Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agents
Gangjee, Aleem, Li, Wei, Kisliuk, Roy L, Cody, Vivian, Pace, Jim, Piraino, Jennifer, Makin, Jennifer
Published in Journal of medicinal chemistry (13.08.2009)
Published in Journal of medicinal chemistry (13.08.2009)
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Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3- d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors
Zhang, Xin, Zhou, Xilin, Kisliuk, Roy L., Piraino, Jennifer, Cody, Vivian, Gangjee, Aleem
Published in Bioorganic & medicinal chemistry (01.06.2011)
Published in Bioorganic & medicinal chemistry (01.06.2011)
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Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes
Cody, Vivian, Pace, Jim, Makin, Jennifer, Piraino, Jennifer, Queener, Sherry F, Rosowsky, Andre
Published in Biochemistry (Easton) (03.03.2009)
Published in Biochemistry (Easton) (03.03.2009)
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Abstract 2676: Unusual binding of TMP in two different sites in the binary complex with the Q35S/N64F double mutant of human dihydrofolate reductase
Cody, Vivian, Piraino, Jennifer, Pace, James, Queener, Sherry F.
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase
Cody, Vivian, Piraino, Jennifer, Pace, Jim, Li, Wei, Gangjee, Aleem
Published in Acta crystallographica. Section D, Biological crystallography. (01.12.2010)
Published in Acta crystallographica. Section D, Biological crystallography. (01.12.2010)
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