The pUL37 tegument protein guides alpha-herpesvirus retrograde axonal transport to promote neuroinvasion
Richards, Alexsia L, Sollars, Patricia J, Pitts, Jared D, Stults, Austin M, Heldwein, Ekaterina E, Pickard, Gary E, Smith, Gregory A
Published in PLoS pathogens (07.12.2017)
Published in PLoS pathogens (07.12.2017)
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Journal Article
GNF-2 Inhibits Dengue Virus by Targeting Abl Kinases and the Viral E Protein
Clark, Margaret J., Miduturu, Chandra, Schmidt, Aaron G., Zhu, Xuling, Pitts, Jared D., Wang, Jinhua, Potisopon, Supanee, Zhang, Jianming, Wojciechowski, Amy, Hann Chu, Justin Jang, Gray, Nathanael S., Yang, Priscilla L.
Published in Cell chemical biology (21.04.2016)
Published in Cell chemical biology (21.04.2016)
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Journal Article
Antiviral activity of N-(4-hydroxyphenyl) retinamide (4-HPR) against Zika virus
Pitts, Jared D., Li, Pi-Chun, de Wispelaere, Melissanne, Yang, Priscilla L.
Published in Antiviral research (01.11.2017)
Published in Antiviral research (01.11.2017)
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Journal Article
Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells
Li, Ruidong, Liclican, Albert, Xu, Yili, Pitts, Jared, Niu, Congrong, Zhang, Jingyu, Kim, Cynthia, Zhao, Xiaofeng, Soohoo, Daniel, Babusis, Darius, Yue, Qin, Ma, Bin, Murray, Bernard P, Subramanian, Raju, Xie, Xuping, Zou, Jing, Bilello, John P, Li, Li, Schultz, Brian E, Sakowicz, Roman, Smith, Bill J, Shi, Pei-Yong, Murakami, Eisuke, Feng, Joy Y
Published in Antimicrobial agents and chemotherapy (17.08.2021)
Published in Antimicrobial agents and chemotherapy (17.08.2021)
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Journal Article
Structure of anellovirus-like particles reveal a mechanism for immune evasion
Liou, Shu-hao, Boggavarapu, Rajendra, Cohen, Noah R., Zhang, Yue, Sharma, Ishwari, Zeheb, Lynn, Mukund Acharekar, Nidhi, Rodgers, Hillary D., Islam, Saadman, Pitts, Jared, Arze, Cesar, Swaminathan, Harish, Yozwiak, Nathan, Ong, Tuyen, Hajjar, Roger J., Chang, Yong, Swanson, Kurt A., Delagrave, Simon
Published in Nature communications (22.08.2024)
Published in Nature communications (22.08.2024)
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Journal Article
Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein
de Wispelaere, Melissanne, Lian, Wenlong, Potisopon, Supanee, Li, Pi-Chun, Jang, Jaebong, Ficarro, Scott B., Clark, Margaret J., Zhu, Xuling, Kaplan, Jenifer B., Pitts, Jared D., Wales, Thomas E., Wang, Jinhua, Engen, John R., Marto, Jarrod A., Gray, Nathanael S., Yang, Priscilla L.
Published in Cell chemical biology (16.08.2018)
Published in Cell chemical biology (16.08.2018)
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Journal Article
Small Molecules Targeting the Flavivirus E Protein with Broad-Spectrum Activity and Antiviral Efficacy in Vivo
Li, Pi-Chun, Jang, Jaebong, Hsia, Chih-Yun, Groomes, Patrice V, Lian, Wenlong, de Wispelaere, Melissanne, Pitts, Jared D, Wang, Jinhua, Kwiatkowski, Nicholas, Gray, Nathanael S, Yang, Priscilla L
Published in ACS infectious diseases (08.03.2019)
Published in ACS infectious diseases (08.03.2019)
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Journal Article
Sialyltransferase regulates nervous system function in Drosophila
Repnikova, Elena, Koles, Kate, Nakamura, Michiko, Pitts, Jared, Li, Haiwen, Ambavane, Apoorva, Zoran, Mark J, Panin, Vladislav M
Published in The Journal of neuroscience (05.05.2010)
Published in The Journal of neuroscience (05.05.2010)
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Journal Article
Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice
Pruijssers, Andrea J., George, Amelia S., Schäfer, Alexandra, Leist, Sarah R., Gralinksi, Lisa E., Dinnon, Kenneth H., Yount, Boyd L., Agostini, Maria L., Stevens, Laura J., Chappell, James D., Lu, Xiaotao, Hughes, Tia M., Gully, Kendra, Martinez, David R., Brown, Ariane J., Graham, Rachel L., Perry, Jason K., Du Pont, Venice, Pitts, Jared, Ma, Bin, Babusis, Darius, Murakami, Eisuke, Feng, Joy Y., Bilello, John P., Porter, Danielle P., Cihlar, Tomas, Baric, Ralph S., Denison, Mark R., Sheahan, Timothy P.
Published in Cell Reports (21.07.2020)
Published in Cell Reports (21.07.2020)
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Web Resource
Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants
Pitts, Jared, Li, Jiani, Perry, Jason K, Du Pont, Venice, Riola, Nicholas, Rodriguez, Lauren, Lu, Xianghan, Kurhade, Chaitanya, Xie, Xuping, Camus, Gregory, Manhas, Savrina, Martin, Ross, Shi, Pei-Yong, Cihlar, Tomas, Porter, Danielle P, Mo, Hongmei, Maiorova, Evguenia, Bilello, John P
Published in Antimicrobial agents and chemotherapy (21.06.2022)
Published in Antimicrobial agents and chemotherapy (21.06.2022)
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Journal Article
Anellovirus Structure Reveals a Mechanism for Immune Evasion
Swanson, Kurt A, Shu-Hao Liou, Delagrave, Simon, Hajiar, Roger, Chang, Yong, Yozwiak, Nathan, Ong, Tuyen, Rodgers, Hillary, Cohen, Noah, Zhang, Yue, Acharekar, Nidhi Mukund, Islam, Saadman, Zaheb, Lynn, Arze, Cesar, Swaminathan, Harish, Pitts, Jared
Published in bioRxiv (02.07.2022)
Published in bioRxiv (02.07.2022)
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Paper
Prodrugs of a 1′-CN-4-Aza-7,9-dideazaadenosine C‑Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV
Mackman, Richard L, Hui, Hon C, Perron, Michel, Murakami, Eisuke, Palmiotti, Christopher, Lee, Gary, Stray, Kirsten, Zhang, Lijun, Goyal, Bindu, Chun, Kwon, Byun, Daniel, Siegel, Dustin, Simonovich, Scott, Du Pont, Venice, Pitts, Jared, Babusis, Darius, Vijjapurapu, Arya, Lu, Xianghan, Kim, Cynthia, Zhao, Xiaofeng, Chan, Julie, Ma, Bin, Lye, Diane, Vandersteen, Adelle, Wortman, Sarah, Barrett, Kimberly T, Toteva, Maria, Jordan, Robert, Subramanian, Raju, Bilello, John P, Cihlar, Tomas
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Journal Article
Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection
Vermillion, Meghan S, Murakami, Eisuke, Ma, Bin, Pitts, Jared, Tomkinson, Adrian, Rautiola, Davin, Babusis, Darius, Irshad, Hammad, Seigel, Dustin, Kim, Cynthia, Zhao, Xiaofeng, Niu, Congrong, Yang, Jesse, Gigliotti, Andrew, Kadrichu, Nani, Bilello, John P, Ellis, Scott, Bannister, Roy, Subramanian, Raju, Smith, Bill, Mackman, Richard L, Lee, William A, Kuehl, Philip J, Hartke, Jim, Cihlar, Tomas, Porter, Danielle P
Published in Science translational medicine (23.02.2022)
Published in Science translational medicine (23.02.2022)
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Journal Article
Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys
Mackman, Richard L., Kalla, Rao V., Babusis, Darius, Pitts, Jared, Barrett, Kimberly T., Chun, Kwon, Du Pont, Venice, Rodriguez, Lauren, Moshiri, Jasmine, Xu, Yili, Lee, Michael, Lee, Gary, Bleier, Blake, Nguyen, Anh-Quan, O’Keefe, B. Michael, Ambrosi, Andrea, Cook, Meredith, Yu, Joy, Dempah, Kassibla Elodie, Bunyan, Elaine, Riola, Nicholas C., Lu, Xianghan, Liu, Renmeng, Davie, Ashley, Hsiang, Tien-Ying, Dearing, Justin, Vermillion, Meghan, Gale, Michael, Niedziela-Majka, Anita, Feng, Joy Y., Hedskog, Charlotte, Bilello, John P., Subramanian, Raju, Cihlar, Tomas
Published in Journal of medicinal chemistry (14.09.2023)
Published in Journal of medicinal chemistry (14.09.2023)
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Journal Article
Mechanism and spectrum of inhibition of a 4′-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses
Gordon, Calvin J., Walker, Simon M., Tchesnokov, Egor P., Kocincova, Dana, Pitts, Jared, Siegel, Dustin S., Perry, Jason K., Feng, Joy Y., Bilello, John P., Götte, Matthias
Published in The Journal of biological chemistry (01.08.2024)
Published in The Journal of biological chemistry (01.08.2024)
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Journal Article
Identification of small molecule inhibitors targeting the Zika virus envelope protein
Pitts, Jared, Hsia, Chih-Yun, Lian, Wenlong, Wang, Jinhua, Pfeil, Marc-Philipp, Kwiatkowski, Nicholas, Li, Zhengnian, Jang, Jaebong, Gray, Nathanael S., Yang, Priscilla L.
Published in Antiviral research (01.04.2019)
Published in Antiviral research (01.04.2019)
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Journal Article
Intravenous delivery of GS-441524 is efficacious in the African green monkey model of SARS-CoV-2 infection
Pitts, Jared, Babusis, Darius, Vermillion, Meghan S., Subramanian, Raju, Barrett, Kim, Lye, Diane, Ma, Bin, Zhao, Xiaofeng, Riola, Nicholas, Xie, Xuping, Kajon, Adriana, Lu, Xianghan, Bannister, Roy, Shi, Pei-Yong, Toteva, Maria, Porter, Danielle P., Smith, Bill J., Cihlar, Tomas, Mackman, Richard, Bilello, John P.
Published in Antiviral research (01.07.2022)
Published in Antiviral research (01.07.2022)
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