Search Results - "Plé, Patrick A" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a Novel, Highly Selective, Orally Available, Dual-Specific c-Src/Abl Kinase Inhibitor

N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a Novel, Highly Selective, Orally Available, Dual-Specific c-Src/Abl Kinase Inhibitor

by Hennequin, Laurent F, Allen, Jack, Breed, Jason, Curwen, Jon, Fennell, Michael, Green, Tim P, Lambert-van der Brempt, Christine, Morgentin, Rémy, Norman, Richard A, Olivier, Annie, Otterbein, Ludovic, Plé, Patrick A, Warin, Nicolas, Costello, Gerard
Published in Journal of medicinal chemistry (02.11.2006)

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Journal Article

Investigation of (E)‑3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

Investigation of (E)‑3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

by Degorce, Sébastien L, Bailey, Andrew, Callis, Rowena, De Savi, Chris, Ducray, Richard, Lamont, Gillian, MacFaul, Philip, Maudet, Mickael, Martin, Scott, Morgentin, Rémy, Norman, Richard A, Peru, Aurélien, Pink, Jennifer H, Plé, Patrick A, Roberts, Bryan, Scott, James S
Published in Journal of medicinal chemistry (23.04.2015)

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Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases

Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases

by Plé, Patrick A., Jung, Frédéric, Ashton, Sue, Hennequin, Laurent, Laine, Romuald, Morgentin, Rémy, Pasquet, Georges, Taylor, Sian
Published in Bioorganic & medicinal chemistry letters (01.01.2012)

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Discovery of a New Class of Anilinoquinazoline Inhibitors with High Affinity and Specificity for the Tyrosine Kinase Domain of c-Src

Discovery of a New Class of Anilinoquinazoline Inhibitors with High Affinity and Specificity for the Tyrosine Kinase Domain of c-Src

by Plé, Patrick A, Green, Tim P, Hennequin, Laurent F, Curwen, Jon, Fennell, Michael, Allen, Jack, Lambert-van der Brempt, Christine, Costello, Gerard
Published in Journal of medicinal chemistry (12.02.2004)

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Novel 4-Anilinoquinazolines with C-7 Basic Side Chains: Design and Structure Activity Relationship of a Series of Potent, Orally Active, VEGF Receptor Tyrosine Kinase Inhibitors

Novel 4-Anilinoquinazolines with C-7 Basic Side Chains: Design and Structure Activity Relationship of a Series of Potent, Orally Active, VEGF Receptor Tyrosine Kinase Inhibitors

by Hennequin, Laurent F, Stokes, Elaine S. E, Thomas, Andrew P, Johnstone, Craig, Plé, Patrick A, Ogilvie, Donald J, Dukes, Michael, Wedge, Stephen R, Kendrew, Jane, Curwen, Jon O
Published in Journal of medicinal chemistry (14.03.2002)

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Correction to Investigation of (E)‑3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

Correction to Investigation of (E)‑3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

by Degorce, Sébastien L, Bailey, Andrew, Callis, Rowena, De Savi, Chris, Ducray, Richard, Lamont, Gillian, MacFaul, Philip, Maudet, Mickael, Martin, Scott, Morgentin, Rémy, Norman, Richard A, Peru, Aurélien, Pink, Jennifer H, Plé, Patrick A, Roberts, Bryan, Scott, James S
Published in Journal of medicinal chemistry (14.04.2016)

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Discovery of new quinoline ether inhibitors with high affinity and selectivity for PDGFR tyrosine kinases

Discovery of new quinoline ether inhibitors with high affinity and selectivity for PDGFR tyrosine kinases

by Plé, Patrick A., Jung, Frédéric, Ashton, Sue, Hennequin, Laurent, Laine, Romuald, Lambert-van der Brempt, Christine, Morgentin, Rémy, Pasquet, Georges, Taylor, Sian
Published in Bioorganic & medicinal chemistry letters (01.05.2012)

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Design and Structure−Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors

Design and Structure−Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors

by Hennequin, Laurent F, Thomas, Andrew P, Johnstone, Craig, Stokes, Elaine S. E, Plé, Patrick A, Lohmann, Jean-Jacques M, Ogilvie, Donald J, Dukes, Mike, Wedge, Steve R, Curwen, Jon O, Kendrew, Jane, Lambert-van der Brempt, Christine
Published in Journal of medicinal chemistry (30.12.1999)

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Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530

Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530

by Green, Tim P., Fennell, Mike, Whittaker, Robin, Curwen, Jon, Jacobs, Vivien, Allen, Jack, Logie, Armelle, Hargreaves, Judith, Hickinson, D. Mark, Wilkinson, Robert W., Elvin, Paul, Boyer, Brigitte, Carragher, Neil, Plé, Patrick A., Bermingham, Alun, Holdgate, Geoffrey A., Ward, Walter H.J., Hennequin, Laurent F., Davies, Barry R., Costello, Gerard F.
Published in Molecular oncology (01.06.2009)

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A convergent synthesis of Mycophenolic acid

A convergent synthesis of Mycophenolic acid

by Plé, Patrick A., Hamon, Annie, Jones, Geraint
Published in Tetrahedron (03.03.1997)

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Investigation of (E)-344-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

Investigation of (E)-344-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

by Degorce, Sebastien L., Bailey, Andrew, Callis, Rowena, De Savi, Chris, Ducray, Richard, Lamontt, Gillian, MacFaul, Philip, Maudet, Mickael, Martin, Scott, Morgentin, Remy, Norman, Richard A., Peru, Aurelien, Pink, Jennifer H., Ple, Patrick A., Roberts, Bryan, Scott, James S.
Published in Journal of medicinal chemistry (23.04.2015)

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Enantioselective syntheses of (+)- and (-)-conduritol C from benzene via microbial oxidation and enzymatic asymmetrization

Enantioselective syntheses of (+)- and (-)-conduritol C from benzene via microbial oxidation and enzymatic asymmetrization

by JOHNSON, C. R, PLE, P. A, ADAMS, J. P
Published in Journal of the Chemical Society. Chemical communications (1991)

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ChemInform Abstract: Discovery of AZD2932 (I), a New Quinazoline Ether Inhibitor with High Affinity for VEGFR-2 and PDGFR Tyrosine Kinases

ChemInform Abstract: Discovery of AZD2932 (I), a New Quinazoline Ether Inhibitor with High Affinity for VEGFR-2 and PDGFR Tyrosine Kinases

by Ple, Patrick A., Jung, Frederic, Ashton, Sue, Hennequin, Laurent, Laine, Romuald, Morgentin, Remy, Pasquet, Georges, Taylor, Sian
Published in ChemInform (15.05.2012)

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Oximes: A new class of methoxytetrahydropyranyl inhibitors of leukotriene biosynthesis with high in vitro and in vivo potency

Oximes: A new class of methoxytetrahydropyranyl inhibitors of leukotriene biosynthesis with high in vitro and in vivo potency

by Plé, Patrick A., Geoffrey, T., Bird, C.
Published in Bioorganic & medicinal chemistry letters (23.01.1996)

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ENANTIOSELECTIVE SYNTHESES OF CONDURAMINES FROM BENZENE BY MICROBIAL OXIDATION, ENZYMATIC ASYMMETRIZATION AND RESOLUTION IN ORGANIC MEDIA

ENANTIOSELECTIVE SYNTHESES OF CONDURAMINES FROM BENZENE BY MICROBIAL OXIDATION, ENZYMATIC ASYMMETRIZATION AND RESOLUTION IN ORGANIC MEDIA

by JOHNSON, CR, PLE, PA, LIN, S, HEEG, MJ, ADAMS, JP
Published in Synlett (01.05.1992)

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CHROMENONE COMPOUNDS AS PI 3 -KINASE INHIBITORS FOR THE TREATMENT OF CANCER PI3

CHROMENONE COMPOUNDS AS PI 3 -KINASE INHIBITORS FOR THE TREATMENT OF CANCER PI3

by LAMBERT-VAN DER BREMPT, Christine Marie Paul, LOHMANN, Jean-Jacques Marcel, PLE, Patrick, DEGORCE, Sebastien Louis, BARLAAM, Bernard, Christophe
Year of Publication 03.10.2014

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Patent

Impeller for centrifugal pump

Impeller for centrifugal pump

by PLE PATRICK, SCHARN THORSTEN
Year of Publication 22.12.2023

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Patent

Quinazoline derivatives as SRC tyrosine kinase inhibitors

Quinazoline derivatives as SRC tyrosine kinase inhibitors

by PLE PATRICK
Year of Publication 12.12.2007

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Patent

Quinazoline derivatives

Quinazoline derivatives

by PLE PATRICK, JUNG FREDERIC HENRI
Year of Publication 31.07.2013

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Patent

Quinazoline derivatives

Quinazoline derivatives

by PLE, PATRICK
Year of Publication 16.10.2004

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Patent