Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
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DNA methylation controls Foxp3 gene expression
Polansky, Julia K, Kretschmer, Karsten, Freyer, Jennifer, Floess, Stefan, Garbe, Annette, Baron, Udo, Olek, Sven, Hamann, Alf, von Boehmer, Harald, Huehn, Jochen
Published in European journal of immunology (01.06.2008)
Published in European journal of immunology (01.06.2008)
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Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development
Durek, Pawel, Nordström, Karl, Gasparoni, Gilles, Salhab, Abdulrahman, Kressler, Christopher, de Almeida, Melanie, Bassler, Kevin, Ulas, Thomas, Schmidt, Florian, Xiong, Jieyi, Glažar, Petar, Klironomos, Filippos, Sinha, Anupam, Kinkley, Sarah, Yang, Xinyi, Arrigoni, Laura, Amirabad, Azim Dehghani, Ardakani, Fatemeh Behjati, Feuerbach, Lars, Gorka, Oliver, Ebert, Peter, Müller, Fabian, Li, Na, Frischbutter, Stefan, Schlickeiser, Stephan, Cendon, Carla, Fröhler, Sebastian, Felder, Bärbel, Gasparoni, Nina, Imbusch, Charles D., Hutter, Barbara, Zipprich, Gideon, Tauchmann, Yvonne, Reinke, Simon, Wassilew, Georgi, Hoffmann, Ute, Richter, Andreas S., Sieverling, Lina, Chang, Hyun-Dong, Syrbe, Uta, Kalus, Ulrich, Eils, Jürgen, Brors, Benedikt, Manke, Thomas, Ruland, Jürgen, Lengauer, Thomas, Rajewsky, Nikolaus, Chen, Wei, Dong, Jun, Sawitzki, Birgit, Chung, Ho-Ryun, Rosenstiel, Philip, Schulz, Marcel H., Schultze, Joachim L., Radbruch, Andreas, Walter, Jörn, Hamann, Alf, Polansky, Julia K.
Published in Immunity (Cambridge, Mass.) (15.11.2016)
Published in Immunity (Cambridge, Mass.) (15.11.2016)
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A comprehensive analysis of 195 DNA methylomes reveals shared and cell-specific features of partially methylated domains
Salhab, Abdulrahman, Nordström, Karl, Gasparoni, Gilles, Kattler, Kathrin, Ebert, Peter, Ramirez, Fidel, Arrigoni, Laura, Müller, Fabian, Polansky, Julia K, Cadenas, Cristina, G Hengstler, Jan, Lengauer, Thomas, Manke, Thomas, Walter, Jörn
Published in Genome Biology (28.09.2018)
Published in Genome Biology (28.09.2018)
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Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4+ memory T cells
Truong, Kim-Long, Schlickeiser, Stephan, Vogt, Katrin, Boës, David, Stanko, Katarina, Appelt, Christine, Streitz, Mathias, Grütz, Gerald, Stobutzki, Nadja, Meisel, Christian, Iwert, Christina, Tomiuk, Stefan, Polansky, Julia K., Pascher, Andreas, Babel, Nina, Stervbo, Ulrik, Sauer, Igor, Gerlach, Undine, Sawitzki, Birgit
Published in Nature communications (22.05.2019)
Published in Nature communications (22.05.2019)
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Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression
Goldstein, Jérémie D, Burlion, Aude, Zaragoza, Bruno, Sendeyo, Kélhia, Polansky, Julia K, Huehn, Jochen, Piaggio, Eliane, Salomon, Benoit L, Marodon, Gilles
Published in PloS one (14.04.2016)
Published in PloS one (14.04.2016)
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reChIP-seq reveals widespread bivalency of H3K4me3 and H3K27me3 in CD4+ memory T cells
Kinkley, Sarah, Helmuth, Johannes, Polansky, Julia K., Dunkel, Ilona, Gasparoni, Gilles, Fröhler, Sebastian, Chen, Wei, Walter, Jörn, Hamann, Alf, Chung, Ho-Ryun
Published in Nature communications (17.08.2016)
Published in Nature communications (17.08.2016)
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Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus
Toker, Aras, Engelbert, Dirk, Garg, Garima, Polansky, Julia K, Floess, Stefan, Miyao, Takahisa, Baron, Udo, Düber, Sandra, Geffers, Robert, Giehr, Pascal, Schallenberg, Sonja, Kretschmer, Karsten, Olek, Sven, Walter, Jörn, Weiss, Siegfried, Hori, Shohei, Hamann, Alf, Huehn, Jochen
Published in The Journal of immunology (1950) (01.04.2013)
Published in The Journal of immunology (1950) (01.04.2013)
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Targeted De-Methylation of the FOXP3-TSDR Is Sufficient to Induce Physiological FOXP3 Expression but Not a Functional Treg Phenotype
Kressler, Christopher, Gasparoni, Gilles, Nordström, Karl, Hamo, Dania, Salhab, Abdulrahman, Dimitropoulos, Christoforos, Tierling, Sascha, Reinke, Petra, Volk, Hans-Dieter, Walter, Jörn, Hamann, Alf, Polansky, Julia K
Published in Frontiers in immunology (07.01.2021)
Published in Frontiers in immunology (07.01.2021)
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Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
Polansky, Julia K., Schreiber, Lisa, Thelemann, Christoph, Ludwig, Leif, Krüger, Melanie, Baumgrass, Ria, Cording, Sascha, Floess, Stefan, Hamann, Alf, Huehn, Jochen
Published in Journal of molecular medicine (Berlin, Germany) (01.10.2010)
Published in Journal of molecular medicine (Berlin, Germany) (01.10.2010)
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Epigenetic control of the foxp3 locus in regulatory T cells
Floess, Stefan, Freyer, Jennifer, Siewert, Christiane, Baron, Udo, Olek, Sven, Polansky, Julia, Schlawe, Kerstin, Chang, Hyun-Dong, Bopp, Tobias, Schmitt, Edgar, Klein-Hessling, Stefan, Serfling, Edgar, Hamann, Alf, Huehn, Jochen
Published in PLoS biology (01.02.2007)
Published in PLoS biology (01.02.2007)
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Foxp3 occupancy and regulation of key target genes during T-cell stimulation
von Boehmer, Harald, Young, Richard A, Marson, Alexander, Kretschmer, Karsten, Frampton, Garrett M, Jacobsen, Elizabeth S, Polansky, Julia K, MacIsaac, Kenzie D, Levine, Stuart S, Fraenkel, Ernest
Published in Nature (22.02.2007)
Published in Nature (22.02.2007)
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CD137+CD154- Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures
Nowak, Anna, Lock, Dominik, Bacher, Petra, Hohnstein, Thordis, Vogt, Katrin, Gottfreund, Judith, Giehr, Pascal, Polansky, Julia K, Sawitzki, Birgit, Kaiser, Andrew, Walter, Jörn, Scheffold, Alexander
Published in Frontiers in immunology (07.02.2018)
Published in Frontiers in immunology (07.02.2018)
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Single-cell profiling reveals age-associated immunity in atherosclerosis
Smit, Virginia, de Mol, Jill, Schaftenaar, Frank H, Depuydt, Marie A C, Postel, Rimke J, Smeets, Diede, Verheijen, Fenne W M, Bogers, Laurens, van Duijn, Janine, Verwilligen, Robin A F, Grievink, Hendrika W, Bernabé Kleijn, Mireia N A, van Ingen, Eva, de Jong, Maaike J M, Goncalves, Lauren, Peeters, Judith A H M, Smeets, Harm J, Wezel, Anouk, Polansky, Julia K, de Winther, Menno P J, Binder, Christoph J, Tsiantoulas, Dimitrios, Bot, Ilze, Kuiper, Johan, Foks, Amanda C
Published in Cardiovascular research (25.11.2023)
Published in Cardiovascular research (25.11.2023)
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The enhancer landscape predetermines the skeletal regeneration capacity of stromal cells
Hochmann, Sarah, Ou, Kristy, Poupardin, Rodolphe, Mittermeir, Michaela, Textor, Martin, Ali, Salaheddine, Wolf, Martin, Ellinghaus, Agnes, Jacobi, Dorit, Elmiger, Juri A J, Donsante, Samantha, Riminucci, Mara, Schäfer, Richard, Kornak, Uwe, Klein, Oliver, Schallmoser, Katharina, Schmidt-Bleek, Katharina, Duda, Georg N, Polansky, Julia K, Geissler, Sven, Strunk, Dirk
Published in Science translational medicine (22.03.2023)
Published in Science translational medicine (22.03.2023)
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Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction
Schmidt, Florian, Gasparoni, Nina, Gasparoni, Gilles, Gianmoena, Kathrin, Cadenas, Cristina, Polansky, Julia K, Ebert, Peter, Nordström, Karl, Barann, Matthias, Sinha, Anupam, Fröhler, Sebastian, Xiong, Jieyi, Dehghani Amirabad, Azim, Behjati Ardakani, Fatemeh, Hutter, Barbara, Zipprich, Gideon, Felder, Bärbel, Eils, Jürgen, Brors, Benedikt, Chen, Wei, Hengstler, Jan G, Hamann, Alf, Lengauer, Thomas, Rosenstiel, Philip, Walter, Jörn, Schulz, Marcel H
Published in Nucleic acids research (09.01.2017)
Published in Nucleic acids research (09.01.2017)
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Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases
Saggau, Carina, Bacher, Petra, Esser, Daniela, Rasa, Mahdi, Meise, Silja, Mohr, Nicola, Kohlstedt, Nora, Hutloff, Andreas, Schacht, Sarah-Sophie, Dargvainiene, Justina, Martini, Gabriela Rios, Stürner, Klarissa H., Schröder, Ina, Markewitz, Robert, Hartl, Johannes, Hastermann, Maria, Duchow, Ankelien, Schindler, Patrick, Becker, Mareike, Bautista, Carolin, Gottfreund, Judith, Walter, Jörn, Polansky, Julia K., Yang, Mingxing, Naghavian, Reza, Wendorff, Mareike, Schuster, Ev-Marie, Dahl, Andreas, Petzold, Andreas, Reinhardt, Susanne, Franke, Andre, Wieczorek, Marek, Henschel, Lea, Berger, Daniel, Heine, Guido, Holtsche, Maike, Häußler, Vivien, Peters, Christian, Schmidt, Enno, Fillatreau, Simon, Busch, Dirk H., Wandinger, Klaus-Peter, Schober, Kilian, Martin, Roland, Paul, Friedemann, Leypoldt, Frank, Scheffold, Alexander
Published in Immunity (Cambridge, Mass.) (08.10.2024)
Published in Immunity (Cambridge, Mass.) (08.10.2024)
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The life-saving benefit of dexamethasone in severe COVID-19 is linked to a reversal of monocyte dysregulation
Knoll, Rainer, Helbig, Elisa T., Dahm, Kilian, Bolaji, Olufemi, Hamm, Frederik, Dietrich, Oliver, van Uelft, Martina, Müller, Sophie, Bonaguro, Lorenzo, Schulte-Schrepping, Jonas, Petrov, Lev, Krämer, Benjamin, Kraut, Michael, Stubbemann, Paula, Thibeault, Charlotte, Brumhard, Sophia, Theis, Heidi, Hack, Gudrun, De Domenico, Elena, Nattermann, Jacob, Becker, Matthias, Beyer, Marc D., Hillus, David, Georg, Philipp, Loers, Constantin, Tiedemann, Janina, Tober-Lau, Pinkus, Lippert, Lena, Millet Pascual-Leone, Belén, Tacke, Frank, Rohde, Gernot, Suttorp, Norbert, Witzenrath, Martin, Saliba, Antoine-Emmanuel, Ulas, Thomas, Polansky, Julia K., Sawitzki, Birgit, Sander, Leif E., Schultze, Joachim L., Aschenbrenner, Anna C., Kurth, Florian
Published in Cell (08.08.2024)
Published in Cell (08.08.2024)
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Imprinting of Skin/Inflammation Homing in CD4+ T Cells Is Controlled by DNA Methylation within the Fucosyltransferase 7 Gene
Pink, Matthias, Ratsch, Boris A, Mardahl, Maibritt, Durek, Pawel, Polansky, Julia K, Karl, Martin, Baumgrass, Ria, Wallner, Stefan, Cadenas, Cristina, Gianmoena, Kathrin, Floess, Stefan, Chen, Wei, Nordstroem, Karl, Tierling, Sascha, Olek, Sven, Walter, Jörn, Hamann, Alf, Syrbe, Uta
Published in The Journal of immunology (1950) (15.10.2016)
Published in The Journal of immunology (1950) (15.10.2016)
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Strong Expansion of Human Regulatory T Cells for Adoptive Cell Therapy Results in Epigenetic Changes Which May Impact Their Survival and Function
Ou, Kristy, Hamo, Dania, Schulze, Anne, Roemhild, Andy, Kaiser, Daniel, Gasparoni, Gilles, Salhab, Abdulrahman, Zarrinrad, Ghazaleh, Amini, Leila, Schlickeiser, Stephan, Streitz, Mathias, Walter, Jörn, Volk, Hans-Dieter, Schmueck-Henneresse, Michael, Reinke, Petra, Polansky, Julia K.
Published in Frontiers in cell and developmental biology (18.11.2021)
Published in Frontiers in cell and developmental biology (18.11.2021)
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