Synthesis of Highly Functionalized 4-Iodo-7-azaindazoles via Condensation/Diels-Alder/Retro-Diels-Alder Cyclization of Iodoalkynones and 2-Hydrazineylpyrimidines
Swift, Elizabeth C., Sales, Zachary S., Wu, Dongpei, Matviitsuk, Anastassia, Pippel, Daniel J., Lebold, Terry P.
Published in Organic letters (08.12.2023)
Published in Organic letters (08.12.2023)
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Blue Light-Mediated, Photocatalyst-Free Decarboxylative Alkylation of Heteroaryl Sulfinimines
Zhou, Zhe, Sales, Zachary S., Pippel, Daniel J., Qian, Michael, Martin, Connor L.
Published in Journal of organic chemistry (04.11.2022)
Published in Journal of organic chemistry (04.11.2022)
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Design, Synthesis, and Preclinical Evaluation of 3‑Methyl-6-(5-thiophenyl)-1,3-dihydro-imidazo[4,5‑b]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treatment of Mood Disorders
Chrovian, Christa C, Soyode-Johnson, Akinola, Stenne, Brice, Pippel, Daniel J, Schoellerman, Jeffrey, Lord, Brian, Needham, Alexandra S, Xia, Chungfang, Coe, Kevin J, Sepassi, Kia, Schoetens, Freddy, Scott, Brian, Nguyen, Leslie, Jiang, Xiaohui, Koudriakova, Tatiana, Balana, Bartosz, Letavic, Michael A
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Novel Octahydropyrrolo[3,4‑c]pyrroles Are Selective Orexin‑2 Antagonists: SAR Leading to a Clinical Candidate
Letavic, Michael A., Bonaventure, Pascal, Carruthers, Nicholas I., Dugovic, Christine, Koudriakova, Tatiana, Lord, Brian, Lovenberg, Timothy W., Ly, Kiev S., Mani, Neelakandha S., Nepomuceno, Diane, Pippel, Daniel J., Rizzolio, Michele, Shelton, Jonathan E., Shah, Chandra R., Shireman, Brock T., Young, Lana K., Yun, Sujin
Published in Journal of medicinal chemistry (23.07.2015)
Published in Journal of medicinal chemistry (23.07.2015)
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Temperature- and Electrophile-Dependent Stereocontrol: A Structural and Mechanistic Investigation of (−)-Sparteine-Mediated Asymmetric Lithiation−Substitution Sequences of N-Boc-N-(p-Methoxyphenyl)cinnamylamine
Weisenburger, Gerald A, Faibish, Neil C, Pippel, Daniel J, Beak, Peter
Published in Journal of the American Chemical Society (20.10.1999)
Published in Journal of the American Chemical Society (20.10.1999)
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Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin‑1 Antagonists: Discovery of JNJ-54717793
Préville, Cathy, Bonaventure, Pascal, Koudriakova, Tatiana, Lord, Brian, Nepomuceno, Diane, Rizzolio, Michele, Mani, Neelakandha, Coe, Kevin J, Ndifor, Anthony, Dugovic, Christine, Dvorak, Curt A, Coate, Heather, Pippel, Daniel J, Fitzgerald, Anne, Allison, Brett, Lovenberg, Timothy W, Carruthers, Nicholas I, Shireman, Brock T
Published in ACS medicinal chemistry letters (08.10.2020)
Published in ACS medicinal chemistry letters (08.10.2020)
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Lead Optimization of 5‑Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ‑8
Ravula, Suchitra, Savall, Brad M, Wu, Nyantsz, Lord, Brian, Coe, Kevin, Wang, Kai, Seierstad, Mark, Swanson, Devin M, Ziff, Jeannie, Nguyen, Minh, Leung, Perry, Rynberg, Ray, La, David, Pippel, Daniel J, Koudriakova, Tatiana, Lovenberg, Timothy W, Carruthers, Nicholas I, Maher, Michael P, Ameriks, Michael K
Published in ACS medicinal chemistry letters (09.08.2018)
Published in ACS medicinal chemistry letters (09.08.2018)
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Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: Synthesis and preliminary SAR analysis
Gomez, Laurent, Hack, Michael D., Wu, Jiejun, Wiener, John J.M., Venkatesan, Hari, Santillán, Alejandro, Pippel, Daniel J., Mani, Neelakandha, Morrow, Brian J., Motley, S. Timothy, Shaw, Karen Joy, Wolin, Ronald, Grice, Cheryl A., Jones, Todd K.
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
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Solid-State Structural Investigation of an Organolithium (−)-Sparteine Complex: η3-N-Boc-N-(p-methoxyphenyl)-3-phenylallyllithium⋅(−)-Sparteine
Pippel, Daniel J., Weisenburger, Gerald A., Wilson, Scott R., Beak, Peter
Published in Angewandte Chemie (International ed.) (02.10.1998)
Published in Angewandte Chemie (International ed.) (02.10.1998)
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NF-kB 유도 키나아제의 소분자 억제제
KREUTTER KEVIN D, CHAI WENYING, LEBSACK ALEC D, PIPPEL DANIEL J, HERRMANN AARON T, ROVIRA ALEXANDER R, HACK MICHAEL D, BARBAY J. KENT, ECCLES WENDY, JONES WILLIAM M, KRAWCZUK PAUL J, WOLIN RONALD L
Year of Publication 08.03.2022
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Year of Publication 08.03.2022
Patent
Mechanism of Electrophilic Chlorination: Experimental Determination of a Geometrical Requirement for Chlorine Transfer by the Endocyclic Restriction Test
Lee, Suk Joong, Terrazas, Michael S, Pippel, Daniel J, Beak, Peter
Published in Journal of the American Chemical Society (18.06.2003)
Published in Journal of the American Chemical Society (18.06.2003)
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Complex-Induced Proximity Effects: Stereoselective Carbon−Carbon Bond Formation in Chiral Auxiliary Mediated β-Lithiation−Substitution Sequences of β-Substituted Secondary Carboxamides
Pippel, Daniel J, Curtis, Michael D, Du, Hua, Beak, Peter
Published in Journal of organic chemistry (09.01.1998)
Published in Journal of organic chemistry (09.01.1998)
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On the coupling reaction of lithium azaenolates of chiral oxazolines with carbonyl compounds
Florio, Saverio, Capriati, Vito, Luisi, Renzo, Abbotto, Alessandro, Pippel, Daniel J
Published in Tetrahedron (30.07.2001)
Published in Tetrahedron (30.07.2001)
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34- DISUBSTITUTED OCTAHYDROPYRROLO[34-c]PYRROLES AS OREXIN RECEPTOR MODULATORS
SAVALL BRAD M, CHAI WENYING, SHAH CHANDRAVADAN R, LETAVIC MICHAEL A, LY KIEV S, PIPPEL DANIEL J, STOCKING EMILY M, SWANSON DEVIN M, RUDOLPH DALE A, STROTHER KATHLEEN C, SOYODE JOHNSON AKINOLA, SHIREMAN BROCK T
Year of Publication 11.12.2017
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Year of Publication 11.12.2017
Patent
34- DISUBSTITUTED OCTAHYDROPYRROLO[34-c]PYRROLES AS OREXIN RECEPTOR MODULATORS
SAVALL BRAD M, CHAI WENYING, SHAH CHANDRAVADAN R, LETAVIC MICHAEL A, LY KIEV S, PIPPEL DANIEL J, STOCKING EMILY M, SWANSON DEVIN M, RUDOLPH DALE A, STROTHER KATHLEEN C, SOYODE JOHNSON AKINOLA, SHIREMAN BROCK T
Year of Publication 08.12.2017
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Year of Publication 08.12.2017
Patent
Hindered Biaryl Bond Construction and Subsequent Diastereomeric Crystallization to Produce an Atropisomeric Covalent KRASG12C Inhibitor ARS-2102
Yang, Xiaogen, Li, Zhiwen, Xu, Wenwen, Zhu, Guanming, Feng, Xiantong, Zhang, Jun, Zhao, Hongbin, Chen, Yuyin, Kong, Jianshe, Mai, Wanping, Li, Lian-Sheng, Pippel, Daniel J., Ren, Pingda, Deng, Xiaohu
Published in Organic process research & development (20.01.2023)
Published in Organic process research & development (20.01.2023)
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Hindered Biaryl Bond Construction and Subsequent Diastereomeric Crystallization to Produce an Atropisomeric Covalent KRAS G12C Inhibitor ARS-2102
Yang, Xiaogen, Li, Zhiwen, Xu, Wenwen, Zhu, Guanming, Feng, Xiantong, Zhang, Jun, Zhao, Hongbin, Chen, Yuyin, Kong, Jianshe, Mai, Wanping, Li, Lian-Sheng, Pippel, Daniel J., Ren, Pingda, Deng, Xiaohu
Published in Organic process research & development (20.01.2023)
Published in Organic process research & development (20.01.2023)
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