Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus
Whitesell, Luke, Robbins, Nicole, Huang, David S., McLellan, Catherine A., Shekhar-Guturja, Tanvi, LeBlanc, Emmanuelle V., Nation, Catherine S., Hui, Raymond, Hutchinson, Ashley, Collins, Cathy, Chatterjee, Sharanya, Trilles, Richard, Xie, Jinglin L., Krysan, Damian J., Lindquist, Susan, Porco, John A., Tatu, Utpal, Brown, Lauren E., Pizarro, Juan, Cowen, Leah E.
Published in Nature communications (24.01.2019)
Published in Nature communications (24.01.2019)
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The MYCN 5′ UTR as a therapeutic target in neuroblastoma
Volegova, Marina P., Brown, Lauren E., Banerjee, Ushashi, Dries, Ruben, Sharma, Bandana, Kennedy, Alyssa, Porco, John A., George, Rani E.
Published in Cell reports (Cambridge) (28.05.2024)
Published in Cell reports (Cambridge) (28.05.2024)
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Enantioselective Synthesis of the Complex Rocaglate (-)-Silvestrol
Gerard, Baudouin, Cencic, Regina, Pelletier, Jerry, Porco, John A. Jr
Published in Angewandte Chemie (International ed.) (01.01.2007)
Published in Angewandte Chemie (International ed.) (01.01.2007)
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Biomimetic Photocycloaddition of 3-Hydroxyflavones: Synthesis and Evaluation of Rocaglate Derivatives as Inhibitors of Eukaryotic Translation
Roche, Stéphane P, Cencic, Regina, Pelletier, Jerry, Porco, John A. Jr
Published in Angewandte Chemie (International ed.) (03.09.2010)
Published in Angewandte Chemie (International ed.) (03.09.2010)
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Journal Article
Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation
Itoua Maïga, Rayelle, Cencic, Regina, Chu, Jennifer, Waller, Daniel D., Brown, Lauren E., Devine, William G., Zhang, Wenhan, Sebag, Michael, Porco Jr, John A., Pelletier, Jerry
Published in Scientific reports (04.02.2019)
Published in Scientific reports (04.02.2019)
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Journal Article
Synthesis and Biological Evaluation of ABCD Ring Fragments of the Kibdelones
Sloman, David L, Mitasev, Branko, Scully, Stephen S, Beutler, John A, Porco, John A. Jr
Published in Angewandte Chemie (International ed.) (07.03.2011)
Published in Angewandte Chemie (International ed.) (07.03.2011)
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Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis
Kärkäs, Markus D, Porco, John A, Stephenson, Corey R. J
Published in Chemical reviews (14.09.2016)
Published in Chemical reviews (14.09.2016)
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Discovery of new antimalarial chemotypes through chemical methodology and library development
Brown, Lauren E, Chih-Chien Cheng, Ken, Wei, Wan-Guo, Yuan, Pingwei, Dai, Peng, Trilles, Richard, Ni, Feng, Yuan, Jing, MacArthur, Ryan, Guha, Rajarshi, Johnson, Ronald L, Su, Xin-zhuan, Dominguez, Melissa M, Snyder, John K, Beeler, Aaron B, Schaus, Scott E, Inglese, James, Porco, John A. Jr
Published in Proceedings of the National Academy of Sciences - PNAS (26.04.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (26.04.2011)
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Journal Article
Dearomatization Strategies in the Synthesis of Complex Natural Products
Roche, Stéphane P., Porco Jr, John A.
Published in Angewandte Chemie International Edition (26.04.2011)
Published in Angewandte Chemie International Edition (26.04.2011)
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Studies toward the Synthesis of (−)-Zampanolide: Preparation of the Macrocyclic Core
Troast, Dawn M., Yuan, Jiayi, Porco Jr, John A.
Published in Advanced synthesis & catalysis (04.08.2008)
Published in Advanced synthesis & catalysis (04.08.2008)
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Journal Article
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer
Wolfe, Andrew L., Singh, Kamini, Zhong, Yi, Drewe, Philipp, Rajasekhar, Vinagolu K., Sanghvi, Viraj R., Mavrakis, Konstantinos J., Jiang, Man, Roderick, Justine E., Van der Meulen, Joni, Schatz, Jonathan H., Rodrigo, Christina M., Zhao, Chunying, Rondou, Pieter, de Stanchina, Elisa, Teruya-Feldstein, Julie, Kelliher, Michelle A., Speleman, Frank, Porco, John A., Pelletier, Jerry, Rätsch, Gunnar, Wendel, Hans-Guido
Published in Nature (London) (04.09.2014)
Published in Nature (London) (04.09.2014)
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Journal Article
BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling
Shaashua, Lee, Ben-Shmuel, Aviad, Pevsner-Fischer, Meirav, Friedman, Gil, Levi-Galibov, Oshrat, Nandakumar, Subhiksha, Barki, Debra, Nevo, Reinat, Brown, Lauren E., Zhang, Wenhan, Stein, Yaniv, Lior, Chen, Kim, Han Sang, Bojmar, Linda, Jarnagin, William R., Lecomte, Nicolas, Mayer, Shimrit, Stok, Roni, Bishara, Hend, Hamodi, Rawand, Levy-Lahad, Ephrat, Golan, Talia, Porco, John A., Iacobuzio-Donahue, Christine A., Schultz, Nikolaus, Tuveson, David A., Lyden, David, Kelsen, David, Scherz-Shouval, Ruth
Published in Nature communications (31.10.2022)
Published in Nature communications (31.10.2022)
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Journal Article
CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A
Chu, Jennifer, Galicia-Vázquez, Gabriela, Cencic, Regina, Mills, John R., Katigbak, Alexandra, Porco, John A., Pelletier, Jerry
Published in Cell reports (Cambridge) (14.06.2016)
Published in Cell reports (Cambridge) (14.06.2016)
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Journal Article
Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F
Chu, Jennifer, Zhang, Wenhan, Cencic, Regina, O’Connor, Patrick B.F., Robert, Francis, Devine, William G., Selznick, Asher, Henkel, Thomas, Merrick, William C., Brown, Lauren E., Baranov, Pavel V., Porco, John A., Pelletier, Jerry
Published in Cell reports (Cambridge) (25.02.2020)
Published in Cell reports (Cambridge) (25.02.2020)
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