isaac, Khan, Omer, Khan, Shaharyar, Sanyal, Arun
Published in Journal of hepatology (01.04.2019)
Published in Journal of hepatology (01.04.2019)
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5. Protein-mediated mtDNA Transfection (“Protofection®”) Increases Respiration and Mitochondrial DNA Gene Copy Numbers and Expression in G11778A LHON Cybrids
Iyer, Shilpa, Khan, Shaharyar, Portell, Francisco, Thomas, Ravindar, Borland, Kate, Quigley, Caitlin, Dunham, Lisa, Bennett, James P.
Published in Mitochondrion (01.02.2009)
Published in Mitochondrion (01.02.2009)
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Recombinant Mitochondrial Transcription Factor A with N-terminal Mitochondrial Transduction Domain Increases Respiration and Mitochondrial Gene Expression in G11778A Leber's Hereditary Optic Neuropathy Cybrid Cells
Iyer, Shilpa, Thomas, Ravindar, Portell, Francisco, Dunahm, Lisa, Quigley, Caitlin, Bennett, James
Published in Nature precedings (18.07.2008)
Published in Nature precedings (18.07.2008)
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