Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri
Zhou, Wenxu, Debnath, Anjan, Jennings, Gareth, Hahn, Hye Jee, Vanderloop, Boden H, Chaudhuri, Minu, Nes, W David, Podust, Larissa M
Published in PLoS pathogens (01.09.2018)
Published in PLoS pathogens (01.09.2018)
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Targeting Ergosterol Biosynthesis in Leishmania donovani: Essentiality of Sterol 14alpha-demethylase
McCall, Laura-Isobel, Aroussi, Amale El, Choi, Jun Yong, Vieira, Debora F, De Muylder, Geraldine, Johnston, Jonathan B, Chen, Steven, Kellar, Danielle, Siqueira-Neto, Jair L, Roush, William R, Podust, Larissa M, McKerrow, James H
Published in PLoS neglected tropical diseases (01.03.2015)
Published in PLoS neglected tropical diseases (01.03.2015)
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Enzymatic hydroxylation of an unactivated methylene C-H bond guided by molecular dynamics simulations
Narayan, Alison R H, Jiménez-Osés, Gonzalo, Liu, Peng, Negretti, Solymar, Zhao, Wanxiang, Gilbert, Michael M, Ramabhadran, Raghunath O, Yang, Yun-Fang, Furan, Lawrence R, Li, Zhe, Podust, Larissa M, Montgomery, John, Houk, K N, Sherman, David H
Published in Nature chemistry (01.08.2015)
Published in Nature chemistry (01.08.2015)
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X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action
Parsonage, Derek, Sheng, Fang, Hirata, Ken, Debnath, Anjan, McKerrow, James H., Reed, Sharon L., Abagyan, Ruben, Poole, Leslie B., Podust, Larissa M.
Published in Journal of structural biology (01.05.2016)
Published in Journal of structural biology (01.05.2016)
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Journal Article
Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole
Chen, Chiung-Kuang, Leung, Siegfried S F, Guilbert, Christophe, Jacobson, Matthew P, McKerrow, James H, Podust, Larissa M
Published in PLoS neglected tropical diseases (01.04.2010)
Published in PLoS neglected tropical diseases (01.04.2010)
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Journal Article
CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)
Debnath, Anjan, Calvet, Claudia M, Jennings, Gareth, Zhou, Wenxu, Aksenov, Alexander, Luth, Madeline R, Abagyan, Ruben, Nes, W David, McKerrow, James H, Podust, Larissa M
Published in PLoS neglected tropical diseases (01.12.2017)
Published in PLoS neglected tropical diseases (01.12.2017)
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New Reactions and Products Resulting from Alternative Interactions between the P450 Enzyme and Redox Partners
Zhang, Wei, Liu, Yi, Yan, Jinyong, Cao, Shaona, Bai, Fali, Yang, Ying, Huang, Shaohua, Yao, Lishan, Anzai, Yojiro, Kato, Fumio, Podust, Larissa M, Sherman, David H, Li, Shengying
Published in Journal of the American Chemical Society (05.03.2014)
Published in Journal of the American Chemical Society (05.03.2014)
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Journal Article
Solution Conformations and Dynamics of Substrate-Bound Cytochrome P450 MycG
Tietz, Drew R., Podust, Larissa M., Sherman, David H., Pochapsky, Thomas C.
Published in Biochemistry (Easton) (30.05.2017)
Published in Biochemistry (Easton) (30.05.2017)
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Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against Trypanosoma cruzi
Barbosa Da Silva, Elany, Sharma, Vandna, Hernandez-Alvarez, Lilian, Tang, Arthur H, Stoye, Alexander, O’Donoghue, Anthony J, Gerwick, William H, Payne, Richard J, McKerrow, James H, Podust, Larissa M
Published in Journal of medicinal chemistry (10.03.2022)
Published in Journal of medicinal chemistry (10.03.2022)
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Journal Article
Miconazole-like Scaffold is a Promising Lead for Naegleria fowleri-Specific CYP51 Inhibitors
Sharma, Vandna, Madia, Valentina Noemi, Tudino, Valeria, Nguyen, Jennifer V., Debnath, Anjan, Messore, Antonella, Ialongo, Davide, Patacchini, Elisa, Palenca, Irene, Basili Franzin, Silvia, Seguella, Luisa, Esposito, Giuseppe, Petrucci, Rita, Di Matteo, Paola, Bortolami, Martina, Saccoliti, Francesco, Di Santo, Roberto, Scipione, Luigi, Costi, Roberta, Podust, Larissa M.
Published in Journal of medicinal chemistry (28.12.2023)
Published in Journal of medicinal chemistry (28.12.2023)
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4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection
Calvet, Claudia Magalhaes, Choi, Jun Yong, Thomas, Diane, Suzuki, Brian, Hirata, Ken, Lostracco-Johnson, Sharon, de Mesquita, Liliane Batista, Nogueira, Alanderson, Meuser-Batista, Marcelo, Silva, Tatiana Araujo, Siqueira-Neto, Jair Lage, Roush, William R, de Souza Pereira, Mirian Claudia, McKerrow, James H, Podust, Larissa M
Published in PLoS neglected tropical diseases (27.12.2017)
Published in PLoS neglected tropical diseases (27.12.2017)
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Essential Role of Loop Dynamics in Type II NRPS Biomolecular Recognition
Corpuz, Joshua C., Patel, Ashay, Davis, Tony D., Podust, Larissa M., McCammon, J. Andrew, Burkart, Michael D.
Published in ACS chemical biology (21.10.2022)
Published in ACS chemical biology (21.10.2022)
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Journal Article
Directing Group-Controlled Regioselectivity in an Enzymatic C–H Bond Oxygenation
Negretti, Solymar, Narayan, Alison R. H, Chiou, Karoline C, Kells, Petrea M, Stachowski, Jessica L, Hansen, Douglas A, Podust, Larissa M, Montgomery, John, Sherman, David H
Published in Journal of the American Chemical Society (02.04.2014)
Published in Journal of the American Chemical Society (02.04.2014)
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Journal Article
The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development
Ziniel, Peter D, Karumudi, Bhargava, Barnard, Andrew H, Fisher, Ethan M S, Thatcher, Gregory R J, Podust, Larissa M, Williams, David L
Published in PLoS neglected tropical diseases (01.12.2015)
Published in PLoS neglected tropical diseases (01.12.2015)
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Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease Mpro and Papain-like Protease PLpro of SARS-CoV‑2
Santos, Lucianna H., Kronenberger, Thales, Almeida, Renata G., Silva, Elany B., Rocha, Rafael E. O., Oliveira, Joyce C., Barreto, Luiza V., Skinner, Danielle, Fajtová, Pavla, Giardini, Miriam A., Woodworth, Brendon, Bardine, Conner, Lourenço, André L., Craik, Charles S., Poso, Antti, Podust, Larissa M., McKerrow, James H., Siqueira-Neto, Jair L., O’Donoghue, Anthony J., da Silva Júnior, Eufrânio N., Ferreira, Rafaela S.
Published in Journal of chemical information and modeling (26.12.2022)
Published in Journal of chemical information and modeling (26.12.2022)
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