Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530
Green, Tim P., Fennell, Mike, Whittaker, Robin, Curwen, Jon, Jacobs, Vivien, Allen, Jack, Logie, Armelle, Hargreaves, Judith, Hickinson, D. Mark, Wilkinson, Robert W., Elvin, Paul, Boyer, Brigitte, Carragher, Neil, Plé, Patrick A., Bermingham, Alun, Holdgate, Geoffrey A., Ward, Walter H.J., Hennequin, Laurent F., Davies, Barry R., Costello, Gerard F.
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Published in Molecular oncology (01.06.2009)
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N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a Novel, Highly Selective, Orally Available, Dual-Specific c-Src/Abl Kinase Inhibitor
Hennequin, Laurent F, Allen, Jack, Breed, Jason, Curwen, Jon, Fennell, Michael, Green, Tim P, Lambert-van der Brempt, Christine, Morgentin, Rémy, Norman, Richard A, Olivier, Annie, Otterbein, Ludovic, Plé, Patrick A, Warin, Nicolas, Costello, Gerard
Published in Journal of medicinal chemistry (02.11.2006)
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Investigation of (E)‑3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators
Degorce, Sébastien L, Bailey, Andrew, Callis, Rowena, De Savi, Chris, Ducray, Richard, Lamont, Gillian, MacFaul, Philip, Maudet, Mickael, Martin, Scott, Morgentin, Rémy, Norman, Richard A, Peru, Aurélien, Pink, Jennifer H, Plé, Patrick A, Roberts, Bryan, Scott, James S
Published in Journal of medicinal chemistry (23.04.2015)
Published in Journal of medicinal chemistry (23.04.2015)
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Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases
Plé, Patrick A., Jung, Frédéric, Ashton, Sue, Hennequin, Laurent, Laine, Romuald, Morgentin, Rémy, Pasquet, Georges, Taylor, Sian
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Discovery of a New Class of Anilinoquinazoline Inhibitors with High Affinity and Specificity for the Tyrosine Kinase Domain of c-Src
Plé, Patrick A, Green, Tim P, Hennequin, Laurent F, Curwen, Jon, Fennell, Michael, Allen, Jack, Lambert-van der Brempt, Christine, Costello, Gerard
Published in Journal of medicinal chemistry (12.02.2004)
Published in Journal of medicinal chemistry (12.02.2004)
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Novel 4-Anilinoquinazolines with C-7 Basic Side Chains: Design and Structure Activity Relationship of a Series of Potent, Orally Active, VEGF Receptor Tyrosine Kinase Inhibitors
Hennequin, Laurent F, Stokes, Elaine S. E, Thomas, Andrew P, Johnstone, Craig, Plé, Patrick A, Ogilvie, Donald J, Dukes, Michael, Wedge, Stephen R, Kendrew, Jane, Curwen, Jon O
Published in Journal of medicinal chemistry (14.03.2002)
Published in Journal of medicinal chemistry (14.03.2002)
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Correction to Investigation of (E)‑3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators
Degorce, Sébastien L, Bailey, Andrew, Callis, Rowena, De Savi, Chris, Ducray, Richard, Lamont, Gillian, MacFaul, Philip, Maudet, Mickael, Martin, Scott, Morgentin, Rémy, Norman, Richard A, Peru, Aurélien, Pink, Jennifer H, Plé, Patrick A, Roberts, Bryan, Scott, James S
Published in Journal of medicinal chemistry (14.04.2016)
Published in Journal of medicinal chemistry (14.04.2016)
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Discovery of new quinoline ether inhibitors with high affinity and selectivity for PDGFR tyrosine kinases
Plé, Patrick A., Jung, Frédéric, Ashton, Sue, Hennequin, Laurent, Laine, Romuald, Lambert-van der Brempt, Christine, Morgentin, Rémy, Pasquet, Georges, Taylor, Sian
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
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Design and Structure−Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors
Hennequin, Laurent F, Thomas, Andrew P, Johnstone, Craig, Stokes, Elaine S. E, Plé, Patrick A, Lohmann, Jean-Jacques M, Ogilvie, Donald J, Dukes, Mike, Wedge, Steve R, Curwen, Jon O, Kendrew, Jane, Lambert-van der Brempt, Christine
Published in Journal of medicinal chemistry (30.12.1999)
Published in Journal of medicinal chemistry (30.12.1999)
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Investigation of (E)-344-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators
Degorce, Sebastien L., Bailey, Andrew, Callis, Rowena, De Savi, Chris, Ducray, Richard, Lamontt, Gillian, MacFaul, Philip, Maudet, Mickael, Martin, Scott, Morgentin, Remy, Norman, Richard A., Peru, Aurelien, Pink, Jennifer H., Ple, Patrick A., Roberts, Bryan, Scott, James S.
Published in Journal of medicinal chemistry (23.04.2015)
Published in Journal of medicinal chemistry (23.04.2015)
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ChemInform Abstract: Discovery of AZD2932 (I), a New Quinazoline Ether Inhibitor with High Affinity for VEGFR-2 and PDGFR Tyrosine Kinases
Ple, Patrick A., Jung, Frederic, Ashton, Sue, Hennequin, Laurent, Laine, Romuald, Morgentin, Remy, Pasquet, Georges, Taylor, Sian
Published in ChemInform (15.05.2012)
Published in ChemInform (15.05.2012)
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